T39924 |
NF-κΒ activator 2
|
|
NF-κB
|
|
NF-κΒ activator 2 is a potent and orally active NF-κB activator, with an EC 50 of 1.58 μM. NF-κΒ activator 2 induces SOD... |
T3893 |
Forsythoside B
|
|
NF-κB
,
TNF
|
|
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythosid... |
T6S0781 |
Phellodendrine
|
Phallodendrin |
Akt
,
NF-κB
,
Others
|
|
1. Phellodendrine has anti-nephritic activity, may be due to its ability to inhibit the proliferation or the migration o... |
T7030 |
Anemarsaponin B
|
|
NO Synthase
,
p38 MAPK
,
MEK
,
NF-κB
,
COX
|
|
Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhi... |
T8705 |
BOT-64
|
|
IκB/IKK
|
|
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-... |
T9105 |
NF-κB-IN-1
|
1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- |
IκB/IKK
,
NF-κB
|
|
NF-κB-IN-1 is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 directly inh... |
T13265 |
Urolithin B
|
|
NF-κB
,
Akt
,
AMPK
,
Endogenous Metabolite
,
JNK
,
ERK
|
|
Urolithin B is one of the gut microbial metabolites of ellagitannins and is found in diverse plant foods, including pome... |
T0708 |
Oxaprozin
|
Oxaprozinum,Wy21743 |
COX
,
NF-κB
|
|
Oxaprozin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibito... |
TD0099 |
Malachite green oxalate
|
|
Others
,
NF-κB
,
IκB/IKK
,
Apoptosis
|
|
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reac... |
T2872 |
Ginsenoside Re
|
Sanchinoside Re,Ginsenoside B2,Chikusetsusaponin Ivc,Panaxoside Re |
NF-κB
,
Beta Amyloid
,
Endogenous Metabolite
,
JNK
|
|
Ginsenoside Re may have properties that inhibit or prevent the growth of tumors. |
T3826 |
Polygalasaponin F
|
|
TLR
,
NF-κB
,
Akt
,
PI3K
|
|
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO in... |
T4S21320 |
ISOGINKGETIN
|
4',4'''-Dimethylamentoflavone |
Others
,
MMP
|
|
1. Isoginkgetin, a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion with potency ... |
T2279 |
Tizoxanide
|
Desacetyl-nitazoxanide,TIZ |
HIV Protease
,
Autophagy
,
Antiviral
,
Antibacterial
|
|
Desacetyl-nitazoxanide is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) i... |
T3417 |
Amentoflavone
|
3',8''-Biapigenin,Amenthoflavone,Didemethyl-ginkgetin |
Opioid Receptor
,
RSV
,
Antibacterial
,
Antifungal
,
Apoptosis
,
P450
,
Reactive Oxygen Species
,
COX
,
Phospholipase
|
|
Amentoflavone, as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 a... |
T25465 |
GS143
|
GS 143,GS-143 |
NF-κB
,
E1/E2/E3 Enzyme
,
IκB/IKK
|
|
GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. G... |
TP1313L |
Cecropin B acetate
|
Cecropin B acetate(80451-05-4 Free base) |
P450
,
Parasite
,
Retinoid Receptor
|
|
Cecropin B acetate induces NF-κB activation and suppresses CYP3A29 by disrupting the association of the PXR/retinoid X r... |
T6823 |
E3330
|
|
HIF/HIF Prolyl-Hydroxylase
,
DNA/RNA Synthesis
|
|
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity. |
T3772 |
Maslinic acid
|
Crategolic acid,2α-Hydroxyoleanoic Acid,2α-Hydroxyoleanolic acid |
HIV Protease
,
NF-κB
,
DNA/RNA Synthesis
,
Antibacterial
|
|
Maslinic acid is a DNA polymerase B inhibitor. |
T11096 |
DRI-C21045
|
|
NF-κB
|
|
Dri-c21045 showed concentration-dependent inhibition of NF- B activation and all CD40L induced by B cell proliferation. ... |
T7302 |
CU-CPT9b
|
TLR8-specific antagonist 1,CU-CPT-9b |
TLR
|
|
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR... |