Search Result

Search Results for " plasmodium "

Targets

Others P450 Dehydrogenase Antibiotic Parasite

103

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1491	Atovaquone	Atavaquone	Others , P450 , Dehydrogenase , Antibiotic , Parasite
	Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.		Others , P450 , Dehydrogenase , Antibiotic , Parasite
T8767	PfDHODH-IN-2		Dehydrogenase , Parasite
	PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m...		Dehydrogenase , Parasite
T12438	PfDHODH-IN-1		Dehydrogenase , Parasite
	PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity.		Dehydrogenase , Parasite
T12909	SID 26681509		Cysteine Protease , Parasite
	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).		Cysteine Protease , Parasite
T5421	KDU691		Parasite , PI4K
	KDU691 is a PI4K inhibitor.		Parasite , PI4K
T16269	Nanaomycin A		DNA Methyltransferase , Dehydrogenase , Parasite
	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).		DNA Methyltransferase , Dehydrogenase , Parasite
T10378	Artelinic acid		Others
	Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum.		Others
T67694	ZY-19489		Parasite
	ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.		Parasite
T10356	AQ-13 dihydrochloride		Parasite
	AQ-13 dihydrochloride is an antimalarial drug. It is effective against drug-resistant strains of Plasmodium falciparum.		Parasite
T13246	UCT943		Parasite , PI4K
	UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).		Parasite , PI4K
T40417	Ethylhydrocupreine hydrochloride	Optochin hydrochloride	Antibacterial , Parasite
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of...		Antibacterial , Parasite
T11027	DHODH-IN-4		Dehydrogenase
	DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity.		Dehydrogenase
T27400L	Ganaplacide phosphate	Ganaplacide phosphate (1261113-96-5 Free base)	Others
	Ganaplacide phosphate exerts multi-stage antimalarial activity against Plasmodium symptomatic asexual blood-stage infections, and is able to prevent transmission and block infection in animal models.		Others
T21022	Deacylketoconazole	Deacyl ketoconazole	Antifungal
	Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent. Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole.		Antifungal
T16125	MMV390048		Parasite , PI4K
	MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal...		Parasite , PI4K
T3266	Lumefantrine	Benflumetol,dl-Benflumelol	Others , Parasite , Autophagy
	Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects again...		Others , Parasite , Autophagy
T14766	BPH-715		Others , Parasite
	BPH-715 inhibits the liver-stage growth of P. falciparum with an IC50 of 10 μM for P. falciparum exoerythrocytic forms in HepG2 cells.		Others , Parasite
T79535	Antimalarial agent 30		Parasite
	Antimalarial agent 30 has anti-Plasmodium berghei liver stage parasite activity and antimalarial activity for the study of malarial infections.		Parasite
T10903	CWHM-1552		Parasite
	CWHM-1552 is an effective Plasmodium falciparum inhibitor. For the 3D7 and Dd2 strains, the IC50s are 51 nM and 53 nM.		Parasite
T4220	BQR-695	BQR695,NVP-BQR695	PI3K , Parasite , PI4K
	BQR-695 (NVP-BQR695) is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.		PI3K , Parasite , PI4K
T15276	Ferroquine	SSR97193,Ferrochloroquine	Others
	Ferroquine (Ferrochloroquine) is a ferrocenyl analogue of Chloroquine with antimalarial activity. Ferroquine induces oxidative stress and the subsequent destruction of the membrane, resulting in parasiticidal effect on P...		Others
T11558	Hexyl gallate	Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate	Antibacterial
	Hexyl gallate (Gallic acid hexyl ester), an alkyl ester derivative of gallic acid, exhibits potent antimalarial activity against Plasmodium falciparum (IC50: 0.11 mM).		Antibacterial
T74696	SpdSyn binder-1		Parasite
	SpdSyn binder-1 is a weak binding agent that binds to the active site of Plasmodium falciparum spermidine synthase, which is partially inhibitory to malaria and can be used to study malaria.		Parasite
T5420	Cycloguanil hydrochloride	Chloroguanide Triazine	Parasite , Drug Metabolite
	Cycloguanil hydrochloride (Chloroguanide Triazine) is an active metabolite of the antimalarial compound proguanil. It acts as an inhibitor of dihydrofolate reductase (Kis: 0.3 and 1.5 nM for Plasmodium and human forms, r...		Parasite , Drug Metabolite
T9858	5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole		Parasite
	Antileishmanial agent-2 is a 3-Br-isoxazoline-Based Inhibitors against Plasmodium falciparum (D10 and W2 strains) and Leishmania spp. (L. infantum and L. tropica) Promastigotes with IC50s of 0.035, 0.058, 3.5 and 7.5 μM.		Parasite
T17257L	WR99210 hydrochloride(47326-86-3 free base)	WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine	Others
	WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target. It has subnanomolar potency for the wild type, double mutant and quadruple mut...		Others
T28824	SNX0723	SNX 0723,SNX- 0723	HSP
	SNX0723 is a potent Hsp90 Inhibitor with anti-Plasmodium activity. SNX0723 shows high binding affinity for HsHsp90 and PfHsp90 with Kis of 4.4 and 47 nM, respectively. SNX0723 inhibits liver-stage P. berghei ANKA parasit...		HSP
T11030	DHODH-IN-8		Dehydrogenase
	DHODH-IN-8 has antimalarial activity. DHODH-IN-8 is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50 of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively.		Dehydrogenase
T0049	Azlocillin sodium salt	Sodium azlocillin,Azlocillin sodium	Antibacterial , Antibiotic , Parasite
	Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics		Antibacterial , Antibiotic , Parasite
T4382	Proguanil hydrochloride	Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil	Others , Dehydrogenase , DNA/RNA Synthesis , Antifolate , Parasite
	Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine ...
T5493	Pyronaridine		Others
	Pyronaridine is an orally active, mannitol-containing anti-malarial compound that acts by interfering with the replication of the malaria parasite (Plasmodium) within red blood cells. Pyronaridine is often used in combin...		Others
T0850	Primaquine diphosphate	Primaquine phosphate,Primaquine bisphosphate	Antibiotic , Parasite
	Primaquine diphosphate is the phosphate salt form of primaquine, a synthetic, 8-aminoquinoline derivative with antimalarial properties. Although its mechanism of action is unclear, primaquine bind to and alter the proper...		Antibiotic , Parasite
T30612	Bulaquine
	Bulaquine is a derivative of 8-aminoquinoline and has effective activity against the liver stage of plasmodium falciparum and the dormant bodies of Plasmodium vivax and Plasmodium ovale.
T24490	MMV666693	MMV-666693,MMV 666693
	MMV666693 is a selective allosteric Plasmodium Kinesin-5 inhibitor.
T68421	MMV019662
	MMV019662 is a novel inhibitor of Plasmodium falciparum.
T23935	D44	D 44,D-44
	D44 is a Plasmodium FKBPs inhibitor.
T33457	MMV007839	MMV-007839,MMV 007839
	MMV007839 is a potent Plasmodium lactate transporter PfFNT.
T71061	DSM267
	DSM267 is a novel Plasmodium falciparum Dihydroorotate Dehydrogenase (PfDHODH) Inhibitor.
T40087	DSM502
	DSM502, a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor, demonstrates potent nanomolar activity against Plasmodium DHODH and Plasmodium parasites, while not inhibiting mammalian DHODHs.
T31178	Dabequin	dabechin,G 800
	Dabequin is a derivative of aminoquinoline. It is said to have pharmacological activity against Plasmodium fukiparum.
T20910	Dibemethine	Dibemetina,DBMA,AI3-26795,Dibemethinum
	Dibemethine is active against chloroquinone-resistant Plasmodium falciparum by the inhibition of P. falciparum chloroquine-resistance transporter (PfCRT).
T40291	DSM705	DSM705
	DSM705 is a pyrrole-based inhibitor of Dihydroorotate Dehydrogenase (DHODH). It demonstrates high potency in the nanomolar range against Plasmodium DHODH and Plasmodium parasites, while not interfering with mammalian DHO...
T25815	Mirincamycin HCl	U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride
	Mirincamycin HCl is a close analog of the drug clindamycin used for the treatment of Plasmodium falciparum blood stages.
T11331L	FTI 276		Others
	FTI-276 is an inhibitor of protein farnesyltransferase (PFT) (IC50s: 0.9 and 0.5 nM for Plasmodium falciparum and human).		Others
T23625	ACT-451840	ACT451840
	ACT-451840 is a drug of antimalarial activity. It has effective activity against sensitive and resistant Plasmodium falciparum strains.
T25524	IDI-3783
	IDI-3783 is a mutant-selective inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T25448	Genz-669178
	Genz-669178 is a wild-type inhibitor of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).
T71841	MMV085203
	MMV08520 is a novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites.
T79719	8304-vs		Parasite
	8304-vs is a macrocyclic anti-Plasmodial compound that irreversibly binds to and inhibits the Plasmodium proteasome, effectively halting the growth of Plasmodium falciparum [1].		Parasite
T11331	FTI 276 TFA		Others
	FTI 276 TFA is effective against plasmodium falciparum and humans.It is a protein-based nikyltransferase (PFT) inhibitor with an IC50s of 0.9 nM and 0.5 nM, respectively.		Others

Compounds

Atovaquone

T1491

Synonym: Atavaquone

Target: Others, P450, Dehydrogenase, Antibiotic, Parasite

PfDHODH-IN-2

T8767

Synonym:

Target: Dehydrogenase, Parasite

PfDHODH-IN-1

T12438

Synonym:

Target: Dehydrogenase, Parasite

SID 26681509

T12909

Synonym:

Target: Cysteine Protease, Parasite

KDU691

T5421

Synonym:

Target: Parasite, PI4K

Nanaomycin A

T16269

Synonym:

Target: DNA Methyltransferase, Dehydrogenase, Parasite

AQ-13 dihydrochloride

Target: Parasite, PI4K

Ethylhydrocupreine hydrochloride

T40417

Synonym: Optochin hydrochloride

Target: Antibacterial, Parasite

DHODH-IN-4

T11027

Synonym:

Target: Dehydrogenase

Ganaplacide phosphate

T27400L

Synonym: Ganaplacide phosphate (1261113-96-5 Free base)

Target: Others

Deacylketoconazole

T21022

Synonym: Deacyl ketoconazole

Target: Parasite, PI4K

Lumefantrine

T3266

Synonym: Benflumetol,dl-Benflumelol

Target: Others, Parasite, Autophagy

BPH-715

T14766

Synonym:

Target: Others, Parasite

Antimalarial agent 30

Synonym: BQR695,NVP-BQR695

Target: PI3K, Parasite, PI4K

Ferroquine

T15276

Synonym: SSR97193,Ferrochloroquine

Target: Others

Hexyl gallate

T11558

Synonym: Gallic acid hexyl ester,Hexyl 3,4,5-trihydroxybenzoate

Target: Antibacterial

Cycloguanil hydrochloride

T5420

Synonym: Chloroguanide Triazine

Target: Parasite, Drug Metabolite

5-(3-bromo-4,5-dihydroisoxazol-5-yl)-3-(4-(tert-butyl)phenyl)-1,2,4-oxadiazole

T9858

Synonym:

Target: Parasite

WR99210 hydrochloride(47326-86-3 free base)

T17257L

Synonym: WR99210 hydrochloride(47326-86-3 free base),6,6-Dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,6-dihydro-1,3,5-triazine-2,4-diamine

Target: Others

SNX0723

T28824

Synonym: SNX 0723,SNX- 0723

Target: Dehydrogenase

Azlocillin sodium salt

T0049

Synonym: Sodium azlocillin,Azlocillin sodium

Target: Antibacterial, Antibiotic, Parasite

Proguanil hydrochloride

T4382

Synonym: Paludrine hydrochloride,Chlorguanide hydrochloride,Chloroquanil

Target: Others, Dehydrogenase, DNA/RNA Synthesis, Antifolate, Parasite

Primaquine diphosphate

T0850

Synonym: Primaquine phosphate,Primaquine bisphosphate

Target: Antibiotic, Parasite

Synonym: MMV-666693,MMV 666693

Synonym: MMV-007839,MMV 007839

Synonym: dabechin,G 800

Target:

Dibemethine

T20910

Synonym: Dibemetina,DBMA,AI3-26795,Dibemethinum

Synonym: U24,729A,U-24,729A,U-24729 A,U 24729 A,U 24,729A,Mirincamycin hydrochloride

Cat No.	Product Name	Synonyms	Targets
TN7103	13,21-Dihydroeurycomanone	Pasakbumin C	Anti-infection , Parasite
	13,21-Dihydroeurycomanone (Pasakbumin C) is a natural product isolated from the root of Eurycoma longifolia with antiparasitic activity such as Plasmodium falciparum and Toxoplasma gondii.		Anti-infection , Parasite
T6S0084	Tuberostemonine	Tuberstemonine	Parasite
	1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.		Parasite
TN2027	Oxysanguinarine	8-Oxosanguinarine,Hydroxysanguinarine	Parasite
	Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.		Parasite
T3682	(-)-Catechin gallate	(-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate	Others , COX
	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat...		Others , COX
TN1190	14,15 β-Dihydroxyklaineanone	14,15beta-Dihydroxyklaineanone	Parasite
	14,15 β-Dihydroxyklaineanone（14,15beta-Dihydroxyklaineanone） is a bittersweet compound isolated from Eurycoma longifolia with antitumor-promoting, antischistosomal and plasmodium-killing activities.		Parasite
TN3790	Dehydroabietinol	Pomiferin A,Dehydroabietyl alcohol	Antifection
	Dehydroabietinol (Pomiferin A) inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).		Antifection
T0392	Artemisinin	Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine	HCV Protease , Ferroptosis , Akt , Parasite
	Artemisinin (Qinghaosu) is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium ...		HCV Protease , Ferroptosis , Akt , Parasite
T3327	Artemotil	SM-227,β-Arteether,Beta-Arteether,Arteether,(+)-Arteether	CXCR , CCR , Parasite
	Artemotil (SM-227) is a new, fast-acting antimalarial drug.		CXCR , CCR , Parasite
TN1019	Beta-mangostin	β-Mangostin	Apoptosis , Antibacterial , Parasite
	Beta-mangostin (β-Mangostin) is a xanthone compound with antibacterial and antimalarial activities. Beta-mangostin present in Cratoxylum arborescens and exhibits antimycobacterial activity against Mycobacterium tuberculo...		Apoptosis , Antibacterial , Parasite
T35749	Thymohydroquinone	Thymoquinol	Antioxidant , Reactive Oxygen Species
	Thymohydroquinone (Thymoquinol) is a monoterpenoid phenolic compound found in thyme, oregano, and other plants in the labiaceae family. Thymohydroquinone inhibits cancer cell growth, reduces oxidative stress and modulate...		Antioxidant , Reactive Oxygen Species
TN3466	Atherosperminine		cAMP , Calcium Channel , AChR , Parasite
	Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t...		cAMP , Calcium Channel , AChR , Parasite
TN4314	Isonardoperoxide		Antifection
	Isonardoperoxide shows strong antimalarial activity against Plasmodium falciparum malaria (6.0 × 10-7 M).		Antifection
T11681	Isochondrodendrine	Isochondrodendrin	Others
	Isochondodendrine has strong antiplasmodial activity against Plasmodium falciparum. Isochondrodendrine is a class of bisbenzylisoquinoline alkaloid isolated from Isolona ghesquiereina.		Others
TN4717	Oplopanone		Antifection
	Oplopanone exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strain.		Antifection
TN2485	1,2-Dihydrotanshinone	1,2-Dihydrotanshinquinone	Antifection
	1,2 Dihydrotanshinquinone is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
TN3583	Canophyllal		Antifection
	Canophyllal shows antiplasmodial activity against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.		Antifection
TN3563	Caesalmin B		Antifection
	Caesalmin B shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.		Antifection
TN2747	2-Acetoxy-3-deacetoxycaesaldekarin E		Antifection
	2-Acetoxy-3-deacetoxycaesaldekarin E shows significant dose-dependent inhibitory effects on Plasmodium falciparum FCR-3/A2 growth in vitro.		Antifection
T11509	Guanfu base H	Atisinium chloride	Others
	Guanfu base H is a diterpenoid alkaloid isolated from Aconitum coreanum. It has antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1 (IC50s: 4 μM and 3.6 μM).		Others
TN1930	Methylenetanshinquinone		Antifection
	Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.		Antifection
TN1442	Betulinic acid methyl ester		Antifection
	Betulinic acid methyl ester showed antiplasmodial activity against chloroquine-resistant Plasmodium falciparum parasites in vitro.It also inhibited B16 2F2 cell proliferation by induction of apoptosis.		Antifection
TN4666	Norcaesalpinin E		Antifection
	Norcaesalpinin E shows antimalarial activity against the malaria parasite Plasmodium falciparum FCR-3/A2 clone in vitro, with an IC50 value of 0.090 microM.		Antifection
TN4202	(-)-Heraclenol		Antifection
	(-)-Heraclenol shows in vitro anti-plasmodial activity against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.(-)-Heraclenol has moderate antibacterial and antifungal activities.		Antifection
TN5657	Goniotriol
	Goniotriol shows antimycobacterial activity against Mycobacterium tuberculosis (MIC =100 microg/mL). It exhibits antiplasmodial activity against Plasmodium falciparum (IC50=2.6 microg/mL). Goniotriol shows cytotoxicity a...
T79984	Chaparrinone		Parasite
	Chaparrinone, a quassinoid derived from the root of Eurycoma harmandiana, exhibits antimalarial and cytotoxic properties, with IC50 values of 0.037 μg/mL against Plasmodium falciparum and 0.34 μg/mL against P-388 cells [...		Parasite
TN3124	5-Hydroxysophoranone		Antibacterial , Parasite , Antifection
	5-Hydroxysophoranone is extracted from Erythrina subumbrans stems and exhibits high antiplasmodial activity against Plasmodium falciparum (IC50 = 2.5 μg/mL).		Antibacterial , Parasite , Antifection
TN2738	2,6-Dimethoxy-1-acetonylquinol		Antifection
	2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.		Antifection
TN4716	Oplodiol		Influenza Virus
	Oplodiol exhibits noteworthy anti-plasmodial activity against Plasmodium falciparum strains. Oplodiol has a stimulative effect on significantly proliferation and differentiation of culture osteoblasts; it also shows mode...		Influenza Virus
T75450	P-orlandin
	P-orlandin, a fungal metabolite, effectively impedes Plasmodium falciparum infection in mosquitoes by preventing FREP1 from binding to gametocytes or ookinetes [1].
T1235L	Lincomycin	U 10149,U10149,U-10149
	Lincomycin is a lincosamide antibiotic that comes from the actinomycete Streptomyces lincolnensis. Although similar in structure, antibacterial spectrum, and mechanism of action to macrolides, lincomycin is also effectiv...
T11802	L-Canaline		Others
	L-Canaline, a nonprotein amino acid found in many leguminous plants, exhibits potent anticancer and antiproliferative effects. It effectively inhibits the growth of the malaria parasite Plasmodium falciparum with an IC50...		Others
T75568	Z-Antiepilepsirine
	Z-Antiepilepsirine, an amide alkaloid present in Piper capense L.f., exhibits antiplasmodial properties, demonstrating an IC50 value of 27 µM against the W2 strain of Plasmodium falciparum [1].
T75447	Asperaculane B
	Asperaculane B, a fungal metabolite, exhibits anti-malarial activity by inhibiting Plasmodium falciparum transmission and its asexual development, with IC50 values of 7.89 µM and 3 µM, respectively. Additionally, it is n...
TN4113	Garcinone E		Antifection
	Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent...		Antifection
TN4449	Longistylin C		Antifection
	Longistylin A and longistylin C show some cytotoxic effects, with IC(50) values of 0.7-14.7 microM against the range of cancer cell lines. Longistylin A and longistylin C, and betulinic acid show a moderately high in vit...		Antifection
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...
TN4683	Nyasol		ERK , IL Receptor , IκB/IKK , NOS , NF-κB , Akt , Antifection
	Nyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells. Nyasol shows anti-inflammatory properties by inhibiting iNOS expression; it also has antif...

Natural Products

13,21-Dihydroeurycomanone

TN7103

Synonym: Pasakbumin C

Target: Anti-infection, Parasite

Tuberostemonine

T6S0084

Synonym: Tuberstemonine

Target: Parasite

Oxysanguinarine

TN2027

Synonym: 8-Oxosanguinarine,Hydroxysanguinarine

Target: Parasite

(-)-Catechin gallate

T3682

Synonym: (-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate

Target: Others, COX

14,15 β-Dihydroxyklaineanone

TN1190

Synonym: 14,15beta-Dihydroxyklaineanone

Target: Parasite

Dehydroabietinol

TN3790

Synonym: Pomiferin A,Dehydroabietyl alcohol

Target: Antifection

Artemisinin

T0392

Synonym: Qinghaosu,Artemisinine,Qinghaosu,NSC 369397,Artemisinine

Target: HCV Protease, Ferroptosis, Akt, Parasite

Artemotil

T3327

Synonym: SM-227,β-Arteether,Beta-Arteether,Arteether,(+)-Arteether

Target: CXCR, CCR, Parasite

Beta-mangostin

TN1019

Synonym: β-Mangostin

Target: Apoptosis, Antibacterial, Parasite

Thymohydroquinone

T35749

Synonym: Thymoquinol

Target: Antioxidant, Reactive Oxygen Species

Atherosperminine

TN3466

Synonym:

Target: cAMP, Calcium Channel, AChR, Parasite

Synonym: Isochondrodendrin

1,2-Dihydrotanshinone

TN2485

Synonym: 1,2-Dihydrotanshinquinone

2-Acetoxy-3-deacetoxycaesaldekarin E

Synonym: Atisinium chloride

Target: Others

Methylenetanshinquinone

TN1930

Synonym:

Target: Antifection

Betulinic acid methyl ester

Target: Antibacterial, Parasite, Antifection

2,6-Dimethoxy-1-acetonylquinol

Target: Influenza Virus

Synonym: U 10149,U10149,U-10149

Target: ERK, IL Receptor, IκB/IKK, NOS, NF-κB, Akt, Antifection

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-03143	PFD0110w Protein, Plasmodium falciparum, Recombinant	Plasmodium falciparum	E. coli
	During the asexual blood stage, binds to a sialic acid containing receptor on the surface of the host erythrocyte and thus is involved in merozoite invasion. Binds erythrocytes via a neuraminidase sensitive and trypsin-,...
TMPH-03137	PFS230 Protein, Plasmodium falciparum, Recombinant	Plasmodium falciparum	E. coli
	Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with erythrocytes.
TMPH-03140	Plasmepsin-1 Protein, Plasmodium falciparum, Recombinant (His)	Plasmodium falciparum	E. coli
	During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an ess...
TMPH-03144	SEY1 Protein, Plasmodium knowlesi, Recombinant (His)	Plasmodium knowlesi	in vitro E. coli expression system
	Probable GTP-binding protein that may be involved in cell development.
TMPH-03138	GST Protein, Plasmodium falciparum, Recombinant (His)	Plasmodium falciparum	Yeast
	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).
TMPH-03141	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (His & Myc)	Plasmodium falciparum	Baculovirus
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host...
TMPH-03139	MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO)	Plasmodium falciparum	E. coli
	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
TMPH-03136	L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc)	Plasmodium berghei	E. coli
	L-lactate dehydrogenase Protein, Plasmodium berghei, Recombinant (His & Myc) is expressed in E. coli.
TMPH-03142	Plasmepsin-2 Protein, Plasmodium falciparum, Recombinant (E. coli, His & Myc)	Plasmodium falciparum	E. coli
	During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation. May cleave preferentially denatured hemoglobin that has been cleaved by PMI. Digestion of host...
TMPH-00990	ACKR1 Protein, Human, Recombinant (His)	Human	in vitro E. coli expression system
	ACKR1 Protein, Human, Recombinant (His) is expressed in in vitro E. coli expression system.
TMPY-04180	PfLDH Protein, P. falciparum, Recombinant (His)	P. falciparum	E. coli
	Plasmodium falciparum lactate dehydrogenase (PfLDH) is a key enzyme for energy generation of malarial parasites and is considered to be a potential antimalarial target. The ability of PfLDH- or PfIDEh-based immuno-PCR as...
TMPY-00981	ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480,DDDDK)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-01142	ICAM-1/CD54 Protein, Human, Recombinant (His)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-01349	ICAM-1/CD54 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-05017	ICAM-1/CD54 Protein, Rhesus, Recombinant (His)	Rhesus	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-04765	PKLR Protein, Human, Recombinant (His)	Human	E. coli
	Pyruvate kinase (PKLR) is a critical erythrocyte enzyme that is required for glycolysis and production of ATP. Pyruvate kinase deficiency (PKD) is the most frequent red blood cell enzyme abnormality of the glycolytic pat...
TMPJ-00292	CD36 Protein, Human, Recombinant (hFc)	Human	Human Cells
	Platelet Glycoprotein 4 (CD36) is an integral membrane glycoprotein that has multiple physiological functions. It is broadly expressed on a variety of cell types including microvascular endothelium, adipocytes, skeletal ...
TMPJ-00293	CD36 Protein, Mouse, Recombinant (Avi & His), Biotinylated	Mouse	Human Cells
	Platelet Glycoprotein 4(CD36) is belongs to the class B scavenger receptor family. The molecule CD36 is synthesized as a 472 amino acid (aa) protein that contains a 6 aa N-terminal cytoplasmic domain, a 22 aa N-terminal ...
TMPJ-00294	CD36 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Platelet Glycoprotein 4(CD36) is belongs to the class B scavenger receptor family. The molecule CD36 is synthesized as a 472 amino acid (aa) protein that contains a 6 aa N-terminal cytoplasmic domain, a 22 aa N-terminal ...
TMPY-06778	ICAM-1/CD54 Protein, Human, Recombinant (aa 1-480, LEVLFQ)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-01320	ICAM-1/CD54 Protein, Mouse, Recombinant (His & hFc)	Mouse	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-00825	ICAM-1/CD54 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-00239	ICAM-1/CD54 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-05393	ICAM-1/CD54 Protein, Human, Recombinant (hFc)	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-06777	ICAM-1/CD54 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-02017	ICAM-1/CD54 Protein, Rat, Recombinant (His)	Rat	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPY-06753	ICAM-1/CD54 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	Intercellular adhesion molecule-1 (ICAM-1, or CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. IC...
TMPH-01073	CD81 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalizati...