Histone Methyltransferase

Histone methyltransferases (HMT) are histone-modifying enzymes , that catalyze the transfer of one, two, or three methyl groups to lysine and arginine residues of histone proteins. The attachment of methyl groups occurs predominantly at specific lysine or arginine residues on histones H3 and H4.

Cat. No.	Product name	CAS No.	Purity
T28112	MS0124	1197196-63-6	98%
T28112	MS0124 is a potent and selective G9A-like protein (GLP) inhibitor with IC50 values of 13±4 nM and 440±63 nM, respectively.
T10882	CPUY074020	902279-44-1	98%
T10882	CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
T9700	EZH2-IN-2	2238821-31-1	98%
T9700	EZH2-IN-2 is a EZH2 inhibitor with an IC50 of 64 nM (Patent WO2018133795A1, Compound Example 69).
T6810	CPI-360	1802175-06-9	98%
T6810	CPI-360 is a small molecule EZH2 inhibitor (IC50: 0.002 μM, EC50: 0.080 μM) that shows antitumor activity in an EZH200-dependent tumor xenograft model.
T4334	EPZ020411 2HCl (1700663-41-7(free base))	T4334	98%
T4334	EPZ020411 is an effective and specific small molecule PRMT6 inhibitor (IC50=10 nM).
T4314	EPZ020411	1700663-41-7	98%
T4314	EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
T1987	PFI-2	1627676-59-8	98%
T1987	PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferase...
T3081L	EPZ004777 hydrochloride	1380316-03-9	98%
T3081L	EPZ004777 hydrochloride is a potent, selective DOT1L inhibitor with IC50 of 0.4 nM.
T13279	Valemetostat tosylate	1809336-93-3	98%
T13279	Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.
T12886	SGC-iMLLT	2255338-25-9	98%
T12886	SGC-iMLLT is a potent and selective MLLT1/3-histone interactions inhibitor(IC50 of 0.26 μM),and is a first-in-class chemical probe.
T12428	PF-06726304 acetate	2080306-28-9	98%
T12428	PF-06726304 acetate is a selective inhibitor of EZH2, with robust antitumor growth activity.
T11500L	GSK3368715 dihydrochloride	1628925-77-8	98%
T11500L	GSK3368715 dihydrochloride is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) in...
T12939	SMYD2-IN-1	2023788-96-5	98%
T12939	SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
T11185	EML741	2328074-38-8	98%
T11185	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barri...
T36798L	SW2_110A acetate		98%
T36798L	SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD). SW2_110A acetate ...
T11500	GSK3368715	1629013-22-4	98%
T11500	GSK3368715 is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor (IC50s: ...
T11082	Dot1L-IN-2	1940206-71-2	98%
T11082	Dot1l-in-2 is an effective, selective and oral bioutilization inhibitor of histone methyltransferase Dot1L, with IC50 and Ki of 0.4 nM and 0.08 nM, respectively....
T15240	Tazemetostat trihydrochloride	1403255-00-4	98%
T15240	Tazemetostat trihydrochloride is a selective and orally available inhibitor of EZH2 (IC50: 4 nM for rat EZH2). It inhibits the activity of human PRC2-containing ...
T11081	Dot1L-IN-1	2088518-50-5	98%
T11081	The Ki value of DOT1L-in-1 is 2pm.It is a highly effective, selective and novel Dot1L inhibitor.
T12541	PRMT5-IN-1	2366149-83-7	98%
T12541	PRMT5-IN-1 is a covalent inhibitor of protein arginine methyltransferase 5 (PRMT5)(IC50 of 11 nM for PRMT5/MEP50).