coenzyme a

Coenzyme A is an obligatory cofactor in all living cells synthesized from pantothenate (Vitamin B5), adenosine triphosphate (ATP), and cysteine.

Linoleoyl-coenzyme A is a substrate used to investigate the specificity and kinetics of acyl-CoA.

Pentanoyl Coenzyme A (pentanoyl-CoA) Free acid is a short-chain acyl-CoA. It acts as a metabolite of 3-oxopropionyl-CoA.

Heptanoyl-coenzyme A (Heptanoyl-CoA) tetrasodium is a derivative of coenzyme A. It acts as an inhibitor of butyryl-CoA acetate-CoA transferase (BUT), thus hindering the synthesis of butyrate. Additionally, Heptanoyl-coenzyme A tetrasodium can block the improvement of motor function induced by the isoquinoline alkaloid berberine.

Lauroyl-coenzyme A can function as an acyl group carrier, acetyl-CoA. It can be used as an intermediate in lipid metabolism and is involved in lipid biosynthesis and fatty acid transport.

Myristoyl coenzyme A (myristoyl-CoA) is a derivative of CoA that contains the long-chain fatty acid myristic acid . It is a substrate for N-myristoyltransferase during myristoylation, a process that adds a myristoyl group to proteins either during translation to modify protein activity or post-translationally in apoptotic cells. It is also a substrate in the de novo synthesis of phosphatidylinositol .

Acetoacetyl Coenzyme A sodium hydrate is a precursor of poly-β-hydroxybutyrate, which is closely related to the body's energy metabolism.

Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency.

Ethylmalonyl coenzyme A (CoA) is a key intermediate in the ethylmalonyl-CoA pathway for carbon metabolism in certain bacteria, such asM. extorquens, which uses this pathway when grown on ethylamine.1,2It is produced from crotonyl-CoA by crotonyl-CoA reductase/carboxylase and modified by ethylmalonyl-CoA mutase to make methylsuccinyl-CoA. 1.Good, N.M., Martinez-Gomez, N.C., Beck, D.A.C., et al.Ethylmalonyl coenzyme A mutase operates as a metabolic control point in Methylobacterium extorquens AM1J. Bacteriol.197(4)727-735(2015) 2.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011)

Methylmalonyl coenzyme A (methylmalonyl-CoA) is an intermediate in multiple metabolic pathways in bacteria and eukaryotes.1,2,3It is an intermediate in carbon assimilation in certain bacteria and carbon fixation in plants.1,2Methylmalonyl-CoA is converted to succinyl-CoA by methylmalonyl-CoA mutase with vitamin B12as a coenzyme.3A deficiency in vitamin B12leads to a build-up of methylmalonyl-CoA.4 1.Anthony, C.How half a century of research was required to understand bacterial growth on C1 and C2 compounds; the story of the serine cycle and the ethylmalonyl-CoA pathwaySci. Prog.94(Pt 2)109-137(2011) 2.Tabita, F.R.The hydroxypropionate pathway of CO2 fixation: Fait accompliProc. Natl. Acad. Sci. U.S.A.106(50)21015-21016(2009) 3.Medicine, I.o.Vitamin B12Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline306-356(1998) 4.Cardinale, G.J., Carty, T.J., and Abeles, R.H.Effect of methylmalonyl coenzyme A, a metabolite which accumulates in vitamin B12 deficiency, on fatty acid synthesisJ. Biol. Chem.245(15)3771-3775(1970)

Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudomonas, binding to each protein to induce derepression of various genes.2

Cyclohexanoyl coenzyme A (CHCoA) is an acyl CoA that contains a cyclohexane group. It is the activated form of cyclohexane carboxylic acid (CHC) in R. palustris. CHC is converted to CHCoA by a succinyl-CoA CHC CoA transferase, and CHCoA is then degraded by a dehydrogenase. CHCoA is converted to hippuric acid in submitochondrial fractions isolated from guinea pig liver.

Octanoyl coenzyme A lithium, a derivative of fatty acid acyl coenzyme A, inhibits citrate synthase and glutamate dehydrogenase (IC50: 0.4-1.6 mM).

Acetyl-coenzyme A (Acetyl-CoA) lithium, a membrane-impermeant central metabolic intermediate, is integral to the TCA cycle and oxidative phosphorylation, regulates cellular mechanisms by serving as the sole donor of acetyl groups for post-translational acetylation of proteins, and is a critical precursor in lipid synthesis [1] [2] [3] [4].

Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways, participating in the tricarboxylic acid cycle, fatty acid synthesis, and oxidative phosphorylation metabolism, among others, regulating various cellular metabolic mechanisms and reflecting cellular energy status.

Lauroyl coenzyme A lithium salt is a type of coenzyme A that acts as an acyl carrier, specifically acetyl-CoA. Lauryl-CoA (C12-CoA) is a long-chain (C-12) saturated fatty acyl-CoA involved in lipid metabolism, lipid biosynthesis, and fatty acid transport. It serves as a substrate for the FAM34A protein and is a product of firefly luciferase.

β-Methylcrotonyl coenzyme A lithium, a key intermediate in leucine metabolism, serves as a substrate to investigate the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase) [1].

DL-β-Hydroxybutyryl coenzyme A lithium, an intermediate in butyric acid fermentation and lysine and tryptophan metabolism, is synthesized from β-hydroxybutyric acid by short-chain-CoA synthase [1] [2].

Arachidonoyl coenzyme A lithium, an unsaturated fatty acyl coenzyme A derivative, results from the condensation of coenzyme A's thiol group with arachidonic acid's carboxyl group [1].

Decanoyl coenzyme A (Decanoyl CoA) acts as a primer for the fatty acid elongation system in Mycobacterium smegmatis [1].

Acetoacetyl coenzyme A sodium, a pivotal endogenous metabolite, exhibits a K m of 1.10 mM at pH 7.5 and plays a crucial role in the synthesis of phosphotransbutyrylase (PTB) and poly-3-hydroxybutyrate (PHB) [1] [2].

Acyl coenzyme A synthetase (ACS), also known as acetyl coenzyme A synthetase, catalyzes the activation of fatty acids via coenzyme A through a two-step thioesterification process, forming acyl coenzyme A. It is crucial in anabolic and catabolic lipid metabolism pathways and contributes to the tricarboxylic acid (TCA) cycle during aerobic respiration [1].

Oleoyl coenzyme A lithium (Oleoyl-CoA lithium) is an oleic acid and coenzyme A thioester, an efficient h15-LOX-2 allosteric inhibitor that inhibits h12-LOX and h15-LOX-2. It is used in the study of metabolic and cardiovascular diseases.

Glutaryl coenzyme A lithium, a derivative of the endogenous metabolite glutaryl coenzyme A, is utilized in experiments related to HMG-CoA or glutaryl-CoA.