Search Result

Search Results for " nadph "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T19467	NADPH tetracyclohexanamine	NADPH (tetracyclohexanamine)	Ferroptosis
	NADPH tetracyclohexanamine (NADPH (tetracyclohexanamine)) is a cofactor and biological reducing agent.		Ferroptosis
T7092	NADPH tetrasodium salt		Others , Ferroptosis , Endogenous Metabolite
	NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate, which acts as an electron donor in a variety of biological reactions. NADPH tetrasodium salt is also an end...		Others , Ferroptosis , Endogenous Metabolite
T4359	VAS2870		NADPH
	VAS2870 is an inhibitor of NADPH oxidase (NOX).		NADPH
T8107	GLX351322		NADPH-oxidase , NADPH
	GLX351322 is NADPH Oxidase 4 Inhibitor with IC50 of 5 μM.		NADPH-oxidase , NADPH
T8408	GKT136901	AK120765	NADPH-oxidase , NADPH
	GKT136901 (AK120765) is an inhibitor of NOX1/4.It acts as Selective and Direct Scavenger of Peroxynitrite		NADPH-oxidase , NADPH
T7042	1,5-Isoquinolinediol		PARP
	1, 5-Isoquinolinediol is an inhibitor of poly(ADP-ribose) synthetase (PARP1; IC50: 0.39 μM). The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis. 1, 5-Isoquinolinediol...		PARP
T15433	GSK2795039		Apoptosis , Reactive Oxygen Species , ROS , NADPH
	GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2 (NOX2) (pIC50: 6 in different cell-free assays).		Apoptosis , Reactive Oxygen Species , ROS , NADPH
T6099	Setanaxib	GKT137831	NADPH-oxidase , Ferroptosis , NADPH
	Setanaxib (GKT137831) is a potent, specific dual NADPH oxidase (NOX1/4) inhibitor.		NADPH-oxidase , Ferroptosis , NADPH
T22990	ML-090	Fluoflavine	NADPH-oxidase , Others
	ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM).		NADPH-oxidase , Others
T7191	Diphenyleneiodonium chloride	DPI	NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel
	Diphenyleneiodonium chloride (DPI)(DPI) is an irreversible inhibitor of iNOS and eNOS (IC50 values of 50 nM and 0.3 μM, respectively),and displays broad-spectrum bactericidal activity.		NOS , Reactive Oxygen Species , NADPH , TRP/TRPV Channel
T8132	Iron sucrose	Iron saccharate,Sucroferric oxyhydroxide	Reactive Oxygen Species
	Iron sucrose (Sucroferric oxyhydroxide) is treatment of iron deficiency anemia.		Reactive Oxygen Species
T10353	APX-115 free base	Ewha-18278 free base	NADPH-oxidase , NADPH
	APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid...		NADPH-oxidase , NADPH
T2569	Chlorotrianisene	tris(p-methoxyphenyl)chloroethylene,CTA,tri-p-anisylchloroethylene,TACE	Estrogen Receptor/ERR , Estrogen/progestogen Receptor , COX
	Chlorotrianisene (tri-p-anisylchloroethylene) is an orally bioavailable, highly lipophilic, synthetic triphenylethylene (TPE) derivative and selective estrogen receptor modulator (SERM), with predominantly estrogenic but...		Estrogen Receptor/ERR , Estrogen/progestogen Receptor , COX
T8640	G6PDi-1		Dehydrogenase
	G6PDi-1 is an effective G6PD inhibitor. It depletes NADPH and decreases inflammatory cytokine production.		Dehydrogenase
T83625	INOS-IN-14	3-bromo-1H-indazole-7-carbonitrile	NOS
	iNOS-IN-14 (3-bromo-1H-indazole-7-carbonitrile) is a potent nitric oxide synthase (NOS) inhibitor that inhibits the NADPH oxidase activity of nNOS.		NOS
T38423	CL097	CL097	Reactive Oxygen Species , TLR
	CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.		Reactive Oxygen Species , TLR
T29097	VAS 3947	VA-S3947,VA S3947,VAS3947	Apoptosis , NADPH-oxidase
	VAS 3947 is a specific inhibitor of NADPH oxidase (NOX).VAS 3947 has a potent anti-platelet effect, inducing apoptosis through UPR activation, mainly due to protein aggregation and misfolding, independent of anti-NOX act...		Apoptosis , NADPH-oxidase
T7575L1	[Sar1, Ile8]-Angiotensin II acetate		RAAS
	[Sar1, Ile8]-Angiotensin II acetate activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells. [Sar1, Ile8]-Angiotensin II acetate has multiple effects on vascu...		RAAS
T22096	L 012 sodium salt
	L 012 sodium salt, a luminol analogue, is a widely used chemiluminescent (CL) probe for active oxygen and active nitrogen. L 012 sodium salt is widely used to detect the superoxides (O2•−) derived from NADPH oxidase (Nox...
T15300	Fluorofenidone	AKF-PD	Others
	Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway. Fluorofenidone is an an...		Others
T13112	Tat-NR2B9c	Tat-NR2Bct,NA-1	NO Synthase , iGluR
	Tat-NR2B9c (NA-1) is a postsynaptic density-95 (PSD-95) inhibitor with neuroprotective and antiepileptic effects.Tat-NR2B9c inhibits PSD-95d2, PSD-95d1, and PSD-95, which prevents the activation of NMDA-induced NADPH oxi...		NO Synthase , iGluR
TP1886L1	NoxA1ds acetate(1435893-78-9 free base)		NADPH-oxidase
	NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human col...		NADPH-oxidase
T10354	APX-115	Ewha-18278	NADPH-oxidase
	APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.		NADPH-oxidase
T19032	Nitro blue tetrazolium chloride	NBT	NO Synthase
	Nitro blue tetrazolium chloride (NBT) is a NADPH-diaphorase substrate that competitively inhibits nitric oxide synthase (IC50 = 3-4 M). A well-known scavenger of superoxide anions.Nitro blue tetrazolium chloride, a subst...		NO Synthase
T11518L	GW274150		NOS
	GW274150 is an orally active, selective and potent dual inhibitor of NADPH-dependent human nitric oxide synthase (iNOS) (Kd=40 nM) and rat inducible nitric oxide synthase (iNOS).GW274150 has a low activity against endoth...		NOS
T8138	Phenazine methylsulfate	Phenazine methosulfate	Apoptosis , Antibacterial , Antibiotic
	Phenazine methylsulfate is anti-bacterial agents.		Apoptosis , Antibacterial , Antibiotic
T6851	NADP sodium salt	Sodium NADP	Others
	NADP sodium salt (Sodium NADP) is a coenzyme that is widely distributed in living matter. Participates in oxidation-reduction reactions.		Others
T0825	Ebselen	SPI-1005,PZ-51,CCG-39161	Phosphatase , Virus Protease , Calcium Channel , COX , HIV Protease
	Ebselen (CCG-39161) is a organoselenium compound with anti-inflammatory, anti-oxidant and cytoprotective activity. Ebselen acts as a glutathione peroxidase mimetic and is thereby able to prevent cellular damage induced b...
T12781	RV01		Others
	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...		Others
T69630	Diphenyleneiodonium (free base)
	Diphenyleneiodonium (free base) is an NADPH oxidase inhibitor.
T71513	GK-136901
	GK-136901 is a first-in-class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitor.
T80243	Gp91 ds-tat
	Gp91phox ds-tat, a biologically active peptide, functions as an inhibitor of NADPH oxidase assembly.
T80057	Cytochrome P450 reductase
	Cytochrome P450 reductase, a NADPH-cytochrome reductase, facilitates an optimal conformation of aromatase for substrate binding [1].
T76207	Glucose dehydrogenase (GDH)
	Glucose dehydrogenase (GDH) is an oxidoreductase enzyme that facilitates the oxidation of β-D-glucose into β-D-glucono-1,5-lactone, while concurrently reducing cofactor NADP+ to NADPH, and to a lesser degree, NAD+ to NAD...
T73896	Glucose-6-phosphate dehydrogenase
	Glucose-6-phosphate dehydrogenase, the crucial rate-limiting enzyme in the pentose phosphate pathway, plays a vital role in generating NADPH. This compound is indispensable for numerous critical cellular functions such a...
T35393	Gp91ds-tat	gp91ds-tat	NADPH-oxidase
	gp91ds-tat is a useful organic compound for research related to life sciences and the catalog number is T35393.		NADPH-oxidase
T78592	Diapocynin	Dehydrodiacetovanillone
	Diapocynin (Dehydrodiacetovanillone), a dimer of Apocynin, acts as an orally administered inhibitor of NADPH oxidase. It exhibits anti-inflammatory, neuroprotective, and antioxidant properties [1].
T75813	Ac9-25 TFA
	Ac9-25 TFA, an N-terminal peptide of Annexin I, functions as a formyl peptide receptor (FPR) agonist, activating neutrophil NADPH oxidase via FPR [1] [2].
T11518	GW274150 phosphate		NOS
	GW274150 phosphate is a selective, orally active, and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50: 2.19 μM; Kd: 40 nM) and rat iNOS (ED50: 1.15 μM).		NOS
T11333	Fulvene-5		Others
	Fulvene-5 is a chemical compound that exhibits antitumor activity. It functions as a potent inhibitor of NADPH oxidase 4 (NOX4) and possesses antioxidant properties. Additionally, Fulvene-5 acts as a reactive oxygen spec...		Others
TP2083	Ac9-25
	N-terminal peptide of Annexin I (AI/Lipocortin I) that inhibits leukocyte extravasation. Acts as a formyl peptide receptor 1 (FPR1) ligand and stimulates neutrophil NADPH oxidase activation.
T75815	WKYMVM-NH2 TFA
	WKYMVM-NH2 TFA, a potent agonist for N-formyl peptide receptor (FPR1) and FPRL1/2, activates key leukocyte effector functions including chemotaxis, complement receptor-3 mobilization, and NADPH oxidase activation, as doc...
T60517	CL097 hydrochloride
	CL097 hydrochloride is a potent TLR7 and TLR8 agonist. CL097 hydrochloride induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production [2].
T11806	L-NIO dihydrochloride		NOS
	L-NIO dihydrochloride, a potent and non-selective NADPH-dependent nitric oxide synthase (NOS) inhibitor, consistently induces focal ischemic infarct in rats. It exhibits inhibitory constants (Kis) of 1.7, 3.9, and 3.9 μM...		NOS
T78548	3-Hydroxyxanthone	3-Hydroxy-xanthen-9-one	Integrin
	3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein endothelial cells (HUVECs) and suppresses TNF-alpha-induced IC...		Integrin
T36173	L-Glutathione, oxidized (sodium salt)
	Glutathione can occur in reduced (GSH), oxidized (GSSG), or in mixed disulfide forms and is ubiquitous in multiple biological systems serving as the major thiol-disulfide redox buffer of the cell. GSSG is the oxidized fo...
T36058	Dibutyl-3-Hydroxybutyl Phosphate
	Dibutyl 3-hydroxybutyl phosphate is a compound produced from the metabolism of the organophosphorus solvent, tributyl phosphate (TBP). Incubation of goldfish liver microsomes in the presence of NADPH has been shown to co...
TP1585	Sgp91 ds-tat Peptide 2, scrambled
	This peptide is a scrambled sequence of NADPH oxidase assembly peptide inhibitor gp91 ds-tat. It is used as a control peptide. It is two amino acid residues shorter at the N-terminus compared to the scrambled gp91 ds-tat...
T38646	GKT136901 hydrochloride	GKT136901 hydrochloride
	GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochlor...
TP1948	PBP10	PBP 10
	Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2 binding activity in vitro...

Compounds

NADPH tetracyclohexanamine

T19467

Synonym: NADPH (tetracyclohexanamine)

Target: Ferroptosis

NADPH tetrasodium salt

T7092

Synonym:

Target: Others, Ferroptosis, Endogenous Metabolite

Target: NADPH-oxidase, NADPH

GKT136901

T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Target: Apoptosis, Reactive Oxygen Species, ROS, NADPH

Setanaxib

T6099

Synonym: GKT137831

Target: NADPH-oxidase, Ferroptosis, NADPH

ML-090

T22990

Synonym: Fluoflavine

Target: NADPH-oxidase, Others

Diphenyleneiodonium chloride

T7191

Synonym: DPI

Target: NOS, Reactive Oxygen Species, NADPH, TRP/TRPV Channel

Iron sucrose

T8132

Synonym: Iron saccharate,Sucroferric oxyhydroxide

Target: Reactive Oxygen Species

APX-115 free base

T10353

Synonym: Ewha-18278 free base

Target: NADPH-oxidase, NADPH

Chlorotrianisene

T2569

Synonym: tris(p-methoxyphenyl)chloroethylene,CTA,tri-p-anisylchloroethylene,TACE

Target: Estrogen Receptor/ERR, Estrogen/progestogen Receptor, COX

G6PDi-1

T8640

Synonym:

Target: Dehydrogenase

iNOS-IN-14

T83625

Synonym: 3-bromo-1H-indazole-7-carbonitrile

Target: Reactive Oxygen Species, TLR

VAS 3947

T29097

Synonym: VA-S3947,VA S3947,VAS3947

Target: Apoptosis, NADPH-oxidase

[Sar1, Ile8]-Angiotensin II acetate

Synonym: Tat-NR2Bct,NA-1

Target: NO Synthase, iGluR

NoxA1ds acetate(1435893-78-9 free base)

TP1886L1

Synonym:

Target: NADPH-oxidase

APX-115

T10354

Synonym: Ewha-18278

Target: NADPH-oxidase

Nitro blue tetrazolium chloride

Phenazine methylsulfate

T8138

Synonym: Phenazine methosulfate

Target: Apoptosis, Antibacterial, Antibiotic

Synonym: SPI-1005,PZ-51,CCG-39161

Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease

Diphenyleneiodonium (free base)

Cytochrome P450 reductase

T80057

Synonym:

Target:

Glucose dehydrogenase (GDH)

T76207

Synonym:

Target:

Glucose-6-phosphate dehydrogenase

Target: NADPH-oxidase

Diapocynin

T78592

Synonym: Dehydrodiacetovanillone

L-NIO dihydrochloride

Synonym: 3-Hydroxy-xanthen-9-one

Target: Integrin

L-Glutathione, oxidized (sodium salt)

T36173

Synonym:

Target:

Dibutyl-3-Hydroxybutyl Phosphate

T36058

Synonym:

Target:

sgp91 ds-tat Peptide 2, scrambled

TP1585

Synonym:

Target:

GKT136901 hydrochloride

T38646

Synonym: GKT136901 hydrochloride

Cat No.	Product Name	Synonyms	Targets
T8347	Rifamycin S		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
	Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria		Reactive Oxygen Species , ROS , Antibacterial , Antibiotic
T6391	Apocynin	Acetovanillone,Acetoguaiacone,NSC 2146	Apoptosis , NADPH , Autophagy
	Apocynin (NSC 2146) is a specific NADPH-oxidase inhibitor (IC50: 10 μM).		Apoptosis , NADPH , Autophagy
TN2126	Quercetin-3-O-glucose-6''-acetate	6"-O-Acetylisoquercitrin	NADPH-oxidase , ROS , NADPH
	Quercetin-3-O-glucose-6''-acetate (6"-O-Acetylisoquercitrin) is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.		NADPH-oxidase , ROS , NADPH
T22446	NADP disodium salt	Disodium NADP,Triphosphopyridine nucleotide disodium salt	Others
	NADP disodium salt (Disodium NADP) is a nicotinamide adenine dinucleotide. NADP disodium salt is a key redox cofactor for electron transfer in the metabolism, serves as an electron carrier in a number of reactions, being...		Others
T5S2343	Acetylshikonin	Acetyl shikonin	Others , P450 , AChE
	1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...		Others , P450 , AChE
TN2039	Panaxydol		cAMP , p38 MAPK , JNK
	Panaxydol has anti-cancer activity, can inhibit the growth and apoptosis of cancer cells, the signaling mechanisms involve a [Ca(2+)](i) increase, JNK and p38 MAPK activation, cAMP, MAP kinase and ROS generation through ...		cAMP , p38 MAPK , JNK
TN3069	4beta-Carboxy-19-nortotarol		NADPH-oxidase
	4 beta-Carboxy-19-nortotarol can inhibit microsomal lipid peroxidation induced by Fe(III)-ADP/NADPH and mitochondrial lipid peroxidation induced by Fe(III)-ADP/ NADH, it inhibits linoleic acid autoxidation but not genera...		NADPH-oxidase
TN6515	Selaginellin
	Selaginellin has a neuroprotective effect against L-glutamate-induced neurotoxicity through mechanisms related to anti-oxidation and anti-apoptosis via scavenging reactive oxygen species and up-regulating the expression ...

Natural Products

Rifamycin S

T8347

Synonym:

Target: Reactive Oxygen Species, ROS, Antibacterial, Antibiotic

Apocynin

T6391

Synonym: Acetovanillone,Acetoguaiacone,NSC 2146

Target: Apoptosis, NADPH, Autophagy

Quercetin-3-O-glucose-6''-acetate

TN2126

Synonym: 6"-O-Acetylisoquercitrin

Target: NADPH-oxidase, ROS, NADPH

NADP disodium salt

T22446

Synonym: Disodium NADP,Triphosphopyridine nucleotide disodium salt

Target: Others

Acetylshikonin

T5S2343

Synonym: Acetyl shikonin

Target: Others, P450, AChE

Panaxydol

TN2039

Synonym:

Target: cAMP, p38 MAPK, JNK

4beta-Carboxy-19-nortotarol

TN3069

Synonym:

Target: NADPH-oxidase

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPH-02801	CYPOR Protein, Mouse, Recombinant (His)	Mouse	E. coli
	CYPOR Protein, Mouse, Recombinant (His) is expressed in E. coli.
TMPH-01748	CYPOR Protein, Human, Recombinant (GST)	Human	E. coli
	This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
TMPH-00098	AtAER Protein, Arabidopsis thaliana, Recombinant	Arabidopsis thaliana	E. coli
	Involved in the detoxification of reactive carbonyls. Acts on lipid peroxide-derived reactive aldehydes. Specific to a double bond activated by an adjacent carbonyl group. Can use both quinones and diamide as substrates,...
TMPH-00097	AtAER Protein, Arabidopsis thaliana, Recombinant (His & SUMO)	Arabidopsis thaliana	E. coli
	Involved in the detoxification of reactive carbonyls. Acts on lipid peroxide-derived reactive aldehydes. Specific to a double bond activated by an adjacent carbonyl group. Can use both quinones and diamide as substrates,...
TMPH-01040	CBR1 Protein, Human, Recombinant (His)	Human	Yeast
	NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction...
TMPH-01039	CBR1 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction...
TMPH-00160	Cytochrome P450 BM-3 Protein, Bacillus megaterium, Recombinant (His & Myc)	Bacillus megaterium	E. coli
	Cytochrome P450 BM-3 Protein, Bacillus megaterium, Recombinant (His & Myc) is expressed in E. coli.
TMPJ-00848	NCF1 Protein, Human, Recombinant (His)	Human	E. coli
	Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a mem...
TMPH-03751	CYBB Protein, Human, Recombinant (His)	Human	E. coli
	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membr...
TMPH-00625	FMN reductase Protein, E. coli, Recombinant (His)	E. coli	Baculovirus
	Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin.
TMPJ-00836	G6PD Protein, Human, Recombinant (His)	Human	Human Cells
	Glucose-6-Phosphate 1-Dehydrogenase (G6PD) is a cytosolic enzyme that belongs to the glucose-6-phosphate dehydrogenase family. G6PD participates in the pentose phosphate pathway that supplies reducing energy to cells by ...
TMPH-02398	ASA dehydrogenase Protein, Legionella pneumophila, Recombinant (His)	Legionella pneumophila	E. coli
	Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.
TMPH-03057	Chorismate synthase Protein, Neurospora crassa, Recombinant (His)	Neurospora crassa	E. coli
	Bifunctional enzyme that possesses chorismate synthase and intrinsic flavin reductase activity, it uses NADPH to reduce FMN.
TMPY-03660	P67phox Protein, Human, Recombinant	Human	Baculovirus-Insect Cells
	NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPH-02140	CYP21A2 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d...
TMPH-02618	CYP2E1 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electr...
TMPH-00564	FabG Protein, E. coli, Recombinant (His & Myc)	E. coli	E. coli
	Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.
TMPH-00626	GPR Protein, E. coli, Recombinant (His)	E. coli	E. coli
	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.
TMPY-03619	P67phox Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	NCF2 (Neutrophil Cytosolic Factor 2, also known as NCF-2 and p67phox) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. This gene encodes neutrophil cytosolic factor 2, the 67-kilodalto...
TMPY-03867	CBR3 Protein, Human, Recombinant (His)	Human	E. coli
	CBR3, also known as hCBR3, belongs to the short-chain dehydrogenases/reductases (SDR) family. CBR3 is expressed in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate...
TMPY-04475	RFK Protein, Human, Recombinant (His)	Human	E. coli
	Flavokinase is a member of the transferases family, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. Flavokinase is an essential enzyme that catalyzes ...
TMPH-02141	CYP21A2 Protein, Human, Recombinant (His)	Human	Yeast
	A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-d...
TMPJ-01009	BLVRA Protein, Human, Recombinant (His)	Human	E. coli
	Human Biliverdin reductase A (BLVRA) is belonged to the Gfo/Idh/MocA family and Biliverdin reductase subfamily. BLVRA is an enzyme that in humans is encoded by the BLVRA gene. BLVRA plays an important role in reducing th...
TMPH-02309	KCNAB2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability. Promotes expressi...
TMPH-03584	Shikimate dehydrogenase Protein, S. epidermidis, Recombinant (His & Myc)	Staphylococcus epidermidis	E. coli
	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). It can also u...
TMPH-01746	NOX4 Protein, Human, Recombinant (E. coli, His)	Human	E. coli
	Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor...
TMPH-02106	SH3PXD2A Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides...
TMPH-01745	NOX4 Protein, Human, Recombinant (Cell-Free, His)	Human	in vitro E. coli expression system
	Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox. Regulates signaling cascades probably through phosphatases inhibition. May function as an oxygen sensor...
TMPH-02139	CYP17A1 Protein, Human, Recombinant (GST)	Human	E. coli
	A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen sy...
TMPY-00481	AKR1C4 Protein, Human, Recombinant (His)	Human	E. coli
	Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation ...
TMPY-03617	GMPR Protein, Human, Recombinant (His)	Human	E. coli
	GMPR, also known as GMPR1, belongs to the IMPDH/GMPR family.This familyofenzymesincludesIMP dehydrogenaseandGMP reductase. These enzymes are involved inpurine metabolism and adopt aTIM barrelstructure. GMPR is an enzyme ...
TMPJ-00946	TALDO1 Protein, Human, Recombinant (His)	Human	Human Cells
	Transaldolase (TALDO1) belongs to the transaldolase family of Type 1 subfamily. TALDO1 is expressed selectively in oligodendrocytes of the brain. TALDO1 is a key enzyme of the nonoxidative pentose phosphate pathway provi...
TMPH-02137	FDFT1 Protein, Human, Recombinant (His)	Human	E. coli
	Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate in...
TMPH-03170	PvdA Protein, Pseudomonas aeruginosa, Recombinant (His & SUMO)	Pseudomonas aeruginosa	E. coli
	Catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as pyoverdin. Pyoverdin is a hydroxamate siderophore composed of a 6,7...
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His)	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using ...
TMPJ-00460	MECR Protein, Human, Recombinant (His)	Human	Human Cells
	Trans-2-Enoyl-CoA Reductase Mitochondrial (MECR) belongs to the zinc-containing alcohol dehydrogenase family. MECR localizes to the mitochondrion. It is highly expressed in skeletal and heart muscle and expressed at lowe...
TMPY-02438	AKR1B1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldose reductase (AKR1B1) belongs to the aldo/keto reductase superfamily. AKR1B1 is a NADPH-dependent aldo-keto reductase best known as the rate-limiting enzyme of the polyol pathway. Expression of AKR1B1 was the highest...
TMPY-03460	DCXR Protein, Human, Recombinant (His)	Human	E. coli
	DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and dist...
TMPH-01084	CYP11A1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholester...
TMPH-00851	HSD3B1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the...
TMPY-02461	AKR1A1 Protein, Human, Recombinant (His)	Human	E. coli
	Aldehyde reductase (AKR1A1) is a member of the aldo-keto reductase superfamily, which consists of more than 40 known enzymes and proteins that includes variety of monomeric NADPH-dependent oxidoreductases, such as aldehy...
TMPJ-00955	MDH1 Protein, Human, Recombinant (His)	Human	E. coli
	Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate...
TMPY-02439	Rac2 Protein, Human, Recombinant (His)	Human	E. coli
	Ras-related C3 botulinum toxin substrate 2 (Rac2) is a small G-protein belonging to the Ras subfamily of the GTPase family. Rac2 acts as an "on / off" switch for signal transduction cascades and motilities. When GDP is a...
TMPJ-01106	NAD(P) transhydrogenase/NNT Protein, Human, Recombinant (His)	Human	E. coli
	NAD(P)+transhydrogenase (NNT) is located in the inner mitochondrial membrane and catalyzes a reversible hydride transfer between NAD(H) and NADP(H) that is coupled to proton translocation between the intermembrane space ...
TMPH-00297	S100A9 Protein, Bovine, Recombinant (His & Myc & SUMO)	Bovine	E. coli
	S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal act...
TMPY-02519	BLVRB Protein, Human, Recombinant (His)	Human	E. coli
	Biliverdin reductase (hBVR) is a serine/threonine kinase that catalyzes reduction of the heme oxygenase (HO) activity product, biliverdin, to bilirubin. BVR consists of an N-terminal dinucleotide-binding domain (Rossmann...
TMPY-01187	Rac1 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	RAC1 is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal re...