g12

G12 (Ras 5-17) is a wild-type Ras peptide comprising amino acids 5-17, specifically KLVVVGAGGVGKS, and serves as a control in studies investigating mutant Ras peptides such as V12.

G12 (Ras5-17) TFA is a wild-type Ras peptide comprising amino acids 5-17 (KLVVVGAGGVGKS). It serves as a control in studies involving mutant Ras peptides, such as V12.

2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.

GLPG1205 is a potent, orally active GPR84 (G protein-coupled receptor) antagonist with anti-inflammatory activity. GLPG1205 shows good PK/PD characteristics and can be used to study pulmonary fibrosis.

KRAS G12C inhibitor 16 is a potent inhibitor of KRAS G12C.

KRas G12C inhibitor 1 is a compound that selectively inhibits the KRas G12C protein.

G12Si-5 is a covalent inhibitor of the K-RasG12S mutant with a Ki value of 26 μM. It binds to the S-IIP structural domain, inhibiting oncogenic signaling and reducing ERK phosphorylation levels in KRAS G12S mutant cells.

m-PEG12-NHS ester is a PEG backbone PROTAC linker commonly used in the synthesis of PROTAC molecules, and the NHS ester can covalently bind to primary amines (-NH2) on biomolecule.

K-Ras(G12C) inhibitor 9 is an allosteric inhibitor of oncogenic K-Ras(G12C).

m-PEG12-amine is a PEG-based PROTAC linker and a non-cleavable 12-unit PEG ADC linker used in the synthesis of PROTACs [1] and antibody-drug conjugates (ADCs) [2].

Amino-PEG12-amine (H2N-PEG12-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Amino-PEG12-Boc, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Azide-PEG12-alcohol, a PEG-based PROTAC linker, is utilized in PROTAC synthesis.

Azido-PEG12-acid (PROTAC Linker 13) is a polyethylene glycol-based linker utilized in the synthesis of PROTACs.

Boc-NH-PEG12-NH2 (NHBoc-PEG12-amine) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Fmoc-PEG12-NHS ester, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands, crucial for the formation of PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Hydroxy-PEG12-Boc (Hydroxy-PEG12-T-Butyl Ester) is a PEG-based PROTAC linker. Hydroxy-PEG12-Boc can be used in the synthesis of PROTACs.

m-PEG12-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs.

m-PEG12-OH (Dodecaethylene Glycol Monomethyl Ether) is a PEG-based PROTAC linker. m-PEG12-OH can be used in the synthesis of PROTACs. m-PEG12-OH is also a non-cleavable 12 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Propargyl-PEG12-bromide, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

K-Ras G12C-IN-1 is a novel, irreversible inhibitor of mutant K-Ras G12C.

K-Ras G12C-IN-2 is a covalent KRAS G12C inhibitor.

Heterocyclic compounds as covalent inhibitors of G12C mutant K-Ras protein useful for treating cancers.K-Ras G12C-IN-3 is a novel and irreversible inhibitor of mutant K-ras G12C.