T12940 |
SMYD3-IN-1
|
2095160-79-3
|
98%
|
|
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
|
T10427 |
AZ505 ditrifluoroacetate
|
1035227-44-1
|
98%
|
|
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
|
TN5096 |
Tanshindiol B
|
97465-70-8
|
98%
|
|
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
|
T6292 |
3-Deazaneplanocin A
|
102052-95-9
|
98%
|
|
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
|
T16577 |
PRMT5-IN-2
|
1989620-04-3
|
98%
|
|
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5.
|
T22342 |
GSK3368715 3HCl
|
2227587-26-8
|
98%
|
|
GSK3368715, a potent inhibitor of type I protein arginine methyltransferases (PRMT), could inhibit PRMT1, 3, 4, 6 and 8 with Kiapp vaules ranging from 1.5 to 81 ...
|
TN5097 |
Tanshindiol C
|
97465-71-9
|
98%
|
|
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
|
T11436 |
GNA002
|
1385035-79-9
|
98%
|
|
GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).
|
T12541 |
PRMT5-IN-1
|
2366149-83-7
|
98%
|
|
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
|
T11081 |
Dot1L-IN-1
|
2088518-50-5
|
98%
|
|
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
|
T4334 |
EPZ020411 2HCl (1700663-41-7(free base))
|
T4334
|
98%
|
|
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
|
T3081L |
EPZ004777 hydrochloride
|
1380316-03-9
|
98%
|
|
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
|
T15240 |
Tazemetostat trihydrochloride
|
1403255-00-4
|
98%
|
|
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
|
T11082 |
Dot1L-IN-2
|
1940206-71-2
|
98%
|
|
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
|
T11500 |
GSK3368715
|
1629013-22-4
|
98%
|
|
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
|
T1987 |
PFI-2
|
1627676-59-8
|
98%
|
|
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
|
T11185 |
EML741
|
2328074-38-8
|
98%
|
|
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
|
T12939 |
SMYD2-IN-1
|
2023788-96-5
|
98%
|
|
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
|
T11500L |
GSK3368715 dihydrochloride
|
1628925-77-8
|
98%
|
|
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
|
T12428 |
PF-06726304 acetate
|
2080306-28-9
|
98%
|
|
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
|