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Results for "

IGF-1R

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    93
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Linsitinib
OSI-906
T6017867160-71-2
OSI-906 (Linsitinib (OSI-906)) is an orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.
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TargetMol | Inhibitor Hot
AZ7550 trimesylate salt
AZ7550 trimesylate salt (1421373-99-0 free base), AZ7550 Mesylate
T13564L22319837-99-3
AZ7550 trimesylate salt (AZ7550 Mesylate) is the active metabolite of ositinib, AZ7550 trimesylate salt inhibits IGF1R activity and can be used in the study of non-small cell lung cancer.
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IGF-1R inhibitor-4
T204141443097-57-2
IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.
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10-14 weeks
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IGF-1R inhibitor-5
T204262331652-38-1
IGF-1Rinhibitor-5 (compound 19) is a potent IGF-1R inhibitor with an IC50 of 6 μM, showing potential for cancer research.
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10-14 weeks
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URMC-099
T60571229582-33-5
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19 42 14 150 nM, for MLK1 MLK2 MLK3 DLK), and also inhibits LRRK2 activity (IC50: 11 nM).
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NVP-ADW742
ADW742, ADW
T6079475488-23-4
NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
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Teprotumumab
R 1507, HZN 001
T767271036734-93-6
Teprotumumab is a human monoclonal antibody that blocks the IGF-1 receptor (IGF-1R). Teprotumumab binds to the extracellular α-subunit domain ligand of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab reduces TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used in the study of thyroid-associated eye diseases.
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Xentuzumab
BI 836845
T767951417158-65-6
Xentuzumab (BI836845) is a recombinant monoclonal antibody to humanised IGF ligand that inhibits IGF1 and IGF2 growth-promoting signalling and inhibits AKT activation for the study of solid tumours.
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Ganitumab
AMG 479
T76810905703-97-1
Ganitumab (AMG 479) is a highly potent monoclonal antibody targeting the type 1 insulin-like growth factor receptor (IGF1R). Recognized for binding IGF1R at low concentrations with a KD value of 0.22 nM, Ganitumab inhibits IGF1R interactions with IGF1 and IGF2 in mice, making it useful for cancer research.
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Lonigutamab
VB-421, VB421, hz208F2-4
T77071
Lonigutamab (hz208F2-4) is a humanized monoclonal antibody targeting the insulin-like growth factor-1 receptor (IGF-1R) for the study of thyroid eye disease.
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Cixutumumab
NSC742460, NSC 742460, LY3012217, LY 3012217, IMC-A12, IMCA12
T78279947687-12-9
Cixutumumab (IMC-A12) is a humanized IgG monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF1R). It has anticancer activity, inhibits ligand-dependent receptor activation and downstream signaling, and can be used in the study of non-small cell lung and prostate cancer.
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Tyrphostin AG 538
AG 538
T67707133550-18-2In house
Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.
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8-10weeks
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WAY-270250
T77624852367-46-5
WAY-270250 is an IGF-1R SRC inhibitor.
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TargetMol | Inhibitor Sale
cis-NVP-ADW742
T2107475489-15-7
NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
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Protonstatin-1
T71812521972-99-6
Protonstatin-1 is used as a hypoglycemic agent and as a compound for the treatment of Alzheimer's disease, inhibits IGFIR kinase activity and can be used in cancer research.
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6-8 weeks
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IGF-1R inhibitor-2
T385021116236-15-7
IGF-1R inhibitor-2 (example 121) is a compound that inhibits the insulin-like growth factor-1 receptor (IGF-1R), potentially reversing the transformed phenotype of tumor cells and increasing their susceptibility to apoptosis.
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IGF-1R inhibitor-3
T867061227753-12-9
IGF-1R Inhibitor-3 (Compound C11) serves as an allosteric inhibitor targeting the kinase of insulin-like growth factor receptor 1 (IGF-1R), exhibiting an IC50 value of 0.2 μM [1].
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10-14 weeks
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IGF-1R modulator 1
T886152375424-89-6
IGF-1Rmodulator 1 (Example 5) is an IGF-1R modulator featuring an EC50 of 0.29 μM (FGFR1), 0.25 μM (IGF1R), 0.34 μM (TrkA), and 0.39 μM (TrkB). This compound is useful in research on diseases characterized by impaired signaling of neurotrophic and or other trophic factors, such as Alzheimer's disease.
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10-14 weeks
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Insulin (human)
Insulin(human), INSULIN
T822111061-68-0
Insulin (human) is a peptide hormone that promotes glycogen synthesis and regulates glucose levels in the blood. Insulin (human) has hypoglycemic activity and is used clinically to treat hyperglycemia in diabetic patients.
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TargetMol | Inhibitor Hot
GIP (3-42), human
Gastric Inhibitory Polypeptide (3-42) (human)
T375891802086-25-4
GIP (3-42), human (Gastric Inhibitory Polypeptide (3-42) (human)) is a peptide that acts as a glucose-dependent proinsulinotropic polypeptide (GIP) receptor antagonist and regulates insulin secretion and the metabolic effects of GIP in vivo, which can be used to study type 2 diabetes.
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Urolithin C
TN7108165393-06-6
Urolithin C is a gut metabolite of ellagic acid. Urolithin C induces apoptosis in PC12 cells through a mitochondria-mediated pathway.
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Robatumumab
School 717454, Sch717454, Sch 717454, MK-7454, MK7454, 19D12
T76759934235-44-6
Robatumumab (Sch 717454) is a fully human anti-insulin-like growth factor receptor type 1 (IGF-1R) monoclonal antibody with antitumor and antiproliferative activity.Robatumumab is used in the study of ovarian cancer.
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Insulin efsitora alfa
LY-3209590, LY3209590
T770372131038-11-2
Insulin efsitora alfa (LY-3209590) is a selective insulin receptor (IR) agonist and fusion protein that combines a novel single-chain insulin variant with the structural domain of human IgG Fc for the study of type 2 diabetes.
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Dusigitumab
MEDI 573
T806051204390-13-5
Dusigitumab (MEDI 573) is a human IgG2λ monoclonal antibody targeting insulin-like growth factors IGF2 and IGF1, offering therapeutic potential for conditions related to these proteins [1].
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2-4 weeks
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