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Results for "

nsclc

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    188
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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    TargetMol | Peptide_Products
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    TargetMol | Inhibitory_Antibodies
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    TargetMol | Isotope_Products
Leptomycin B
LMB, CI 940
T1573587081-35-4
Leptomycin B (LMB) is a potent inhibitor of the nuclear export of proteins and is a potent antifungal antibiotic blocking the eukaryotic cell cycle. Leptomycin B inactivates CRM1 exportin 1 by covalent modification at a cysteine residue.
  • $213
In Stock
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TargetMol | Inhibitor Hot
MRTX-1719
T402542630904-45-7
MRTX-1719 is a potent and selective inhibitor of the PRMT5 MTA complex with an IC50 value of <10 nM against PRMT5 MTAMTAPDELSDMA cell lines.
  • $172
In Stock
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TargetMol | Inhibitor Hot
Sotorasib
AMG-510
T86842296729-00-3
Sotorasib (AMG-510) is an orally active and selective covalent inhibitor of KRAS G12C. Sotorasib binds to the GDP state of the inactive conformation of KRAS G12C and inhibits KRAS and its downstream signaling. Sotorasib exhibits inhibitory activity against KRAS G12C mutant tumors.
  • $31
In Stock
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TargetMol | Inhibitor Hot
PF-06459988
T164921428774-45-1In house
PF-06459988 is a novel, effective, orally active, irreversible, and selective epidermal growth factor receptor (EGFR) mutant inhibitor. PF-06459988 has high efficiency and high affinity for EGFRs double mutants containing T790M, and has minimal activity against WT EGFR. PF-06459988 makes a candidate drug for the treatment of cancer.
  • $149
5 days
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iMDK
T9460881970-80-5In house
iMDK quarterhydrate is a potent PI3K inhibitor that inhibits the growth factor MDK (also known as midkine or MK). iMDK quarterhydrate synergistically inhibits non-small cell lung cancer (NSCLC) with MEK inhibitors without harming normal cells and mice.
  • $54
In Stock
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Pivanex
Pivalyloxymethyl butyrate, AN-9
T16545122110-53-6
Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis.
  • $35
In Stock
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Afatinib Dimaleate
BIBW2992, BIBW 2992MA2, Afatinib (BIBW2992) Dimaleate, Afatinib
T1773850140-73-7
Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the receptor tyrosine kinase (RTK) epidermal growth factor receptor (ErbB; EGFR) family, with antineoplastic activity.
  • $33
In Stock
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Triglycidyl isocyanurate
Tris(2,3-epoxypropyl) Isocyanurate, TGIC, TGI, Teroxirone
T224432451-62-9
Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry.
  • $29
In Stock
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Heptadecanoic acid
T4903506-12-7
Heptadecanoic acid is a fatty acid of exogenous (primarily ruminant) origin. Many odd length long chain amino acids are derived from the consumption of dairy fats (milk and meat). Heptadecanoic acid constitutes 0.61% of milk fat and 0.83% of ruminant me
  • $31
In Stock
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TNO155
Batoprotafib
T131761801765-04-7
TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity.
  • $91
In Stock
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TAS6417
T169961661854-97-2
Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor that uniquely binds to the ATP binding site of the EGFR hinge region with an IC50 value of 1.1-8.0 nM.
  • $89
In Stock
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Taletrectinib
DS-6051b, AB-106
T223181505515-69-4
Taletrectinib (AB-106) is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectively.
  • $68
In Stock
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Glumetinib
SCC244
T54141642581-63-2
Glumetinib (SCC244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).
  • $50
In Stock
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TargetMol | Inhibitor Sale
Almonertinib
HS-10296
T54621899921-05-1
Almonertinib (HS-10296) is an inhibitor specifically targeting EGFR activation mutations and the resistant EGFR T790M mutation, exhibiting limited activity against wild-type EGFR.
  • $91
In Stock
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Almonertinib hydrochloride
HS-10296 hydrochloride
T56752134096-03-8
Almonertinib hydrochloride (HS-10296 hydrochloride) is a small molecule inhibitor of EGFR-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.
  • $93
In Stock
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WZ8040
T67341214265-57-2
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
  • $40
In Stock
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Ramucirumab
T9929947687-13-0
Ramucirumab, a human VEGFR-2 antagonist, is used for the treatment of solid tumors.
  • $216
In Stock
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Polyporenic acid C
TN1153465-18-9
Polyporenic acid C shows inhibitory activity against human collagenase.
  • $64
In Stock
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QTY
TargetMol | Inhibitor Sale
Protohypericin
TN2108548-03-8
Protohypericin, a naphthodianthrone derivative found in the plant Hypericum perforatum, exhibits photocytotoxicity and is utilized in tumor necrosis targeted radiotherapy through its radioiodinated form.
  • $88
In Stock
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TargetMol | Inhibitor Sale
Olafertinib
RX-518, EGFR-IN-3, CK-101
TQ02551660963-42-7
Olafertinib (RX-518) is a novel mutant-selective, irreversible, orally available EGFR inhibitor. It can overcome T790M-mediated resistance in NSCLC.
  • $41
In Stock
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anti-NSCLC agent-1
T206126
anti-NSCLC agent-1 (compound 8dc) is an inhibitor of tyrosine kinase inhibitors (TKI), and demonstrates IC50 values of 0.05 μM in A549 cells and 0.09 μM in NCI-H441 cells. It exhibits anti-NSCLC activity by inhibiting colony formation, as well as cell migration and invasion.
  • Inquiry Price
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Lorlatinib
PF-6463922, PF-06463922, Loratinib
T30611454846-35-5
Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), with potential antineoplastic activity.
  • $30
In Stock
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TargetMol | Inhibitor Hot
Bemcentinib
R428, BGB324
T62691037624-75-1
Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.
  • $34
In Stock
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TargetMol | Inhibitor Hot
CDK9-IN-7
T107452369981-71-3In house
CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM).
  • $83
In Stock
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TargetMol | Inhibitor Sale