ligand for e3 ligase

E3ligaseLigand 44 is a ligand for the E3 ligase and is employed in synthesizing [PROTACAR Degrader-7].

E3ligaseLigand 45 is an E3 ligase ligand used in the synthesis of Setidegrasib, a PROTAC degrader for Ras.

E3 ligase Ligand 65 is a ligand of E3 ligase, which is useful in the synthesis of AZ'3137.

E3 ligase Ligand 23 is a cereblon binding agent that degrades Ikaros or Aiolos via the ubiquitin proteasome.

E3 ligase Ligand 8, a ligand for E3 ubiquitin ligase, can be connected to protein ligands through linkers to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins.

(S)-(S,R,S,R)-AHPC-Me-N3 is an E3 ligase ligand for PROTACSMARCA2 degrader-32, utilized in the synthesis of PROTACs.

(S)-Deoxy-thalidomide-Br is a ligand for E3 ligase, utilized in the synthesis of PROTACFHD-609.

Lenalidomide-F serves as the E3 ligase ligand for LWY713. LWY713 is a PROTAC-based FLT3 degrader (DC50= 0.64 nM) that selectively induces the degradation of FLT3 through a cereblon and proteasome-dependent mechanism.

4-Methylphenoxyacetic acid-Oxindole-CF3 is the E3 ligase ligand component of L134. It is suitable for use in PROTAC synthesis.

OICR-8268-acrylic acid is a ligand for E3 ubiquitin ligase. This compound can be linked to a target protein ligand via a linker to form OICR41114, which is applicable in cancer research.

N-Boc-SBP-0636457-OH is a ligand for the E3 ubiquitin ligase, facilitating the recruitment of the IAPE3 ligase for the degradation of Bcl-xL. It can be linked to a Bcl-xL ligand via a linker to form PROTACBcl-xLdegrader-1.

JY-5 is an E3 ligase ligand (E3 ligase Ligand) suitable for the synthesis of PROTAC JY-21.

Thalidomide-O-COOH (Cereblon ligand 3) is a Thalidomide-based Cereblon ligand utilized for recruiting the CRBN protein and can be linked to a protein ligand via a linker to create PROTACs.

Deruxtecan-Eribulin is a Drug-Linker Conjugate for ADC comprised of a linker and two cytotoxic molecules: Exatecan (a DNA topoisomerase I inhibitor) and Eribulin (a microtubule inhibitor). This compound is utilized in the synthesis of ADCs.

Thalidomide-benzo is a Thalidomide-based cereblon ligand that recruits CRBN proteins. By using a linker, Thalidomide-benzo can connect with a target protein ligand to form a PROTAC molecule.

VHL-SF2 is a VHL ligand used in the synthesis of PROTACs.

KLHDC2ligand 1 is an E3 ligase ligand (E3 ligase Ligand) that can be utilized in the synthesis of PROTACBRD4 Degrader-31.

KLHDC2-IN-1 (Compound 6) is a ligand that specifically targets the ubiquitin E3 ligase KLHDC2 with a dissociation constant (Kd) of 160 nM. It can be synthesized into a PROTAC capable of effectively degrading BRD4 within cells.

XB2M54 is a selective XIAP antagonist that inhibits NOD2-mediated inflammatory signaling. It acts as an E3 ligase ligand and is utilized in the synthesis of PROTACERαDegrader-1.

OICR-41103 is a potent, selective, and cell-active small molecule chemical probe targeting the DCAF1WDR domain, effectively replacing the viral Vpr protein. The binding affinity (Ki) of OICR-41103 for DCAF1 is less than 2 nM.

OICR-41103N is the negative control for OICR-41103. OICR-41103 is a potent, selective, and cell-active small molecule chemical probe (Ki<2 nM) that targets the DCAF1WDR domain, replacing the viral Vpr protein.

Thalidomide-C-amide-C5-amine serves as an E3 ligase ligand (E3 ligase Ligand) and can be utilized in the synthesis of PROTAC BET Degrader-10.

(R,S,R)-AHPC-Me-Ac is an E3 ligase ligand utilized in the synthesis of PROTACSHP2 protein degrader-2.

(S,S,S)-VH032-cyclopropane-F is an E3 ubiquitin ligase ligand. It can be linked to a target protein ligand using a linker to form PROTACcis-VZ185.