T16699 |
PYZD-4409
|
423148-78-1
|
98%
|
|
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells...
|
T11980 |
MD-224
|
2136247-12-4
|
98%
|
|
MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.
|
T6149 |
YH239-EE
|
1364488-67-4
|
98%
|
|
YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.
|
T7889 |
C25-140
|
1358099-18-9
|
98%
|
|
C25-140 is a small-molecule inhibitor of TRAF6-Ubc13.
|
T5199 |
COH000
|
1534358-79-6
|
98%
|
|
COH000 is a covalent and irreversible inhibitor of small ubiquitin-like modifier (SUMO)-activating enzyme and inhibited SUMOylation (IC50: ~ 0.2 μM in vitro).
|
T2947 |
Indole-3-carbinol
|
700-06-1
|
98%
|
|
Indole-3-carbinol, a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
|
T9500 |
M435-1279
|
1359431-16-5
|
98%
|
|
M435-1279 is a UBE2T inhibitor. M435-1279 blocks UBE2T-mediated degradation of RACK1, leading to inhibit the hyperactivation of Wnt/β-catenin signaling pathway.
|
T12261 |
NSC232003
|
1905453-18-0
|
98%
|
|
NSC232003 is a highly potent and cell-permeable inhibitor of UHRF1.
|
T7379 |
2-D08
|
144707-18-6
|
98%
|
|
2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.
|
T5555 |
Siremadlin
|
1448867-41-1
|
98%
|
|
Siremadlin is a potent, orally bioavailable and highly specific p53-MDM2 interaction inhibitor.
|
T6585 |
SAR405838
|
1303607-60-4
|
98%
|
|
MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
|
T13090 |
TAS4464 hydrochloride
|
1848959-11-4
|
98%
|
|
TAS4464 hydrochloride is a highly potent and selective NEDD8 activating enzyme (NAE) inhibitor(IC50 of 0.955 nM).
|
T2243 |
Serdemetan
|
881202-45-5
|
98%
|
|
Serdemetan is an orally bioavailable HDM2 antagonist with potential antineoplastic activity.
|
T1493 |
BH3I-1
|
300817-68-9
|
98%
|
|
BH3I-1 is a Bcl-2 antagonist.
|
T8428 |
Subasumstat
|
1858276-04-6
|
98%
|
|
TAK-981 is a selective the SUMOylation enzymatic cascade inhibitor, has potential immune-activating and antineoplastic activities.
|
T16102 |
ML-792
|
1644342-14-2
|
98%
|
|
ML-792 is a specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor. Compared with NAE/NEDD8 and UAE/ubiquitin (IC50s of 32 μM and >100 μ...
|
T7415 |
DKM 2-93
|
65836-72-8
|
98%
|
|
DKM 2-93 is a relatively selective inhibitor of UBA5(IC50 : 430 μM).
|
T4S0181 |
Hinokiflavone
|
19202-36-9
|
98%
|
|
Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spli...
|
T8816 |
NAE-IN-M22
|
864420-54-2
|
98%
|
|
NAE-IN-M22 is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis...
|
T6023 |
Nutlin-3a
|
675576-98-4
|
98%
|
|
Nutlin-3a, the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein.
|