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STING antagonist-3
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Catalog No. T218454 Copy Product Info
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STINGantagonist-3 is a potent STING antagonist with an IC50 value of 2.3 nM against human wild-type STING. It effectively inhibits both human wild-type STING and gain-of-function STING mutants N154S and V155M. In stimulated human whole blood, STINGantagonist-3 suppresses the production of IFN-α2a. Additionally, it inhibits IP-10 production in activated human skin microvascular endothelial cells (HMVEC-d). This compound is applicable for research in autoimmune and autoinflammatory diseases, interferonopathies, and fibrotic disorders.
STING antagonist-3
Cas No. 3106554-00-8
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | STINGantagonist-3 is a potent STING antagonist with an IC50 value of 2.3 nM against human wild-type STING. It effectively inhibits both human wild-type STING and gain-of-function STING mutants N154S and V155M. In stimulated human whole blood, STINGantagonist-3 suppresses the production of IFN-α2a. Additionally, it inhibits IP-10 production in activated human skin microvascular endothelial cells (HMVEC-d). This compound is applicable for research in autoimmune and autoinflammatory diseases, interferonopathies, and fibrotic disorders. |
| In vitro | STING antagonist-3 (Example 21) inhibits human wild-type STING R232 in a competitive HTRF binding assay with an IC50 of 2.3 nM. In a DSF experiment, STING antagonist-3 (100 μM; temperature ramp from 15°C to 95°C over 160 cycles) stabilizes human wild-type STING protein against thermal denaturation, showing a ΔTm of 29 K. Additionally, STING antagonist-3 (10 μM; 60 min pre-incubation; 22 h post-stimulation) suppresses cGAMP-induced IFNα2α production in human whole blood with an IC50 of 0.029 μM. Furthermore, STING antagonist-3 (pre-incubation 1 hour; stimulation 6 hours) inhibits dsDNA-induced IP-10 production in human HMVEC cells with an IC50 of 6.8 nM. |
| Molecular Weight | 577.72 |
| Formula | C35H39N5O3 |
| Cas No. | 3106554-00-8 |
| Smiles | C(C)(C)C=1C(=NN(C1C)C2=C(C)N=C(C=C2)[C@@H]3CC[C@@H](C(O)=O)CC3)C=4C=5C(=NN(C[C@H](O)C6=CC=CC=C6)C5)C=CC4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: STING antagonist-3 in vitro | STING antagonist-3 formula | STING antagonist-3 molecular weight
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