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Results for "

hdac6

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    254
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    1
    TargetMol | Peptide_Products
  • PROTAC Products
    12
    TargetMol | PROTAC
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    3
    TargetMol | Natural_Products
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    2
    TargetMol | Recombinant_Protein
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    TargetMol | Antibody_Products
BChE/HDAC6-IN-2
T776582925457-33-4In house
BChE HDAC6-IN-2 is a selective and potent dual inhibitor of BChE and HDAC6 with neuroprotective and reactive oxygen species (ROS) scavenging activity. BChE HDAC6-IN-2 is a metal ion co-agonist that inhibits tau phosphorylation and can be used in the study of immune and neurological diseases.
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4-6 weeks
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Vorinostat
suberoylanilide hydroxamic acid, SAHA, MK0683
T1583149647-78-9
Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1 2 3 6 7 11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.
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TargetMol | Inhibitor Hot
MPI_5a
T161291259296-46-2
MPI_5a is an effective and selective inhibitor of HDAC6 (IC50=36 nM). MPI_5a weakly inhibits other HDAC isoforms and it also inhibits acyl-tubulin accumulation in cells (IC50: 210 nM).
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6-8 weeks
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TargetMol | Inhibitor Hot
ACY-1083
T102441708113-43-2In house
ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.
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6-8 weeks
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BRD 9757
N-Hydroxy-1-cyclopentene-1-carboxamide, BRD-9757, BRD9757
T251751423058-85-8In house
BRD 9757 (N-Hydroxy-1-cyclopentene-1-carboxamide) is a selective inhibitor of HDAC6 (IC50 = 30 nM).
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6-8 weeks
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SantacruzaMate A
CAY-10683
T22661477949-42-0
SantacruzaMate A (CAY-10683) is a potent and selective HDAC inhibitor.
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Ricolinostat
Rocilinostat, ACY-1215
T24891316214-52-4
Ricolinostat (Rocilinostat) is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.
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ACY-738
ACY 738
T35091375465-91-0
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
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Tubastatin A Hydrochloride
Tubastatin A HCl, TSA HCl
T61611310693-92-5
Tubastatin A Hydrochloride (TSA HCl) is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).
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Tubacin
T6327537049-40-4
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
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Nexturastat A
T18191403783-31-2
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
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BG45
T2294926259-99-6
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3 1 2 6 in cell-free assays, respectively.
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HDAC-IN-40
T600822463198-51-6
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.
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Droxinostat
NS 41080
T648199873-43-5
Droxinostat (NS 41080) is a selective HDAC inhibitor, primarily targeting HDACs 6 and 8 with IC50 values of 2.47 μM and 1.46 μM, respectively. It is over 8-fold more selective against HDAC3 and shows no inhibition for HDAC1, 2, 4, 5, 7, 9, and 10.
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KA2507
T91481636894-46-6
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
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abexinostat
PCI-24781, PCI24781, PCI 24781, CRA 24781, CRA 024781
T0431783355-60-2
PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1 2.
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AES-135
T102552361659-61-0
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
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CRA-026440
PCI-34051
T10883847460-34-8
CRA-026440(PCI-34051) is a highly potent HDAC inhibitor with inhibitory effects on HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki values of 4,14,11,15,7 and 20 nM, respectively. CRA-026440 has anti-tumor and anti-angiogenic activity and can be used to study colon cancer.
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6-8 weeks
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Pracinostat
SB939
T1890929016-96-6
Pracinostat (SB939) is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Data demonstrate that Pracinostat is a potent and effective anti-tumor drug with potential as an oral therapy for a variety of human hematological and solid tumors.
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Tubastatin A
Tubastatin A BASE
T19661252003-15-8
Tubastatin A (Tubastatin A BASE) is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except HDAC8.
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CAY10603
HDAC6 Inhibitor, BML-281
T19831045792-66-2
CAY10603 (BML-281) is a potent and selective HDAC6 inhibitor.
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HPOB
T24301429651-50-2
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
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CUDC-101
CUDC101, CUDC 101
T31081012054-59-9
CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC50s of 4.4 nM, 2.4 nM, and 15.7 nM, respectively.
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Citarinostat
HDAC-IN-2, ACY241
T36611316215-12-9
ACY-241, also known as Citarinostat (ACY241), is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis.
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