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Phosphatase

A phosphatase is an enzyme that uses water to cleave a phosphoric acid monoester into a phosphate ion and an alcohol. Because a phosphatase enzyme catalyzes the hydrolysis of its substrate, it is a subcategory of hydrolases. Phosphatase enzymes are essential to many biological functions, because phosphorylation (e.g. by protein kinases) and dephosphorylation (by phosphatases) serve diverse roles in cellular regulation and signaling. Whereas phosphatases remove phosphate groups from molecules, kinases catalyze the transfer of phosphate groups to molecules from ATP. Together, kinases and phosphatases direct a form of post-translational modification that is essential to the cell's regulatory network. Phosphatase enzymes are not to be confused with phosphorylase enzymes, which catalyze the transfer of a phosphate group from hydrogen phosphate to an acceptor. Due to their prevalence in cellular regulation, phosphatases are an area of interest for pharmaceutical research
Cat. No. Product name CAS No. Purity Chemical Structure
T15243 Ertiprotafib 251303-04-5 98%
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
T12934 SMAP-2 1809068-70-9 98%
SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhib...
T3930 Taraxerol acetate 2189-80-2 98%
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
TN2887 3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid 329975-47-5 98%
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
T16517 PGMI-004A 1313738-90-7 98%
PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).
T16724 Razuprotafib 1008510-37-9 98%
Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
T14037 3α-Aminocholestane 2206-20-4 98%
3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
TN3525 Boehmenan 57296-22-7 98%
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
T10060L DT-061 1809427-19-7 98%
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
TN3505 Beta-Peltoboykinolic acid 24778-48-1 98%
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
T5806 Growth hormone releasing peptide 87616-84-0 98%
Growth hormone releasing peptide ia a natual product ,and has anti-inflammatory effects, due to its inhibitory effect on PKC-induced activation of p38, JNK and N...
T7381 TCS 401 243966-09-8 98%
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
TN4551 Methyl orsellinate 3187-58-4 98%
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
T3827 Rhein-8-glucoside calcium 113443-70-2 98%
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
T11687 Itacitinib adipate 1334302-63-4 98%
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelo...
T10877 CPDA 1415834-63-7 98%
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
T4671 BN82002 396073-89-5 98%
BN82002 is a synthetic inhibitor of CDC25 phophatases
T12577 PTP1B-IN-3 809272-64-8 98%
PTP1B-IN-3 is a potent and selective inhibitor of PTP1B (PTP1B and TCPTP with IC50s of 120 nM and 120 nM , respectively).
T11735 K-Ras G12C-IN-1 1629265-17-3 98%
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
TN2913 3-Acetoxy-11-ursen-28,13-olide 35959-08-1 98%
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...
Ertiprotafib
T15243
Ertiprotafib is a PTP1B, IkB kinase β (IKK-β), and a dual PPARα and PPARβ agonist inhibitor ( IC50s: 1.6 μM for PTP1B, 400 nM for IKK-β, an EC50 of ~1 μM for PPA...
SMAP-2
T12934
SMAP-2 is an orally bioavailable activator of phosphatase 2A (PP2A) which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A. It inhib...
Taraxerol acetate
T3930
Taraxeryl acetate shows the significant antiviral activity against herpes simplex virus (type II). It has less effect on cell cycle arrest and apoptosis of AGS c...
3,4-Secocucurbita-4,24-diene-3,26,29-trioic acid
TN2887
(24E)-3,4-Seco-cucurbita-4,24-diene-3,26,29-trioic acid can inhibit the activity of protein tyrosine phosphatase 1B (PTP1B), with IC 50 values of 0.4uM.
PGMI-004A
T16517
PGMI-004A is an effective inhibitor of phosphoglycerate mutase 1 (IC50: 13.1 μM).
Razuprotafib
T16724
Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. Razuprotafib is a protein tyrosine phosphatase ß (HPTPß) inh...
3α-Aminocholestane
T14037
3α-Aminocholestane , a selective SH2 domain-containing inositol-5′-phosphatase 1 (SHIP1) , inhibitor with an IC50 of ~2.5 μM.
Boehmenan
TN3525
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in ...
DT-061
T10060L
DT-061 is an orally bioavailable protein phosphatase 2A (PP2A) activator. It could be applied in the therapy of KRAS-mutant and MYC-driven tumorigenesis.
Beta-Peltoboykinolic acid
TN3505
Beta-Peltoboykinolic acid has in vitro protein tyrosine phosphatase 1B (PTP1B) inhibitory, it inhibits PTP1B with IC50 values of 5.2+/-0.5 microM. It also has cy...
Growth hormone releasing peptide
T5806
Growth hormone releasing peptide ia a natual product ,and has anti-inflammatory effects, due to its inhibitory effect on PKC-induced activation of p38, JNK and N...
TCS 401
T7381
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B; Ki = 0.29 µM)
Methyl orsellinate
TN4551
Methyl orsellinate is a phytotoxic compound, it exhibits antifungal activity, it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus...
Rhein-8-glucoside calcium
T3827
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
Itacitinib adipate
T11687
Itacitinib adipate is an orally bioavailable and selective JAK1 inhibitor,Itacitinib adipate has been tested for efficacy and safety in a phase II trial in myelo...
CPDA
T10877
CPDA is a new potent inhibitor of SH2 domain-containing inositol phosphatase 2 (SHIP2).
BN82002
T4671
BN82002 is a synthetic inhibitor of CDC25 phophatases
PTP1B-IN-3
T12577
PTP1B-IN-3 is a potent and selective inhibitor of PTP1B (PTP1B and TCPTP with IC50s of 120 nM and 120 nM , respectively).
K-Ras G12C-IN-1
T11735
K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C.
3-Acetoxy-11-ursen-28,13-olide
TN2913
3β-Acetoxy-urs-11-en-28,13-olide exhibits significant protein tyrosine phosphatase 1B (PTP1B) inhibitory activity, it is a mixed-type PTP1B inhibitor. It exhibit...
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