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Co-stimulatory Immune Checkpoint Proteins

Stimulating immune checkpoint proteins weaken the immune system in contrast to inhibitory pathways, and co-stimulatory molecules may fight malignant cells by enhancing the immune response. Malignant cells usually promote tumorigenesis by inhibiting the co-stimulatory pathway. Checkpoint stimulatory molecules such as OX40, GITR, ICOS, 4-1BB, CD40 play a key role in regulating T cell effector function, and activation of the co-stimulatory pathway may enhance checkpoint inhibition effect and lead to durable anti-tumor response.

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Species
Canine (9)
Cynomolgus (37)
Cynomolyus (1)
Human (136)
Mouse (64)
Rabbit (2)
Rat (27)
Rhesus (21)
Rhesus macaque (5)
Source
Baculovirus-Insect Cells (2)
E. coli (3)
HEK293 (244)
Human Cells (35)
Label
AVI (32)
C-6His (12)
C-6His-Avi (2)
C-Avi-6His (2)
C-Fc (6)
C-Fc-6His (4)
C-Fc-Avi (1)
C-His (9)
C-His-Avi (19)
C-hFc (4)
C-hFc-Avi (2)
C-mFc (1)
Fc (1)
His (98)
N-10His (1)
N-6His (3)
N-6His-Avi (1)
N-6His-Flag (2)
N-8His (1)
N-His (4)
N-His-Avi (2)
N-His-Flag (2)
N-monomeric hFc (1)
None (2)
Tag Free (5)
hFc (82)
mFc (12)
rFc (8)
Cat No. product name / Synonyms Species Source
TMPJ-00064 OX40L Protein, Human, Recombinant (His)
OX40L Protein, Human, Recombinant (His)
Human Human Cells
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells,...
TMPJ-00075 CD27L Protein, Mouse, Recombinant (His)
CD27L Protein, Mouse, Recombinant (His)
Mouse Human Cells
CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular ...
TMPJ-00099 CD28 Protein, Mouse, Recombinant (hFc & His)
CD28 Protein, Mouse, Recombinant (hFc & His)
Mouse Human Cells
T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signal...
TMPJ-00102 Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
Human,Cynomolyus Human Cells
T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belon...
TMPJ-00128 SLAMF2 Protein, Mouse, Recombinant (His)
SLAMF2 Protein, Mouse, Recombinant (His)
Mouse Human Cells
CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on...
TMPJ-00130 SLAMF2 Protein, Human, Recombinant (hFc & His)
SLAMF2 Protein, Human, Recombinant (hFc & His)
Human Human Cells
CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains ...
TMPJ-00138 4-1BBL Protein, Human, Recombinant (His & Flag)
4-1BBL Protein, Human, Recombinant (His & Flag)
Human Human Cells
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B...
TMPJ-00140 4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
Cynomolgus Human Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
TMPJ-00141 4-1BB Protein, Cynomolgus, Recombinant (hFc)
4-1BB Protein, Cynomolgus, Recombinant (hFc)
Cynomolgus Human Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros...
TMPJ-00142 4-1BB Protein, Cynomolgus, Recombinant (His)
4-1BB Protein, Cynomolgus, Recombinant (His)
Cynomolgus Human Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros...
TMPJ-00143 4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated
4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated
Human Human Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
TMPJ-00144 4-1BB Protein, Human, Recombinant (hFc & His)
4-1BB Protein, Human, Recombinant (hFc & His)
Human Human Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
TMPJ-00145 4-1BB Protein, Mouse, Recombinant (hFc)
4-1BB Protein, Mouse, Recombinant (hFc)
Mouse Human Cells
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte acti...
TMPJ-00150 CD40L Protein, Human, Recombinant (Mammalian)
CD40L Protein, Human, Recombinant (Mammalian)
Human Human Cells
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00151 CD40L Protein, Human, Recombinant
CD40L Protein, Human, Recombinant
Human E. coli
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00152 CD40L Protein, Human, Recombinant (His & Avi), Biotinylated
CD40L Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00153 CD40L Protein, Human, Recombinant (His & Flag)
CD40L Protein, Human, Recombinant (His & Flag)
Human Human Cells
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
TMPJ-00219 BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN...
TMPJ-00353 ILDR2 Protein, Human, Recombinant (His)
ILDR2 Protein, Human, Recombinant (His)
Human Human Cells
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasi...
TMPJ-00421 CD27 Protein, Human, Recombinant (hFc & His)
CD27 Protein, Human, Recombinant (hFc & His)
Human Human Cells
CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it...
OX40L Protein, Human, Recombinant (His)
TMPJ-00064
Tumor necrosis factor ligand superfamily member 4(TNFSF4/OX40L) is a single-pass type II membrane protein.OX40L is expressed on the surface of activated B cells,...
CD27L Protein, Mouse, Recombinant (His)
TMPJ-00075
CD27 Ligand (CD70) is a 30 kDa type 2 transmembrane glycoproteinis that belongs to the tumor necrosis factor (TNF) ligand family.Human CD27 Ligand extracellular ...
CD28 Protein, Mouse, Recombinant (hFc & His)
TMPJ-00099
T-cell-specific surface glycoprotein CD28, contains an Ig-like V-type domain. CD28 is one of the proteins expressed on T cells that provide co-stimulatory signal...
Cynomolgus CD28 Protein, Human, Recombinant (hFc & Avi), Biotinylated
TMPJ-00102
T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belon...
SLAMF2 Protein, Mouse, Recombinant (His)
TMPJ-00128
CD48 is a GPI-linked protein in the CD2 family of immunoglobulin superfamily proteins. CD48 is expressed on most lineage-committed hematopoietic cells but not on...
SLAMF2 Protein, Human, Recombinant (hFc & His)
TMPJ-00130
CD48 antigen, also known as B-lymphocyte activation marker BLAST-1, BCM1 surface antigen, Leukocyte antigen MEM-102, TCT.1, CD48, BCM1,and BLAST1, CD48 contains ...
4-1BBL Protein, Human, Recombinant (His & Flag)
TMPJ-00138
Tumor necrosis factor ligand superfamily member 9(4-1BBL) is single-pass type II membrane protein which is a member of the the tumor necrosis factor family. 4-1B...
4-1BB Protein, Cynomolgus, Recombinant (His & Avi), Biotinylated
TMPJ-00140
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
4-1BB Protein, Cynomolgus, Recombinant (hFc)
TMPJ-00141
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros...
4-1BB Protein, Cynomolgus, Recombinant (His)
TMPJ-00142
Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necros...
4-1BB Protein, Human, Recombinant (Avi & His), Biotinylated
TMPJ-00143
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
4-1BB Protein, Human, Recombinant (hFc & His)
TMPJ-00144
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is an inducible T cell surface protein belonging to the TNF receptor superfamily. It is a single-pas...
4-1BB Protein, Mouse, Recombinant (hFc)
TMPJ-00145
Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte acti...
CD40L Protein, Human, Recombinant (Mammalian)
TMPJ-00150
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
CD40L Protein, Human, Recombinant
TMPJ-00151
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
CD40L Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00152
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
CD40L Protein, Human, Recombinant (His & Flag)
TMPJ-00153
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer i...
BTN3A2 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-00219
Butyrophilin subfamily 3 member A2, also known as BT3.2, BTF3, BTF4 and BTN3A2, is a single-pass type I membrane protein. It is a member of the butyrophilin (BTN...
ILDR2 Protein, Human, Recombinant (His)
TMPJ-00353
ILDR2 is a member of the B7-like family of proteins that regulate T cell activity, is also a known endoplasmic reticulum molecule that regulates lipid homeostasi...
CD27 Protein, Human, Recombinant (hFc & His)
TMPJ-00421
CD27 antigen is also known as CD27L receptor, T-cell activation antigen CD27, Tumor necrosis factor receptor superfamily member 7, T14 and TNFRSF7. In humans, it...
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TargetMol