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MAPK

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis.
Cat. No. Product name CAS No. Purity Chemical Structure
TN2511 Britannilactone diacetate 1286694-67-4 98%
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN4107 Ganoderic acid X 86377-53-9 98%
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
TN4300 Isojacareubin 50597-93-8 98%
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
TN1645 Flavokawain C 56798-34-6 98%
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
TN2844 (2R,3S)-Dihydrodehydroconiferyl alcohol 126253-41-6 98%
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
TN3805 Dehydrogeijerin 16850-91-2 98%
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
TN4956 Scandoside 18842-99-4 98%
Scandoside exerts anti-inflammatory effect via suppressing NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation...
TN4877 Quercetin 3,4'-dimethyl ether 33429-83-3 98%
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
TN4489 Manassantin A 88497-87-4 98%
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
TN2694 2,3-Dihydro-3-methoxywithaferin A 21902-96-5 98%
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
TN3397 Alpinumisoflavone 34086-50-5 98%
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
TN3691 Communic acid 2761-77-5 98%
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN1338 7Beta-Hydroxycholesterol 566-27-8 98%
7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells...
TN4315 Isonardosinone 27062-01-7 98%
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
TL0017 Aristolactam AIIIa 97399-91-2 98%
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
TN4094 Gallocatechin gallate 5127-64-0 98%
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN4114 Gardenin A 21187-73-5 98%
Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
TN1269 3β-Methoxy-2,3-dihydrowithaferin A 73365-94-3 98%
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
TN2123 Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside 53171-28-1 98%
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
TN3587 Capillarisin 56365-38-9 98%
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Britannilactone diacetate
TN2511
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
Ganoderic acid X
TN4107
Ganoderic acid X is a potential Mdm2 inhibitor(K(i) = 16nM). It is a potential anticancer drug, inhibits topoisomerases and induces apoptosis of cancer cells.
Isojacareubin
TN4300
Isojacareubin displays potent activity against H. pylori HP40 clinical isolate with MIC 23.9 uM, which is approximately two times greater than that of the standa...
Flavokawain C
TN1645
Flavokawain C is a melanogenesis inhibitor, it inhibited melanogenesis with IC50 values of 6.9 μM. Flavokawain C has anti-tumor activity, it inhibited cell cycle...
(2R,3S)-Dihydrodehydroconiferyl alcohol
TN2844
(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such...
Dehydrogeijerin
TN3805
Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of...
Scandoside
TN4956
Scandoside exerts anti-inflammatory effect via suppressing NF-κB and MAPK signaling pathways in LPS-induced RAW 264.7 macrophages.It also inhibits LDL-oxidation...
Quercetin 3,4'-dimethyl ether
TN4877
Quercetin 3,4'-dimethyl ether shows anti-lipid peroxidation activity (IC 50 values of 0.3 uM), it also shows anti-inflammatory activity. Quercetin 3,4'-dimethyl ...
Manassantin A
TN4489
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effec...
2,3-Dihydro-3-methoxywithaferin A
TN2694
2,3-Dihydro-3-methoxywithaferin A is a natural withanolide , is cytotoxic to human cancer cells, and is a candidate anticancer natural compound. It protects norm...
Alpinumisoflavone
TN3397
Alpinumisoflavone has atheroprotective effects, may result from their ability to upregulate mechanisms promoting HDL-cholesterol and bile acid formation, it is e...
Communic acid
TN3691
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
7Beta-Hydroxycholesterol
TN1338
7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells...
Isonardosinone
TN4315
Isonardosinone shows potential role in the treatment of neuroinflammation conditions, it inhibits NF-κB- and MAPK-mediated inflammatory pathways.
Aristolactam AIIIa
TL0017
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plate...
Gallocatechin gallate
TN4094
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Gardenin A
TN4114
Gardenin A has antihyperlipidemic and hepatoprotective effects , it also promotes neuritogenesis through the activation of MAPK/ERK-, PKC-, and PKA-dependent, bu...
3β-Methoxy-2,3-dihydrowithaferin A
TN1269
3beta-Methoxy-2,3-dihydrowithaferin A has cytoprotective activity, it protects normal cells against stress.
Quercetin 3-O-(6''-galloyl)-β-D-galactopyranoside
TN2123
Quercetin 3-O-(6''-galloyl)-beta-D-galactopyranoside can effectively induce apoptosis via p53, MAPKs and the mitochondrial apoptotic pathways.
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
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