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Ubiquitination DUB

DUB

Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases, ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins and other molecules. Ubiquitin is attached to proteins in order to regulate the degradation of proteins via the proteasome and lysosome; coordinate the cellular localisation of proteins; activate and inactivate proteins; and modulate protein-protein interactions.DUBs can reverse these effects by cleaving the peptide or isopeptide bond between ubiquitin and its substrate protein. In humans there are nearly 100 DUB genes, which can be classified into two main classes: cysteine proteases and metalloproteases. The cysteine proteases comprise ubiquitin-specific proteases (USPs), ubiquitin C-terminal hydrolases (UCHs), Machado-Josephin domain proteases (MJDs) and ovarian tumour proteases (OTU). The metalloprotease group contains only the Jab1/Mov34/Mpr1 Pad1 N-terminal+ (MPN+) (JAMM) domain proteases.
Cat No. product name
T9217 USP7-IN-8 USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
T5461 4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7...
T2424 P22077 P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
T1937 Spautin-1 Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-indu...
T3089 Thioguanine Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
T1757 ML323 ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (...
T3951 NSC632839 NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).
T3555 ML364 ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
T1862 PR619 PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
T6697 TCID TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
T6107 IU1 IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
T1924 LDN57444 LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
T6925 P005091 P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
T4338 USP7/USP47 inhibitor USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
T4067 VLX1570 VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.
T4634 GEN6776 GNE-6776 is a selective USP7 inhibitor.
T7678 SJB2-043 SJB2-043 is an inhibitor of  USP1-UAF1 ( IC50 : 544 nM).
T9122 XL177A XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
T13268 USP7-IN-1 USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
T15729 LDN-91946 LDN-91946 is an effective, selective, and uncompetitive inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki: 2.8 μM).
T15604 IU1-47 IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM)....
T15464 HBX 19818 HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
T13271 USP7-IN-6 USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
T13270 USP7-IN-5 USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).
T13269 USP7-IN-3 USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
T11485 GSK2643943A GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor (IC50: 160 nM for USP20/Ub-Rho).
T11110 DUB-IN-1 Dub-in-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
T11209 EOAI3402143 EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits  Usp5/Usp24 andUsp9x.
T15351 FT827 FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 µM...
T12621L FT671 FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
T14852 C527 C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
T11112 DUB-IN-3 DUB-IN-3 is IC50 of 0.56 μM for USP8,is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c.
T11111 DUB-IN-2 Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
T1932 B-AP15 B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...
USP7-IN-8
T9217CAS 2009273-60-1
USP7-IN-8 is a selective ubiquitin-specific protease 7 (USP7) inhibitor with an IC50 of 1.4 μM. USP7-IN-8 has anticancer effects.
4-[2-amino-4-ethyl-5-(1H-indazol-5-yl)pyridin-3-yl]phenol
T5461CAS 2009273-67-8
GNE-6640 is a non-covalent inhibitor of ubiquitin epecific peptidase 7 (USP7), with IC50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7...
P22077
T2424CAS 1247819-59-5
P22077 is an inhibitor of ubiquitin-specific protease USP7 with EC50 of 8.6 μM. It also inhibits the closely related USP47.
Spautin-1
T1937CAS 1262888-28-7
Spautin-1 is a novel autophagy inhibitor, IM inhibited the growth of K562 cells with IC50 of 1.03 μM. In contrast, co-treatment with Spautin-1 increased IM-indu...
Thioguanine
T3089CAS 154-42-7
Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
ML323
T1757CAS 1572414-83-5
ML323 is a reversible and effective USP1-UAF1 inhibitor in a Ub-Rho assay (IC50: 76 nM) and in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) (...
NSC632839
T3951CAS 157654-67-6
NSC632839 is a nonselective isopeptidase inhibitor, which inhibits USP2 (EC50: 45±4 μM), USP7 (EC50: 37±1 μM), and SENP2 (EC50: 9.8±1.8 μM).
ML364
T3555CAS 1991986-30-1
ML364 is an inhibitor of ubiquitin specific peptidase 2 (USP2) and can be used for the research of breast cancer.
PR619
T1862CAS 2645-32-1
PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs).
TCID
T6697CAS 30675-13-9
TCID(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1.
IU1
T6107CAS 314245-33-5
IU1(IC50=4.7 μ M), a reversible, specific human USP14 proteasome inhibitor, can penetrate the cell.
LDN57444
T1924CAS 668467-91-2
LDN-57444 is a reversible, competitive proteasome Uch-L1 inhibitor(IC50=0.88 μM) .
P005091
T6925CAS 882257-11-6
P005091 is a selective and potent inhibitor of ubiquitin-specific protease 7 (USP7) with EC50 of 4.2 μM.
USP7/USP47 inhibitor
T4338CAS 1247825-37-1
USP7/USP47 inhibitor is a selective ubiquitin-specific protease 7/47 (USP7/USP47) inhibitor, with EC50s of 0.42 μM and 1.0 μM, respectively.
VLX1570
T4067CAS 1431280-51-1
VLX1570 is a competitive inhibitor of proteasome DUB activity with IC50 ranging from 4.2 uM to 8.6 uM. It has potent inhibition for USP14.
GEN6776
T4634CAS 2009273-71-4
GNE-6776 is a selective USP7 inhibitor.
SJB2-043
T7678CAS 63388-44-3
SJB2-043 is an inhibitor of  USP1-UAF1 ( IC50 : 544 nM).
XL177A
T9122CAS 2417089-74-6
XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34 nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.
USP7-IN-1
T13268CAS 1381291-36-6
USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 77 μM) and used for cancer.
LDN-91946
T15729CAS 439946-22-2
LDN-91946 is an effective, selective, and uncompetitive inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki: 2.8 μM).
IU1-47
T15604CAS 670270-31-2
IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM)....
HBX 19818
T15464CAS 1426944-49-1
HBX 19818 is a specific ubiquitin-specific protease 7 (USP7) inhibitor (IC50: 28.1 μM).
USP7-IN-6
T13271CAS 2166586-47-4
USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).
USP7-IN-5
T13270CAS 2166599-74-0
USP7-IN-5 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 49.9 nM).
USP7-IN-3
T13269CAS 2202738-42-7
USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).
GSK2643943A
T11485CAS T11485
GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor (IC50: 160 nM for USP20/Ub-Rho).
DUB-IN-1
T11110CAS 924296-18-4
Dub-in-1, with an IC50 value of 0.24 for USP8, is an active inhibitor of ubiquitin-specific protease (USPs).
EOAI3402143
T11209CAS 1699750-95-2
EOAI3402143 is a deubiquitinase (DUB) inhibitor, which inhibits dose-dependently inhibits  Usp5/Usp24 andUsp9x.
FT827
T15351CAS 1959537-86-0
FT827 is a selective and covalent inhibitor of ubiquitin-specific protease 7 (USP7) (Ki: 4.2 µM). FT827 binds to the USP7 catalytic domain (apparent Kd: 7.8 µM...
FT671
T12621LCAS 1959551-26-8
FT671 is a non-covalent and selective inhibitor of USP7 (IC50: 52 nM) It also binds to the USP7 catalytic domain (Kd: 65 nM).
C527
T14852CAS 192718-06-2
C527 is a is a pan DUB enzyme inhibitor. Which has a high potency for the USP1/UAF1 complex (IC50=0.88 μM).
DUB-IN-3
T11112CAS 924296-17-3
DUB-IN-3 is IC50 of 0.56 μM for USP8,is a potent deubiquitinase (USP) enzyme inhibitor extracted from reference compound 22c.
DUB-IN-2
T11111CAS 924296-19-5
Dub-in-2, with an IC50 value of 0.28 for USP8, is an effective deubiquitinase inhibitor.
B-AP15
T1932CAS 1009817-63-3
B-AP15(NSC687852) is a selective inhibitor of the deubiquitinating enzymes Usp14 and UCHL5 of the 26S proteasome. It blocks the deubiquitinating activity of the ...