double — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12019	Methylproamine		Others
	Methylproamine is a DNA-binding radioprotector , acts by repair of transient radiation-induced oxidative species on DNA.		Others
TN1637	Eurycomalactone		Anti-infection , NF-κB
	Eurycomalactone is a natural product isolated from Eurycoma longifolia Jack., acts as a potent NF-κB inhibitor( IC50 of 0.5 μM). Eurycomalactone inhibits protein synthesis, depletes cyclin D1, but does not affect TNFα-in...		Anti-infection , NF-κB
T6878	LJI308		S6 Kinase
	LJI308 is a potent, and pan-RSK (p90 ribosomal S6 kinase) inhibitor with IC50 of 6 nM, 4 nM, and 13 nM for RSK1, RSK2, and RSK3, respectively.		S6 Kinase
T9168	NSC 617145	NSC617145,NSC-617145	DNA/RNA Synthesis
	NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner.		DNA/RNA Synthesis
T24925	UNC-2170	UNC2170 Maleate,UNC-2170 Maleate,UNC 2170 Maleate	Others
	UNC-2170 (UNC2170 Maleate) is the methyl-lysine binding protein, 53BP1 ligand.		Others
T12516	Polyinosinic-polycytidylic acid sodium	Poly(I:C) sodium	Apoptosis , Others , TLR
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors (RIG-I and MD...		Apoptosis , Others , TLR
T4327	Prexasertib dihydrochloride	LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368	Apoptosis , Chk , S6 Kinase
	Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively.		Apoptosis , Chk , S6 Kinase
T4310	Prexasertib	LY2606368	Apoptosis , Chk
	Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity.		Apoptosis , Chk
T27830	Lifarizine	RS 87476,RS 87476-000,RS-87476,RS-87476-000,RS87476	Calcium Channel
	Lifarizine (RS-87476), a calcium-sodium channel antagonist, shows neuroprotective activity in a simplified rat survival model of double vessel occlusion.		Calcium Channel
T20041	2'-Deoxyadenosine	NSC-141848,NSC141848,NSC 141848	Endogenous Metabolite
	2'-Deoxyadenosine (NSC-141848) is the DNA nucleoside A. It pairs with deoxythymidine (T) in double-stranded DNA.		Endogenous Metabolite
T18883	2-Di-1-ASP		Others
	2-Di-1-ASP is a mono-stryryl dye and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. It has selective for G-quadruplex (G4) and double-stranded DNA.		Others
T20318	Benzylideneaniline	N-Benzylideneaniline	Others
	Benzylideneaniline (N-Benzylideneaniline) is a potent inhibitor of xyloglucan-α,β-dioxygenase, a key enzyme in the oxidative cleavage of the central double bond of xyloglucan.		Others
T21498	Phleomycin		DNA/RNA Synthesis , Antibacterial , Antibiotic
	Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin which binds and intercalates DNA to damage the integrity of the double helix.		DNA/RNA Synthesis , Antibacterial , Antibiotic
T13038	Sultamicillin		Antibacterial , Antibiotic
	Sultamicillin is an orally active double prodrug of Ampicillin/Sulbactan. Sulbactam is a semisynthetic β-Lactamase inhibitor.		Antibacterial , Antibiotic
T8880	PFM01		Others
	PFM01 is an inhibitor of MRE11 endonuclease. PFM01 can regulate double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) versus homologous recombination (HR).		Others
T14858	Calicheamicin	Calicheamicin γ1	Others
	Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.		Others
T20511	6-Thioguanosine	6-Mercaptoguanosine,NSC29422,NSC 29422,NSC-29422	Others
	6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double ...		Others
T8240	Cis-5-Dodecenoic Acid		Others
	Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position.		Others
T23171	Polyinosinic-polycytidylic acid	Poly(I:C)	TLR
	Polyinosinic-polycytidylic acid (Poly(I:C)) is a double-stranded RNA (dsRNA) and a TLR3 agonist. Polyinosinic-polycytidylic acid induces natural immunity in mammals.		TLR
T21578	NSC 66811		Mdm2
	NSC 66811is a novel inhibitor of the murine double minute 2 (MDM2)-p53 interaction. It binds to MDM2 with a Ki of 120 nM and activates p53 in cancer cells with a mechanism of action consistent with targeting the MDM2-p53...		Mdm2