Search Result

Search Results for " pump "

Targets

112

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T0712	Suloctidil		ATPase , Platelet aggregation
	Suloctidil is a peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred.		ATPase , Platelet aggregation
T17030	Tegoprazan		ATPase , Proton pump
	Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.5...		ATPase , Proton pump
T1756L	Ilaprazole	IY81149,IY 81149,IY-81149	Proton pump , TOPK
	Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm...		Proton pump , TOPK
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T1756	Ilaprazole sodium	IY-81149 sodium	Proton pump , TOPK
	Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus...		Proton pump , TOPK
T22391	Omeprazole Sodium		P450 , Proton pump , Antibacterial , Autophagy
	Omeprazole Sodium is a proton pump inhibitor(PPI) and suppresses gastric acid secretion. Omeprazole Sodium is a potent neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor). Omeprazole Sodium shows competitive...		P450 , Proton pump , Antibacterial , Autophagy
T11191	EN6		Proton pump , Autophagy
	EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ...		Proton pump , Autophagy
T0490	Chlorpropamide	Diabinese	ATPase , ABC
	Chlorpropamide (Diabinese) is a sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification.		ATPase , ABC
T16682	Pumaprazole	BY-841	Proton pump
	Pumaprazole (BY-841) is an antagonist of a reversible proton pump.		Proton pump
T10435	Linaprazan	AZD0865	Potassium Channel
	Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding with an IC50 of 1.0 μM.		Potassium Channel
T2188	Thonzonium Bromide		Proton pump , Antibacterial , Autophagy
	Thonzonium bromide is a mono-cationic surfactant that is structurally similar to Farnesol as an antimicrobial agent. It inhibits proton transport in a dose-dependent manner (EC50=69 μM). It inhibits RANKL-induced osteocl...		Proton pump , Antibacterial , Autophagy
T8388	Vonoprazan	TAK-438 (free base)	Proton pump
	Vonoprazan (TAK-438 (free base)) is an orally active potassium-competitive acid blocker.Vonoprazan can be used for the treatment of gastroduodenal ulcer and reflux esophagitis		Proton pump
T21254	Vonoprazan Fumarate	TAK-438,TAK 438,Vonoprazan Fumurate,TAK438	Proton pump
	Vonoprazan Fumarate (TAK438) , a novel potassium-competitive acid blocker, inhibits gastric acid secretion. Vonoprazan Fumarate (TAK438) inhibited H+,K+-ATPase activity in porcine gastric microsomes with IC50 value of 19...		Proton pump
T0502	Zinc pyrithione	OM-1563	Proton pump , Antibacterial , Antifungal
	Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.		Proton pump , Antibacterial , Antifungal
T9230	KM 91104		ATPase
	KM 91104 is a cell permeable inhibitor of V-ATPase. KM91104 specifically targets the interaction between V-ATPase subunit A3 and subunit B2.		ATPase
T1651	Rabeprazole sodium	Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium	Apoptosis , Proton pump
	Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch...		Apoptosis , Proton pump
T6700	Tenatoprazole	TU-199	Proton pump
	Tenatoprazole (TU-199), a prodrug of the proton pump inhibitor (PPI) class, can inhibit proton transport (IC50: 3.2 μM).		Proton pump
T2686L	Esomeprazole Sodium	(S)-Omeprazole sodium	ATPase , Proton pump
	Esomeprazole Sodium ((S)-Omeprazole sodium) is the S-isomer of omeprazole with selective and irreversible proton pump inhibitor activity.Esomeprazole acts as an exosome inhibitor by blocking the exosome release via the i...		ATPase , Proton pump
T6443	Chloroprocaine hydrochloride	Chloroprocaine HCl	ATPase , Others
	Chloroprocaine hydrochloride (Chloroprocaine HCl) is a local anesthetic during surgical procedures.		ATPase , Others
T6953	Prilocaine	Citanest,Propitocaine,NSC 40027	ATPase , Sodium Channel
	Prilocaine (NSC-40027) is a local anesthetic of the amino amide type, which acts on the sodium channel on the neuronal membrane and limits the spread of seizures.		ATPase , Sodium Channel
T2621	Rostafuroxin	PST 2238	ATPase , RSV
	Rostafuroxin (PST 2238) has been used in trials studying the treatment of Essential Hypertension.		ATPase , RSV
T1734	Rabeprazole Sulfide	Rabeprazole Related Compound E	Proton pump , Antibacterial
	Rabeprazole Sulfide (Rabeprazole Related Compound E) is an antiulcer drug in the class of proton pump inhibitors.		Proton pump , Antibacterial
T0757	Omeprazole	Losec,Prilosec,H 16868,Antra	Proton pump , Phospholipase , Antibacterial , Autophagy
	Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).		Proton pump , Phospholipase , Antibacterial , Autophagy
T0674	Lansoprazole	A-65006,AG-1749	Proton pump , Phospholipase , Antibacterial
	Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo...		Proton pump , Phospholipase , Antibacterial
T2686	Esomeprazole Magnesium	(S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium	ATPase , Proton pump
	Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by block...		ATPase , Proton pump
T0796	Prilocaine hydrochloride	Prilocaine HCl,Propitocaine hydrochloride,Xylonest	ATPase , Sodium Channel
	Prilocaine hydrochloride (Prilocaine HCl) is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.		ATPase , Sodium Channel
T1021	(R)-Lansoprazole	Dexlansoprazole,T 168390,TAK 390,R-(+)-Lansoprazole	Proton pump
	(R)-Lansoprazole (T 168390) is the R-isomer of lansoprazole and a substituted benzimidazole prodrug with selective and irreversible proton pump inhibitor activity.Lansoprazole (AG 1749) is a potent brain penetrant neutra...		Proton pump
T2176	2,3-Butanedione 2-Monoxime	Diacetyl monoxime,2,3-Butanedione-2-monoxime	Akt
	2,3-Butanedione 2-Monoxime (Diacetyl monoxime) is an inhibitor of skeletal and cardiac muscle contraction.		Akt
T6928	Pantoprazole	SKF96022,BY1023	Apoptosis , Proton pump , Autophagy
	Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Proton pump , Autophagy
T8386	Esomeprazole Magnesium trihydrate	(S)-Omeprazole magnesium trihydrate	Proton pump
	Esomeprazole Magnesium trihydrate ((S)-Omeprazole magnesium trihydrate) is a proton pump inhibitor indicated for the short-term treatment of gastroesophageal reflux disease in patients with a history of erosive esophagit...		Proton pump
T0161	Pantoprazole Sodium Hydrate	SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)	Apoptosis , Potassium Channel , Proton pump , Autophagy
	Pantoprazole Sodium Hydrate (BY1023 (sodium hydrate)) is a proton pump inhibitor drug, used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease.		Apoptosis , Potassium Channel , Proton pump , Autophagy
T6929	Pantoprazole sodium	Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc	Apoptosis , Others , Proton pump , HIF , Autophagy
	Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters...		Apoptosis , Others , Proton pump , HIF , Autophagy
T74478	M7GpppUmpG
	m7GpppUmpG, an oligonucleotide and a trinucleotide cap analogue of M 7 GpppNpG, serves as a chemical tool for the production of RNA with either cap 0 or cap 1 structures [1].
T5449	Bamaquimast	F 10126,L 0042	Proton pump
	Bamaquimast (L 0042) is an inhibitor of proton pump		Proton pump
T12309	Omeprazole metabolite Omeprazole sulfone	Omeprazole sulphone,Omeprazole sulfone	Others
	Omeprazole metabolite Omeprazole sulfone can inhibit proton pump.		Others
T28665	Saviprazole	Hoe731,Hoe 731,Hoe-731	Proton pump
	Saviprazole (Hoe-731), a proton pump inhibitor, is used potentially for treatment of gastric ulcer.		Proton pump
T12374	PAβN dihydrochloride	MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride	Others , Antibacterial
	PAβN dihydrochloride (MC-207,110 dihydrochloride) is an inhibitor of efflux pump.		Others , Antibacterial
T2093L	(S)-PF-03716556		ATPase
	(S)-PF-03716556 can be used as an acid pump inhibitor for the treatment of disease conditions mediated by acid pump inhibitory activity.		ATPase
T23667	AGN-201904	AGN201904,AGN 201904	ATPase
	AGN-201904 is a proton pump inhibitor, an omeprazole prodrug, which delays aging and may be used for the prevention and treatment of peptic ulcers.		ATPase
T2687	Omeprazole sulfide	Omeprazole metabolite Omeprazole sulfide,Ufiprazole	Proton pump , Drug Metabolite
	Omeprazole sulfide (Ufiprazole), a metabolite of Omeprazole, functions as a proton pump inhibitor.		Proton pump , Drug Metabolite
T20155	Lansoprazole sulfone		Others
	Lansoprazole sulfone is a metabolite of the gastric pump inhibitor Lansoprazole.		Others
T16349	NSC-60339		Others , Antibacterial
	NSC-60339 is an inhibitor of efflux pump, and a substrate of AcrAB-TolC, is a polybasic terephthalic acid derivative studied as a potential cancer chemotherapeutic agent.		Others , Antibacterial
T10138	4-Desmethoxy Omeprazole		Drug Metabolite
	4-Desmethoxy Omeprazole is the active metabolite of Omeprazole. Omeprazole is a proton pump inhibitor (PPI). Omeprazole shows competitive inhibition of CYP2C19 activity (Ki: 2 to 6 μM).		Drug Metabolite
T21023	Bedaquiline fumarate	TMC 207,R403323,TMC-207,TMC207,R-403323,R 403323	Antibacterial , Antibiotic
	Bedaquiline fumarate (TMC207), a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections. It blocks the proton pump for ATP synthase of mycobacteria. ...		Antibacterial , Antibiotic
T20714	Levolansoprazole	(S)-Lansoprazole,(-)-Lansoprazole	Proton pump
	Levolansoprazole ((S)-Lansoprazole), a proton pump inhibitor, irreversibly inhibits H+/K+-stimulated ATPase pumps in parietal cells (IC50: 5.2 μM). It also inhibits acid formation in isolated canine parietal cells (IC50:...		Proton pump
T1146	Nifedipine	BAY-a-1040,Procardia XL,Procardia,Adalat	CaMK , Potassium Channel , Calcium Channel , Autophagy
	Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...		CaMK , Potassium Channel , Calcium Channel , Autophagy
T10221	Abeprazan hydrochloride	DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump
	Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat...		Proton pump
T27609	INF55
	INF55 inhibits NorA efflux pump.
T74827	AcrB-IN-2
	Efflux pump-IN-2 is an AcrB efflux pump inhibitor, with ability to potentiate the effect of antibiotics . Efflux pump-IN-2 inhibits Nile Red (a known substrate of AcrB) efflux. Efflux pump-IN-2 does not disrupts the bact...
T25588	L589-420	L 589-420,L-589-420,L-589 420,L 589 420,L589 420
	L589-420 is a sodium pump inhibitor in human erythrocytes.

Compounds

Suloctidil

T0712

Synonym:

Target: ATPase, Platelet aggregation

Tegoprazan

T17030

Synonym:

Target: ATPase, Proton pump

Ilaprazole

T1756L

Synonym: IY81149,IY 81149,IY-81149

Target: Proton pump, TOPK

Esomeprazole

T20626

Synonym:

Target: Proton pump, Cysteine Protease

Ilaprazole sodium

T1756

Synonym: IY-81149 sodium

Target: Proton pump, TOPK

Omeprazole Sodium

T22391

Synonym:

Target: P450, Proton pump, Antibacterial, Autophagy

EN6

T11191

Synonym:

Target: Proton pump, Autophagy

Target: Proton pump

Linaprazan

T10435

Synonym: AZD0865

Target: Potassium Channel

Thonzonium Bromide

T2188

Synonym:

Target: Proton pump, Antibacterial, Autophagy

Vonoprazan

T8388

Synonym: TAK-438 (free base)

Target: Proton pump

Vonoprazan Fumarate

T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438

Target: Proton pump

Zinc pyrithione

T0502

Synonym: OM-1563

Target: Proton pump, Antibacterial, Antifungal

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Tenatoprazole

T6700

Synonym: TU-199

Target: Proton pump

Esomeprazole Sodium

T2686L

Synonym: (S)-Omeprazole sodium

Target: ATPase, Proton pump

Chloroprocaine hydrochloride

T6443

Synonym: Chloroprocaine HCl

Target: ATPase, Others

Prilocaine

T6953

Synonym: Citanest,Propitocaine,NSC 40027

Target: ATPase, Sodium Channel

Synonym: Rabeprazole Related Compound E

Target: Proton pump, Antibacterial

Omeprazole

T0757

Synonym: Losec,Prilosec,H 16868,Antra

Target: Proton pump, Phospholipase, Antibacterial, Autophagy

Lansoprazole

T0674

Synonym: A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Esomeprazole Magnesium

T2686

Synonym: (S)-Omeprazole magnesium,NEXIUM,(-)-Omeprazole magnesium

Target: ATPase, Proton pump

Prilocaine hydrochloride

T0796

Synonym: Prilocaine HCl,Propitocaine hydrochloride,Xylonest

Target: ATPase, Sodium Channel

(R)-Lansoprazole

T1021

Synonym: Dexlansoprazole,T 168390,TAK 390,R-(+)-Lansoprazole

Target: Proton pump

2,3-Butanedione 2-Monoxime

T2176

Synonym: Diacetyl monoxime,2,3-Butanedione-2-monoxime

Target: Akt

Pantoprazole

T6928

Synonym: SKF96022,BY1023

Target: Apoptosis, Proton pump, Autophagy

Esomeprazole Magnesium trihydrate

T8386

Synonym: (S)-Omeprazole magnesium trihydrate

Target: Proton pump

Pantoprazole Sodium Hydrate

T0161

Synonym: SKF96022 sodium hydrate,BY1023 (sodium hydrate),SKF96022 (sodium hydrate)

Target: Apoptosis, Potassium Channel, Proton pump, Autophagy

Pantoprazole sodium

T6929

Synonym: Pantecta,SKF96022 sodium,SKF96022 (sodium),BY1023 (sodium),BY-1023 sodium,Pantoloc

Target: Apoptosis, Others, Proton pump, HIF, Autophagy

Synonym: F 10126,L 0042

Target: Proton pump

Omeprazole metabolite Omeprazole sulfone

T12309

Synonym: Omeprazole sulphone,Omeprazole sulfone

Target: Others

Saviprazole

T28665

Synonym: Hoe731,Hoe 731,Hoe-731

Target: Proton pump

PAβN dihydrochloride

T12374

Synonym: MC-207,110 dihydrochloride,Phe-Arg-β-naphthylamide dihydrochloride

Target: Others, Antibacterial

Synonym: AGN201904,AGN 201904

Target: ATPase

Omeprazole sulfide

T2687

Synonym: Omeprazole metabolite Omeprazole sulfide,Ufiprazole

Target: Proton pump, Drug Metabolite

Target: Others, Antibacterial

4-Desmethoxy Omeprazole

T10138

Synonym:

Target: Drug Metabolite

Bedaquiline fumarate

T21023

Synonym: TMC 207,R403323,TMC-207,TMC207,R-403323,R 403323

Target: Antibacterial, Antibiotic

Levolansoprazole

T20714

Synonym: (S)-Lansoprazole,(-)-Lansoprazole

Target: Proton pump

Nifedipine

T1146

Synonym: BAY-a-1040,Procardia XL,Procardia,Adalat

Target: CaMK, Potassium Channel, Calcium Channel, Autophagy

Abeprazan hydrochloride

T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Synonym: L 589-420,L-589-420,L-589 420,L 589 420,L589 420

Target:

Cat No.	Product Name	Synonyms	Targets
T1719	Bufalin		ATPase
	Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potenti...		ATPase
TQ0184	Chebulinic acid		ATPase , Proton pump , DNA/RNA Synthesis , Antibacterial , TGF-beta/Smad
	Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
TJP2872	Acevaltrate	Acevaltratum,Acetoxyvaltrate	ATPase , Others
	1. Acevaltrate (Acevaltratum) displays high cytotoxicity against GLC(4), a human small-cell lung cancer cell line, and against COLO 320, a human colorectal cancer cell line, with IC50 values of 1-6 uM.		ATPase , Others
T5S0890	Oleandrin	Neriostene,Folinerin,Foliandrin	Apoptosis , ATPase , Potassium Channel , Sodium Channel
	1. Oleandrin (Folinerin), the principal cardiac glycoside component of PBI-524, can quantitatively account for regulation of BDNF at both the protein and transcriptional levels. 2. Oleandrin are known to inhibit the Na, ...		Apoptosis , ATPase , Potassium Channel , Sodium Channel
T0295	Digitoxin	Digitoxoside,Unidigin,Digitoxinum	ATPase , Others
	Digitoxin (Digitoxinum) is an effective Na+/K+-ATPase inhibitor (EC50 value: 0.78 μM).		ATPase , Others
TN1103	Diphyllin		ATPase , Proton pump , Influenza Virus , HIV Protease
	Diphyllin could be characterized as a new V-ATPase inhibitor in treating gastric cancer and inhibiting the phosphorylation of LRP6 in Wnt/β-catenin signaling.		ATPase , Proton pump , Influenza Virus , HIV Protease
TN5073	Strophanthidin	Strophanthidine	ATPase , Calcium Channel
	Strophanthidin (Strophanthidine) can induce calcium overload in vivo.		ATPase , Calcium Channel
T6740	Bafilomycin A1		Apoptosis , Proton pump , Antibacterial , Antibiotic , Autophagy
	Bafilomycin A1 belongs to the macrolide class of antibiotics and is a V-ATPase (IC50=0.44 nM) that is specific and reversible. Bafilomycin A1 is an inhibitor of the late phase of autophagy, blocking the fusion of autopha...
T8183	Deslanoside	Desacetyllanatoside C,Deacetyllanatoside C	ATPase , Drug Metabolite
	Deslanoside (Desacetyllanatoside C) is a rapidly acting cardiac glycoside used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms. Deslanoside inhibits the Na-K-ATPase membrane p...		ATPase , Drug Metabolite
T2922	Phlorizin	Floridzin,NSC 2833,Phloridzin	ATPase , SGLT
	Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .		ATPase , SGLT
T6368	Abscisic Acid	Abscisin II,Dormin,(+)-ABA,Abscisic Acid (Dormin）	Others , Proton pump , Endogenous Metabolite
	Abscisic Acid (Dormin) is a plant hormone, which is involved in many plant developmental processes, modulates ion homeostasis and metabolism, and inhibits germination and seedling growth.		Others , Proton pump , Endogenous Metabolite
T2O2668	Oleic acid	Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid	Apoptosis , ATPase , Others , Endogenous Metabolite
	Oleic acid (Glycon Wo) is a natural product, a common saturated fatty acid found in a variety of animal and vegetable fats and oils. Palmitic acid is a Na+/K+ ATPase activator.		Apoptosis , ATPase , Others , Endogenous Metabolite
T2822	Ginsenoside Rb1	Gypenoside Ⅲ,Gypenoside III	ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
	Ginsenoside Rb1 (Gypenoside Ⅲ) is part of a class of steroid glycosides; may have properties that inhibit or prevent the growth of tumors.		ATPase , Mitophagy , IRAK , NF-κB , Autophagy , HSV
T2831	Glycocholic acid	Glycocholate,cholylglycine	Others , Endogenous Metabolite
	Glycocholic acid (Glycocholate) is a bile acid with anticancer activity. Glycocholic acid targets against pump resistance-related and non-pump resistance-related pathways.		Others , Endogenous Metabolite
TN1493	Chrysosplenol D		IL Receptor , NF-κB , JNK
	Chrysosplenol D, an efflux pump inhibitor that can potentiate the activity of commercially important antibiotics and antimalarials.		IL Receptor , NF-κB , JNK
T21651	Lansoprazole sodium	Lansoprazole (sodium), AG-1749 sodium	Proton pump , Phospholipase , Antibacterial
	Lansoprazole sodium (Lansoprazole (sodium)) is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity which is widely used in the therapy of gastroesophageal reflux and peptic ulcer disease.		Proton pump , Phospholipase , Antibacterial
TQ0302	Thapsigargin		Apoptosis , SARS-CoV , Calcium Channel
	Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking ...		Apoptosis , SARS-CoV , Calcium Channel
T8270	Deserpidine	Harmonyl	RAAS
	Deserpidine (Harmonyl) is only found in individuals that have used or taken this drug. It is an ester alkaloid drug isolated from Rauwolfia canescens (family Apocynaceae) with antipsychotic and antihypertensive propertie...		RAAS
TMA0017	Sideroxylin		Antifection
	Sideroxylin can synergistically enhance the antimicrobial activity of the alkaloid berberine (also a constituent of H. canadensis) against Staphylococcus aureus by inhibition of the NorA multidrug resistance pump.		Antifection
TN5466	Boeravinone B
	Boeravinone B, a novel efflux pump inhibitor, apart from inhibiting the MdeA mediated efflux, also significantly inhibit the biofilm formation of S. aureus, boeravinone B may be used in combination with mupirocin for fur...
T80001	Majoranaquinone		Antibiotic
	Majoranaquinone demonstrates potent antibacterial activity against four Staphylococcus strains, one Moraxella strain, and one Enterococcus strain. It also acts as an effective efflux pump inhibitor in Escherichia coli AT...		Antibiotic
TN5474	Bonducellin
	Bonducellin has anti-inflammatory activities, it can significantly and dose-dependently inhibit the inflammatory mediators; nitric oxide (NO), and cytokines [tumor necrosis factor (TNF)-alpha and interleukin (IL)-12. Bon...

Natural Products

Target: ATPase, Proton pump, DNA/RNA Synthesis, Antibacterial, TGF-beta/Smad

Acevaltrate

TJP2872

Synonym: Acevaltratum,Acetoxyvaltrate

Target: ATPase, Others

Oleandrin

T5S0890

Synonym: Neriostene,Folinerin,Foliandrin

Target: Apoptosis, ATPase, Potassium Channel, Sodium Channel

Digitoxin

T0295

Synonym: Digitoxoside,Unidigin,Digitoxinum

Target: ATPase, Others

Diphyllin

TN1103

Synonym:

Target: ATPase, Proton pump, Influenza Virus, HIV Protease

Strophanthidin

TN5073

Synonym: Strophanthidine

Target: ATPase, Calcium Channel

Bafilomycin A1

T6740

Synonym:

Target: Apoptosis, Proton pump, Antibacterial, Antibiotic, Autophagy

Deslanoside

T8183

Synonym: Desacetyllanatoside C,Deacetyllanatoside C

Target: ATPase, Drug Metabolite

Phlorizin

T2922

Synonym: Floridzin,NSC 2833,Phloridzin

Target: ATPase, SGLT

Abscisic Acid

T6368

Synonym: Abscisin II,Dormin,(+)-ABA,Abscisic Acid (Dormin）

Target: Others, Proton pump, Endogenous Metabolite

Oleic acid

T2O2668

Synonym: Elaidoic acid,9Z-Octadecenoic acid,Oleate,9-Octadecenoic Acid,Glycon Wo,9-cis-Octadecenoic acid

Target: Apoptosis, ATPase, Others, Endogenous Metabolite

Ginsenoside Rb1

T2822

Synonym: Gypenoside Ⅲ,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

Glycocholic acid

T2831

Synonym: Glycocholate,cholylglycine

Target: Others, Endogenous Metabolite

Chrysosplenol D

TN1493

Synonym:

Target: IL Receptor, NF-κB, JNK

Lansoprazole sodium

T21651

Synonym: Lansoprazole (sodium), AG-1749 sodium

Target: Proton pump, Phospholipase, Antibacterial

Thapsigargin

TQ0302

Synonym:

Target: Apoptosis, SARS-CoV, Calcium Channel

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-01892	ATP4A Protein, Human, Recombinant (His & Myc)	Human	E. coli
	The catalytic subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Uses ATP as an energy source to pump H(+) ions to the gastric ...
TMPH-01893	ATP4B Protein, Human, Recombinant (GST)	Human	E. coli
	The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-01894	ATP4B Protein, Human, Recombinant	Human	E. coli
	The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane...
TMPH-02059	ATP2A2 Protein, Human, Recombinant (His)	Human	E. coli
	ATP2A2 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-02310	ATP6V0D1 Protein, Human, Recombinant (GST)	Human	E. coli
	Subunit of the integral membrane V0 complex of the lysosomal proton-transporting V-type ATPase (v-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providin...
TMPH-00785	Bacteriorhodopsin Protein, Halobacterium halobium, Recombinant (His & Myc & SUMO)	Halobacterium halobium	E. coli
	Light-driven proton pump.
TMPH-03139	MDR1 Protein, Plasmodium falciparum, Recombinant (His & SUMO)	Plasmodium falciparum	E. coli
	Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
TMPY-06599	ATP1B4 Protein, Human, Recombinant (His)	Human	E. coli
	ATP1B4 is a member of the X(+)/potassium ATPases subunit beta family. It is highly expressed in skeletal muscle and at a lower level in heart. ATP1B4 gene can be found in all vertebrate genomes sequenced to date. However...