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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Cat. No. Product name CAS No. Purity Chemical Structure
T61275 TRPM4-IN-2 667411-04-3 100%
TRPM4-IN-2, also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an ...
T11172 EIPA hydrochloride 1345839-28-2 98%
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
T15439 GSK3395879 2215852-91-6 98%
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
T37697L D-GsMTx4 TFA 98%
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to th...
TN1583 Dihydromorin 18422-83-8 98%
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
T15434 GSK2798745 1419609-94-1 98%
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
T15634 JYL 1421 401907-26-4 98%
JYL 1421 is an antagonist of TRPV1 receptor (IC50 = 8 nM).
TN2429 Capsiate 205687-01-0 98%
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
T13214 TRPV4 agonist-1 2314467-60-0 98%
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
T13212 TRPA1 Antagonist 1 1984825-08-2 98%
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T13546 AM12 2387510-84-9 98%
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T14067 A-1165442 1221443-94-2 98%
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T2807 Caffeic Acid 331-39-5 99.99%
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
T2298 ML204 5465-86-1 99.98%
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T21623 AS1269574 330981-72-1 99.98%
AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
T22360 MDR-652 1933528-96-1 99.96%
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRP...
T7526 JNJ-17203212 821768-06-3 99.94%
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
T21165 Pellitorine 18836-52-7 99.94%
Pellitorine is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
T15758 Linopirdine 105431-72-9 99.92%
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is...
T10929L D-3263 hydrochloride 1008763-54-9 99.85%
D-3263 hydrochloride is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
TRPM4-IN-2
T61275
TRPM4-IN-2, also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an ...
EIPA hydrochloride
T11172
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
GSK3395879
T15439
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
D-GsMTx4 TFA
T37697L
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to th...
Dihydromorin
TN1583
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
GSK2798745
T15434
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
JYL 1421
T15634
JYL 1421 is an antagonist of TRPV1 receptor (IC50 = 8 nM).
Capsiate
TN2429
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
TRPV4 agonist-1
T13214
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
TRPA1 Antagonist 1
T13212
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
AM12
T13546
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
A-1165442
T14067
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
Caffeic Acid
T2807
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
ML204
T2298
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
AS1269574
T21623
AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
MDR-652
T22360
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRP...
JNJ-17203212
T7526
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
Pellitorine
T21165
Pellitorine is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
Linopirdine
T15758
Linopirdine is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Linopirdine is...
D-3263 hydrochloride
T10929L
D-3263 hydrochloride is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
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