T28112 |
MS0124
|
1197196-63-6
|
98%
|
|
MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
|
T10882 |
CPUY074020
|
902279-44-1
|
98%
|
|
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
|
T9700 |
EZH2-IN-2
|
2238821-31-1
|
98%
|
|
EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM (Patent WO2018133795A1, Compound Example 69).
|
T6810 |
CPI-360
|
1802175-06-9
|
98%
|
|
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
|
T4334 |
EPZ020411 2HCl (1700663-41-7(free base))
|
T4334
|
98%
|
|
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
|
T4314 |
EPZ020411
|
1700663-41-7
|
98%
|
|
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
|
T1987 |
PFI-2
|
1627676-59-8
|
98%
|
|
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
|
T3081L |
EPZ004777 hydrochloride
|
1380316-03-9
|
98%
|
|
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
|
T13279 |
Valemetostat tosylate
|
1809336-93-3
|
98%
|
|
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
|
T12886 |
SGC-iMLLT
|
2255338-25-9
|
98%
|
|
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 of 0.26 μM),and is a first-in-class chemical probe.
|
T12428 |
PF-06726304 acetate
|
2080306-28-9
|
98%
|
|
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
|
T11500L |
GSK3368715 dihydrochloride
|
1628925-77-8
|
98%
|
|
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
|
T12939 |
SMYD2-IN-1
|
2023788-96-5
|
98%
|
|
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
|
T11185 |
EML741
|
2328074-38-8
|
98%
|
|
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
|
T36798L |
SW2_110A acetate
|
|
98%
|
|
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate ...
|
T11500 |
GSK3368715
|
1629013-22-4
|
98%
|
|
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
|
T11082 |
Dot1L-IN-2
|
1940206-71-2
|
98%
|
|
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
|
T15240 |
Tazemetostat trihydrochloride
|
1403255-00-4
|
98%
|
|
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
|
T11081 |
Dot1L-IN-1
|
2088518-50-5
|
98%
|
|
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
|
T12541 |
PRMT5-IN-1
|
2366149-83-7
|
98%
|
|
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
|