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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T61275 TRPM4-IN-2 667411-04-3 100%
TRPM4-IN-2
TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented ...
T11172 EIPA hydrochloride 1345839-28-2 98%
EIPA hydrochloride
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
T15439 GSK3395879 2215852-91-6 98%
GSK3395879
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
T38484 Englerin A 1094250-15-3 98%
Englerin A
Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer ac...
TN1583 Dihydromorin 18422-83-8 98%
Dihydromorin
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
T15434 GSK2798745 1419609-94-1 98%
GSK2798745
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
T15634 JYL 1421 401907-26-4 98%
JYL 1421
JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
T13214 TRPV4 agonist-1 2314467-60-0 98%
TRPV4 agonist-1
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
T13212 TRPA1 Antagonist 1 1984825-08-2 98%
TRPA1 Antagonist 1
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T13546 AM12 2387510-84-9 98%
AM12
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T37429 TRPV3 antagonist 74a 1432051-63-2 98%
TRPV3 antagonist 74a
TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
T14067 A-1165442 1221443-94-2 98%
A-1165442
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T2807 Caffeic Acid 331-39-5 99.99%
Caffeic Acid
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
T2298 ML204 5465-86-1 99.98%
ML204
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T21623 AS1269574 330981-72-1 99.98%
AS1269574
AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.
T22360 MDR-652 1933528-96-1 99.96%
MDR-652
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRP...
T7526 JNJ-17203212 821768-06-3 99.94%
JNJ-17203212
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
T21165 Pellitorine 18836-52-7 99.94%
Pellitorine
Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
T39349 Vocacapsaicin hydrochloride 1931116-92-5 99.94%
Vocacapsaicin hydrochloride
Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.
T15758 Linopirdine 105431-72-9 99.92%
Linopirdine
Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Lino...
TRPM4-IN-2
T61275
TRPM4-IN-2 (NBA), also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented ...
EIPA hydrochloride
T11172
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
GSK3395879
T15439
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
Englerin A
T38484
Englerin A, a TRPC4 and TRPC5 channel agonist, is a compound from the East African plant Phyllanthus engleri with analgesic, anti-inflammatory, and anticancer ac...
Dihydromorin
TN1583
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
GSK2798745
T15434
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
JYL 1421
T15634
JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).
TRPV4 agonist-1
T13214
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
TRPA1 Antagonist 1
T13212
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
AM12
T13546
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
TRPV3 antagonist 74a
T37429
TRPV3 antagonist 74a (TRPV3 74a) is a specific TRPV3 antagonist for the study of neurological disorders.
A-1165442
T14067
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
Caffeic Acid
T2807
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
ML204
T2298
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
AS1269574
T21623
AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.
MDR-652
T22360
MDR-652 is a highly specific and efficacious agonist of nonpungent transient receptor potential vanilloid 1 (TRPV1) with Ki value of 11.4 nM and 23.8 nM for hTRP...
JNJ-17203212
T7526
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
Pellitorine
T21165
Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.
Vocacapsaicin hydrochloride
T39349
Vocacapsaicin hydrochloride (CA-008 hydrochloride) is a non-opioid TRPV1 agonist, a raw material for capsaicin, and is used for pain relief.
Linopirdine
T15758
Linopirdine (DuP 996) is a TRPV1 agonist. Linopirdine is an orally active and selective M-type K+ current (IM; Kv7; KCNQ Channels) inhibitor (IC50: 2.4 μM). Lino...
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TargetMol