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Search Results for " igf-1r "

Targets

46

Compounds

3

Natural Products

11

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T38502 IGF-1R inhibitor-2
IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R). By downregulating the IGF-1R, it has the potential to reverse the transformed phenotype of tumor cells and ...
T2085 PQ401 IGF-1R Inhibitor II Apoptosis , IGF-1R
PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).
T8906 NBI-31772 NBI31772,NBI 31772 IGF-1R
NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM). NBI-31772 can be used in research on IGF-responsive diseases.
T2349 BMS-754807 Trk receptor , c-Met/HGFR , IGF-1R
Dual IGF-1R/InsR Inhibitor BMS-754807 is an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity.
T17267 XL228 IGF-1R , Bcr-Abl , Src , Aurora Kinase
XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).
T6003 GSK1904529A GSK 4529 Apoptosis , Raf , VEGFR , IGF-1R , Syk
GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .
T6017 Linsitinib OSI-906 IGF-1R
OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, whic...
T13564 AZ7550 MLK , FAK , EGFR , FLT , Tyrosine Kinases , PYK2 , MNK , IGF-1R , ACK , BTK , ALK , Drug Metabolite
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T3079 GSK1838705A IGF-1R , JNK , S6 Kinase , ALK
GSK1838705A is an effective IGF-1R inhibitor (IC50: 2.0 nM), modestly potent to IR (IC50: 1.6 nM) and ALK (IC50: 0.5 nM), respectively, and little inhibition to other protein kinases.
T8496 MAZ51 Apoptosis , VEGFR
MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.
T6080 NVP-AEW541 AEW541 FLT , Tyrosine Kinases , IGF-1R , Autophagy
NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based assay.
T1791 Ceritinib LDK378 Serine Protease , IGF-1R , ALK
Ceritinib (LDK378) is a specific ALK inhibitor (IC50: 0.2 nM).
T1918 NVP-TAE 226 TAE226 Apoptosis , FAK , c-Met/HGFR , PYK2 , IGF-1R
NVP-TAE 226 (TAE226) is an effective FAK inhibitor (IC50: 5.5 nM) and most effective to Pyk2(IC50: 3.5 nM); 10- to 100-fold less effective against IGF-1R, InsR, c-Met, and ALK.
T10285 ALK inhibitor 1 FAK , IGF-1R , ALK
ALK inhibitor 1 is a selective ALK kinase inhibitor.
T1967 AZD-3463 ALK/IGF1R inhibitor Apoptosis , IGF-1R , ALK , Autophagy
AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.
T6079 NVP-ADW742 ADW742,ADW,GSK 552602A Apoptosis , IGF-1R
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
T13564L AZ7550 hydrochloride AZ7550 hydrochloride (1421373-99-0 free base) EGFR , IGF-1R
AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T1791L Ceritinib dihydrochloride LDK378 dihydrochloride IGF-1R , ALK
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable and ATP-competitive inhibitor of ALK tyrosine kinase(IC50 of 200 pM), and also inhibits IGF-1R, InsR, and STK22D (IC50 values of 8, 7...
T6419 BMS-536924 HY-10262,BMS 536924,CS-0117 Apoptosis , FAK , MEK , IGF-1R , Src
BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for Akt1, MAPK1/2.
T2693 AG1024 Tyrphostin AG 1024,Tyrphostin,AGS 200 Apoptosis , IGF-1R
AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).
T4324 PQ401 hydrochloride (196868-63-0(free base)) IGF-1R
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.
T77624 WAY-270250 IGF-1R , Src
WAY-270250 is an IGF-1R/SRC inhibitor.
T11593 I-OMe-Tyrphostin AG 538 I-OMe-AG 538 IGF-1R , PI3K
I-OMe-Tyrphostin AG 538 is a specific IGF-1R inhibitor and ATP-competitive inhibitor of PI5P4Kα (IC50: 1 µM).I-OMe-Tyrphostin AG 538 inhibits IGF-1R-mediated signaling and exhibits preferential cytotoxicity to nutrient-d...
T76727 Teprotumumab R 1507,HZN 001 TSH Receptor , IGF-1R
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Te...
T68405 KW-2450 free base IGF-1R
KW-2450 free base is a multiple inhibitor of IGF-1R/IR and tyrosine kinases with antitumor activity.KW-2450 free base shows modest growth inhibitory activity and inhibits IGF-1-induced signaling in a mouse HT-29/GFP colo...
T2341 KW-2449 KW2449 Apoptosis , FGFR , FLT , JAK , Bcr-Abl , Src , c-Kit , Aurora Kinase
KW-2449 is a multiple-targeted inhibitor, mostly for Flt3 (IC50: 6.6 nM), modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.
T5524 Aurora kinase inhibitor-3 Aurora Kinase Inhibitor III Aurora Kinase
Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
T4605 NT157 IGF-1R , STAT
NT157 is a small molecule tyrphostin targeting IRS protein and has the potential to inhibit IGF-1R and STAT3 signaling pathways in TME cancer cells and stromal cells, resulting in decreased cancer cell survival.
T6184 Orantinib SU6668,TSU-68,NSC 702827 Apoptosis , VEGFR , FGFR , PDGFR
Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation. It shows little effect against IGF-1R, Met, Src, Lck, Zap70, A...
T6289 Dovitinib TKI258,CHIR-258 VEGFR , FGFR , FLT , PDGFR , c-Kit
Dovitinib (CHIR-258) (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit, IC50: 1/2 nM), also effective to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs (IC50: 8-13 nM), less potent to E...
T3570 SU4312 SU 4312,NSC 86429 VEGFR , PDGFR
SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...
T25123 AZ12253801 AZ 12253801,AZ-12253801
AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.
T39257 Ugodotin
Ugodotin is an antibody-drug conjugate. Ugodotin can binds IGF-1R with antitumor activity.
T70876 KW-2450 Tosylate
KW-2450 Tosylate is an orally bioavailable inhibitor of IGF-1R and IR tyrosine kinases with potential antineoplastic activity.
T76800 Dalotuzumab
Dalotuzumab (MK-0646) is a humanized recombinant monoclonal antibody (IgG1 type) that targets IGF-1R, inhibiting tumor cell proliferation, IGF-1R autophosphorylation, and Akt phosphorylation mediated by IGF-1 and IGF-2. ...
T77071 Lonigutamab
Lonigutamab (hz208F2-4), a humanized monoclonal antibody targeting IGF-1R, facilitates the creation of antibody-drug conjugates (ADC) [1].
T77044 Istiratumab
Istiratumab (M-6495), a bispecific monoclonal antibody, targets IGF-1R and ErbB3 receptors and facilitates their degradation via the proteasome pathway, offering potential for cancer research [1] [2] [3].
T78279 Cixutumumab NSC742460,IMC-A12
Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding downstream signaling. Additionally, it facilitates the internali...
T68740 NVP-TAC544
NVP-TAC544 is a novel focal adhesion kinase (FAK) inhibitor, potently blocking kinase activity of FAK along with Aurora A, activated Cdc42-associated kinase 1 (ACK1), Met, insulin receptor (IR), TrkA, and IGF-1R.
T70276 Roridin E
Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It al...
T76759 Robatumumab
Robatumumab (Sch 717454), an anti-human insulin-like growth factor receptor-1 (IGF-1R) antibody, exhibits anti-tumor and anti-proliferative effects on cancer cells. It is applicable in research concerning osteosarcoma an...
T3621 Brigatinib AP-26113 EGFR , FLT , ROS , IGF-1R , ALK
Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.
T83911 CYY292
CYY292 is a chemical compound acting as an inhibitor of PDGFRα, PDGFRβ, FGFR1, -2, and -3, with respective IC50 values of 5.35, 4.6, 28, 28, and 78 nM. It exhibits selectivity over FGFR4 (IC50 > 1,000 nM) while also targ...
T11654 Indirubin Derivative E804 Others
Indirubin Derivative E804 is an effective inhibitor of IGF1R, which has an IC50 value of 0.65.
T12102 Mps1-IN-1 Others
Mps1-IN-1 is a potent, selective and ATP-competitive inhibitor of Mps1 kinase (IC50 : 367 nM )
T13564L2 AZ7550 trimesylate salt AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base) MLK
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.

Compounds

IGF-1R inhibitor-2
T38502
Synonym:
Target:
PQ401
T2085
Synonym: IGF-1R Inhibitor II
Target: Apoptosis, IGF-1R
NBI-31772
T8906
Synonym: NBI31772,NBI 31772
Target: IGF-1R
BMS-754807
T2349
Synonym:
Target: Trk receptor, c-Met/HGFR, IGF-1R
XL228
T17267
Synonym:
Target: IGF-1R, Bcr-Abl, Src, Aurora Kinase
GSK1904529A
T6003
Synonym: GSK 4529
Target: Apoptosis, Raf, VEGFR, IGF-1R, Syk
Linsitinib
T6017
Synonym: OSI-906
Target: IGF-1R
AZ7550
T13564
Synonym:
Target: MLK, FAK, EGFR, FLT, Tyrosine Kinases, PYK2, MNK, IGF-1R, ACK, BTK, ALK, Drug Metabolite
GSK1838705A
T3079
Synonym:
Target: IGF-1R, JNK, S6 Kinase, ALK
MAZ51
T8496
Synonym:
Target: Apoptosis, VEGFR
NVP-AEW541
T6080
Synonym: AEW541
Target: FLT, Tyrosine Kinases, IGF-1R, Autophagy
Ceritinib
T1791
Synonym: LDK378
Target: Serine Protease, IGF-1R, ALK
NVP-TAE 226
T1918
Synonym: TAE226
Target: Apoptosis, FAK, c-Met/HGFR, PYK2, IGF-1R
ALK inhibitor 1
T10285
Synonym:
Target: FAK, IGF-1R, ALK
AZD-3463
T1967
Synonym: ALK/IGF1R inhibitor
Target: Apoptosis, IGF-1R, ALK, Autophagy
NVP-ADW742
T6079
Synonym: ADW742,ADW,GSK 552602A
Target: Apoptosis, IGF-1R
AZ7550 hydrochloride
T13564L
Synonym: AZ7550 hydrochloride (1421373-99-0 free base)
Target: EGFR, IGF-1R
Ceritinib dihydrochloride
T1791L
Synonym: LDK378 dihydrochloride
Target: IGF-1R, ALK
BMS-536924
T6419
Synonym: HY-10262,BMS 536924,CS-0117
Target: Apoptosis, FAK, MEK, IGF-1R, Src
AG1024
T2693
Synonym: Tyrphostin AG 1024,Tyrphostin,AGS 200
Target: Apoptosis, IGF-1R
PQ401 hydrochloride (196868-63-0(free base))
T4324
Synonym:
Target: IGF-1R
WAY-270250
T77624
Synonym:
Target: IGF-1R, Src
I-OMe-Tyrphostin AG 538
T11593
Synonym: I-OMe-AG 538
Target: IGF-1R, PI3K
Teprotumumab
T76727
Synonym: R 1507,HZN 001
Target: TSH Receptor, IGF-1R
KW-2450 free base
T68405
Synonym:
Target: IGF-1R
KW-2449
T2341
Synonym: KW2449
Target: Apoptosis, FGFR, FLT, JAK, Bcr-Abl, Src, c-Kit, Aurora Kinase
Aurora kinase inhibitor-3
T5524
Synonym: Aurora Kinase Inhibitor III
Target: Aurora Kinase
NT157
T4605
Synonym:
Target: IGF-1R, STAT
Orantinib
T6184
Synonym: SU6668,TSU-68,NSC 702827
Target: Apoptosis, VEGFR, FGFR, PDGFR
Dovitinib
T6289
Synonym: TKI258,CHIR-258
Target: VEGFR, FGFR, FLT, PDGFR, c-Kit
SU4312
T3570
Synonym: SU 4312,NSC 86429
Target: VEGFR, PDGFR
AZ12253801
T25123
Synonym: AZ 12253801,AZ-12253801
Target:
Ugodotin
T39257
Synonym:
Target:
KW-2450 Tosylate
T70876
Synonym:
Target:
Dalotuzumab
T76800
Synonym:
Target:
Lonigutamab
T77071
Synonym:
Target:
Istiratumab
T77044
Synonym:
Target:
Cixutumumab
T78279
Synonym: NSC742460,IMC-A12
Target:
NVP-TAC544
T68740
Synonym:
Target:
Roridin E
T70276
Synonym:
Target:
Robatumumab
T76759
Synonym:
Target:
Brigatinib
T3621
Synonym: AP-26113
Target: EGFR, FLT, ROS, IGF-1R, ALK
CYY292
T83911
Synonym:
Target:
Indirubin Derivative E804
T11654
Synonym:
Target: Others
Mps1-IN-1
T12102
Synonym:
Target: Others
AZ7550 trimesylate salt
T13564L2
Synonym: AZ7550 Mesylate,AZ7550 trimesylate salt (1421373-99-0 free base)
Target: MLK
Cat No. Product Name Synonyms Targets
T6S1487 Ginsenoside Rg5 NF-κB , COX , IGF-1R
1. Ginsenoside Rg5 could be a beneficial agent for the treatment of Alzheimer's disease. 2. Ginsenoside Rg5 suppresses LPS-induced nitric oxide (NO) production and proinflammatory TNF-α secretion. 3. Ginsenoside Rg5 can ...
T6943 Picropodophyllin AXL1717,Picropodophyllin (PPP),Picropodophyllotoxin,PPP Apoptosis , IGF-1R
Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with...
T3923 Calycosin Cyclosin,3'-Hydroxyformononetin Apoptosis , Tyrosinase
Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer c...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00455 IGF1R/CD221 Protein, Human, Recombinant (His & Avi) Human HEK293
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00658 IGF1R/CD221 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPK-00456 IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated Human HEK293
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, prot...
TMPY-06195 IGF1R/CD221 Protein, Mouse, Recombinant (His) Mouse HEK293
The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide...
TMPY-00150 IGF2/IGF-II Protein, Human, Recombinant Human Yeast
Insulin-like growth factor 2 (IGF-2/IGF-II) is a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele,...
TMPK-00083 IGF1/IGF-I Protein, Human, Recombinant (hFc) Human HEK293
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins.Insulin-like growth factor I (IGF-I)...
TMPK-00061 IGF2/IGF-II Protein, Human, Recombinant (hFc) Human HEK293
The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in c...
TMPY-06596 Claudin-18.2 Protein-VLP, Human, Recombinant Human HEK293
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
TMPY-06942 Claudin-18 Protein, Human, Recombinant (His & Strep) Human HEK293
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
TMPY-06822 Claudin-18 Protein, Human, Recombinant (CLDN18.2), Fluorescent Human HEK293
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
TMPY-06828 Claudin-18 Protein, Human, Recombinant (CLDN18.1) Human HEK293
Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, a...
Cat No. Product Name
L2192 Anti-Pancreatic Cancer Compound Library

2267 compounds
A unique collection of 2267 pancreatic cancer related compounds can be used in HTS and HCS;
TargetMol