Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T2354	UNC 0631	1320288-19-4	98%
T2354	UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
T11082	Dot1L-IN-2	1940206-71-2	98%
T11082	Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
T12940	SMYD3-IN-1	2095160-79-3	98%
T12940	SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
TN5096	Tanshindiol B	97465-70-8	98%
TN5096	Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
TN5097	Tanshindiol C	97465-71-9	98%
TN5097	Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
T4334	EPZ020411 2HCl (1700663-41-7(free base))	T4334	98%
T4334	EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T11500L	GSK3368715 dihydrochloride	1628925-77-8	98%
T11500L	GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
T12939	SMYD2-IN-1	2023788-96-5	98%
T12939	SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T13279	Valemetostat tosylate	1809336-93-3	98%
T13279	Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
T11084	Dot1L-IN-5	2565705-03-3	98%
T11084	Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein ( DOT1L ) inhibitor with an IC 50 SPA DOT1L of 0.17 nM [1].
T11081	Dot1L-IN-1	2088518-50-5	98%
T11081	The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
T15240	Tazemetostat trihydrochloride	1403255-00-4	98%
T15240	Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T1987	PFI-2	1627676-59-8	98%
T1987	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T6810	CPI-360	1802175-06-9	98%
T6810	CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
T12541	PRMT5-IN-1	2366149-83-7	98%
T12541	PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
T10882	CPUY074020	902279-44-1	98%
T10882	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T11500	GSK3368715	1629013-22-4	98%
T11500	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T10427	AZ505 ditrifluoroacetate	1035227-44-1	98%
T10427	AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
T6292	3-Deazaneplanocin A	102052-95-9	98%
T6292	3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
T11083	Dot1L-IN-4	T11083	98%
T11083	Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.