Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T12940	SMYD3-IN-1	2095160-79-3	98%
T12940	SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
T10427	AZ505 ditrifluoroacetate	1035227-44-1	98%
T10427	AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
TN5096	Tanshindiol B	97465-70-8	98%
TN5096	Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
T6292	3-Deazaneplanocin A	102052-95-9	98%
T6292	3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
T16577	PRMT5-IN-2	1989620-04-3	98%
T16577	PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
T22342	GSK3368715 3HCl	2227587-26-8	98%
T22342	GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
TN5097	Tanshindiol C	97465-71-9	98%
TN5097	Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
T11436	GNA002	1385035-79-9	98%
T11436	GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
T12541	PRMT5-IN-1	2366149-83-7	98%
T12541	PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
T11081	Dot1L-IN-1	2088518-50-5	98%
T11081	The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
T4334	EPZ020411 2HCl (1700663-41-7(free base))	T4334	98%
T4334	EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T3081L	EPZ004777 hydrochloride	1380316-03-9	98%
T3081L	EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T15240	Tazemetostat trihydrochloride	1403255-00-4	98%
T15240	Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T11082	Dot1L-IN-2	1940206-71-2	98%
T11082	Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
T11500	GSK3368715	1629013-22-4	98%
T11500	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T1987	PFI-2	1627676-59-8	98%
T1987	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T11185	EML741	2328074-38-8	98%
T11185	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
T12939	SMYD2-IN-1	2023788-96-5	98%
T12939	SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T11500L	GSK3368715 dihydrochloride	1628925-77-8	98%
T11500L	GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
T12428	PF-06726304 acetate	2080306-28-9	98%
T12428	PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.