acetic

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a polyethylene glycol (PEG) derivative used as a linker in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

(4-Oxo-4H-quinazolin-3-yl)-acetic acid is an alkyl chain-derived PROTAC linker applicable for the synthesis of PROTACs [1].

Pomalidomide-PEG2-acetic acid (Pomalidomide-PEG2-CH2COOH) is a compound comprising an E3 ligase ligand and a linker. It can be utilized in the synthesis of PROTACs.

Thalidomide-NH-CH2-COOH ((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine) is a synthesized E3 ligase ligand-linker conjugate containing a Thalidomide-based cereblon ligand and a linker.

Bromo-PEG2-acetic acid is a PROTAC linker belonging to the PEG category. It is utilized in the synthesis of PROTAC molecules.

Amino-PEG6-acetic acid is a PEG-based PROTAC linker used in the synthesis of PROTAC molecules.

m-PEG15-acetic acid is a PROTAC linker classified under the PEG category, suitable for synthesizing PROTAC molecules.

Thiol-PEG3-acetic acid is a PROTAC linker of the PEG class, employed in the synthesis of PROTAC molecules.

Azido-PEG3-aminoacetic acid-NHS ester is a PEGylation-based linker for the synthesis of PROTACs[1], providing a versatile and efficient approach.

(S,R,S)-AHPC-phenylacetic acid, an E3 Ligase Ligand-Linker Conjugate, facilitates the synthesis of PROTAC SMARCA2/4-degrader-15.

Bromoacetic-PEG2-NHS ester is a PROTAC linker belonging to the PEG class, utilized in the synthesis of PROTAC molecules.

Bromoacetic-PEG1-CH2-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTAC molecules.

Phenyl-glutarimide 4'-oxyacetic-amide-C5-amide-Boc is an E3 ligase ligand-linker conjugate used in the synthesis of PROTACSJ995973.

Phenyl-glutarimide 4'-oxyacetic acid, a carboxylic acid-functionalized cerebellar ligand, is utilized in developing PROTAC deactivators due to its superior hydrolytic stability and efficacy. This compound exhibits enhanced binding to PROTAC, [1].

(S,R,S)-AHPC-m-Tolylacetic acid serves as an E3 Ligase Ligand-Linker Conjugate for the synthesis of PROTAC SMARCA2/4-degrader-17. This compound facilitates the targeted degradation of specific proteins by linking to them directly.

NH2-MPAA-NODA, a nitroveratryl-based photocleavable linker featuring a NODA motif and a methyl phenyl acetic acid (MPAA) backbone, serves as a radiolabel when labeled with 18F-fluoride.

Maleimide-PEG4-NHS is a sulfhydryl and amine reactive heterofuncational PEG linker. The chemical bonds formed through Maleimide-PEG4-NHS linker are stable and are not cleavable. The NHS ester reacts with amino groups at pH 7-9 to form stable amide bond wh

PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.