Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

Cat No.	product name / Synonyms	Species	Expression System
TMPJ-00064	OX40L Protein, Human, Recombinant (His) OX40L Protein, Human, Recombinant (His)	Human	Human Cells
TMPJ-00064	Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells,...
TMPJ-00075	CD27L Protein, Mouse, Recombinant (His) CD27L Protein, Mouse, Recombinant (His)	Mouse	Human Cells
TMPJ-00075	CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular ...
TMPJ-00099	CD28 Protein, Mouse, Recombinant (hFc & His) CD28 Protein, Mouse, Recombinant (hFc & His)	Mouse	Human Cells
TMPJ-00099	T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signal...
TMPJ-00102	Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated	Human,Cynomolyus	Human Cells
TMPJ-00102	T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belon...
TMPJ-00128	SLAMF2 Protein, Mouse, Recombinant (His) SLAMF2 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
TMPJ-00128	CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on...
TMPJ-00130	SLAMF2 Protein, Human, Recombinant (hFc & His) SLAMF2 Protein, Human, Recombinant (hFc & His)	Human	Human Cells
TMPJ-00130	CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains ...
TMPJ-00138	4-1BBL Protein, Human, Recombinant (His & Flag) 4-1BBL Protein, Human, Recombinant (His & Flag)	Human	Human Cells
TMPJ-00138	Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B...
TMPJ-00140	4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated 4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated	Cynomolgus	Human Cells
TMPJ-00140	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
TMPJ-00141	4-1BB Protein, Cynomolgus, Recombinant (hFc) 4-1BB Protein, Cynomolgus, Recombinant (hFc)	Cynomolgus	Human Cells
TMPJ-00141	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros...
TMPJ-00142	4-1BB Protein, Cynomolgus, Recombinant (His) 4-1BB Protein, Cynomolgus, Recombinant (His)	Cynomolgus	Human Cells
TMPJ-00142	Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros...
TMPJ-00143	4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated 4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated	Human	Human Cells
TMPJ-00143	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
TMPJ-00144	4-1BB Protein, Human, Recombinant (hFc & His) 4-1BB Protein, Human, Recombinant (hFc & His)	Human	Human Cells
TMPJ-00144	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
TMPJ-00145	4-1BB Protein, Mouse, Recombinant (hFc) 4-1BB Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
TMPJ-00145	Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte acti...
TMPJ-00150	CD40L Protein, Human, Recombinant (Mammalian) CD40L Protein, Human, Recombinant (Mammalian)	Human	Human Cells
TMPJ-00150	CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00151	CD40L Protein, Human, Recombinant CD40L Protein, Human, Recombinant	Human	E. coli
TMPJ-00151	CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00152	CD40L Protein, Human, Recombinant (His & Avi), Biotinylated CD40L Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
TMPJ-00152	CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00153	CD40L Protein, Human, Recombinant (His & Flag) CD40L Protein, Human, Recombinant (His & Flag)	Human	Human Cells
TMPJ-00153	CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00219	BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated	Human	Human Cells
TMPJ-00219	Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN...
TMPJ-00353	ILDR2 Protein, Human, Recombinant (His) ILDR2 Protein, Human, Recombinant (His)	Human	Human Cells
TMPJ-00353	ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasi...
TMPJ-00421	CD27 Protein, Human, Recombinant (hFc & His) CD27 Protein, Human, Recombinant (hFc & His)	Human	Human Cells
TMPJ-00421	CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it...