folate

DSPE-PEG46-Folate is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Folate-PEG3-azide, a PEG-based linker for PROTACs, connects two essential ligands crucial for PROTAC molecule formation and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG2-amine is a PEG-based linker for PROTACs that joins two essential ligands, facilitating selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-alkyne is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Folate-PEG3-NHS ester is a PROTAC linker from the PEG family and is utilized in the synthesis of PROTAC molecules.

Folate-PEG1-mal is a PROTAC linker of the PEG class, used in the synthesis of PROTAC molecules.

Folate-MS432 is a PROTAC that degrades MEKs selectively in cancer cells via folate receptor-dependent pathways.

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

L-Serine-S2-PEG-Formic acid is a linker used in FGT-4, which acts as a TLR7 agonist and is a chimeric molecule that targets folate receptor beta (FR-β).

FGT-4 is a chimeric molecule targeting folate receptor β (FR-β) and functions as a TLR7 agonist. It enhances the secretion of iNOS and the pro-inflammatory cytokine IL-6 associated with M1 macrophages and promotes the proliferation of cytotoxic CD8+ T cells. FGT-4 demonstrates antitumor activity in the 4T1 breast cancer mouse model and is applicable for cancer immunotherapy research.