nb 1

kb NB 142-70 is a selective protein kinase D (PKD) inhibitor with IC50 values of 28.3 nM, 58.7 nM, and 53.2 nM for PKD1, PKD2, and PKD3 respectively.

LfcinB 17–28 TFA, a fragment of Bovine Lactoferricin (LfcinB), exhibits weak antimicrobial activity, with a minimum inhibitory concentration (MIC) of 200 μM against E. coli [1].

NB001 (HTS 09836) is an adenyl cyclase 1 inhibitor that affects both neural and non-neural pain.

PPC-NB is a glutathione-cleavable linker used in antibody-drug conjugates (ADC) [1].

NB-64 is a HIV-1 entry inhibitor. NB-64 interferes the gp41 six-helix bundle formation and blocks virus fusion.

TEI-9648, an analogue of Vitamin D3 Lactone, acts as a potent and specific antagonist to the vitamin D receptor (VDR). This compound effectively blocks the genomic actions mediated by VDR and the Vitamin D responsive element (VDRE) of 1α,25(OH)2D3. Furthermore, TEI-9648 prevents the differentiation of HL-60 cells induced by 1α,25(OH)2D3, indicating its utility in bone metabolism studies[1][2].

NB-216 is a macrocyclic peptidic BACE-1 inhibitor.

NB-533 is a macrocyclic peptidic BACE-1 inhibitor.

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20), an auristatins-glucuronide conjugate, exhibits in vitro antiproliferative effects on cancer cells, both β-glucuronidase pretreated and untreated, with an IC50 range of 5.7 nM to 9.7 nM. Demonstrating powerful antitumor efficacy in an HCT-116 xenograft mouse model, this compound does not induce side effects [1].

YG1702, a potent inhibitor specific to ALDH18A1, suppresses the proliferation of MYCN-amplified neuroblastoma (NB) and reduces MYCN expression. This compound exhibits high-affinity physical interaction with ALDH18A1, which may influence its enzymatic activity [1].

Compound 17, known as Mal-PEG4-VCP-NB, is a degradable ADC linker that features a maleimide group, four PEG units, and VCP NB [1].

Mal-PEG3-VCP-NB (Compound 25c) is a degradable ADC linker comprising a maleimide group, a 3-unit PEG, and VCP NB [1].