cdk4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T39957	CDK4/6-IN-6		CDK
	CDK4/6-IN-6 is a potent CDK4/CDK6 inhibitor with Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.		CDK
T10736	CDK4/6-IN-2		CDK
	CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16 nM).		CDK
T10735	CDK4/6/1 Inhibitor	Crozbaciclib	CDK
	CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer...		CDK
T39956	CDK4/6-IN-5	CDK4/6-IN-5
	CDK4/6-IN-5 is a highly effective inhibitor of CDK4 and CDK6, with Ki values of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively (WO2019207463A1, example A93).
T21720	GP-82996	Cdk4/6 Inhibitor IV,CINK4	CDK
	GP-82996 (CINK4) is a pharmacological inhibitor specifically targeting CDK4/6, exhibiting IC50 values of 1.5 μM for CDK4/cyclin D1, 5.6 μM for CDK6/cyclin D1, and 25 μM for Cdk5/p35. It effectively induces apoptosis in U...		CDK
T2381	Abemaciclib	CDK4/6 dual inhibitor,LY2835219	CDK
	Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity. Abemaciclib has antitumor activity and is used to treat advanced or metastatic breast cancer.		CDK
T10738	Abemaciclib metabolite M20	CDK4/6-IN-4,LSN3106726	CDK
	Abemaciclib metabolite M20 (CDK4/6-IN-4) is an active metabolite of Abemaciclib. Abemaciclib metabolite M20 is a selective CDK4/6 inhibitor and can be used for researches on the treatment of cancer.		CDK
T2082	CDK4-IN-1		CDK
	CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50=5.265 uM) respectively.		CDK
T10737	CDK4/6-IN-3		CDK
	CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM.		CDK
T79046	CDK4-IN-2		CDK
	CDK4-IN-2 (A17) is a potent inhibitor of CDK4, exhibiting K i and IC 50 values of less than 10 nM and is utilized in cancer research [1].		CDK
T60328	CDK4/6-IN-12
	CDK4/6-IN-12 is a potent cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. CDK4/6-IN-12 has enzymatic inhibitory activity against CDK4 and CDK6 with IC 50 of 592.3 nM and 3090 nM, respectively. CDK4/6-IN-12 can be used in ...
T62605	CDK4/6-IN-13
	Compounds 10B and 10C, functioning as cdk4/6 inhibitors, demonstrated low nanomolar activity, optimal antiproliferative effects, excellent metabolic properties, and acceptable pharmacokinetics targeting cdk4/6.
T72928	CDK4/6-IN-15
	CDK4/6-IN-15, an orally active and selective inhibitor of CDK4/6, effectively halts the growth of cancer cells by arresting the cell cycle at the G1 phase and inhibiting the phosphorylation of the retinoblastoma tumor su...
T72836	SHP2/CDK4-IN-1
	SHP2/CDK4-IN-1 (compound 10) is a dual inhibitor targeting SHP2 and CDK4, exhibiting oral activity and high potency with IC50 values of 4.3 nM for SHP2 and 18.2 nM for CDK4. It effectively induces G0/G1 arrest, inhibitin...
T61892	CDK4/6-IN-8
	CDK4/6-IN-8 (Compound 7p) is a selective inhibitor of CDK4 (IC50=5.01 nM) and CDK6 (IC50=3.97 nM).
T62192	CDK4/6-IN-9
	CDK4/6-IN-9 (compound 10) is a selective inhibitor of CDK4/6, capable of acting on CDK6/cyclin D1 (IC50: 905 nM). CDK4/6-IN-9 has potential research value in multiple myeloma (MM).
T79112	CDK4/6-IN-17		CDK
	CDK4/6-IN-17 (compound 12) is an orally bioavailable inhibitor of CDK4/6, demonstrating potent activity with IC50 values between 10-100 nM in BE(2) cells. It has shown efficacy in inhibiting tumor growth in the COLO205 x...		CDK
T61738	CDK4/6-IN-7
	CDK4/6-IN-7, a highly potent and selective orally active inhibitor of CDK4/6, demonstrates impressive inhibition activity with IC50 values of 1.58 nM and 4.09 nM respectively. This compound is particularly valuable for b...
T74370	CDK4/6-IN-11
	CDK4/6-IN-11 is a potent PROTAC CDK4/6 degrader.
T63135	FLT3/CDK4-IN-1
	FLT3/CDK4-IN-1 is a highly selective, potent, orally active dual inhibitor of FLT3/CDK4, acting on FLT3 (IC50: 7 nM) and CDK4 (IC50: 11 nM).FLT3/CDK4-IN-1 has good anti-tumour effects in vivo, showing anti-proliferative ...