pam

BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.

VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).

VU-1545 is mGlu5 positive allosteric modulator.

ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).

VU0453595 is a M1 positive allosteric modulator (PAM).

V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.

AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.

BMS986187 is a novel Potent and Selective Positive Allosteric Modulators of the delta-Opioid Receptor.

Ro0711401 is an agonist of mGlu1 receptor.

Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.

CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.

Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.

Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist

Pam 1392 is a chemotherapeutic agent.

Pam2Cys is an L-cysteine thioether where the hydrogen of the thiol group is replaced by a 2,3-di(palmitoyloxy)propyl group. It acts as a Toll-like receptor 2 agonist and a metabolite of Mycoplasma genitalium. Additionally, Pam2Cys is associated with the function of palmitoleic acid.

Pam3-Cys-Ala-Gly, a synthetic bacterial lipopeptide, is a potent activator of macrophages and B cells [1].

Pam2CSK4 TFA (PUL-042 TFA) is a potent dual agonist of TLR2 and TLR6, a peptide that mimics bacterial lipoproteins.Pam2CSK4 TFA promotes platelet aggregation, and can be used to study the effects of lipoproteins on the periodontium.

Pam3CSK4-Biotin (Pam3Cys-Ser-(Lys)4-Biotin) TFA is the biotinylated version of Pam3CSK4. It acts as an agonist for Toll-like receptor 1/2 (TLR1/2).

Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2 PAM, respectively.Darigabat is used in the study of anxiety disorders and epilepsy.

Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents).

JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).