ubiquitin-proteasome system

PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.

Amino-PEG9-alcohol is a PEG-based linker for PROTACs [Proteolysis Targeting Chimeras], facilitating the conjugation of two essential ligands for PROTAC formation and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Fmoc-PEG12-NHS ester, a PEG-based linker for PROTACs, facilitates the joining of two essential ligands, crucial for the formation of PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

ARV-393 is a PROTAC degrader targeting BCL6 with the advantage of being highly potent and orally available.ARV-393 recruits BCL6 and E3 ligase cerebellum to rapidly degrade BCL6 through the cell's natural ubiquitin proteasome system for the treatment of diffuse large b-cell lymphoma (DLBCL) and non-Hodgkin's lymphoma (NHL).

2-(Benzyloxy)ethanol is a PEG-based linker for PROTACs, facilitating the connection of two essential ligands necessary for forming PROTAC molecules, thereby enabling selective protein degradation via the ubiquitin-proteasome system within cells.

3,4-Dibromo-Mal-PEG2-N-Boc is a PEGylated PROTAC linker that enables conjugation between target-binding ligands and E3 ligase ligands during PROTAC assembly. 3,4-Dibromo-Mal-PEG2-N-Boc supports the design of heterobifunctional degraders that exploit the ubiquitin–proteasome system for selective protein degradation。

Acid-C2-PEG3-NHS ester is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Acid-PEG1-C2-Boc is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Acid-PEG2-C2-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Acid-PEG3-PFP ester is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Acid-PEG5-C2-Boc, a PEG-based linker for PROTACs, facilitates the connection of two essential ligands necessary for PROTAC molecule formation, enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Acid-PEG5-TEMPO is a PEG-based linker for PROTACs, joining two essential ligands crucial for PROTAC molecule formation, and facilitates selective protein degradation using the ubiquitin-proteasome system within cells.

Acid-PEG6-C2-Boc is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Acid-PEG9-NHS ester is a PEG-based linker for PROTACs [proteolysis-targeting chimeras], facilitating the conjugation of two essential ligands, essential for PROTAC molecule formation, and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Ald-C2-PEG4-azide is a PEG-based linker for PROTACs that joins two essential ligands, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Ald-CH2-PEG4-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, and enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG2-NH-Boc is a PEG-based linker for PROTACs, joining two essential ligands crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG4-Boc is a PEG-based linker for PROTACs which joins two essential ligands crucial for forming PROTAC molecules, and Ald-Ph-PEG4-Boc enables targeted protein degradation through the ubiquitin–proteasome system by facilitating effective ternary complex formation, thus advancing the design, optimization, and mechanistic study of next-generation protein degradation therapeutics in chemical biology and drug discovery workflows.

Ald-Ph-PEG4-NH-Boc, a PEG-based linker for PROTACs, connects two essential ligands, crucial for forming PROTAC molecules. This linker facilitates selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG6-acid is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Ald-Ph-PEG6-Boc is a PEG-based linker for PROTACs that joins two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Alkyne-ethyl-PEG1-Boc is a PEG-based linker for PROTACs that connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Alkyne-PEG4-maleimide is a PEG-based bifunctional linker designed for the construction of PROTAC molecules, enabling covalent conjugation between ligand moieties via its terminal alkyne and maleimide groups, and facilitating selective protein degradation through ubiquitin–proteasome system recruitment.

Amino-PEG1-C2-acid is a PEG-based PROTAC Linker for synthesizing PROTAC molecules.