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GPR

G-protein coupled receptors (GPRs) are a family of seven-transmembrane receptors, which play an important role in the response to peptide hormones, neurotransmitters, and free fatty acids.
Cat. No. Product name CAS No. Purity Chemical Structure
T15448 GW-1100 306974-70-9 98%
GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist.
T12778L RTI-13951-33 2244884-08-8 98%
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).
T12883 Fezagepras 1002101-19-0 98%
Setogepram is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84,with anti-inflammatory, anti-fibroticand anti-proliferative actions...
T11460 GPR4 antagonist 1 1197879-16-5 98%
GPR4 antagonist 1 is a GPR4 antagonist (IC50: 189 nM).
T62420 P2Y2R/GPR17 antagonist 1 2395016-49-4 98%
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist. P2Y2R/GPR17 antagonist 1 shows IC50 values of 3.17 µM and 1.67 µM against P2Y2R and...
T15283 Firuglipel 1371591-51-3 98%
Firuglipel is an orally available and selective agonist of GPR119.
TQ0051 MK-7246 1218918-62-7 98%
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
T7359 CAY10471 Racemate 844639-57-2 98%
CAY 10471 is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and...
T5406 SNAP 94847 487051-12-7 98%
SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake i...
T10507 GPR40 Agonist 2 1147729-48-3 98%
GPR40 Agonist 2 is a GPR40 agonist extracted from patent WO2009054479A1. It can be used in the research of diabetes.
T14202 AM-4668 1011531-27-3 98%
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respec...
TQ0241 TUG-770 1402601-82-4 98%
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
T12375 Fezagepras sodium 1254472-97-3 98%
Setogepram sodium salt is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-prolif...
T2351L TAK-875 Hemihydrate 1374598-80-7 98%
TAK-875 is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid.
TP2166 Urotensin II, mouse TFA (9047-55-6 free base) TP2166 98%
Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.
T11462 GPR84 antagonist 8 1445846-30-9 98%
GPR84 antagonist 8 is a selective GPR84 antagonist.
T11044 Dihydromunduletone 674786-20-0 98%
Dihydromunduletone (DHM) is a carotenoid derivative and selective strong adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonists, does ...
T11452 GPR120 Agonist 1 1628448-77-0 98%
GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GP...
T14200 AM-1638 1142214-62-7 98%
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
T15388 GLPG0974 1391076-61-1 98%
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
GW-1100
T15448
GW-1100 is a selective antagonist of GPR40 (pIC50: 6.9). GW1100 also plays the role of a GPR40 inverse agonist.
RTI-13951-33
T12778L
RTI-13951-33 is an effective and brain-penetrant GPR88 agonist (EC50: 25 nM, in GPR88 cAMP functional assay).
Fezagepras
T12883
Setogepram is an orally active GPR40 agonist and is an antagonist or inverse agonist of GPR84,with anti-inflammatory, anti-fibroticand anti-proliferative actions...
GPR4 antagonist 1
T11460
GPR4 antagonist 1 is a GPR4 antagonist (IC50: 189 nM).
P2Y2R/GPR17 antagonist 1
T62420
P2Y2R/GPR17 antagonist 1 (Compound 14m) is a dual P2Y2R and GPR17 antagonist. P2Y2R/GPR17 antagonist 1 shows IC50 values of 3.17 µM and 1.67 µM against P2Y2R and...
Firuglipel
T15283
Firuglipel is an orally available and selective agonist of GPR119.
MK-7246
TQ0051
MK-7246 is a potent and specific CRTH2 antagonist (Ki: 2.5 nM).
CAY10471 Racemate
T7359
CAY 10471 is a potent, highly selective CRTH2/DP 2 receptor antagonist. CAY10471 binds to the human CRTH2/DP2, DP1, and TP receptors( Ki values of 0.6, 1200, and...
SNAP 94847
T5406
SNAP-94847 is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake i...
GPR40 Agonist 2
T10507
GPR40 Agonist 2 is a GPR40 agonist extracted from patent WO2009054479A1. It can be used in the research of diabetes.
AM-4668
T14202
AM-4668 is a type 2 diabetes GPR40 agonist. For GPR40, in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), the EC50s are 3.6 nM and 36 nM, respec...
TUG-770
TQ0241
TUG-770 is a highly potent agonist of free fatty acid receptor 1 (FFA1/GPR40, EC50: 6 nM for hFFA1).
Fezagepras sodium
T12375
Setogepram sodium salt is an orally active GPR40 agonist and is an antagonist or inverse agonist for GPR84, with anti-fibrotic, anti-inflammatory and anti-prolif...
TAK-875 Hemihydrate
T2351L
TAK-875 is a selective GPR40 agonist with EC50 of 14 nM, 400-fold more potent than oleic acid.
Urotensin II, mouse TFA (9047-55-6 free base)
TP2166
Urotensin II, mouse TFA is an endogenous ligand for the orphan GPR14 or SENR. It is a potent vasoconstrictor.
GPR84 antagonist 8
T11462
GPR84 antagonist 8 is a selective GPR84 antagonist.
Dihydromunduletone
T11044
Dihydromunduletone (DHM) is a carotenoid derivative and selective strong adhesion G protein-coupled receptor (aGPCR) (GPR56 and GPR114/ADGRG5) antagonists, does ...
GPR120 Agonist 1
T11452
GPR120 Agonist 1 is a selective GPR120 agonist. In GPR120 transfected HEK293 cells, GPR120 Agonist 1 displays good EC50 of 42 nM and 77 nM for human and mouse GP...
AM-1638
T14200
AM-1638 is a full agonist of GPR40/FFA1 (EC50: 0.16 μM).
GLPG0974
T15388
GLPG0974 is an antagonist of FFA2/GPR43 with IC50 of 9 nM.
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