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SARS-CoV

Severe acute respiratory syndrome coronavirus (SARS-CoV or SARS-CoV-1) is a strain of virus that causes severe acute respiratory syndrome (SARS). It is an enveloped, positive-sense, single-stranded RNA virus which infects the epithelial cells within the lungs. The virus enters the host cell by binding to the ACE2 receptor. It infects humans, bats, and palm civets.

  • Chloroquine
    T868954-05-7
    Chloroquine is a Toll-like receptor inhibitor that inhibits autophagy. Chloroquine has anti-malarial and anti-inflammatory activity and is widely used in the treatment of malaria and rheumatoid arthritis. Chloroquine also has anti-SARS-CoV-2 (COVID-19) activity and anti-HIV-1 activity.
    • $54
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  • Remdesivir
    T77661809249-37-3
    Remdesivir (GS-5734) is a nucleoside analog, a broad-spectrum antiviral compound that exerts its activity by inhibiting the RNA-dependent RNA polymerase of viruses. Remdesivir is active against Ebola, SARS, and MERS viruses, and is potentially therapeutic against COVID-19.
    • $122
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  • Molnupiravir
    T609512492423-29-5
    Molnupiravir (MK-4482) (EIDD-2801) is a prodrug of the ribonucleoside analog EIDD-1931 which is orally bioavailable. Molnupiravir can be used in COVID-19, seasonal and pandemic influenza research that has broad spectrum antiviral activity against multiple coronaviruses and influenza virus, for example, SARS-CoV-2, MERS-CoV, SARS-CoV [1][2].
    • $34
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  • Dexamethasone
    T107650-02-2
    Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist and an IL receptor modulator. Dexamethasone has anti-inflammatory and immunosuppressive activity and induces autophagy. Dexamethasone inhibits LPS-induced inflammatory responses in macrophages.
    • $29
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  • Nirmatrelvir
    T93512628280-40-8
    PF-07321332 is a potent and orally active inhibitor of SARS-CoV 3C-like protease (3CLPRO) .
    • $53
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  • Favipiravir
    T6833259793-96-9
    Favipiravir (T-705) (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
    • $41
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  • Thapsigargin
    TQ030267526-95-8
    Thapsigargin is a natural product, an inhibitor of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) and an endoplasmic reticulum stress inducer. Thapsigargin increases cytoplasmic calcium concentration by blocking the ability of cells to pump calcium into the sarcoplasmic and endoplasmic reticulum.
    • $82
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  • Emodin
    T2869518-82-1
    • $45
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  • Umifenovir hydrochloride
    T0104131707-23-8
    Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
    • $50
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  • Chloroquine phosphate
    T019450-63-5
    Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
    • $42
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  • Hydroxychloroquine
    T9287118-42-3
    Hydroxychloroquine (2-[[4-[(7-Chloroquinolin-4-yl)amino]pentyl](ethyl)amino]ethanol) (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a medication used to prevent and treat malaria, and it's also being studied as an experimental treatment for COVID-19.
    • $30
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  • EIDD-1931
    T84983258-02-4
    EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity.It inhibits replication of severe acute respiratory syndrome coronavirus (SARS-CoV) in Vero 76 cells, Middle East respiratory syndrome coronavirus (MERS-CoV) in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s =0.1, 0.15 and 0.3 μM, respectively)
    • $33
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  • Ritonavir
    T1525155213-67-5
    Ritonavir (ABT 538) is a peptidomimetic agent that inhibits both HIV-1 and HIV-2 proteases. Ritonavir is highly inhibited by serum proteins but boosts the effect of other HIV proteases by blocking their degradation by cytochrome P450.
    • $31
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  • PLpro/RBD-IN-1
    T787041282451-83-5In house
    PLpro/RBD-IN-1 is a dual inhibitor of SARS-CoV-2 PLpro and the spiny protein RBD, with anti-novel coronavirus activity, and is seen for the study of viral infections.
    • $293 TargetMol
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  • Setrobuvir
    T287621071517-39-9In house
    Setrobuvir (ANA-598) is an orally active non-nucleoside HCV NS5B polymerase inhibitor with inhibitory effects on de novo RNA synthesis and primer extension with IC50s between 4 and 5 nM. setrobuvir shows good binding affinity for SARS-CoV-2 RdRp and induces inhibition of RdRp.
    • $240
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  • Azelastine
    T021158581-89-8
    Azelastine (Azelastinum) is a phthalazine derivative, and is an histamine antagonist and mast cell stabilizer.
    • $50
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  • Pinokalant
    T70540149759-26-2In house
    Pinokalant (LOE-908) is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabolic and electrophysiological status of the ischemic penumbra region, and reduces the size of the lesion on magnetic resonance images in the acute phase after middle cerebral artery occlusion in rats.Pinokalant is a potential SARS-CoV-2 protease inhibitor for the study of stroke.
    • $195
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  • SARS-CoV-2 Mpro-IN-2
    T630982768834-39-3In house
    SARS-CoV-2 Mpro-IN-2 is a selective SARS-CoV-2M pro inhibitor with an IC50 value of 0.40 μM.SARS-CoV-2 Mpro-IN-2 has good antiviral activity and can be used to study COVID-19.
    • $397
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  • Sonedenoson
    T34685131865-88-8In house
    Sonedenoson (MRE0094) is an adenosine A(2A) receptor agonist and potential inhibitor potentially targeting SARS-CoV-2 coronavirus 2;-O-ribose methyltransferase, and may be used in the study of diabetic foot ulcers.
    • $293 TargetMol
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  • SARS-CoV-2 3CLpro-IN-16
    T79659352659-40-6In house
    SARS-CoV-2 3CLpro-IN-16 is a covalent SARS-CoV-2 3CLpro inhibitor that inhibits 3CLpro activity and achieves its inhibitory effect by forming a covalent bond with Cys145.
    • $195 TargetMol
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  • Ensitrelvir
    T97162647530-73-0In house
    Ensitrelvir (S-217622) is an orally active inhibitor of SARS-CoV-2 3CL protease with IC50 of 13 nM.
    • $50
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  • Theodrenaline hydrochloride
    T13142L2572-61-4In house
    Theodrenaline hydrochloride is an inhibitor targeting SARS-CoV-2 for the study of hypotension induced by spinal anesthesia.
    • $158
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  • GRL-0496
    T96721087243-14-8In house
    GRL-0496 is a potent inhibitor with an enzyme inhibitory activity against SARS-CoV 3CLpro with an IC50 of 30 nM and antiviral potency with an EC50 value of 6.9 μM.
    • $51
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  • Lopinavir
    T1623192725-17-0
    Lopinavir (ABT-378) is a peptidomimetic HIV protease inhibitor that retains activity against HIV protease with the Val 82 mutation. Lopinavir is less affected by binding to serum proteins than the structurally-related drug ritonavir.
    • $41
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  • Imiquimod
    T013499011-02-6
    Imiquimod (R 837) is an immune response modifier that acts as a toll-like receptor 7 agonist.
    • $37
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  • Azelastine hydrochloride
    T0211L79307-93-0
    Azelastine hydrochloride (Astelin) is a phthalazinone derivative with antihistaminergic activity.
    • $30
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  • Punicalagin
    T392165995-63-3
    Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and ch
    • $130
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  • Scutellarein
    T3319529-53-3
    Scutellarein (6-Hydroxyapigenin) reduces inflammatory responses by inhibiting Src kinase activity.
    • $110
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  • Camostat mesylate
    T239159721-29-8
    Camostat mesylate (FOY-S980) is a trypsin-like protease inhibitor and inhibits airway epithelial sodium channel (ENaC) function.
    • $43
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  • Hydroxychloroquine sulfate
    T0951747-36-4
    Hydroxychloroquine sulfate (Acidum iopanoicum) inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
    • $48
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  • Carmofur
    T130761422-45-5
    Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
    • $34
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  • GC376 sodium
    T51881416992-39-6
    GC376 is an inhibitor of 3C-like proteases (3CLpro) with IC50 values range from 0.49~4.35 μM.
    • $42
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  • Boceprevir
    T4988394730-60-0
    Boceprevir (SCH 503034) is a novel, potent, highly selective, orally bioavailable HCV NS3 protease inhibitor with Ki of 14 nM in both enzyme assay and EC90 of 350 nM in cell-based replicon assay.
    • $65
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  • Imatinib
    T6230152459-95-5
    Imatinib (STI571) is a multi-targeted receptor tyrosine kinase inhibitor that selectively inhibits the kinase activities of BCR/ABL, v-Abl, PDGFR, and c-kit with oral activity. Imatinib has antitumor activity for the treatment of chronic granulocytic leukemia.
    • $36
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  • GS-441524
    T72221191237-69-0
    GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
    • $34
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  • Auranofin
    T130334031-32-8
    Auranofin (SKF-39162) is an antirheumatic agent, is used to treat rheumatoid arthritis, improves arthritis symptoms including painful or tender and swollen joints and morning stiffness.
    • $37
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  • Atazanavir
    T0100L198904-31-3
    Atazanavir (BMS-232632)(BMS-232632) is an highly effective HIV-1 protease inhibitor.
    • $39
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  • Dihydrotanshinone I
    T337487205-99-0
    Dihydrotanshinone I (DHTS) is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
    • $51
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  • Andrographolide
    T28985508-58-7
    Andrographolide (Andrographis)(Andrographis), an irreversible antagonist of NF-κB, has anti-inflammatory and anti-platelet aggregation activities and potential antineoplastic.
    • $48
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  • Suramin Sodium Salt
    T2160129-46-4
    Suramin Sodium Salt (BAY-205) is a sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis.
    • $41
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  • Nafamostat mesylate
    T239282956-11-4
    Nafamostat mesylate (FUT-175), a synthetic serine protease inhibitor, has been used for the treatment of allergic disorders such as asthma, allergic rhinitis and atopic dermatitis.
    • $39
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  • SARS-CoV-2-IN-64
    T81207
    SARS-CoV-2-IN-64 (compound 9), derived from chenodeoxycholic acid, serves as a potent inhibitor of the SARS-CoV-2 spike glycoprotein [1].
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  • SARS-CoV-2-IN-62
    T812092350285-18-4
    SARS-CoV-2-IN-62 (Compound R3b) effectively inhibits SARS-CoV-2 replication in Vero E6 and Calu-3 cells, demonstrating low cytotoxicity and EC50 values of 2.97 μM and 3.82 μM, respectively [1].
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  • GRL-1720 TFA
    T82257
    GRL-1720 TFA is a potent SARS-CoV-2 Mpro inhibitor, demonstrating anti-SARS-CoV-2 activity with an EC50 of 15 μM [1].
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  • MAT-POS-e194df51-1
    T81849
    MAT-POS-e194df51-1 is an orally active, non-covalent, non-peptide inhibitor of the SARS-CoV-2 main protease (M^pro) with an IC_50 of 37nM. It exhibits cytotoxicity, with EC_50 values of 64nM in A549-ACE2-TMPRSS2 cells and 126nM in HeLa-ACE2 cells [1].
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  • HCoV-OC43-IN-1
    T822302809363-81-1
    HCoV-OC43-IN-1 (Compound IV-16) serves as an inhibitor of the coronavirus HCoV-OC43, exhibiting antiviral efficacy with an EC50 of 90 nM. It effectively inhibits the mRNA levels and expression of the viral nucleocapsid protein (NP) [1].
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  • Bofutrelvir
    T371732103278-86-8
    Bofutrelvir (FB2001) is a SARS-CoV-2 3CL protease inhibitor with antiviral activity for the study of novel coronavirus pneumonia (COVID-19) infections.
    • $198
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  • Kansuinine B
    T4066057685-46-8
    Kansuinine B inhibits Stat3 activation induced by IL-6. Kansuinine B exhibits anti-viral activity and could be used in COVID-19 research.
    • $322
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  • GS-621763
    T402762647442-13-3
    GS-621763, a prodrug of GS-441524, exhibits antiviral activity against SARS-CoV-2 pathogenesis.
    • $135
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  • Narsoplimab
    T768702108782-45-0
    Narsoplimab (OMS 721) is a selective whole-human immunoglobulin gamma-4 (IgG4) monoclonal antibody, a mannan-binding lectin-associated serine protease-2 (MASP-2) inhibitor that binds MASP-2 and prevents lectin pathway activation. It can inhibit the agglutinin pathway. Narsoplimab can be used to study diseases associated with hematopoietic stem cell transplantation in adults.
    • $347
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