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TRP/TRPV Channel

TRPV is a family of transient receptor potential cation channels (TRP channels) in animals. All TRPVs are highly calcium selective. TRP channels are a large group of ion channels consisting of six protein families, located mostly on the plasma membrane of numerous human and animal cell types, and in some fungi.
Cat. No. Product name CAS No. Purity Chemical Structure
T29968 AMG-0347 946615-43-6 98%
AMG-0347 is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in ...
T70540 Pinokalant 149759-26-2 98%
Pinokalant is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabo...
T41233 Cis-22a 1819366-84-1 98%
Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative ...
T14087 ABT-239 460746-46-7 98%
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist. Its a transient receptor potential vanilloid type 1 (TRPV1) antagonist.
T5786 TETRAHYDROPIPERINE 23434-88-0 98%
TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
T61275 TRPM4-IN-2 667411-04-3 98%
TRPM4-IN-2, also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an ...
T11172 EIPA hydrochloride 1345839-28-2 98%
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
T15439 GSK3395879 2215852-91-6 98%
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
T37697L D-GsMTx4 TFA 98%
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to th...
TN1583 Dihydromorin 18422-83-8 98%
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
T15434 GSK2798745 1419609-94-1 98%
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
T15634 JYL 1421 401907-26-4 98%
JYL 1421 is an antagonist of TRPV1 receptor (IC50 = 8 nM).
TN2429 Capsiate 205687-01-0 98%
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
T13214 TRPV4 agonist-1 2314467-60-0 98%
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
T13212 TRPA1 Antagonist 1 1984825-08-2 98%
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
T13546 AM12 2387510-84-9 98%
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
T14067 A-1165442 1221443-94-2 98%
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
T2807 Caffeic Acid 331-39-5 98%
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
T2298 ML204 5465-86-1 98%
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
T21623 AS1269574 330981-72-1 98%
AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
AMG-0347
T29968
AMG-0347 is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in ...
Pinokalant
T70540
Pinokalant is a novel non-selective cation channel inhibitor.Pinokalant significantly reduces cortical infarct volume in in vivo experiments, improves the metabo...
Cis-22a
T41233
Cis-22a is a TRPV6 inhibitor (IC50 = 0.32 μM), which exhibits selectivity against related TRPV channels and calcium channels. cis-22a displays antiproliferative ...
ABT-239
T14087
ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist. Its a transient receptor potential vanilloid type 1 (TRPV1) antagonist.
TETRAHYDROPIPERINE
T5786
TETRAHYDROPIPERINE is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
TRPM4-IN-2
T61275
TRPM4-IN-2, also known as NBA, is a highly effective inhibitor of transient receptor potential melastatin 4 (TRPM4). Its inhibitory potency is represented by an ...
EIPA hydrochloride
T11172
EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 ...
GSK3395879
T15439
GSK3395879 is a selective and orally bioavailable antagonist of transient receptor potential vanilloid-4 (TRPV4) (IC50: 1 nM for hTRPV4).
D-GsMTx4 TFA
T37697L
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1/6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to th...
Dihydromorin
TN1583
trans-Dihydromorin is an effective hypopigmenting agent in normal skin cells, hypopigmenting agents effective in melanoma system may not be effective on normal m...
GSK2798745
T15434
GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in ...
JYL 1421
T15634
JYL 1421 is an antagonist of TRPV1 receptor (IC50 = 8 nM).
Capsiate
TN2429
Capsiate is an orally active TRPV1 agonist, a non-irritating capsaicin analog that acts as an antiallergic agent with anti-inflammatory, antioxidant, hypoglycemi...
TRPV4 agonist-1
T13214
TRPV4 agonist-1 is an agonist of TRPV4 (EC50: 60 nM in the hTRPV4 Ca2+ assay).
TRPA1 Antagonist 1
T13212
TRPA1 Antagonist 1 is an antagonist of TRPA1(IC50: 8 nM) and is a methylene phosphate prodrug which converts to its active parent drug.
AM12
T13546
AM12 inhibits Lanthanide-evoked TRPC5 activity (IC50: 0.28 μM).
A-1165442
T14067
A-1165442 is a competitive TRPV1 antagonist. For human TRPV, the IC50 values is 9 nM.
Caffeic Acid
T2807
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
ML204
T2298
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
AS1269574
T21623
AS 1269574 is a potent, orally available GPR119 agonist. AS1269574 has the potential for the research of type 2 diabetes.
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