subtypes — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6923	Ozanimod	RPC-1063	S1P Receptor , LPL Receptor
	Ozanimod (RPC-1063) (RPC1063) is a specific oral S1P Receptor 1 modulator. Ozanimod has been used in trials studying the treatment of Crohn's Disease, Ulcerative Colitis, Multiple Sclerosis, and Relapsing Multiple Sclero...		S1P Receptor , LPL Receptor
T12643	(R)-Terazosin		Adrenergic Receptor
	(R)-Terazosin is an active R-enantiomer of Terazosin. (R)-Terazosin is a potent antagonist of α1-adrenoceptor (α1a, α1b and α1d-adrenoceptor with Ki values of 6.51 nM, 1.01 nM and 1.97 nM, respectively).		Adrenergic Receptor
T15643	Kainic acid		Others
	In the CNS, Kainic acid is an effective agonist at excitatory amino acid receptor subtypes.		Others
T26854	BMS641	BMS-641,BMS-209641,BMS 641	Retinoid Receptor
	BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular maturation into specialized neuronal subtypes.		Retinoid Receptor
T0268	Lobeline hydrochloride	α-Lobeline hydrochloride,L-Lobeline hydrochloride	AChR
	Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes.		AChR
T16936	SS-208		HDAC
	SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.		HDAC
T15575	Indeglitazar	PPM 204	PPAR
	Indeglitazar (PPM 204) is orally available pan-agonist of PPAR (PPAR subtypes alpha (α), delta (δ), and gamma (γ)).		PPAR
T6725	VU 0357121		GluR
	VU0357121, a positive allosteric modulator of mGlu5 (EC50: 33 nM), is inactive or very weakly antagonizing at other mGlu receptor subtypes.		GluR
T15816	LY341495		GluR
	LY341495 is a potent metabotropic glutamate receptor antagonist that exhibits high activity against a wide range of glutamate receptor subtypes and can be used for the study of neurological disorders.		GluR
T9683	VX-150		Sodium Channel
	VX-150 is a highly selective NaV1.8 inhibitor relative to the other sodium channel subtypes (>400-fold).		Sodium Channel
T2542	Prucalopride	R-93877	5-HT Receptor
	Prucalopride (R-93877) is a selective, high-affinity 5-HT4A/4B receptor agonist (Ki: 2.5/8 nM). It has >290-fold selectivity for 5-HT4A/4B receptor than other 5-HT receptor subtypes.		5-HT Receptor
T11014	DFP00173		Aquaporin
	DFP00173 is a potent and selective aquaporin 3 (AQP3) inhibitor. DFP00173 inhibits mouse and human AQP3 with IC50 of ~0.1-0.4 μM. Compared with the homologous AQP subtypes AQP7 and AQP9, DFP00173 is selective for AQP3.		Aquaporin
T5858	Sertindole	Lu 23-174	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Autophagy
	Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
T2004	Ciproxifan maleate	FUB 359 maleate,FUB 359	Histamine Receptor
	Ciproxifan maleate (FUB 359)(FUB-359 maleate) is a highly potent and selective histamin H3-receptor antagonist with IC50 of 9.2 nM, with low apparent affinity at other receptor subtypes.		Histamine Receptor
T76907	Palivizumab	Synagis,MEDI 493	RSV
	Palivizumab (MEDI 493) is a humanized RSV-specific monoclonal antibody that selectively inhibits epitopes at the F protein A antigenic site of RSV subtypes A and B for the prevention of respiratory syncytial virus infect...		RSV
T1049	Oxybutynin chloride	Oxybutynin hydrochloride,Oxybutynin HCl	Potassium Channel , AChR
	Oxybutynin chloride (Oxybutynin HCl) is an anticholinergic medication used to relieve urinary and bladder difficulties. It competitively antagonizes the M1, M2, and M3 subtypes of the muscarinic acetylcholine receptor.		Potassium Channel , AChR
T23331	SC 51089	SC 51089 free base	Prostaglandin Receptor
	SC 51089 is a selective prostaglandin receptor PGE2 antagonist with selectivity for prostaglandin receptor subtypes and anti-injury activity that ameliorates motor deficits and rescues memory loss in the R6/1 mouse model...		Prostaglandin Receptor
T22301	L-838417 D9	CTP354,CTP354 (C-21191),C-21191	GABA Receptor
	L-838417 D9 (C-21191) is a novel deuterated subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].		GABA Receptor
TN1047	Ingenol mebutate	Ingenol 3-Angelate,PEP005	gp120/CD4 , HIV Protease , PKC
	Ingenol mebutate (Ingenol 3-Angelate) is a potent activator of PKC subtypes including PKC-α, PKC-β, PKC-γ, PKC-δ, and PKC-ε with Kis of 0.3, 0.105, 0.162, 0.376, and 0.171 nM. Ingenol mebutate exhibits antiinflammatory a...		gp120/CD4 , HIV Protease , PKC
T76992	Suptavumab	REGN2222	RSV
	Suptavumab (REGN2222) is a human monoclonal antibody. Suptavumab neutralizes conserved epitopes on subtypes A and B on RSV. Suptavumab can be used to study RSV infections and the respiratory system.		RSV