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Results for "

cysteineprotease

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    59
    TargetMol | Inhibitors_Agonists
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    4
    TargetMol | Peptide_Products
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CA-074 methyl ester
Cathepsin B Inhibitor IV, CA-074Me
T3420147859-80-1
CA-074 methyl ester (Cathepsin B Inhibitor IV) is a specific inhibitor of Cathepsin B with neuroprotective, anti-cancer, and anti-inflammatory effects.
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Leupeptin Hemisulfate
T6564103476-89-7
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.
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MIV-247
T120511352817-76-5In house
MIV-247 is a selective and potent inhibitor of cathepsin S (Kis 2.1, 4.2, and 7.5 nM for human, mouse, and wild monkey cathepsin S, respectively), which attenuates mechanical anomalies in preclinical models of neuropathic pain, and can be used to study cardiac muscle injury.
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10-14 weeks
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MK-0674
T16089887781-62-6In house
MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases.
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8-10 weeks
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Papain
T195039001-73-4
Papain, a cysteine protease of the peptidase C1 family, is utilized in the food, pharmaceutical, textile, and cosmetic industries.
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n-ethylmaleimide
NEM, Ethylmaleimide, 1-Ethyl-1H-pyrrole-2,5-dione
T3088128-53-0
N-Ethylmaleimide (NEM) is a reagent for alkylation of free sulfhydryl groups, a cysteine protease inhibitor used in experimental biochemistry. N-Ethylmaleimide is also a deubiquitinating enzyme inhibitor that specifically inhibits phosphate transport in mitochondria.
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2-Aminoethanethiol
β-Mercaptoethylamine, β-MEA, Cysteamine, 2-Mercaptoethylamine
T108060-23-1
2-Aminoethanethiol (Cysteamine) is a Cystine Depleting Agent. The mechanism of action of cysteamine is as a Cystine Disulfide Reduction.
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pmsf
Phenylmethylsulfonyl fluoride, Benzylsulfonyl fluoride
T0789329-98-6
Phenylmethanesulfonyl fluoride (PMSF (Phenylmethylsulfonyl fluoride)) is an enzyme inhibitor that inactivates IRC-50 arvin, subtilisin, and the fatty acid synthetase complex.
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Balicatib
AAE581
T1850354813-19-7
Balicatib (AAE581) is a potent and selective inhibitor of cathepsin K, used in trials studying the treatment of osteoporosis.
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3-Epiursolic acid
TN1249989-30-0
3-Epiursolic acid may have antiinflammatory activity, it shows inhibition on Cathepsins L (catL), the IC50 value of 6.5 μM, cathepsins L (catL) and B play an important role in tumor progression and have been considered promising therapeutic targets in the
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LY 3000328
Cathepsin S inhibitor
TQ01161373215-15-6
LY 3000328 (Cathepsin S inhibitor) is a selective inhibitor of cathepsin S with IC50 values ​​of 7.7 and 1.67 nM for human and mouse cathepsin S, respectively. LY 3000328 (Cathepsin S inhibitor) may slow or prevent abdominal aortic aneurysm (AAA) expansion and or reduce the risk of AAA rupture by inhibiting cathepsin S-mediated degradation of extracellular matrix proteins, elastin and collagen.
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Z-Lys-OH
T658682212-75-1
Z-Lys-OH is a competitive inhibitor of papain, a lysine derivative.
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7-10 days
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Cathepsin X-IN-1
T608122418577-51-0
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor (IC50 = 7.13 μM) that reduces PC-3 cell migration with low cytotoxicity [1].
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6-8 weeks
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L-Homocysteine
T193926027-13-0
L-Homocysteine is a biological thiol associated with various diseases and conditions. It is a marker for atherosclerosis and exacerbates intestinal inflammation in IBD by promoting 5-LOX and COX-2.
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7-10 days
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Petesicatib
RO-5459072, RG 7625, RG-7625, RO 5459072
T164741252637-35-6
Petesicatib (RG 7625) is a small molecule histone-S (Cat-S) inhibitor for the study of primary dry syndrome and autoimmune diseases.
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8-10 weeks
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Calpain Inhibitor XII
Z-L-Nva-CONH-CH2-2-Py
T21949181769-57-3In house
Calpain Inhibitor XII (Z-L-Nva-CONH-CH2-2-Py) is a selective and potent inhibitor of calpain I, inhibits calpain II and cathepsin B. Calpain Inhibitor XII shows antiviral activity against coronavirus in cell culture.
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6-8weeks
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ONO-5334
T16394868273-90-9In house
ONO-5334 is a selective, orally active and potent histone K inhibitor with anti-SAR-COV-2 and anti-bone resorption activity for the study of osteoporosis.
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10-14 weeks
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K777
APC-3316
T15641233277-99-1In house
K777 is a potent, orally active, and irreversible inhibitor of cysteine protease, functioning as a potent CYP3A4 inhibitor (IC50 = 60 nM) and a selective CCR4 antagonist, which inhibits chemotaxis. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypanosoma cruzi, and cathepsins B and L, targeting cathepsin-mediated cell entry and exhibiting broad-spectrum antiviral activity. It inhibits EBOV and SARS-CoV pseudovirus entry with IC50 values of 0.87 nM and 0.68 nM, respectively.
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8-10 weeks
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Z-FY-CHO
Z-Phe-Tyr-CHO
T41236167498-29-5In house
Z-FY-CHO (Z-Phe-Tyr-CHO) is a selective histone L (Cat L) inhibitor that promotes autophagy, reduces the accumulation of P62, and blocks the activation of caspase-3 and PARP.
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10-14 weeks
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FMK 9a
T153031955550-51-2In house
FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.
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6-8 weeks
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Cysteine protease inhibitor-2
T10924612048-23-4In house
Cysteine protease inhibitor 2 is a cysteine protease inhibitor. Cysteine protease inhibitor 2 inhibited DCT116 and PC3 cells with GI50 values of 6.5 μM and 4.4 μM, respectively.
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6-8 weeks
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(S)-(+)-Ibuprofen
Dexibuprofen, (S)-Ibuprofen
T044851146-56-6
(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
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7-10 days
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Esomeprazole
T20626119141-88-7
Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).
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2-Cyanopyrimidine
2-cyano-Pyrimidine
T745114080-23-0
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) is inhibitor of cathepsin K(IC50 : 170 nM)
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