folate

DSPE-PEG46-Folate is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Folate-PEG3-azide, a PEG-based linker for PROTACs, connects two essential ligands crucial for PROTAC molecule formation and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate sodium, as a member of the vitamin B family, can stimulate the hematopoietic system. Folic acid can be used in the treatment and prevention of folate deficiencies and megaloblastic anemia.

Folate-PEG2-amine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-alkyne is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-amine is a three-unit polyethylene glycol (PEG) linker, which is cleavable. This linker is specifically employed in the synthesis of antibody-drug conjugates (ADCs).

DSPE-PEG-Folate, MW 2000 is a folic acid-conjugated PEG (polyethylene glycol) derivative known for its targeting capabilities by binding to folate receptors in cancer cells. It forms micelles/lipid bilayers and is utilized in the study of targeted drug delivery systems.

Folic acid is an orally active essential nutrient involved in the synthesis of DNA/RNA and the production and maintenance of new cells. It exhibits antidepressant-like effects and can reduce the risk of neural tube defects in newborns. Folate deficiency can cause megaloblastic anemia, macrocytic anemia, neural tube closure defects, tumors, and aging-related diseases. Folic acid is also commonly used in research on folate deficiency-related conditions and to induce acute kidney injury models.

Trimethoprim (NSC-106568) is a Dihydrofolate Reductase Inhibitor Antibacterial. The mechanism of action of trimethoprim is as a Dihydrofolate Reductase Inhibitor, and Cytochrome P450 2C8 Inhibitor, and Organic Cation Transporter 2 Inhibitor.

Silver sulfadiazine (Dermazin) is a sulfonamide-based topical agent with antibacterial and antifungal activity.

Folinic Acid Calcium Salt Pentahydrate (Leucovorin Calcium Pentahydrate), a reduced folic acid, is used in combination with other chemotherapeutics.

Ethopabate (Ethyl pabate) is an inhibitor of folate metabolism, used as a coccidiostat in poultry.

EC0489 is a small molecule-drug conjugate (SMDC) that combines folic acid and desacetyl vinblastine hydrazide, serving as a high-affinity ligand for the folate receptor (FR) in refractory or metastatic tumors.

LY309887 is a potent inhibitor of glycinamide ribonucleotide formyltransferase (Ki: 6.5 nM) with antitumor activity.

EC-17 (disodium salt), a folate receptor alpha (FRα) targeting contrast agent, exhibits fluorescent properties within the visible light spectrum, characterized by peak excitation and emission wavelengths of 470/520 nm, respectively.

Tetrahydrofolic acid (5,6,7,8-tetrahydrofolic acid) is a vitamin B9 derivative that is a common one-carbon donor in organisms and is involved in growth and metabolism.

8-Arm-PEG-FA (MW 600) [8-Arm-PEG-folate (MW 600)] is a PEG derivative where each terminal of the PEG chains is linked to a Folic acid molecule. Folic acid has a high affinity for folate receptors and can be utilized for targeting cell membrane receptors in drug delivery.

8-Arm-PEG-FA (MW 2000) (8-Arm-PEG-folate (MW 2000)) is a PEG derivative in which each terminus of the PEG chains is linked to a Folic acid molecule. Folic acid binds with high affinity to folate receptors, making it suitable for targeting cell membrane receptors in drug delivery.

4-Arm-PEG-FA (MW 1000) (4-Arm-PEG-folate (MW 1000)) is a PEG derivative, featuring a Folic acid molecule attached to the end of each PEG chain. With its high affinity for folate receptors, Folic acid is useful for targeting cell membrane receptors in drug delivery applications.

DBCO-PEG-FA (MW 10000) (DBCO-PEG-Folate (MW 10000)) is a copolymer in which PEG serves as a linker between dibenzocyclooctyne (DBCO) and Folic acid (FA). This compound is versatile for various bioconjugation applications and drug delivery purposes.

4-Arm-PEG-FA (MW 10000) [4-Arm-PEG-folate (MW 10000)] is a PEG derivative where each end of the PEG chains is attached to a Folic acid molecule. Folic acid exhibits high affinity for folate receptors, making it suitable for targeting cell membrane receptors in drug delivery applications.

DBCO-PEG-FA (MW 1000) (DBCO-PEG-Folate (MW 1000)) is a copolymer that links dibenzocyclooctyne (DBCO) and folic acid (FA) using a polyethylene glycol (PEG) bridge. DBCO-PEG-FA (MW 1000) is applicable for various bioconjugation and drug delivery applications.

DBCO-PEG-FA (MW 3400), also known as DBCO-PEG-Folate (MW 3400), is a copolymer that connects dibenzocyclooctyne (DBCO) and folic acid (FA) through a PEG linker. This compound is applicable in various bioconjugation processes and drug delivery systems.

8-Arm-PEG-FA (MW 5000) (8-Arm-PEG-folate (MW 5000)) is a PEG derivative where each PEG chain terminates with a Folic acid molecule. Folic acid has a high affinity for folate receptors, making it useful for targeting cell membrane receptors in drug delivery applications.