Search Result

Search Results for " machr "

Targets

135

Compounds

Natural Products

Cat No.	Product Name	Synonyms	Targets
T5655	mAChR-IN-1 hydrochloride		AChR
	mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 Nm.		AChR
T9889	M4 mAChR agonist-1	4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-	AChR
	M4 mAChR agonist-1 (4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-) is an effective agonist of M4 mAChR (EC50 >10 μM).		AChR
T5476	mAChr-in-1		AChR
	mAChR-IN-1 is muscarinic cholinergic receptor(mAChR) antagonist (IC50=17 nM).		AChR
T81888	mAChR antagonist 1
	Compound 4a, a mAChR antagonist, exhibits K i values of 255 nM for M1 and M5 subtypes, and lower values of 121 nM and 158 nM for M3 and M4 subtypes, respectively [1].
T1760	TBPB		AChR
	TBPB is an allosteric M1 mAChR agonist.		AChR
T7555	Piperidolate hydrochloride		AChR
	Piperidolate hydrochloride is an antimuscarinic, could restrain the abnormal activity caused by acetylcholine. inhibits intestinal cramp induced by acetylcholine (rats and dogs).		AChR
T23116	Oxotremorine sesquifumarate		AChR
	Oxotremorine sesquifumarate is a muscarinic agonist.		AChR
T11078	Deschloroclozapine		Serotonin Transporter
	Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.		Serotonin Transporter
T6575	LY2119620		AChR
	LY2119620 is a specific, and allosteric agonist of human M2 and M4 muscarinic acetylcholine receptors.		AChR
T13325	VU 0365114		AChR
	VU 0365114 is a positive allosteric modulator of mAChR M5 (EC50: 2.7 μM).		AChR
T6548	Irsogladine	Dicloguamine	PDE , AChR
	Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.		PDE , AChR
T17244	VU0467154		AChR
	VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor. The response to ACh with pEC50s of 7.75, 6.2, and 6 for a rat, human, and cynomolgus monkey M4 receptor, respectively.		AChR
T7405	Piperidolate		AChR
	Piperidolate inhibits intestinal cramp induced by acetylcholine		AChR
T8219	VU0238441		AChR
	VU0238441 is agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM.		AChR
T9420	Prifinium bromide		Others
	Prifinium bromide is a quaternary ammon antimuscarinic. It inhibits hyperkinesia of the digestive organs and urinary tract and has a spasmolytic action.		Others
T13066	TAK-071		AChR
	TAK-071 is a potent, novel and highly selective modulator of muscarinic acetylcholine receptor 1 (M1R) positive allosteric(EC50 : 520 nM).		AChR
T3993	BQCA	benzylquinolone carboxylic acid	AChR
	BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator.		AChR
T4997	Umeclidinium bromide	GSK573719A	AChR
	Umeclidinium bromide (GSK573719A) is a novel mAChR antagonist.		AChR
T8224	VU0119498		AChR
	VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM),and is a neuroprotective agent.		AChR
T4981	Anisotropine Methylbromide		Prostaglandin Receptor , AChR
	Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.		Prostaglandin Receptor , AChR
T8383	Cyclopentolate Hydrochloride		AChR
	Cyclopentolate Hydrochloride is a muscarinic acetylcholine receptors antagonist with Kis of 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively.		AChR
T1460	Dicyclomine hydrochloride		AChR
	Dicyclomine hydrochloride is a muscarinic antagonist used as an antispasmodic and in urinary incontinence.		AChR
T23508	VU 0255035		AChR
	muscarinic M1 antagonist		AChR
T9019	JHU37152	JHU 37152	AChR
	JHU37152 (JHU 37152) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ...		AChR
T16411	Otenzepad	AF-DX 116	AChR
	Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.		AChR
T0427	Homatropine Methylbromide	Homatropine methobromide	AChR
	Homatropine Methylbromide is the methyl bromide salt of homatropine, a synthetic tertiary amine alkaloid with antimuscarinic properties.		AChR
T29123	VU0152099	VU 0152099,VU-0152099	AChR
	VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).		AChR
T8007	VU 0238429	SCR-1481B1,VU0238429	AChR
	VU 0238429 (SCR-1481B1) is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5)( EC50 : 1.16 μM).		AChR
T9018	JHU37160	JHU 37160	AChR
	JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. ...		AChR
T1179	Tiotropium bromide	Tiopropium,BA679 BR	AChR
	Tiotropium bromide (BA679 BR) is a long-acting, 24 hour, anticholinergic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD). Tiotropium is a muscarinic receptor antagonist, on topical a...		AChR
T28069	ML380	ML 380,ML-380	AChR
	ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM).		AChR
T15942	MK-7622	M1 receptor modulator	AChR
	MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric.		AChR
T22380	Nor-benzetimide		Others , AChR
	Norbenzetimide, an organic compound, is prepared from benzetimide by catalytic transfer hydrogenolysis.		Others , AChR
T0720	Gallamine triethiodide	Benzkurin,Flaxedil	AChR
	Gallamine triethiodide (Benzkurin), a synthetic inhibiting drug, is nondepolarizing.		AChR
T17238	VU0152100	VU152100	AChR
	VU0152100 is an effective and selective allosteric potentiator of M4 mAChR (EC50: 380 ± 93 nM).		AChR
T14345	Atropine methyl bromide	Methylatropine bromide	AChR
	Atropine methyl bromide (Methylatropine bromide) is a quaternary ammonium salt of atropine, characterized as a muscarinic receptor (mAChR) antagonist. It functions as a mydriatic to dilate the pupil during ophthalmic exa...		AChR
T9419	Fesoterodine	(R) Fesoterodine	AChR
	Fesoterodine ((R) Fesoterodine) is an orally active, competitive mAChR antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. It is used for the overactive bladder (OAB).		AChR
T23513	VU10010	VU 10010	AChR
	VU10010 (VU 10010) is allosteric potentiator of M4 acetylcholine receptors.		AChR
T1281	Tropicamide	Ro 1-7683	AChR
	Tropicamide (Ro 1-7683) is a synthetic muscarinic antagonist with actions similar to atropine and with an anticholinergic property. Upon ocular administration, tropicamide binds to and blocks the muscarinic receptors in ...		AChR
T11095L	DREADD agonist 21		5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor
	DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM).
T29137	VU0453595	VU 0453595,VU-0453595	AChR
	VU0453595 is a M1 positive allosteric modulator (PAM).		AChR
T5023	Propiverine hydrochloride		Others , Calcium Channel , AChR
	Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB).		Others , Calcium Channel , AChR
T9694	Emraclidine	CVL-231	AChR
	Emraclidine (CVL-231) is a muscarinic M4 receptor positive allosteric modulator and can be used in neurological diseases studies.		AChR
T7561	Benzetimide hydrochloride	R4929	AChR
	Benzetimide hydrochloride (R4929) is an antagonist of muscarinic acetylcholine receptor.treatment neuroleptic-induced parkinsonism.		AChR
T7392	Revefenacin	TD-4208,GSK1160724	AChR
	Revefenacin (TD-4208) is a mAChR antagonist has a high affinity on M3 receptor( Ki : 0.18 nM),and potentially useful for the treatment of respiratory disease.		AChR
T8147	Solifenacin	YM905 free base	AChR
	Solifenacin (YM905 free base) (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.		AChR
T0111	Solifenacin succinate	YM905	AChR
	Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.		AChR
T0594	Diphenmanil methylsulfate	Diphemanil mesylate,Diphemanil Methylsulfate	AChR
	Diphenmanil methylsulfate (Diphemanil mesylate), a quaternary ammonium anticholinergic, binds muscarinic acetylcholine receptors and thus decreases secretory excretion of stomach acids, sweat, and saliva.		AChR
T1472	Trospium chloride	Spasmex,Sanctura	AChR
	Trospium chloride (Spasmex) is an antispasmodic and anticholinergic agent used to treat urinary incontinence and overactive bladder syndrome. Trospium chloride has not been implicated in causing liver enzyme elevations o...		AChR
T2387	Glycopyrrolate	Gastrodyn,Glycopyrronium bromide,Robinul,Glycopyrrolate bromide	AChR
	Glycopyrrolate (Glycopyrrolate bromide) is a muscarinic antagonist used as an antispasmodic, in some disorders of the gastrointestinal tract, and to reduce salivation with some anesthetics.		AChR

Compounds

mAChR-IN-1 hydrochloride

Synonym: 4-Piperidinecarboxamide, 1-(5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)-

Piperidolate hydrochloride

T7555

Synonym:

Target: AChR

Oxotremorine sesquifumarate

Target: Serotonin Transporter

Synonym: Dicloguamine

Synonym: benzylquinolone carboxylic acid

Anisotropine Methylbromide

T4981

Synonym:

Target: Prostaglandin Receptor, AChR

Cyclopentolate Hydrochloride

T8383

Synonym:

Target: AChR

Dicyclomine hydrochloride

Homatropine Methylbromide

T0427

Synonym: Homatropine methobromide

Target: AChR

VU0152099

T29123

Synonym: VU 0152099,VU-0152099

Target: AChR

VU 0238429

T8007

Synonym: SCR-1481B1,VU0238429

Synonym: Tiopropium,BA679 BR

Target: AChR

ML380

T28069

Synonym: ML 380,ML-380

Target: AChR

MK-7622

T15942

Synonym: M1 receptor modulator

Gallamine triethiodide

T0720

Synonym: Benzkurin,Flaxedil

Atropine methyl bromide

T14345

Synonym: Methylatropine bromide

Target: AChR

Fesoterodine

T9419

Synonym: (R) Fesoterodine

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Histamine Receptor

VU0453595

T29137

Synonym: VU 0453595,VU-0453595

Target: AChR

Propiverine hydrochloride

T5023

Synonym:

Target: Others, Calcium Channel, AChR

Benzetimide hydrochloride

Synonym: TD-4208,GSK1160724

Target: AChR

Solifenacin

T8147

Synonym: YM905 free base

Target: AChR

Solifenacin succinate

T0111

Synonym: YM905

Target: AChR

Diphenmanil methylsulfate

T0594

Synonym: Diphemanil mesylate,Diphemanil Methylsulfate

Target: AChR

Trospium chloride

T1472

Synonym: Spasmex,Sanctura

Target: AChR

Glycopyrrolate

T2387

Synonym: Gastrodyn,Glycopyrronium bromide,Robinul,Glycopyrrolate bromide

Target: AChR

Cat No.	Product Name	Synonyms	Targets
T8196	Arborine	Arborin	Others , AChR
	Arborine (Arborin) is a larval growth inhibitor from glycoslnis pentaphylla.		Others , AChR
T1285	Anethole trithione	Anetholtrithion	Others , AChR
	Anethole trithione (Anetholtrithion) is a bile secretion-stimulating drug that restores salivation and relieves the discomfort of dry mouth in chemotherapy-induced xerostomia.		Others , AChR
T1231	Pilocarpine nitrate	Pilagan,Pilofrin	AChR
	Pilocarpine nitrate (Pilagan) is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.		AChR
T0962	L-Hyoscyamine	Daturine,Hyoscyamine	AChR
	L-Hyoscyamine (Daturine) functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting the parasympathetic activities of acetylcholine on the salivary, bronchial, and sweat glands, as w...		AChR
T0970	Racanisodamine	Anisodamine,7β-Hydroxyhyoscyamine,Raceanisodamine	Adrenergic Receptor , AChR
	Racanisodamine (7β-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.		Adrenergic Receptor , AChR
T8304	Anisodamine Hydrobromide	6-Hydroxyhyoscyamine	Adrenergic Receptor , AChR
	Anisodamine Hydrobromide (6-Hydroxyhyoscyamine) is an anticholinergic and α1-adrenergic receptor antagonist used in the treatment of acute circulatory shock.		Adrenergic Receptor , AChR
T5805	Guvacoline hydrochloride	Norarecoline hydrochloride	AChR
	Guvacoline hydrochloride (Norarecoline hydrochloride) is a muscarinic agonist.		AChR
T0804	Pilocarpine Hydrochloride	NSC 5746 HCl,Pilocarpine HCl,(+)-Pilocarpine hydrochloride	AChR
	Pilocarpine Hydrochloride (NSC 5746 HCl) , a nonselective muscarinic acetylcholine receptor agonist, is utilized to produce an experimental model of epilepsy.		AChR
T2198	Arecoline hydrobromide	Arecoline HBr,Arecoline bromide	AChR
	Arecoline hydrobromide (Arecoline HBr) is a muscarinic acetylcholine receptor agonist.		AChR
T6805	Choline bitartrate	2,3,4-trihydroxy-4-oxobutanoate,2-hydroxyethyl(trimethyl)azanium	Others , AChR
	Choline bitartrate (2-hydroxyethyl(trimethyl)azanium) is a form of the nutrient choline which is found in foods. Choline is necessary for normal liver and kidney function and a component of the neurotransmitter acetylcho...		Others , AChR
T5S0106	Peimisine	Ebeiensine	RAAS , AChR
	1. Peimisine (Ebeiensine) can affect M-receptor, excit β-receptor, restrain the release of internal calcium, and promote to releaseing nitrogen monoxidum in order to relax tracheal smooth muscle and relieve asthma. 2. Pe...		RAAS , AChR
T7056	Dronedarone	SR 33589	P450 , Potassium Channel , Calcium Channel , Sodium Channel , Adrenergic Receptor , AChR , Autophagy
	Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.
T4S1619	L-Hyoscyamine sulfate	Hyoscyamine sulfate hydrate,Levsin Sulfate,Hyoscyamine Sulphate	AChR
	L-Hyoscyamine sulfate (Levsin Sulfate) is the sulfate salt of a belladonna alkaloid derivative and the levorotatory form of racemic atropine isolated from the plants Hyoscyamus niger or Atropa belladonna, which exhibits ...		AChR
TN1653	Fustin		ERK , Beta Amyloid , AChR
	Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death.		ERK , Beta Amyloid , AChR
T19882	Bryonolic acid	UNII-J7YR6A878I,20-epi-Bryonolic acid	Apoptosis , Antioxidant , Calcium Channel
	Bryonolic acid (20-epi-Bryonolic acid), a triterpenoid extracted from Sandoricum indicum, possesses immunomodulatory, anti-inflammatory, antioxidant and anticancer activities and protects PC12 cells from NMDA-induced apo...		Apoptosis , Antioxidant , Calcium Channel