Anti-infection

ABMA is a broad-spectrum inhibitor of intracellular toxins and pathogens, efficiently protecting cells against various pathogens including viruses, intracellular bacteria, and parasites. ABMA selectively acts on host cell late endosomes rather than targeting the toxin or pathogen itself.

Celgosivir (6 O-butanoyl castanospermine) is an inhibitor of α-glucosidase I. In vitro assay, it inhibits bovine viral diarrhoea virus (BVDV) ( IC50: 1.27 μM ).

ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease.

(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia/reperfusion (I/R) in the superior mesenteric artery (SMA) of the rat.

QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK. The IC50 values of QL-X-138 are 9.4 nM for BTK, 107.4 nM for MNK1, 26 nM for MNK2, and 3.5 μM against Dengue 2. QL-X-138 is used in the study of B-cell malignancies and B-cell malignant tumors.

Galidesivir is a viral RNA-dependent RNA polymerase (RdRP) inhibitor and broad spectrum antiviral nucleotide.In vitro, galidesivir displays antiviral activity against a range of RNA viruses, including bunyaviruses, arenaviruses, paramyxoviruses, coronaviruses, and flaviviruses (EC50values range from 3 μM to >100 μM). Galidesivir protects against Ebola and Marburg viral infection in animal models.

Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.

(-)-JNJ-A07 is a selective and potent dengue virus (DENV) inhibitor with an EC50 of 31 nM, exhibiting significant antiviral activity for the study of dengue virus infections.

(+)-JNJ-A07 is a pan-serotypic dengue virus inhibitor that targets NS3-NS4B interaction with high potency. (+)-JNJ-A07 has antiviral activity and can be used to study dengue virus infections.

LabMol-319 is a potent Zika virus (ZIKV) NS5 RdRp inhibitor with antiviral activity for the study of ZIKV virus.

Terpineol possesses antifungal activity against Trichophyton mentagrophytes, it also exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria. α-Terpineol (Terpineol) shows anticonvulsant, and anti-inflammatory activities, it inhibits the gene expression of the IL-6 receptor.

2'-Hydroxy-4'-methylacetophenone, a phenolic compound isolated from Angelicae koreana roots, possesses acaricidal properties and can be used in the preparation of 4'-methyl-2'-[(p-tolylsulfonyl)oxy]acetophenone.

1,3-Dithiane (1,3-Dithian) is a protected formaldehyde anion equivalent that could serve as a useful labeled synthon. 1,3-Dithiane is also a sulfur-containing Maillard reaction products found in boiled beef extracts.

A 21960 (Ethyl 2-chloroacetoacetate) inhibits synapse formation between resolvase and two directly repeated res sites, blocks site-specific recombination reactions, and can be used to study bacterial infections.

2-Furoic acid (Furan-2-carboxylic acid) reduces serum cholesterol and triglyceride levels and exhibits anti-lipidemic effects.

Penicillin G potassium (Benzylpenicillin potassium) is the potassium salt form of penicillin G, a broad-spectrum penicillin antibiotic.

Cefotaxime is an inhibitor of penicillin binding protein.

N-(Hydroxymethyl)nicotinamide (Bilamid) is an antimicrobial agent.

Sorbic acid is a natural product that inhibits various bacteria, including sporeformers,

Octacosanoic acid has antiplatelet and antithrombotic effects.

Sulfadimethoxine is a antimicrobial agent, treatment of respiratory, urinary tract, enteric, and soft tissue infections

3,4,5-Trimethoxybenzaldehyde shows anti-Candida efficacy and inhibits adhesion and biofilms.

Pyromeconic acid (3-hydroxy-4H-pyran-4-one) and derivatives thereof are potent inhibitors of endonuclease

2,5-Dihydroxybenzaldehyde (Gentisaldehyde) has antioxidant activity against Mycobacterium avium subsp. Paratuberculosis. 2,5-Dihydroxybenzaldehyde also inhibits S. aureus strains(MIC50: 500 mg/L).