T2354 |
UNC 0631
|
1320288-19-4
|
98%
|
|
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
|
T11082 |
Dot1L-IN-2
|
1940206-71-2
|
98%
|
|
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
|
T12940 |
SMYD3-IN-1
|
2095160-79-3
|
98%
|
|
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
|
TN5096 |
Tanshindiol B
|
97465-70-8
|
98%
|
|
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
|
TN5097 |
Tanshindiol C
|
97465-71-9
|
98%
|
|
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
|
T4334 |
EPZ020411 2HCl (1700663-41-7(free base))
|
T4334
|
98%
|
|
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
|
T11500L |
GSK3368715 dihydrochloride
|
1628925-77-8
|
98%
|
|
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
|
T12939 |
SMYD2-IN-1
|
2023788-96-5
|
98%
|
|
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
|
T13279 |
Valemetostat tosylate
|
1809336-93-3
|
98%
|
|
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
|
T11084 |
Dot1L-IN-5
|
2565705-03-3
|
98%
|
|
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein ( DOT1L ) inhibitor with an IC 50 SPA DOT1L of 0.17 nM [1].
|
T11081 |
Dot1L-IN-1
|
2088518-50-5
|
98%
|
|
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
|
T15240 |
Tazemetostat trihydrochloride
|
1403255-00-4
|
98%
|
|
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
|
T1987 |
PFI-2
|
1627676-59-8
|
98%
|
|
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
|
T6810 |
CPI-360
|
1802175-06-9
|
98%
|
|
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
|
T12541 |
PRMT5-IN-1
|
2366149-83-7
|
98%
|
|
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
|
T10882 |
CPUY074020
|
902279-44-1
|
98%
|
|
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
|
T11500 |
GSK3368715
|
1629013-22-4
|
98%
|
|
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
|
T10427 |
AZ505 ditrifluoroacetate
|
1035227-44-1
|
98%
|
|
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
|
T6292 |
3-Deazaneplanocin A
|
102052-95-9
|
98%
|
|
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
|
T11083 |
Dot1L-IN-4
|
T11083
|
98%
|
|
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
|