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Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.
Cat. No. Product name CAS No. Purity Chemical Structure
T28112 MS0124 1197196-63-6 98%
MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
T10882 CPUY074020 902279-44-1 98%
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T9700 EZH2-IN-2 2238821-31-1 98%
EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM (Patent WO2018133795A1, Compound Example 69).
T6810 CPI-360 1802175-06-9 98%
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
T4334 EPZ020411 2HCl (1700663-41-7(free base)) T4334 98%
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T4314 EPZ020411 1700663-41-7 98%
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
T1987 PFI-2 1627676-59-8 98%
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T3081L EPZ004777 hydrochloride 1380316-03-9 98%
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T13279 Valemetostat tosylate 1809336-93-3 98%
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
T12886 SGC-iMLLT 2255338-25-9 98%
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 of 0.26 μM),and is a first-in-class chemical probe.
T12428 PF-06726304 acetate 2080306-28-9 98%
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
T11500L GSK3368715 dihydrochloride 1628925-77-8 98%
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
T12939 SMYD2-IN-1 2023788-96-5 98%
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T11185 EML741 2328074-38-8 98%
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
T36798L SW2_110A acetate 98%
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate ...
T11500 GSK3368715 1629013-22-4 98%
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T11082 Dot1L-IN-2 1940206-71-2 98%
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
T15240 Tazemetostat trihydrochloride 1403255-00-4 98%
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T11081 Dot1L-IN-1 2088518-50-5 98%
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
T12541 PRMT5-IN-1 2366149-83-7 98%
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
MS0124
T28112
MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
CPUY074020
T10882
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
EZH2-IN-2
T9700
EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM (Patent WO2018133795A1, Compound Example 69).
CPI-360
T6810
CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
EPZ020411 2HCl (1700663-41-7(free base))
T4334
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
EPZ020411
T4314
EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
PFI-2
T1987
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
EPZ004777 hydrochloride
T3081L
EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
Valemetostat tosylate
T13279
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
SGC-iMLLT
T12886
SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 of 0.26 μM),and is a first-in-class chemical probe.
PF-06726304 acetate
T12428
PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
GSK3368715 dihydrochloride
T11500L
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
SMYD2-IN-1
T12939
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
EML741
T11185
EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
SW2_110A acetate
T36798L
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate ...
GSK3368715
T11500
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
Dot1L-IN-2
T11082
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
Tazemetostat trihydrochloride
T15240
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
Dot1L-IN-1
T11081
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
PRMT5-IN-1
T12541
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
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