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PrNMI

Catalog No. T39024 CAS 1541244-33-0

PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced peripheral neuropathy pain symptoms and cancer-induced bone pain.

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PrNMI, CAS 1541244-33-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 350.00
5 mg	In stock	$ 828.00
10 mg	In stock	$ 1,130.00
25 mg	In stock	$ 1,590.00
50 mg	In stock	$ 1,980.00
100 mg	In stock	$ 2,500.00

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Purity: 99.87%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PrNMI is a highly effective and orally active agonist targeting the peripherally restricted cannabinoid 1 receptor (CB1R). It exhibits pronounced analgesic properties, efficiently suppressing both chemotherapy-induced peripheral neuropathy pain symptoms and cancer-induced bone pain.
In vitro	PrNMI (1 nM-1 μM; 24 h) shows no effects on the viability of 66.1 breast tumor cells in vitro.[2]
In vivo	PrNMI (0.25 mg/kg; Intraplantar ipsilateral administration; i.p.; CIPN rat model) causes significantly greater suppression in mechanical but not cold allodynia on the ipsilateral paw compared to contralateral paw or systemic administration at 2 h post-PrNMI.[1] PrNMI (3.0 mg/kg; i.g.; 48 h; CIPN rat model) dose-dependently suppresses CIPN symptoms in both male and female rats and is equally effective in male and female rats after oral administration.[1] PrNMI (1 mg/kg; p.o.; 48 h; CIPN rat model) exhibits anti-allodynic effects in CIPN mediated mainly by CB1Rs.[1] PrNMI (1 mg/kg; p.o.; daily for two weeks;) shows no significant tolerance to suppression of both mechanical and cold allodynia during the two-week testing period.[1] PrNMI (0.1, 0.3, and 0.6 mg/kg; i.p.) results in a significant, time-related reduction of flinching but not guarding in a dose-dependent manner. This suppression of flinching starts 1 hour post-injection and persists for at least 5 hours.[2]

Molecular Weight	409.56
Formula	C29H31NO
CAS No.	1541244-33-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mulpuri Y, et al. Synthetic peripherally-restricted cannabinoid suppresses chemotherapy-induced peripheral neuropathy pain symptoms by CB1 receptor activation. Neuropharmacology. 2018;139:85-97. 2. Zhang H, et al. Peripherally restricted cannabinoid 1 receptor agonist as a novel analgesic in cancer-induced bone pain. Pain. 2018;159(9):1814-1823. 3. Wiese BM, et al. Brain Penetrant, but not Peripherally Restricted, Synthetic Cannabinoid 1 Receptor Agonists Promote Morphine-Mediated Respiratory Depression. Cannabis Cannabinoid Res. 2022;7(5):621-627.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Cancer Compound Library

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Keywords

PrNMI 1541244-33-0 GPCR/G Protein Cannabinoid Receptor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.