Home Tools
Log in
Cart

Search Result

Search Results for " bbb "

Targets

114

Compounds

10

Natural Products

1

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T33467 MOMIPP PI3K
MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts[1][2].
T22782 FGIN-1-27 Others
high affinity agonist of the translocator protein
T6058 LY2886721 Beta-Secretase , BACE
LY2886721, a BACE inhibitor, is used for the therapy of Alzheimer's Disease.
T2423 P7C3-A20 Others
P7C3-A20 is a derivative of P7C3 that has proneurogenic and neuroprotective activity.
T2225 4-Hydroxyantipyrine COX
4-Hydroxyantipyrine is formed during oxidative deamination of aminopyrine.
T8551 Nitrobenzylthioinosine NBMPR AChR , Adenosine Receptor
Nitrobenzylthioinosine (NBMPR) is an inhibitor of ENT1 transporter that binds to ENT1 transporter with high affinity.
T2671 Regadenoson CVT-3146,Lexiscan Adenosine Receptor
Regadenoson (CVT-3146) is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selectively binds to and activates the A2A adenosine re...
T1993 J-147 J147 Epigenetic Reader Domain , Dopamine Receptor , Monoamine Oxidase
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate...
T7601 Carbetocin Oxytocin Receptor
Carbetocin is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
T24055 FAUC 213 FAUC213,FAUC-213 Dopamine Receptor
FAUC 213 is a selective full antagonist of the dopamine D4 receptor.
T9687 MAGL-IN-4 His121 ARG57 Lipase
MAGL-IN-4 (His121 ARG57) is one of the monoacylglycerol lipase (MAGL) inhibitors in central nervous system-related diseases.
T1065 Baclofen Lioresal GABA Receptor
Baclofen (Lioresal) is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist sp...
T9146 Ms48107 Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Others
MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). It is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion chann...
T7476 AS057278 3-Methylpyrazole-5-carboxylic acid Others
AS057278 (3-Methylpyrazole-5-carboxylic acid) is an D-amino acid oxidase (DAAO) inhibitor.
T29856 Aleplasinin PAZ 417,PAZ417,PAZ-417 PAI-1
Aleplasinin (PAZ 417) is a selective and orally active inhibitor of Plasminogen activator inhibitor-1(PAI-1) and a key negative regulator of the fibrinolytic system. Aleplasinin can be used in Alzheimer's disease studies...
T4494 CLOZAPINE N-OXIDE Dopamine Receptor , 5-HT Receptor , AChR , Drug Metabolite
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopa...
T1628 Rivastigmine tartrate SDZ-ENA 713,ENA 713 AChR , AChE
Rivastigmine tartrate (SDZ-ENA 713) is a carbamate-derived reversible CHOLINESTERASE INHIBITOR that is selective for the CENTRAL NERVOUS SYSTEM and is used for the treatment of DEMENTIA in ALZHEIMER DISEASE and PARKINSON...
T8630 Baclofen hydrochloride 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride GABA Receptor
Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) is a GAMMA-AMINOBUTYRIC ACID derivative that is a specific GABA-B RECEPTORS agonist. It is used in the treatment of MUSCLE SPASTICITY, espe...
T7601L Carbetocin acetate Carbetocin acetate(37025-55-1 free base) Oxytocin Receptor
Carbetocin acetate is an obstetric drug used to control postpartum hemorrhage and bleeding after giving birth.
T0229 Rivastigmine SDZ-ENA 713,S-Rivastigmine,Exelon AChE
Rivastigmine (Exelon) is a Cholinesterase Inhibitor, used for therapy of Alzheimer disease.
T23046 N-tert-butyl-α-Phenylnitrone (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide ROS , COX
N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxyge...
T12895 SHA 68 Neuropeptide Y Receptor
SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
T7196 HG-10-102-01 LRRK2
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
T2344 LY 344864 LY344864 5-HT Receptor
LY 344864, a specifc receptor agonist, is an affinity of 6 nM (Ki) at the recently cloned 5-HT1F receptor.
T41143 PCPA methyl ester hydrochloride 4-Chloro-DL-phenylalanine methyl ester hydrochloride 5-HT Receptor , Hydroxylase
pCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) is an inhibitor of tryptophan hydroxylase inhibitor and 5-HT synthesis. pCPA methyl ester hydrochloride is permeable across the blood...
T38165 FBBBE
FBBBE is a derivatized fluorescein compound that is used to detect the production hydrogen peroxide (H2O2) by cells. Intracellular H2O2, but not extracellular H2O2, initiates the conversion of FBBBE to fluorescein, resul...
T6845 GNE-317 GNE317 PI3K , mTOR
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
T31091 CRANAD-28 CRANAD28 Others
CRANAD-28 can mark plaques and cerebral amyloid angiopathy. It is a blood-brain barrier (BBB) penetrating two-photon imaging probe.
T67764 HMAO-B-IN-4 MAO
hMAO-B-IN-4 is a selective, reversible and blood–brain barrier (BBB) penetrable inhibitor of human monoamine oxidase-B (hMAO-B, IC50=0.067 μM, Ki= 0.03 μM, hMAO-A, IC50= 33.82 μM).
T11471 GSK-3β inhibitor 2 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy- GSK-3
GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50 = 1.1 nM). GSK-3β inhibitor 2 can be used in studies about Al...
T10630 BuChE-IN-TM-10 TM-10 AChR
BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and goo...
T10202 A 1070722 GSK-3
A 1070722 is a potent and selective GSK-3 inhibitor, with a Ki of 0.6 nM for both GSK-3α and GSK-3β. It can penetrate the blood-brain barrier (BBB) and accumulates in brain regions, thus potential for PET radiotracer for...
T19376 Ioversol MP-328 Others
Ioversol (MP-328) is a nonionic iodinated contrast agent.
T18988 FITC-Dextran (MW 10000) FITC-Dextran Others
FITC-Dextran (MW 10000) (FITC-Dextran) is a marker consisting of coupling fluorescein-isothiocyanate to dextran (10 kDa). FITC-Dextran can be used to determine ion, solute, and protein permeability of the blood-brain bar...
TQ0236 Tirabrutinib ONO-4059,GS-4059,Velexbru BTK
Tirabrutinib (GS-4059) (ONO-4059) is an orally active Bruton’s Tyrosine Kinase (Btk) inhibitor (can cross the blood-brain barrier (BBB)), with an IC50 of 6.8 nM. Tirabrutinib irreversibly and covalently binds to Btk and ...
T32191 Irdabisant CEP-26401,CEP 26401,CEP26401 Histamine Receptor
Irdabisant (CEP-26401) (CEP-26401) is a selective, orally active and blood-brain barrier (BBB) penetrant antagonist/inverse agonist of histamine H3 receptor (H3R) (rat H3R Ki= 7.2 nM, human H3R Ki= 2.0 nM). Irdabisant ex...
T2507 Azeliragon TTP488 Beta Amyloid , advanced glycation end products
Azeliragon (TTP488) is an antagonist at the Receptor for Advanced Glycation End products; is evaluated as a potential treatment for patients with mild-to-moderate Alzheimer_acute_s disease (AD).
T6951 Pramipexole dihydrochloride hydrate Pramipexole 2HCl Monohydrate,Mirapex Dopamine Receptor
Pramipexole dihydrochloride hydrate (Mirapex) is the hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and su...
T12179 Nav1.1 activator 1 Others
Nav1.1 activator 1 is a highly potent activator of Nav1.1 with BBB penetration.
T38093 NT1-O12B NT1-O12B
NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorpo...
T21219 Isatin-O Isatin-3-oxime
Isatin-O acts as a neutral BBB crossing reactivator for acetylcholinesterase inhibited by paraoxon and is also an anticonvulsant.
T83130 AMCPy
AMCPy, a potent electron paramagnetic resonance (EPR) brain imaging agent, boasts excellent lipophilicity, facilitating its penetration through the blood-brain barrier (BBB) [1].
T69768 WSD0922-FU
WSD0922-FU is a blood-brain-barrier (BBB) penetrable selective inhibitor of epidermal growth factor receptor (EGFR) and various EGFR mutations, including but not limited to the EGFR variant III (EGFRvIII) mutant form, wi...
T78681 ITH12711 Phosphatase
ITH12711, a PP2A ligand, can traverse the blood-brain barrier (BBB) and exerts neuroprotection by restoring PP2A-phosphatase activity [1].
T40428 TfR-T12 TfR-T12
TfR-T12 is a transferrin receptor (TfR) binding peptide that can penetrate the blood-brain barrier (BBB), exhibiting a high binding affinity within the nanomolar (nM) range.
T68763 PQQ-TME
PQQ-TME exhibits greater inhibitory activity against fibrillation of α-synuclein, Aβ1-42, and prion protein than PQQ. PQQ-TME also has twice the BBB permeability than PQQ in vitro.
T83317 4-Hydroperoxyifosfamide
4-Hydroperoxyifosfamide is an anticancer agent capable of penetrating the blood-brain barrier (BBB) [1].
T61666 SUN13837
SUN13837 is an orally active, potent modulator of the fibroblast growth factor receptor (FGFR) with the ability to penetrate the blood-brain barrier (BBB). It exhibits neuroprotective activity and holds promise for furth...
T72765 EphA2 agonist 2
EphA2 agonist 2 (Lead compound) is a selective EphA2 agonist with antitumor activities. EphA2 agonist 2 can cross the BBB .
T61845 AChE-IN-21
AChE-IN-21 (Compound I-8) is a highly potent and selective orally active inhibitor of acetylcholinesterase (AChE). It exhibits an impressive inhibitory concentration (IC50) of 2.66 nM. Additionally, AChE-IN-21 demonstrat...

Compounds

MOMIPP
T33467
Synonym:
Target: PI3K
FGIN-1-27
T22782
Synonym:
Target: Others
LY2886721
T6058
Synonym:
Target: Beta-Secretase, BACE
P7C3-A20
T2423
Synonym:
Target: Others
4-Hydroxyantipyrine
T2225
Synonym:
Target: COX
Nitrobenzylthioinosine
T8551
Synonym: NBMPR
Target: AChR, Adenosine Receptor
Regadenoson
T2671
Synonym: CVT-3146,Lexiscan
Target: Adenosine Receptor
J-147
T1993
Synonym: J147
Target: Epigenetic Reader Domain, Dopamine Receptor, Monoamine Oxidase
Carbetocin
T7601
Synonym:
Target: Oxytocin Receptor
FAUC 213
T24055
Synonym: FAUC213,FAUC-213
Target: Dopamine Receptor
MAGL-IN-4
T9687
Synonym: His121 ARG57
Target: Lipase
Baclofen
T1065
Synonym: Lioresal
Target: GABA Receptor
ms48107
T9146
Synonym: Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro-
Target: Others
AS057278
T7476
Synonym: 3-Methylpyrazole-5-carboxylic acid
Target: Others
Aleplasinin
T29856
Synonym: PAZ 417,PAZ417,PAZ-417
Target: PAI-1
CLOZAPINE N-OXIDE
T4494
Synonym:
Target: Dopamine Receptor, 5-HT Receptor, AChR, Drug Metabolite
Rivastigmine tartrate
T1628
Synonym: SDZ-ENA 713,ENA 713
Target: AChR, AChE
Baclofen hydrochloride
T8630
Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride
Target: GABA Receptor
Carbetocin acetate
T7601L
Synonym: Carbetocin acetate(37025-55-1 free base)
Target: Oxytocin Receptor
Rivastigmine
T0229
Synonym: SDZ-ENA 713,S-Rivastigmine,Exelon
Target: AChE
N-tert-butyl-α-Phenylnitrone
T23046
Synonym: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide
Target: ROS, COX
SHA 68
T12895
Synonym:
Target: Neuropeptide Y Receptor
HG-10-102-01
T7196
Synonym:
Target: LRRK2
LY 344864
T2344
Synonym: LY344864
Target: 5-HT Receptor
pCPA methyl ester hydrochloride
T41143
Synonym: 4-Chloro-DL-phenylalanine methyl ester hydrochloride
Target: 5-HT Receptor, Hydroxylase
FBBBE
T38165
Synonym:
Target:
GNE-317
T6845
Synonym: GNE317
Target: PI3K, mTOR
CRANAD-28
T31091
Synonym: CRANAD28
Target: Others
hMAO-B-IN-4
T67764
Synonym:
Target: MAO
GSK-3β inhibitor 2
T11471
Synonym: 5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-
Target: GSK-3
BuChE-IN-TM-10
T10630
Synonym: TM-10
Target: AChR
A 1070722
T10202
Synonym:
Target: GSK-3
Ioversol
T19376
Synonym: MP-328
Target: Others
FITC-Dextran (MW 10000)
T18988
Synonym: FITC-Dextran
Target: Others
Tirabrutinib
TQ0236
Synonym: ONO-4059,GS-4059,Velexbru
Target: BTK
Irdabisant
T32191
Synonym: CEP-26401,CEP 26401,CEP26401
Target: Histamine Receptor
Azeliragon
T2507
Synonym: TTP488
Target: Beta Amyloid, advanced glycation end products
Pramipexole dihydrochloride hydrate
T6951
Synonym: Pramipexole 2HCl Monohydrate,Mirapex
Target: Dopamine Receptor
Nav1.1 activator 1
T12179
Synonym:
Target: Others
NT1-O12B
T38093
Synonym: NT1-O12B
Target:
Isatin-O
T21219
Synonym: Isatin-3-oxime
Target:
AMCPy
T83130
Synonym:
Target:
WSD0922-FU
T69768
Synonym:
Target:
ITH12711
T78681
Synonym:
Target: Phosphatase
TfR-T12
T40428
Synonym: TfR-T12
Target:
PQQ-TME
T68763
Synonym:
Target:
4-Hydroperoxyifosfamide
T83317
Synonym:
Target:
SUN13837
T61666
Synonym:
Target:
EphA2 agonist 2
T72765
Synonym:
Target:
AChE-IN-21
T61845
Synonym:
Target:
1 2 3
Cat No. Product Name Synonyms Targets
T6830 Epoxomicin BU-4061T,BU-4061T,Aids010837 Apoptosis , Proteasome
Epoxomicin (BU-4061T,Aids010837) is a selective proteasome inhibitor with anti-inflammatory activity, inhibits primarily the CH-L activity of the 20S proteasome, while T-L and PGPH catalytic activities are also inhibited...
T8193 α-Thujone Thujone,ALPHA-(-)-THUJONE Apoptosis , Reactive Oxygen Species , GABA Receptor , AChR , Parasite , Autophagy
α-Thujone is an inhibitor of ACh with an IC50 value of 24.7μM.
TN1048 Cnidilin Knidilin
Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
T5S1262 Methylophiopogonanone A Others
1. Methylophiopogonanone A has anti-inflammatory and anti-oxidative properties. 2. Methylophiopogonanone A has therapeutic potential against cerebral I/R injury through its ability to attenuate BBB disruption by regulati...
T6S0077 Byakangelicol COX
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...
T3893 Forsythoside B TNF , NF-κB
Forsythoside B binds to LPS and reduces the biological activity of serum LPS, and inhibits NF-κB activation. Forsythoside B inhibits the inflammatory response and has antioxidant properties. Potent neuroprotective effect...
T5S1632 Barlerin 8-O-Acetylshanzhiside methyl ester,ND01 VEGFR , TNF , NF-κB , Akt , Caspase
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...
T13493 3-Acetyldeoxynivalenol Others
3-Acetyldeoxynivalenol is a trichothecene mycotoxin deoxynivalenol acetylated derivative and a blood-brain barrier (BBB) permeable mycotoxin.
TN3008 4',4''-Dihydroxyanigorootin Others
4',4''-Dihydroxyanigorootin is a natural product from Musa cv."Thepanom" (BBB).
TN2775 2-Methoxystypandrone MMP , BCL , IκB/IKK , GSK-3 , TNF , NOS , NF-κB , Wnt/beta-catenin , COX , JAK , STAT
2-Methoxystypandrone displays an immunomodulatory effect in a cellular model, it blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrit...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00481 PDGF R beta/CD140b Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Platelet-derived growth factor receptor (PDGFR) signaling is involved in proliferation and survival in a wide array of cell types.PDGFR-β signalling, via TGF-β signalling, may be crucial for restoration of BBB integrity ...
Cat No. Product Name
L5900 CNS-Penetrant Compound Library

516 compounds
A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
TargetMol