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Results for "

lysosomal

" in TargetMol Product Catalog
  • Inhibitors & Agonists
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    TargetMol | Inhibitors_Agonists
Naphthazarin
DHNQ, 5,8-Dihydroxy-1,4-naphthoquinone
T8678475-38-7
Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. It triggers apoptosis and has anti-tumor effects
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Concanamycin A
X 4357B, Antibiotic X 4357B
T1499580890-47-7
Concanamycin A (Folimycin), a polycyclic lactone antibiotic, is a selective inhibitor of vacuolar H+-ATPase (V-ATPase) and lysosomal acidification, and can be used to study inflammation.Concanamycin A enhances the immune clearance of infected progenitor cells by cytotoxic T lymphocytes, and inhibits Nef et al. from different branches of HIV and simian immunodeficiency virus. Concanamycin A enhances immune clearance of cytotoxic T lymphocytes from infected progenitor cells, inhibits the Nef allele from different branches of HIV and simian immunodeficiency virus, and can be used to study HIV infection.
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Lyso-Globotriaosylceramide (d18:1)
Lyso-Globotriaosylceramide (d18:1)
T37291126550-86-5
Lyso-globotriaosylceramide is a form of globotriaosylceramide that is lacking the fatty acyl group. It binds to Shiga toxin 1 (Stx1) in the presence of cholesterol and phosphatidylcholine but does not bind Stx2. It also reduces viability and aggregation of human neutrophils induced by phorbol 12-myristate 13-acetate when used at concentrations of 50 and 1 μM, respectively. Lyso-globotriaosylceramide accumulates in the brain, heart, kidney, liver, lung, and spleen in a mouse model of Fabry disease, a lysosomal storage disorder characterized by a deficiency in the enzyme α-galactosidase A. It also accumulates in the urine, kidney, and plasma of patients with Fabry disease. Lyso-globotriaosylceramide levels decrease in response to administration of the α-galactosidase inhibitor 1-deoxygalactonojirimycin in a transgenic mouse model of Fabry disease. Decreases in plasma and urine concentrations of lyso-globotriaosylceramide have been used as a biomarker for efficacy of enzyme replacement therapy (ERT) and other therapies in the treatment of Fabry disease.
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20-DEOXYINGENOL
T568954706-99-9
20-DEOXYINGENOL is a natual product.
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Glucosylsphingosine
Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-Glucosylsphingosine
T7849352050-17-6
Glucosylsphingosine (Lyso-Gb1) is a naturally occurring glycosyl ceramide, a metabolite of GBA (acid β-glucosidase), involved in cellular recognition, signaling, and intercellular interactions.Glucopsychosine accumulates in certain neurodegenerative diseases (e.g., Gaucher disease), disrupts lysosomal function through activation of mammalian target of rapamycin complex 1 (mTORC1), and is a noncompetitive inhibitor of glucocerebrosidase.
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Euphorblin R
EOF2
T824282230806-06-9
Euphorblin R (EOF2), a rhamnyl diterpenoid extracted from Euphorbia resinifera, has been shown to enhance lysosomal biogenesis, suggesting its utility in researching lysosome-associated diseases.
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Gossypetin
TN1711489-35-0
Gossypetin, a hexahydroxylated flavonoid extractable from Rhodiola rosea Linn. is a potent MKK3 and MKK6 inhibitor that strongly attenuates the MKK3 6-p38 signaling pathway.Gossypetin exhibits antimutagenic, antiatherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects.It inhibits bone resorption by downregulating lysosomal caspase K activity and inducing autophagy-associated proteins in actin ring osteoclasts. Gossypetin has anti-mutagenic, anti-atherosclerotic, anti-oxidant, cytoprotective and antibacterial effects, and it inhibits bone resorption by down-regulating lysosomal caspase K activity and by inducing autophagy-associated protein in actin ring osteoblasts.
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Swainsonine
Tridolgosir
TN234472741-87-8
Swainsonine (Tridolgosir) is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2 M phase.
    7-10 days
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    Benzosceptrin C
    TN76391204605-36-6
    Benzosceptrin C is a PD-L1 inhibitor that promotes the degradation of programmed cell death ligand (PD-L1) via a lysosomal pathway, enhances T-cell cytotoxicity, and demonstrates antitumor activity [1].
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