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P22074

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Catalog No. T28284Cas No. 90680-28-7
Alias P-22074

P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.

P22074

P22074

Copy Product Info
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Catalog No. T28284Alias P-22074Cas No. 90680-28-7
P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$147In StockIn Stock
5 mg$348In StockIn Stock
10 mg$475In StockIn Stock
25 mg$667In StockIn Stock
50 mg$887In StockIn Stock
100 mg$1,220In StockIn Stock
200 mg$1,630-In Stock
1 mL x 10 mM (in DMSO)$265In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Batch Information

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Purity:>99.99%
Appearance:Solid
Color:Yellow
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Product Introduction

P22074 AI Summary
P22074 inhibits USP7 and USP47 enzymes, showing an IC50 value greater than 50,000.0 nM for full-length recombinant USP7 (Ub-PLA2 assay), an IC50 value of 14,000.0 nM for USP47, and an IC50 value greater than 31,600.0 nM for USP7 based on other assays. This compound exhibits specific inhibitory activity against these enzymes at the specified concentration levels..
Note: Summary generated by AI. Data source: ChEMBL
Bioactivity
Description
P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.
SynonymsP-22074
Chemical Properties
Molecular Weight279.33
FormulaC12H9NO3S2
Cas No.90680-28-7
SmilesS(C1=C(N(=O)=O)C=C(C(C)=O)S1)C2=CC=CC=C2
Relative Density.1.42 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 11 mg/mL (39.38 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.5800 mL17.9000 mL35.7999 mL178.9997 mL
5 mM0.7160 mL3.5800 mL7.1600 mL35.7999 mL
10 mM0.3580 mL1.7900 mL3.5800 mL17.9000 mL
20 mM0.1790 mL0.8950 mL1.7900 mL8.9500 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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