pam

CB2R PAM is an orally active cannabinoid type 2 receptor (CB2Rs) positive allosteric modulator that enhances CP 55940 and 2-Arachidonylglycerol-stimulated [35S]GTPγS binding to CB2 receptors without affecting receptor activity in the absence of agonists. CB2R PAM shows anti-injury activity in a mouse model of neuropathic pain.

TRPC6-PAM-C20 is a selective TRPC6 positive allosteric modulator that induces a transient increase in intracellular Ca2+ with an EC50 of 2.37 μM in HEK cells expressing TRPC6 and enhances OAG-induced platelet aggregation.

Pam3CSK4-Biotin is a biotinylated derivative of Pam3CSK4, functioning as a Toll-like receptor 1/2 (TLR1/2) agonist.

Pam3CSK4 TFA (Pam3Cys-Ser-(Lys)4 TFA) is a Toll-like receptor 1/2 agonist with EC50 of 0.47 ng/mL for human TLR1/2.

Pam3CSK4 is a synthetic triacylated lipopeptide (LP) that mimics the acylated amino terminus of bacterial LPs.

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-α production in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

BPAM344 is a potent positive allosteric modulator (PAM) of the KAR subunits GluK1b, GluK2a, and GluK3a.

V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes.

AZD7325 (AZD-7325) is a GABA-Aα2,3 -selective receptor modulator.

Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2 PAM, respectively.Darigabat is used in the study of anxiety disorders and epilepsy.

Pralidoxime Chloride (2-PAM chloride) is a useful agent in the treatment of organophosphate poisoning. Pralidoxime binds to organophosphate-inactivated acetylcholinesterase, used to combat poisoning by organophosphates or acetylcholinesterase inhibitors (nerve agents).

JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM).

Pralidoxime Iodide is an effective AChE reactivator and antidote for organophosphorus poisoning, reactivating AChE inhibited by nerve agents through nucleophilic attack on the phosphorus centre of the neurotoxin.

Melphalan is an orally bioavailable DNA alkylating agent exhibiting antitumour activity, commonly employed in cancer chemotherapy.

HM5023507, an orally active dual inhibitor of δγ isoforms in immune signaling. HM5023507 inhibited PI3Kδ and PI3Kγ isoforms with greater than 100-fold selectivity against PI3Kα and PI3Kβ in recombinant enzymatic assays and in primary human immune cells with an exquisite selectivity against other targets.

Polyacrylamide, Anion, Mw 10-12 million (PAM, Anion, Mw 10-12 million), is a biochemical reagent that can be utilized as a biomaterial or an organic compound in life science research.

Polyacrylamide, Anion, Mw 14-16 million (PAM, Anion, Mw 14-16 million) is a biochemical reagent that can be used as a biomaterial or organic compound in life science research.

Polyacrylamide, Anion, Mw 18 million (PAM, Anion, Mw 18 million) is utilized in synthesizing water-soluble polymers. It serves as a biomaterial or organic compound applicable in life science research.

Polyacrylamide, average Mn 40000 (PAM, average Mn 40000), is a versatile polymer known for its moisture-retaining properties. It can be utilized as a biomaterial or organic compound in life science research.

Polyacrylamide, average Mn 150000 (PAM, average Mn 150000), is a versatile polymer with moisturizing properties. It can be utilized as a biomaterial or organic compound in life science research.

Pam 1392 is a chemotherapeutic agent.

biotinylated Pam2CSK4, a toll-like receptor 2/6 agonist

Pam2Cys is an L-cysteine thioether where the hydrogen of the thiol group is replaced by a 2,3-di(palmitoyloxy)propyl group. It acts as a Toll-like receptor 2 agonist and a metabolite of Mycoplasma genitalium. Additionally, Pam2Cys is associated with the function of palmitoleic acid.

Pam3-Cys-Ala-Gly, a synthetic bacterial lipopeptide, is a potent activator of macrophages and B cells [1].