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Pluripotin (SC1) (SC1), which keep embryonic stem cell (ESC) self-renewal, is a dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP.

NSC 122393 is a fluorescent dye that inhibits the interaction between Bax and Bcl-X and induces apoptosis in Bcl-X overexpressing breast cancer cells.

Compound SC-1 is a a derivative of the multiple tyrosine kinase inhibitor sorafenib. Compound SC-1 potently inhibits the phosphorylation of STAT3 by blocking STAT3 phosphorylation and activation, and induces apoptosis in hepatocellular carcinoma cell lines[1].

NSC 191412 interacts with a variety of enzymes and receptors, including acetylcholinesterase and receptors for the neurotransmitter dopamine, and is an agonist or activator of these enzymes and receptors.

NSC 146109 hydrochloride is an activator of p53 targeting MDMX. NSC 146109 hydrochloride can be used for studies on breast cancer.

NSC 15830 (S-(1,2-Dichlorovinyl)-L-cysteine) hydrochloride is a nephrotoxic compound that serves as a metabolite of trichloroethylene. This compound is capable of inhibiting TNF-α stimulated by pathogens.

Chk2 inhibitor,ATP-competitive

SC 19220 is a prostaglandin E2 receptor EP1 antagonist.SC 19220 inhibits RANKL-induced osteoclastogenesis by inhibiting the RANK RANKL signaling pathway in osteoclast precursors.

NSC 105204 is a bioactive chemical.

NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM) and attenuates mitochondrial ATP synthesis. Exhibits antiproliferative activity in a number of leukemias in vivo.

NSC 144698 is a bioactive chemical.

NSC 152737 is a therapeutic agent.

NSC 157449 is a bioactive chemical.

NSC 174121 is a methotrexate derivative.

NSC 184692 is a aminopterin-derivative.

NSC 15364 (1,3-Bis(4-aminophenyl)urea) can be used for screening of ALR inhibitors by detection of hydrogen peroxide production Measured in Biochemical System.

NSC 12 is an orally active pan-FGF trap that inhibits FGF-dependent tumor cell proliferation, angiogenesis, and metastasis.NSC 12 binds FGF2 and interferes with its interaction with FGFR1, but does not affect the ability of FGF2 to bind heparin or heparan sulfate proteoglycans (HSPGs), with potential antitumor activity.NSC 12 also organizes several other FGF isoforms to form the HSPG FGF FGFR ternary complex.

NSC 185058, an inhibitor of ATG4B (a major cysteine protease), can also attenuate autophagic activity.

NSC 107512 is a class of sangivamycin-like molecules (SLM). NSC 107512 is a potent cyclin-dependent kinase 9(CDK9) inhibitor that inhibits multiple myeloma tumors growth and induces apoptosis [1].

SC 11927 is an aldosterone antagonist.

SC 19886 is an antimineralocorticoid that acts as a potent inhibitor of aldosterone biosynthesis.

NSC 135130 (compound 11a), a BOC-protected ADC linker, facilitates the synthesis of drug conjugates by attaching to tubulin-targeting inhibitors [1].

NSC 194308, an enhancer of U2AF2-RNA complexes, promotes the association of the U2AF1-U2AF2-SF1-splice site RNA complex by targeting a site between U2AF2 RNA recognition motifs (RRM1 and RRM2). It inhibits pre-mRNA splicing by stalling spliceosome assembly at the stage where U2AF recruits U2 snRNP to the branchpoint. Additionally, NSC 194308 strengthens the binding of pre-mRNA to U2AF2, selectively inducing cell death in leukemia cell lines with spliceosome mutations [1].

SC-2001 is a MCL-1 inhibitor. SC-2001 inhibits STAT3 phosphorylation through enhancing SHP-1 expression and induces apoptosis in human breast cancer cells. SC-2001 overcomes STAT3-mediated sorafenib resistance through RFX-1 SHP-1 activation in hepatocellu