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Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.
Cat. No. Product name CAS No. Purity Chemical Structure
T2354 UNC 0631 1320288-19-4 98%
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
T11082 Dot1L-IN-2 1940206-71-2 98%
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
T12940 SMYD3-IN-1 2095160-79-3 98%
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
TN5096 Tanshindiol B 97465-70-8 98%
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
TN5097 Tanshindiol C 97465-71-9 98%
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
T4334 EPZ020411 2HCl (1700663-41-7(free base)) T4334 98%
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T11500L GSK3368715 dihydrochloride 1628925-77-8 98%
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
T12939 SMYD2-IN-1 2023788-96-5 98%
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T13279 Valemetostat tosylate 1809336-93-3 98%
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
T11084 Dot1L-IN-5 2565705-03-3 98%
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein ( DOT1L ) inhibitor with an IC 50 SPA DOT1L of 0.17 nM [1].
T11081 Dot1L-IN-1 2088518-50-5 98%
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
T15240 Tazemetostat trihydrochloride 1403255-00-4 98%
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T1987 PFI-2 1627676-59-8 98%
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T6810 CPI-360 1802175-06-9 98%
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
T12541 PRMT5-IN-1 2366149-83-7 98%
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
T10882 CPUY074020 902279-44-1 98%
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T11500 GSK3368715 1629013-22-4 98%
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T10427 AZ505 ditrifluoroacetate 1035227-44-1 98%
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
T6292 3-Deazaneplanocin A 102052-95-9 98%
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
T11083 Dot1L-IN-4 T11083 98%
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
UNC 0631
T2354
UNC0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).
Dot1L-IN-2
T11082
Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
SMYD3-IN-1
T12940
SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
Tanshindiol B
TN5096
Tanshindiol B possesses a unique anti-cancer activity whose mechanism involves the inhibition of EZH2 activity and would provide chemically valuable information ...
Tanshindiol C
TN5097
Tanshindiol C protects macrophages from oxLDL induced foam cell formation via activation of Prdx1/ABCA1 signaling and that Prdx1 may be a novel target for therap...
EPZ020411 2HCl (1700663-41-7(free base))
T4334
EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
GSK3368715 dihydrochloride
T11500L
GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
SMYD2-IN-1
T12939
SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
Valemetostat tosylate
T13279
Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
Dot1L-IN-5
T11084
Dot1L-IN-5 is a potent disruptor of telomeric silencing 1-like protein ( DOT1L ) inhibitor with an IC 50 SPA DOT1L of 0.17 nM [1].
Dot1L-IN-1
T11081
The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
Tazemetostat trihydrochloride
T15240
Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
PFI-2
T1987
PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
CPI-360
T6810
CPI-360 is a potent, selective, and SAM-competitive EZH1 inhibitor with IC50 of 102.3 nM, >100-fold selectivity over other methyltransferases.
PRMT5-IN-1
T12541
PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).
CPUY074020
T10882
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
GSK3368715
T11500
GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
AZ505 ditrifluoroacetate
T10427
AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
3-Deazaneplanocin A
T6292
3-Deazaneplanocin A (DZNep) is an attractive epigenetic anticancer agent through the inhibition of the cellular enhancer of zeste homolog 2 (EZH2) protein.
Dot1L-IN-4
T11083
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM.
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