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Search Results for " triple "

115

Compounds

23

Recombinant Proteins

1

Libraries

Cat No. Product Name
T9407 Rasarfin Others , Ras
Rasarfin inhibits Ras and ARF6.
T41256 SP-96 Aurora Kinase
SP-96 is a highly effective and selective inhibitor of Aurora B with an IC50 of 0.316 nM. SP-96 shows selective growth i...
T9468 FR054 Others
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer eff...
T10860 Col003 HSP
Col003 is a selective and potent inhibitor of Hsp47 and competitively binds to the collagen-binding site on Hsp47 (IC50:...
T13780 MS1943 Apoptosis , Histone Methyltransferase
MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM).
T6797 Telaglenastat CB 839,CB839,CB-839 transporter , Glutaminase , Autophagy
Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, f...
T19664 ON1231320 GBO-006 Apoptosis , PLK
ON1231320 (GBO-006) is a Polo-like kinase 2 (PLK2) inhibitor.
T7530 PD146176 NSC168807 Ferroptosis , Lipoxygenase , Autophagy
PD146176 (NSC-168807) is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 ...
T2655 CEP-37440 CEP37440 FAK , ALK
CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and...
T9320 YK-3-237 B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid Sirtuin
YK-3-237 (B-[2-Methoxy-5-[(1E)-3-oxo-3-(3,4,5-trimethoxyphenyl)-1-propen-1-yl]phenyl]boronic acid) reduces acetylation o...
T8808L LYN-1604 dihydrochloride LYN-1604 2HCl(2216753-86-3 free base) Apoptosis , Autophagy
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophag...
T13044 Mevociclib SY-1365 CDK
Mevociclib (SY-1365) is a highly selective covalent inhibitor of CDK7. SY-1365 possesses therapeutic potential in both h...
T4123 LYN-1604 LYN1604 Apoptosis , Autophagy
LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autopha...
T35528 TD52 Apoptosis , Phosphatase , Akt
TD52 is an orally active inhibitor of cancerous inhibitor of PP2A (CIP2A). TD52 is an Erlotinib derivative and indirectl...
T70353 JG-231 HSP
JG-231 is a JG-98 analog with anticancer activity.JG-231 inhibits the MDA-MB-231 xenograft tumor model of triple-negativ...
T2092 Amitifadine hydrochloride DOV-21947 hydrochloride,EB-1010 hydrochloride Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Norepinephrine
Amitifadine hydrochloride (EB-1010 hydrochloride) is a triple reuptake inhibitor (TRI) or serotonin-norepinephrine-dopam...
T6224 Iniparib NSC-746045,IND-71677,BSI-201 PARP , Influenza Virus
Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).
T8569 DMH-25 mTOR
DMH25 is a novel covalent and potent inhibitor of mTOR and shows in vivo antitumor activity against triple-negative brea...
T5001 Nintedanib esylate Intedanib,BIBF 1120 (esylate),Nintedanib Ethanesulfonate Salt,BIBF 1120 VEGFR , FGFR , PDGFR
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β
T9583 HJ-PI01 N-Acetylphenoxazine,10-acetylphenoxazine Pim
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative...
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Cat No. Product Name Species Source
TMPY-01395 CTHRC1 Protein, Human, Recombinant (His) Human HEK293
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to ...
TMPY-06775 CTHRC1 Protein, Human, Recombinant (hFc) Human HEK293
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to ...
TMPY-04288 CTHRC1 Protein, Rat, Recombinant (His) Rat HEK293
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to ...
TMPY-06826 CTHRC1 Protein, Human, Recombinant (His & AVI), Biotinylated Human HEK293
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to ...
TMPY-06795 CTHRC1 Protein, Mouse, Recombinant (His) Mouse HEK293
Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to ...
TMPY-03166 DDR2 Protein, Rat, Recombinant (His) Rat HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-03098 DDR2 Protein, Rat, Recombinant (hFc) Rat HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-03625 DDR2 Protein, Human, Recombinant (His) Human HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-01728 DDR2 Protein, Mouse, Recombinant (His) Mouse HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-04361 DDR2 Protein, Human, Recombinant (aa 422-855, His & GST) Human Baculovirus-Insect Cells
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-03593 DDR2 Protein, Rhesus, Recombinant (His) Rhesus HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-00773 DDR2 Protein, Human, Recombinant (hFc) Human HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-03642 DDR2 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR...
TMPY-04817 Syntenin Protein, Human, Recombinant (His) Human E. coli
Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy.
TMPY-03272 COL4A3 Protein, Rat, Recombinant (hFc) Rat HEK293
COL4A3 is a major structural component of basement membranes. It is composed of 3 alpha subunits, which are encoded by 6 different genes, alpha 1 through alpha 6. Each of these alpha subunits can form a triple helix structure with 2 other subunits to form COL4A3. Autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli can cause goodpasture syndrome. COL4A3 is also linked to an autosomal recessive form of alport syndrome. COL4A3 is organized in a he...
TMPY-03809 COL5A2 Protein, Human, Recombinant (mFc) Human HEK293
COL5A2 is a component of type V collagen. It is known as the pro-alpha2(V) chain. COL5A2, together with two pro-alpha1(V) chains can form type V procollagen. These triple-stranded, rope-like procollagen molecules arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers. Type V collagen can be detected in tissues containing type I collagen and appears to regulate the ...
TMPJ-00133 MBL-2 Protein, Mouse, Recombinant Mouse Human Cells
Mannose-binding Lectin (MBL) is an acute phase protein bearing to the family of collectins produced by the liver as a monomer that forms a triple helix. Once released in serum, it further polymerizes forming dimers to octamers. The degree of serum polymerization is critical for the biological activity of MBL. MBL has higher affinity to microbial polysaccharides or their glycoconjugates. MBL was shown earlier to bind cell surfaces of bacteria, fungi, protozoa and viruses and acts as an acute-phas...
TMPY-06250 CCK4/PTK7 Protein, Cynomolgus, Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
Protein tyrosine kinase 7 (PTK7) is a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway. PTK7 regulates various processes in embryonic development and tissue homeostasis. On a cellular level PTK7 affects the establishment of cell polarity, the regulation of cell movement and migration as well as cell invasion. The PTK7 receptor interacts with ligands, co-receptors, and intracellular transducers of Wnt signaling pathways, pointing to a function in t...
TMPY-06249 CCK4/PTK7 Protein, Human, Recombinant (His) Human HEK293
Protein tyrosine kinase 7 (PTK7) is a highly conserved but catalytically inactive receptor tyrosine kinase in the Wnt signaling pathway. PTK7 regulates various processes in embryonic development and tissue homeostasis. On a cellular level PTK7 affects the establishment of cell polarity, the regulation of cell movement and migration as well as cell invasion. The PTK7 receptor interacts with ligands, co-receptors, and intracellular transducers of Wnt signaling pathways, pointing to a function in t...
TMPJ-00804 COL3A1 Protein, Mouse, Recombinant (His) Mouse Human Cells
Collagen alpha-1(III) chain(Col3a1) is a secreted protein and belongs to the fibrillar collagen family.It contains 1 fibrillar collagen NC1 domain and 1 VWFC domain. Collagen alpha-1(III) chain is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with type I collagen. The COL3A1 gene produces the components of type III collagen, called pro-alpha1(III) chains. Three copies of this chain combine to make a mole...

Recombinant Proteins

CTHRC1 Protein, Human, Recombinant (His)
TMPY-01395
Species: Human
Source: HEK293
CTHRC1 Protein, Human, Recombinant (hFc)
TMPY-06775
Species: Human
Source: HEK293
CTHRC1 Protein, Rat, Recombinant (His)
TMPY-04288
Species: Rat
Source: HEK293
CTHRC1 Protein, Human, Recombinant (His & AVI), Biotinylated
TMPY-06826
Species: Human
Source: HEK293
CTHRC1 Protein, Mouse, Recombinant (His)
TMPY-06795
Species: Mouse
Source: HEK293
DDR2 Protein, Rat, Recombinant (His)
TMPY-03166
Species: Rat
Source: HEK293
DDR2 Protein, Rat, Recombinant (hFc)
TMPY-03098
Species: Rat
Source: HEK293
DDR2 Protein, Human, Recombinant (His)
TMPY-03625
Species: Human
Source: HEK293
DDR2 Protein, Mouse, Recombinant (His)
TMPY-01728
Species: Mouse
Source: HEK293
DDR2 Protein, Human, Recombinant (aa 422-855, His & GST)
TMPY-04361
Species: Human
Source: Baculovirus-Insect Cells
DDR2 Protein, Rhesus, Recombinant (His)
TMPY-03593
Species: Rhesus
Source: HEK293
DDR2 Protein, Human, Recombinant (hFc)
TMPY-00773
Species: Human
Source: HEK293
DDR2 Protein, Rhesus, Recombinant (hFc)
TMPY-03642
Species: Rhesus
Source: HEK293
Syntenin Protein, Human, Recombinant (His)
TMPY-04817
Species: Human
Source: E. coli
COL4A3 Protein, Rat, Recombinant (hFc)
TMPY-03272
Species: Rat
Source: HEK293
COL5A2 Protein, Human, Recombinant (mFc)
TMPY-03809
Species: Human
Source: HEK293
MBL-2 Protein, Mouse, Recombinant
TMPJ-00133
Species: Mouse
Source: Human Cells
CCK4/PTK7 Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-06250
Species: Cynomolgus,Rhesus
Source: HEK293
CCK4/PTK7 Protein, Human, Recombinant (His)
TMPY-06249
Species: Human
Source: HEK293
COL3A1 Protein, Mouse, Recombinant (His)
TMPJ-00804
Species: Mouse
Source: Human Cells
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TargetMol