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Results for "

triple

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    188
    TargetMol | Inhibitors_Agonists
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    TargetMol | Compound_Libraries
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    TargetMol | Antibody_Products
LYN-1604 dihydrochloride
LYN-1604 2HCl(2216753-86-3 free base)
T8808L2310109-38-5
LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
  • $30
In Stock
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FR054
T946835954-65-5
FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect, inducing a dramatic decrease in cell proliferation and survival in various breast cancer cells.
  • $35
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TargetMol | Inhibitor Sale
Col003
T10860328565-16-8
Col003 is a selective and potent inhibitor of Hsp47, competitively binding to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It is useful for researching fibrosis.
  • $39
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RMC-6236
RMC6236, RAS-IN-2, Daraxonrasib
T746982765081-21-6
RMC-6236 is an orally effective and novel triple complex RAS (ON) MULTI inhibitor, which is a potent non covalent inhibitor of multiple RAS variants in GTP binding state. RMC-6236 has anti-tumor activity and can be used in research related to RAS driven tumors. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.
  • $58
In Stock
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TargetMol | Inhibitor Hot
RMC-9805
Zoldonrasib, KRAS G12D inhibitor 18, KRAS G12D IN 18
T782122922732-54-3
RMC-9805 is a novel, mutant-selective, covalent and oral KRASG12D (ON) inhibitor. A stable and high affinity triple complex is formed between RMC-9805, KRASG12D, and cyclophilin A, which inhibits signal transduction downstream of KRASG12D (ON) by disrupting its interaction with downstream effectors. RMC-9805 can induce cell apoptosis and promote tumor regression in preclinical KRASG12D tumor models. With rich experience in compound synthesis, we can provide fast customized synthesis services for this product according to your research needs.
  • $132
In Stock
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TargetMol | Inhibitor Hot
Nintedanib
Intedanib, BIBF 1120
T1777656247-17-5
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34 13 13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69 37 108 nM), PDGFRα, and PDGFRβ (IC50=59 65 nM). Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis.
  • $38
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TargetMol | Inhibitor Hot
Zavondemstat
TACH 101 free base, QC8222 free base
T701211851412-93-5In house
Zavondemstat (QC8222 free base) is a histone lysine demethylase 4 (KDM4) inhibitor with anticancer and antitumor activity for the study of triple-negative and breast cancers.
  • $136
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TargetMol | Inhibitor Hot
BI-4020
T105342664214-60-0In house
BI-4020 is a fourth-generation, orally active, and non-covalent inhibitor of EGFR tyrosine kinase. It exhibits activity against the triple mutant EGFR del19 T790M C797S variant (IC50=0.2 nM in BaF3 cell lines), the double mutant EGFR del19 T790M and primary mutant EGFR del19 (IC50=1 nM), and EGFR wt (IC50=190 nM). BI-4020 also shows high kinome selectivity and good DMPK properties.
  • $173
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Centrinone-B
LCR-323, LCR 323, LCR323
T149261798871-31-4In house
Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor with a Ki of 0.59 nM.
  • $199
In Stock
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MS-444
MS444, BE-34776, BE34776
T16145150045-18-4In house
MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.
  • $865
In Stock
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Pyoluteorin
T2177125683-07-2In house
Pyoluteorin is an antibiotic that inhibits Oomycete fungi, including the plant pathogen Pythium ultimum, and suppresses related plant diseases. Additionally, Pyoluteorin induces apoptosis in human triple-negative breast cancer (MDA-MB-231) cells in vitro.
  • $197
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Liafensine
DB104, BMS-820836, BMS820836, BMS 820836
T327371198790-53-2In house
Liafensine(BMS-820836) is a novel and selective triple monoamine reuptake inhibitor with inhibitory effects on the reuptake of serotonin, norepinephrine, and dopamine for the study of major depressive disorder and central nervous system disorders.
  • $387
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VT103
VT-103, VT 103
T620772290608-13-6In house
VT103 is an orally active and selective inhibitor of TEAD1 protein palmitoylation and is an analog of VT101. VT103 has potential antitumor activity by inhibiting YAP TAZ-TEAD-promoted gene transcriptionment, blocking TEAD auto-palmitoylation, and blocking the interaction between YAP TAZ and TEAD.VT103 can be used in the study of HER2-positive breast cancer, prostate cancer, and triple-negative breast cancer.
  • $126
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GSK-3 inhibitor 4
T773412227279-83-4In house
GSK-3 inhibitor 4 is an orally active and brain-permeable compound that acts as a triple inhibitor of GSK-3, CDK2, and CDK5, with IC50 values of 0.56 nM (GSK-3β), 0.45 nM (GSK-3α), 0.47 μM (CDK2), and 0.68 μM (CDK5). It effectively reduces Tau protein levels and can be used in the study of Alzheimer's disease.
  • $350
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GSK-3 inhibitor 3
T773422227279-84-5In house
GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively.GSK-3 inhibitor 3 reduces the phosphorylation level of tau protein S396 with an IC50 of 10 nM in a triple transgenic mouse model of Alzheimer's disease. GSK-3 inhibitor 3 reduced the phosphorylation level of tau protein S396 in a triple transgenic mouse model of Alzheimer's disease, with an IC50 of 10 nM.GSK-3 inhibitor 3 can be used for the study of neurological diseases.
  • $82
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TargetMol | Inhibitor Sale
BFC1108
T84314692774-37-1In house
BFC1108 targets Bcl-2 and converts it to a pro-apoptotic protein, inhibits the growth of triple-negative breast cancer xenografts with high Bcl-2 expression, inhibits breast cancer lung metastasis, and induces apoptosis of Bcl-2-expressing cancer cells.
  • $47 TargetMol
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SMBA1
T8792906440-37-7In house
SMBA1 is a highly potent Bax agonist with antitumor activity that induces cell cycle arrest and apoptosis in malignant glioma cells. SMBA1 can be used to study triple-negative breast cancer.
  • $98
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HJ-PI01
N-Acetylphenoxazine, 10-acetylphenoxazine
T95836192-43-4In house
HJ-PI01 (HJ-PI01) is a Pim-2 inhibitor. HJ-PI01 (HJ-PI01) induces apoptosis and autophagic cell death in triple-negative human breast cancer.
  • $30
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Nintedanib esylate
Nintedanib Ethanesulfonate Salt, BIBF 1120 (esylate)
T5001656247-18-6
Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor targeting VEGFR1 2 3, FGFR1 2 3, and PDGFRα β.
  • $36
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Benzoquinoquinoxaline
BQQ
T61664207671-99-6
Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with aminoalkyl side chains containing benzo and quinoline ring structures.BQQ is triple-helix specific stabilizing compounds by preferentially binding to DNA triple junctions and inserting between the bases.Complexes of BQQ with 1,10-phenanthroline are able to bind specifically to and cleave double-stranded DNA at the cleave double-stranded DNA at sites that form triple structures.
  • $159
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Nigericin
T1632328380-24-7
Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1 GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt β-catenin signaling downregulation.
  • $32
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Demethylzeylasteral
Demethylzeylasteral (T-96)
T3418107316-88-1
Demethylzeylasteral (T-96), isolated from Tripterygium wilfordii, has anti-inflammatory, immunosuppressive and anti-tumor activities. It inhibits the invasion of triple-negative breast cancer by blocking the TGF-β signaling pathway, and it can significantly reduce atherosclerosis.
  • $45
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TargetMol | Inhibitor Sale
THZ2
CDK7-IN-1
T72961604810-84-5
THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).
  • $77
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TargetMol | Inhibitor Sale
SR-4835
T83252387704-62-1
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNBC) cells
  • $51
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TargetMol | Inhibitor Sale