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Results for "

μ-opioid

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    163
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    45
    TargetMol | Peptide_Products
  • Inhibitory Antibodies
    1
    TargetMol | Inhibitory_Antibodies
  • Natural Products
    9
    TargetMol | Natural_Products
σ1 Receptor/μ Opioid receptor modulator 1
T619012412700-00-4
σ 1 Receptor μ Opioid receiver modulator 1 (Compound 44) is an effective σ 1 receptor antagonist (Ki=1.86 nM) and μ Opioid receptor agonists (Ki=2.1 nM). Opioid receptor modulator 1 shows potent analgesic activity, and can be used for the research of neuropathic pain.
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6-8 weeks
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μ opioid receptor agonist 2
T620252671755-38-5
μ opioid receptor agonist 2 (Compound H-3) is a MOR receptor agonist used for research on pain and pain-related diseases.
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6-8 weeks
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μ opioid receptor agonist 1
T622682667632-83-7
μ opioid receptor agonist 1 (Compound H-1a) is an optically pure oxyheterocyclic substituted pyrroloxypyrazole derivative and an MOR receptor agonist that can be used in the study of pain and pain-related disorders.
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8-10 weeks
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μ opioid receptor agonist 3
T794302378397-91-0
Compound 20, identified as μ opioid receptor agonist 3, is a potent µOR agonist that exhibits an EC50 value of 0.87 nM. It holds promise for research into pain management and neuropsychiatric disorders [1].
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8-10 weeks
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Cebranopadol
GRT6005
T5167863513-91-1
Cebranopadol (GRT6005) is an analgesic NOP and opioid receptor agonist with Kis of 0.9 nM, 0.7 nM, 2.6 nM, 18 nM for human NOP, μ-opioid (MOP), κ-opioid (KOP) and δ-opioid (DOP) receptor, respectively.
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TargetMol | Inhibitor Hot
BAN ORL 24 dihydrochloride
T104571401463-54-4In house
BAN ORL 24 is a highly potent nociceptin orphan FQ (N OFQ) receptor (NOP) antagonist that can be used to study neurological diseases.
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7-10 days
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BPR1M97
T105932059904-66-2In house
BPR1M97 is a mu opioid receptor (MOP) and neuropeptide-orphin FQ (NOP) receptor agonist with blood-brain barrier permeability and potency, with Kis values of 1.8 nM for MOP and 4.2 nM for NOP.BPR1M97 exhibits anti-injurious effects and antinociceptive effects.
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JNJ-20788560
JNJ 20788560
T27667825649-28-3In house
JNJ-20788560 is a delta opioid receptor (DOR) agonist with analgesic activity. It is more selective for DOR than for mu opioid receptors (MOR).
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6-8 weeks
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CP-866087
CP 866087, UNII-MDH21334PI, CP-866,087, CP866087
T31081519052-04-1In house
CP-866087 is a novel, potent and selective mu-opioid receptor antagonist for the study of female sexual dysfunction.
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6-8weeks
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AT-121
T376102099681-31-7In house
AT-121 is a dual μ-opioid and neuropeptide receptor partial agonist (Kis 16.49 and 3.67 nM, respectively). It stimulates [35S]GTPγS binding to cell membranes expressing either μ-opioid receptors or neuropeptide receptors (EC50s of 19.6 and 34.7 nM, respectively.) AT-121 (0.003-0.03 mg kg) reduced capsaicin-induced thermal anisocoria in a dose-dependent manner, but did not increase scratching activity in rhesus monkeys. In rhesus monkey drug self-administration tests, AT-121 at doses of 0.3 to 10 μg kg per injection lacked reinforcing effects (a potential marker of abuse) and did not reduce the reinforcing effects of food pellets.AT-121 (0.01 or 0.03 mg kg) did not induce hyperalgesia, a marker of tolerance, in rhesus monkeys.AT-121 is a safe non-addictive pain reliever with anti-injury and analgesic effects.
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6-8weeks
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Samidorphan HCl
Samidorphan HCl(852626-89-2 free base)
T67888L2328045-02-7In house
Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors. Samidorphan HCl is a novel μ-opioid receptor antagonist, a partial agonist for k-opioid and delta-opioid receptors. Samidorphan HCl can be used to prevent and treat schizophrenia.
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SNC 80
Snc-80, SNC80, NIH 10815
T8414156727-74-1In house
SNC 80 (NIH 10815) is a potent, highly selective and non-peptide δ-opioid receptor agonist, Ki = 1.78 nM, IC50 = 2.73 nM. SNC80 also selectively activates μ-δ heteromer in HEK293 cells with an EC50 of 52.8 nM. SNC80 shows antinociceptive, antihyperalgesic and antidepressant‐like effects. SNC80 has the potential for multiple headache disorders treatment.
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Loperamide hydrochloride
R-18553 (hydrochloride), Loperamide HCl, ADL 2-1294
T020934552-83-5
Loperamide hydrochloride (ADL 2-1294) is a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity.
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Trimebutine
Mebutin
T091839133-31-8
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI disorders. It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form. Trimebutine is not an FDA-Approved Clinical drug, but it is available in Canada and several other international countries.
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Trimebutine maleate
Debridat, Polibutin
T119734140-59-5
Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors served as a spasmolytic drug for therapy of both chronic and acute abdominal pain.
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Methylnaltrexone bromide
Relistor, MOA-728, MOA 728, Methylnaltrexone, MOA728
T2142273232-52-7
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals.
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DAMGO
RX-783006, Dagol, DAGO
T435178123-71-4
DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents. Possible analgesic agent due to μ-opiod receptor interaction.
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SR17018
T44072134602-45-0
SR17018, a mu-opioid receptor (MOR) agonist, binds with GTPγS and has an EC50 of 97 nM.
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ADL-5859
T6175850173-95-4
ADL-5859 (ADL5859 Hydrochloride) is a selective δ-opioid receptor agonist ( Ki: 0.8 nM), selectivity against opioid receptor κ, μ, and little inhibition for the hERG channel.
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BW-180C
DADLE
TP190563631-40-3
BW-180C (DADLE) is a prototypical δ-opioid receptor agonist that also displays activity at the μ-opioid receptor. Displays antinociceptive activity in vivo.
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ML-335
T230021069498-96-9
ML-335 is a μ-δ isomer-targeted agonist, a μOR-δOR-biased ligand that can serve as a scaffold for the development of unique types of (isomer-biased) drugs.ML-335 is a MOR (μ-opioid receptor) DOR (δ-opioid receptor) heterodimer, with anti-injury sensory activity and pain inhibitory activity.
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6-8 weeks
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β-Endorphin (1-27) (human) acetate
β-Endorphin (1-27) (human) acetate(76622-84-9 Free base)
T38193L
β-Endorphin (1-27) (human) acetate, existing in the hypophysis cerebri and hypothalamus, exhibits antinociception activity. β-Endorphin (1-27) (human) acetate is an agonist of opioid receptor, showing preferred affinity for μ-opioid receptor and δ-opioid
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EST73502 HCl
T392842535970-65-9
EST73502 is an agonist of μ-opioid receptor(Ki = 64 nM) agonist and an antagonist of σ1 receptor (Ki = 118 nM). EST73502 displays antinociceptive activity.
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1-(8-carbamimidamidooctyl)guanidine 2HCl
1,1'-(Octane-1,8-diyl)diguanidine 2HCl, 1-(8-carbamimidamidooctyl)guanidine dihydrochloride
T5009125303-05-3
1,1'-(Octane-1,8-diyl)diguanidine dihydrochloride is a synthetic opioid peptide derived from the natural opioid peptide enkephalin. It is a potent agonist of the mu-opioid receptor (MOR) with a Ki of 0.14 nM, making it one of the most potent MOR agonists known to date.
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