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Search Result

Search Results for " antiarrhythmic "

135

Compounds

14

Natural Products

1

Libraries

Cat No. Product Name Synonyms Targets
T72323 Antiarrhythmic agent-1
Antiarrhythmic agent-1 (example I), functioning as an antiarrhythmic agent and an IKr potassium channel blocker (IC 50 <1 μM), effectively inhibits cardiac arrhythmias.
T83102 Antiarrhythmic peptide (cattle atrium)
Antiarrhythmic peptide (cattle atrium), a hexapeptide, exhibits a protective effect against arrhythmias induced by experimental agents [1].
T23652 AFD-21 AFD21,NS-2 Class 1 antiarrhythmic agent
AFD-21 is a class I antiarrhythmic drug. It binds to sodium channels in their inactivated state and exerts use- and voltage-dependent inhibition of sodium channels with unbinding rates comparable to those of class I anti...
T2712 Nifekalant hydrochloride Potassium Channel
Nifekalant hydrochloride is an IKr potassium channel blocker with an IC50 of 10 µM. It is a Class III antiarrhythmic compound and can be used in the study of tachyarrhythmias.
T11353 Gallopamil Methoxyverapamil Calcium Channel
Gallopamil (Methoxyverapamil) inhibits acid secretion in a concentration-dependent manner with an IC50 of 10.9 μM. Gallopamil is a potent antiarrhythmic and vasodilator agent. Gallopamil (Methoxyverapamil), a methoxy der...
T5336 Zacopride hydrochloride Potassium Channel , 5-HT Receptor
Zacopride is a highly potent 5-HT3 receptor antagonist (Kd = 0.38 nM) and 5-HT4 receptor agonist (Ki = 373 nM). It also is a selective IK1 channel agonist.
T11353L Gallopamil hydrochloride Methoxyverapamil hydrochloride Calcium Channel
Gallopamil hydrochloride (Methoxyverapamil hydrochloride) is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.
T16347 NS3623 Potassium Channel
NS3623 is an activator of human ether-a-go-go-related gene potassium channels. NS3623 has a dual mode of action, being an inhibitor of hERG1 channels. NS3623 activates the IKr and Ito currents and has an antiarrhythmic e...
T7811 Pilsicainide HCl SUN 1165 Sodium Channel
Pilsicainide HCl (SUN 1165) is a pure sodium channel blocker
T1496 Amiodarone hydrochloride Amiodar,Amiodarone HCl,Nexterone Potassium Channel , Adrenergic Receptor , Autophagy
Amiodarone hydrochloride (Amiodarone HCl) is an antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM C...
T3574 Sematilide hydrochloride CK-1752A,CK-1752,Sematilide HCl Potassium Channel
Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the ...
T1320 Disopyramide Triombrin,Hypaque sodium,amidotrizoate sodium Potassium Channel , Sodium Channel , AChR
Disopyramide (Triombrin) is a class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the h...
T6476 Dofetilide UK 68789,UK-68798,Tikosyn Potassium Channel
Dofetilide (UK 68789) is a sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ik...
T20843 Aplodan Nergize,Creatinolfosfate,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate Others
Aplodan (creatinol-O-phosphate) exhibits antiischemic and antiarrhythmic capacity and protective action on the cell membrane. Aplodan can be used in research on the ischemic heart or ischemic heart disease with persisten...
T0866 Propafenone Rythmol,Propafenonum Potassium Channel , MRP , Sodium Channel
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....
T1046 Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173 AhR , Sodium Channel
Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myoca...
T20656 Verapamil NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil P450 , Calcium Channel , P-gp
Verapamil (CP-16533-1) is a calcium channel blocker and an orally active and effective inhibitor of P-gp. Verapamil inhibits CYP3A4 and can be used in studies about the treatment of high blood pressure, heart arrhythmias...
T19335 Danegaptide Hydrochloride GAP-134 (Hydrochloride),ZP 1609 Hydrochloride Gap Junction Protein
Danegaptide Hydrochloride (GAP-134 (Hydrochloride)) (GAP-134 Hydrochloride) is a selective modifier of the gap junction protein.
T1010 Verapamil hydrochloride Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride P450 , Calcium Channel , P-gp
Verapamil hydrochloride (Verapamil HCl) is a calcium channel blocker that is a class IV anti-arrhythmia agent.
T32155 Indecainide Ricainid,Decabid,Indecainidum,Ricainide,Indecainida
Indecainide is a little-used antiarrhythmic drug. Indecainide has local anesthetic activity and belongs to the membrane-stabilized (Class 1) group of antiarrhythmic drugs; It has the characteristics of the electrophysiol...
T26010 Quinacainol PK-10139,RP-54272,RP 54272,PK 10139,PK10139 Others
Quinacainol (RP 54272) is a new antiarrhythmic compound with class I antiarrhythmic effects in rats.
T0249 N-Acetylprocainamide NAPA,Acecainide Potassium Channel , Sodium Channel , Drug Metabolite
N-Acetylprocainamide (NAPA), the N-acetylated metabolite of Procainamide, is a Class III antiarrhythmic agent, while procainamide is a Class Ia antiarrhythmic drug.
T11099 Droxicainide Others
Droxicainide is an antiarrhythmic agent.
T12858 Bidisomide SC40230 Others
Bidisomide (SC40230) is an agent of class I antiarrhythmic.
T7531 Pirmenol Others
Pirmenol is a new antiarrhythmic drug
T68050L Dazolicin HCl Dazolicine HCl,Dazolicine hydrochloride Others
Dazolicin HCl (Dazolicine HCl) is an orally available antiarrhythmic compound.
T10634 Bunaftide Bunaphtide,Meregon,Bunaftine Others
Bunaftide (Bunaphtid) has antiarrhythmic effects and inhibits aconitine-induced ventricular tachycardia.
T67960 Recainam
Recainam is a novel, orally available compound with potent class I antiarrhythmic activity.
T4539 Nicainoprol RU-42924 Sodium Channel
Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent.
T11239 Ethacizine hydrochloride NIK-244,Ethacizin,NIK-244 hydrochloride Sodium Channel
Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.
T26287 Transcainide R54718,R 54718,R-54718 Sodium Channel
Transcainide(R 54718), a new lidocaine analog, is an orally active antiarrhythmic agent.Transcainide blocks the open state of BTX-activated sodium channels in bovine heart and rat skeletal muscle.
T7386 Bretylium tosylate Others
Bretylium tosylate is an inhibitor of the presynaptic release of vasoconstrictor neurotransmitters, a available antiarrhythmic drug for ventricular arrhythmias.
T7219 Flecainide acetate Flecainide (acetate),R-818 Sodium Channel
Flecainide acetate (R-818) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
T68077 Furnidipine
Furnidipine significantly reduced AoD and AF and had antiarrhythmic and cardioprotective effects at low doses in a rat model.
T7198 E-4031 EGFR , Potassium Channel
E-4031 is a methanesulfonanilide class III antiarrhythmic agent that prolongs cardiac action potential duration by blocking ERG K+ channels (IC50 = 29 nM)
T77550 O-Desmethyl Quinidine Others
O-Desmethyl Quinidine is a novel quinidine analog with significant antiarrhythmic activity and low acute toxicity that may be useful in the treatment of cardiac arrhythmias.
T7505 Azimilide Dihydrochloride NE-10064 Dihydrochloride Potassium Channel
Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current
T13021 Sulamserod RS-100302 5-HT Receptor
Sulamserod (RS 100302) is a potent 5-HT4 receptor antagonist with antiarrhythmic activity for the study of atrial fibrillation and cardiovascular related diseases.
T60322 Procainamide Biocoryl,Novocainamide DNA Methyltransferase
Procainamide (Novocainamide) is a specific and potent DNA methyltransferase 1 ( DNMT1 ) inhibitor. Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmia...
T8182L Guan-fu base A hydrochloride(1394-48-5 free base) P450
Guan-fu base A hydrochloride is an antiarrhythmic alkaloid was isolated from Aconitum coreanum. Guanfu base A is hydrochloride a CYP2D6 inhibitor of human, monkey, and dog isoforms.
T0098 Ipratropium bromide monohydrate Ipratropium bromide hydrate AChR
Ipratropium bromide monohydrate (Ipratropium bromide hydrate) is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial...
T13177 Taquidil
Tocainide hydrochloride is a sodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is an orally effective antiarrhythmic agent, structurally and ...
T30249 AZD 7009 AZD-7009,AZD7009 Sodium Channel
AZD 7009 is a novel antiarrhythmic compound that inhibits the sodium current of hNav1.5 in CHO K1 cells with an IC50 of 11 uM. AZD 7009 inhibited late sodium current in isolated rabbit atrial and ventricular myocytes, an...
T0018 Procainamide hydrochloride Procapan,Procainamide HCl,Pronestyl,Procanbid DNA Methyltransferase , Sodium Channel , AChR , Autophagy
Procainamide Hydrochloride (Procapan) is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to...
T1012 Acebutolol hydrochloride Acebutolol HCl Adrenergic Receptor
Acebutolol hydrochloride (Acebutolol HCl) acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Acebutolol hydrochloride is the hydro...
T6541 Ibutilide Fumarate Corvert Fumarate,U70226E Calcium Channel , Sodium Channel
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar...
T0802 Procaine hydrochloride Novocaine HCl,Procaine HCl Histone Demethylase , 5-HT Receptor , DNA/RNA Synthesis , Sodium Channel , NMDAR , AChR
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannel...
T1144 Lidocaine hydrochloride Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin Apoptosis , ERK , NF-κB , MEK , Sodium Channel
Lidocaine hydrochloride (Lignocaine hydrochloride) is a local anesthetic and cardiac depressant used as an antiarrhythmic agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its ...
T67956L Litoxetine HCl litoxetine HCL(86811-09-8 Free base) 5-HT Receptor
Litoxetine HCl is a selective 5-hydroxytryptamine (5-HT) reuptake inhibitor (SSRI) and mixed 5-hydroxytryptamine antagonist used in the treatment of urinary incontinence. Litoxetine HCl in the absence of antimuscarinic c...
T23677 AHR-10718 AHR10718,AHR 10718
AHR-10718 has an antiarrhythmic effect.

Compounds

Antiarrhythmic agent-1
T72323
Synonym:
Target:
Antiarrhythmic peptide (cattle atrium)
T83102
Synonym:
Target:
AFD-21
T23652
Synonym: AFD21,NS-2 Class 1 antiarrhythmic agent
Target:
Nifekalant hydrochloride
T2712
Synonym:
Target: Potassium Channel
Gallopamil
T11353
Synonym: Methoxyverapamil
Target: Calcium Channel
Zacopride hydrochloride
T5336
Synonym:
Target: Potassium Channel, 5-HT Receptor
Gallopamil hydrochloride
T11353L
Synonym: Methoxyverapamil hydrochloride
Target: Calcium Channel
NS3623
T16347
Synonym:
Target: Potassium Channel
Pilsicainide HCl
T7811
Synonym: SUN 1165
Target: Sodium Channel
Amiodarone hydrochloride
T1496
Synonym: Amiodar,Amiodarone HCl,Nexterone
Target: Potassium Channel, Adrenergic Receptor, Autophagy
Sematilide hydrochloride
T3574
Synonym: CK-1752A,CK-1752,Sematilide HCl
Target: Potassium Channel
Disopyramide
T1320
Synonym: Triombrin,Hypaque sodium,amidotrizoate sodium
Target: Potassium Channel, Sodium Channel, AChR
Dofetilide
T6476
Synonym: UK 68789,UK-68798,Tikosyn
Target: Potassium Channel
Aplodan
T20843
Synonym: Nergize,Creatinolfosfate,creatinol-O-phosphate,Creatinolfosfate, Creatinol Phosphate
Target: Others
Propafenone
T0866
Synonym: Rythmol,Propafenonum
Target: Potassium Channel, MRP, Sodium Channel
Mexiletine hydrochloride
T1046
Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173
Target: AhR, Sodium Channel
Verapamil
T20656
Synonym: NSC 135784,NSC-135784,CP-16533-1,(±)-Verapamil
Target: P450, Calcium Channel, P-gp
Danegaptide Hydrochloride
T19335
Synonym: GAP-134 (Hydrochloride),ZP 1609 Hydrochloride
Target: Gap Junction Protein
Verapamil hydrochloride
T1010
Synonym: Manidon,(±)-Verapamil hydrochlorid,Verapamil HCl,Calcan hydrochloride
Target: P450, Calcium Channel, P-gp
Indecainide
T32155
Synonym: Ricainid,Decabid,Indecainidum,Ricainide,Indecainida
Target:
Quinacainol
T26010
Synonym: PK-10139,RP-54272,RP 54272,PK 10139,PK10139
Target: Others
N-Acetylprocainamide
T0249
Synonym: NAPA,Acecainide
Target: Potassium Channel, Sodium Channel, Drug Metabolite
Droxicainide
T11099
Synonym:
Target: Others
Bidisomide
T12858
Synonym: SC40230
Target: Others
Pirmenol
T7531
Synonym:
Target: Others
Dazolicin HCl
T68050L
Synonym: Dazolicine HCl,Dazolicine hydrochloride
Target: Others
Bunaftide
T10634
Synonym: Bunaphtide,Meregon,Bunaftine
Target: Others
Recainam
T67960
Synonym:
Target:
Nicainoprol
T4539
Synonym: RU-42924
Target: Sodium Channel
Ethacizine hydrochloride
T11239
Synonym: NIK-244,Ethacizin,NIK-244 hydrochloride
Target: Sodium Channel
Transcainide
T26287
Synonym: R54718,R 54718,R-54718
Target: Sodium Channel
Bretylium tosylate
T7386
Synonym:
Target: Others
Flecainide acetate
T7219
Synonym: Flecainide (acetate),R-818
Target: Sodium Channel
Furnidipine
T68077
Synonym:
Target:
E-4031
T7198
Synonym:
Target: EGFR, Potassium Channel
O-Desmethyl Quinidine
T77550
Synonym:
Target: Others
Azimilide Dihydrochloride
T7505
Synonym: NE-10064 Dihydrochloride
Target: Potassium Channel
Sulamserod
T13021
Synonym: RS-100302
Target: 5-HT Receptor
Procainamide
T60322
Synonym: Biocoryl,Novocainamide
Target: DNA Methyltransferase
Guan-fu base A hydrochloride(1394-48-5 free base)
T8182L
Synonym:
Target: P450
Ipratropium bromide monohydrate
T0098
Synonym: Ipratropium bromide hydrate
Target: AChR
Taquidil
T13177
Synonym:
Target:
AZD 7009
T30249
Synonym: AZD-7009,AZD7009
Target: Sodium Channel
Procainamide hydrochloride
T0018
Synonym: Procapan,Procainamide HCl,Pronestyl,Procanbid
Target: DNA Methyltransferase, Sodium Channel, AChR, Autophagy
Acebutolol hydrochloride
T1012
Synonym: Acebutolol HCl
Target: Adrenergic Receptor
Ibutilide Fumarate
T6541
Synonym: Corvert Fumarate,U70226E
Target: Calcium Channel, Sodium Channel
Procaine hydrochloride
T0802
Synonym: Novocaine HCl,Procaine HCl
Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR
Lidocaine hydrochloride
T1144
Synonym: Lidocaine HCL,Lignocaine hydrochloride,Xyloneural,Lidothesin
Target: Apoptosis, ERK, NF-κB, MEK, Sodium Channel
Litoxetine HCl
T67956L
Synonym: litoxetine HCL(86811-09-8 Free base)
Target: 5-HT Receptor
AHR-10718
T23677
Synonym: AHR10718,AHR 10718
Target:
1 2 3
Cat No. Product Name Synonyms Targets
T3S0081 Oxypeucedanin (+-)-Oxypeucedanin,Oxypeucadanin Potassium Channel
1. Oxypeucedanin ((+-)-Oxypeucedanin) has novel anticancer effect, mediated via induction of G2-M cell cycle arrest and apoptosis in human prostate carcinoma DU145 cells. 2. Oxypeucedanin is a kind of open-channel blocke...
T5S1882 Songorine Napellonine,Zongorine,Bullatine G Others , GABA Receptor
Songorine (Napellonine) shows favorable anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.
T1334 Hydroquinidine Hydroconchinine,Dihydroquinidine,Hydroconquinine,(+)-Hydroquinidine,Dihydroquinine Potassium Channel , Sodium Channel
Hydroquinidine ((+)-Hydroquinidine) is an organic compound, used as an antiarrhythmic agent.
T0792 (-)-Sparteine sulfate pentahydrate (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate Sodium Channel
(-)-Sparteine sulfate pentahydrate ((-)-Sparteine Sulfate) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
T0853 Adenosine D-Adenosine,Adenine riboside Apoptosis , Nucleoside Antimetabolite/Analog , Endogenous Metabolite , Autophagy
Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities.
T7853 (+)-Sparteine Pachycarpine AChR
(+)-Sparteine (Pachycarpine) is a natural product extracted from scotch broom, is a sodium channel blocker and a class 1a antiarrhythmic agent
T4842 1H-pyrazole 1,2-Diazole,Pyrazole Others , Endogenous Metabolite
1H-pyrazole (1,2-Diazole), is a versatile building block, with a vast applications in organic synthesis. The derivatives of Pyrazole are used in medicine, for their analgesic, anti-inflammatory, antipyretic, antiarrhythm...
T7938 Quinidine Parasite
Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.
TMA2106 (-)-Sparteine P450
Sparteine is a class 1a antiarrhythmic agent, a sodium channel blocker. The deficient debrisoquine hydroxylation of Sparteine is due to the absence of P-450IID1 protein in the livers of poor metabolizers.
T3029 Sparteine sulfate Depasan,Tocosimplex,Actospar Others , Sodium Channel
Sparteine sulfate (Tocosimplex) is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
TN1577 Dicentrine Others
Dicentrine, a selective α±(1)-adrenoceptor antagonist with potent antiarrhythmic and antihypertensive activities, it also has antinociception in different models of chemical pain.
TN5235 Vinorine Others
Vinorine is a direct biosynthetic precursor along the complex pathway to the monoterpenoid indole alkaloid ajmaline, an antiarrhythmic drug from the Indian medicinal plant Rauvolfia serpentina.
TN1412 Astringin trans-Astringin IL Receptor , Others
Astringinin is a potent antiarrhythmic agent with cardioprotective activity in ischemic and ischemic-reperfused rat heart, the beneficial effects of astringinin in the ischemic and ischemic-reperfused hearts may be corre...
T21266 Quinine sulfate
Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a blocker of K + channel with an IC 50 of 19.9 μM. Quinidine has potential to be used ...

Natural Products

Oxypeucedanin
T3S0081
Synonym: (+-)-Oxypeucedanin,Oxypeucadanin
Target: Potassium Channel
Songorine
T5S1882
Synonym: Napellonine,Zongorine,Bullatine G
Target: Others, GABA Receptor
Hydroquinidine
T1334
Synonym: Hydroconchinine,Dihydroquinidine,Hydroconquinine,(+)-Hydroquinidine,Dihydroquinine
Target: Potassium Channel, Sodium Channel
(-)-Sparteine sulfate pentahydrate
T0792
Synonym: (-)-Sparteine Sulfate,Lupinidine sulfate pentahydrate,(-)-Sparteine sulfate salt,sulfate pentahydrate
Target: Sodium Channel
Adenosine
T0853
Synonym: D-Adenosine,Adenine riboside
Target: Apoptosis, Nucleoside Antimetabolite/Analog, Endogenous Metabolite, Autophagy
(+)-Sparteine
T7853
Synonym: Pachycarpine
Target: AChR
1H-pyrazole
T4842
Synonym: 1,2-Diazole,Pyrazole
Target: Others, Endogenous Metabolite
Quinidine
T7938
Synonym:
Target: Parasite
(-)-Sparteine
TMA2106
Synonym:
Target: P450
Sparteine sulfate
T3029
Synonym: Depasan,Tocosimplex,Actospar
Target: Others, Sodium Channel
Dicentrine
TN1577
Synonym:
Target: Others
Vinorine
TN5235
Synonym:
Target: Others
Astringin
TN1412
Synonym: trans-Astringin
Target: IL Receptor, Others
Quinine sulfate
T21266
Synonym:
Target:
Cat No. Product Name
L6110 Alkaloid Natural Product Library

468 compounds
A unique collection of 468 natural alkaloids can be used for high throughput and high content screening；

Libraries

Alkaloid Natural Product Library
L6110
Compounds: 468
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