E1/E2/E3 Enzyme

Ubiquitin (UB) is a protein modifier that regulates many essential cellular processes. To initiate protein modification by UB, the E1 enzyme activates the C-terminal carboxylate of UB to launch its transfer through the E1-E2-E3 cascade onto target proteins. The E1 enzyme is the activating enzyme, to which ubiquitin is attached in an ATP-dependent reaction by a thioester bond. The E2 enzyme is the conjugating enzyme, to which the ubiquitin is transferred from the E1. The E3 is the ubiquitin ligase, which directly or indirectly catalyzes the transfer of the ubiquitin to the target protein (the substrate), with the formation of an isopeptide bond.

Cat. No.	Product name	CAS No.	Purity
T13090L	TAS4464	1848959-10-3	98.27%
T13090L	TAS4464 is a highly potent and selective inhibitor of the NEDD8 activating enzyme (IC50: 0.955 nM).
T78194	Skp2 inhibitor 2	2760612-77-7	98%
T78194	Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound ta...
T78221	TRAF6 peptide TFA		98%
T78221	TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA. This peptide demonstrates prom...
T78721	Smurf1-IN-1	1824708-03-3	98%
T78721	Smurf1-IN-1, a selective E3 ubiquitin protein ligase 1 (SMURF1) inhibitor, exhibits oral activity with an IC50 of 92 nM and demonstrates considerable efficacy in...
T79133	UC-764864	278806-03-4	98%
T79133	UC-764864, a UBE2N inhibitor, impedes the enzymatic activity of UBE2N and exhibits cytotoxic effects through the disruption of UBE2N-dependent signaling in leuke...
T79893	Cbl-b-IN-6	2815221-33-9	98%
T79893	Cbl-b-IN-6 (Compound 246) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (I...
T79894	Cbl-b-IN-7	2815221-35-1	98%
T79894	Cbl-b-IN-7 (Compound 248) is an inhibitor of casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting inhibitory half-maximal inhibitory concentrations (IC50s)...
T79895	Cbl-b-IN-8	2815223-33-5	98%
T79895	Cbl-b-IN-8 (Compound 293) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half maximal inhibitory concentrations (IC50s) of 5....
T79896	Cbl-b-IN-9	2815223-41-5	98%
T79896	Cbl-b-IN-9 (Compound 300) is an inhibitor targeting casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting potent inhibitory activity with half-maximal inhib...
T79897	Cbl-b-IN-10	2815225-12-6	98%
T79897	Cbl-b-IN-10 (Compound 463) is a potent inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s...
T79898	Cbl-b-IN-11	2815225-15-9	98%
T79898	Cbl-b-IN-11 (Compound 466) is an inhibitor of both casitas B-lineage lymphoma-b (Cbl-b) and c-Cbl, exhibiting half-maximal inhibitory concentrations (IC50s) of 6...
T79899	Cbl-b-IN-12	2851871-29-7	98%
T79899	Cbl-b-IN-12 (Example 10) is an inhibitor of casitas B-lineage lymphoma-b (CBL-B), demonstrating a half-maximal inhibitory concentration (IC50) of less than 100 n...
T79900	Cbl-b-IN-13	2368841-85-2	98%
T79900	Cbl-b-IN-13 (Example 520) is a potent Cbl-b inhibitor exhibiting an IC50 of less than 100 nM and is capable of activating T-cells [1].
T2158	Nutlin-3	548472-68-0	99.89%
T2158	Nutlin-3 is an MDM2 antagonist.Nutlin-3 inhibits the MDM2-p53 interaction (IC50: 0.09 μM) and activates p53. Antiproliferative agent; chemotherapeutic agent; ind...
T16888	SJ-172550	431979-47-4	99.87%
T16888	SJ-172550 is a small molecule inhibitor of MDMX (EC50: 5 μM).
T3653	MX69	1005264-47-0	99.78%
T3653	MX69 is the MDM2/XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
T6S2123	Ginkgolic Acid	22910-60-7	99.72%
T6S2123	Ginkgolic Acid (Romanicardic acid) C15:1 represses curli genes and prophage genes in EHEC.
T25465	GS143	916232-21-8	99.72%
T25465	GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 suppresses NF-κB activation and t...
T6611	NSC697923	343351-67-7	99.69%
T6611	NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cel...
T5374	NAcM-OPT	2089293-61-6	99.68%
T5374	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).