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PI3K/Akt/mTOR signaling PI3K

PI3K

Phosphoinositide 3-kinases (PI3Ks), also called phosphatidylinositol 3-kinases, are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer.PI3Ks are a family of related intracellular signal transducer enzymes capable of phosphorylating the 3 position hydroxyl group of the inositol ring of phosphatidylinositol (PtdIns). The pathway, with oncogene PIK3CA and tumor suppressor PTEN, is implicated in the sensitivity of cancer tumors to insulin and IGF1, and in calorie restriction.
Cat No. product name
T6143 PI103HOT PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
T1827 BuparlisibHOT Buparlisib is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).
T2008 LY294002HOT LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
T1056 Isoprenaline hydrochlorideHOT Isoproterenol is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
T1879 3-MethyladenineHOT 3-Methyladenine (3-MA) is a selective PI3KV inhibitor, and the IC50s against ps34 and PI3Kγ were 25/60 μM in HeLa cells, respectively.
T1894 IdelalisibHOT Idelalisib is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/γ.
T2414 TorkinibHOT Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
T1994 PictilisibHOT Pictilisib (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).
T1921 AlpelisibHOT Alpelisib is an orally bioavailable PI3Kα inhibitor (IC50: 5 nM in a cell-free assay) with potential antineoplastic activity and minimal effect on PI3Kβ/γ/δ....
T2235 DactolisibHOT Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
T6072L BGT226 free base Bgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
T2672 TG100-115 TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.
T3348 PIK293 PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
T6557 KU0060648 KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC5...
T2682 Acalisib Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ.
T2461 PIK90 PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
T2616 PIK93 PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T2661 TGX221 TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.
T2248 AS605240 AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).
T6394 AS604850 AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3K...
T2685 KU55933 KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
T2018 Apilimod Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
T0579 Myricetin Myricetin is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source...
T6817 Deguelin Deguelin is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
T2836 Isorhamnetin Isorhamnetin is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents end...
T6168 ZSTK474 PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplasti...
T2287 PIK-75 hydrochloride PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibi...
T2667 PIK75 PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
T2297 PIK294 PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).
T7014 Voxtalisib Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
T6208 AS252424 AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.
T4398 LX2343 LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX...
T5736 CYNARIN CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
T5432 IPI-549 IPI-549 is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)
T5166 Leniolisib Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
T4958 Alkannin Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used fo...
T4976 TGR1202 TGR-1202 is a PI3Kδ inhibitor.
T5S0896 Loureirin A Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced p...
T2P2919 (4S)-4-Hydroxy-L-isoleucine 4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimula...
T6283 Wortmannin Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
T4079 LY-294002 hydrochloride LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a...
T4296 MTX211 MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.
T6704 TG100713 TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
T4219 Autophinib Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamy...
T4220 BQR695 BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
T4199 Desmethyl-VS-5584 Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
T3410 Momordin Ic Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAP...
T3556 NIH12848 NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.
T2357 GSK1059615 GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.
T2377 XL147 analogue XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
T2083 PI3065 PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
T6319 OSI027 OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3...
T2365 Pilaralisib Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials...
T6110 YM201636 YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.
T2660 IC87114 IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).
T3190 PIK-inhibitors PIK-inhibitors is a pan PI3K inhibitors, an analog of PI-103.
T6087 AZD6482 AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
T2265 PI3K-IN-2 PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase i...
T1838 INK 128 INK 128 is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activi...
T6045 Torin 1 Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
T6433 CAY10505 CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).
T6510 GDC0349 GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1....
T1988 Duvelisib Duvelisib is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) wit...
T1970 Gedatolisib Gedatolisib is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.
T3986 SF2523 SF2523 is a highly selective and potent inhibitor.
T2174 Quercetin Quercetin, a natural flavonoid present in vegetables, fruit, and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor.
T2418 A66 A66 is a specific and effective p110α inhibitor(IC50=32 nM).
T3351 CC223 CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
T1949 CZC24832 CZC24832 is a selective inhibitor of PI 3-kinase γ.
T1861 Omipalisib GSK2126458 is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.
T6731 WYE354 WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selec...
T6732 WYE687 WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(...
T6730 WAY600 WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
T1916 Apitolisib Apitolisib, an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in tr...
T3692 GNE 477 GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.
T6322 Copanlisib Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathw...
T6251 PF04691502 PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
T1961 Vistusertib AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
T3541 CC115 CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
T2061 APY0201 APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (P...
T6330 PI3Kδ-IN-2 PI3Kδ-IN-2 is a potent and selective inhibitor of PI3Kδ
T1826 Voxtalisib Analogue Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
T6773 AZD8186 AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).
T6774 AZD8835 AZD8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).
T6757 AMG319 AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
T2433 NU7026 NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR....
T6845 GNE317 GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
T6883 LY3023414 LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
T6945 PIK-III PIK-III, a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.
T7015 VPS34-IN1 Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as cl...
T3705 GDC0084 GDC-0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) si...
T2073 GSK2636771 GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advan...
T2084 ETP46464 ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
T6072 BGT226 BGT226 (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
T2078 PI3K/HDAC Inhibitor CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineop...
T3985 GDC0326 GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).
T1999 Taselisib Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity....
T6938 PF4989216 PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectivel...
T2308 HS173 HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).
T2256 CNX1351 CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
T3153 Serabelisib MLN1117 (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).
T6850 GSK2292767 GSK2292767 is a potent and selective PI3Kδ inhibitor.
T6030 XL388 XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
T6103 VS5584 VS-5584 is a pan-PI3K/mTOR kinase inhibitor.
T5831 Selective PI3Kδ Inhibitor 1 Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).
T6799 IITZ-01 IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
T28297 Parsaclisib HCl Parsaclisib HCl is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
T15431 Nemiralisib Nemiralisib is a potent and highly selective inhibitor of PI3Kδ (pKi: 9.9).
T16841 SAR-260301 SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).
T11818 LAS191954 LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).
T16567 PQR-530 PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phospho...
T16530 BF738735 BF738735 is an inhibitor of phosphatidylinositol 4-kinase III beta (IC50: 5.7 nM).
T16355 NSC781406 NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).
T15800 LY117018 LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.
T15789 LTURM34 LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
T13389 ZD-0892 ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectivel...
T13973 (Z)-GW 5074 (Z)-GW 5074 interacts with both mHTT (mutant huntingtin protein) and LC3.
T15592 IPI-3063 IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
T10804 CHMFL-PI3KD-317 CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3Kδ inhibitor (IC50: 6 nM) with the antiproliferative effects on cancer cells. It inhibits PI...
T16908 Sonolisib Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).
T13311 Vps34-IN-2 Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).
T11610 Idelalisib D5 Idelalisib D5 is a deuterium-labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor.
T10660L2 CAL-130 Racemate CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T10660L CAL-130 Hydrochloride CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T10660 CAL-130 CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
T11381 Pictilisib dimethanesulfonate Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
T11129 Duvelisib R enantiomer Duvelisib R enantiomer is an enantiomer with low activity of Duvelisib and is an inhibitor of PI3K.
T13140 Umbralisib R-enantiomer Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is an inhibitor of PI3Kδ, which is the less active enantiomer of TGR-1202.
T13119 Tenalisib Tenalisib (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)
T15420 GS-9901 GS-9901 is a highly selective and orally active inhibitor of PI3Kδ (IC50: 1 nM). It also has the potential to treat rheumatoid arthritis.
T12831L SAR405 SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. ...
T17066 Umbralisib hydrochloride Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε ...
T14998 Copanlisib dihydrochloride Copanlisib dihydrochloride is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Cop...
TN4213 Hirsutenone Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
T28416 PIK-108 PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
T21938 AS-041164 AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, ...
TQ0003L 740 Y-P(TFA)(1236188-16-1 free base) 740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.
TQ0003L 740 Y-P(TFA)(1236188-16-1 free base) 740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.
T21992 Vacuolin-1 Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin...
T8651 CAL-101 CAL-101 is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, a...
TN5201 Uncarinic acid E Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
TN5050 Sprengerinin C Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
TN4652 Niazimicin Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
TN4263 Isoangustone A Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN4046 Excisanin A ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
T2S0606 Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TMA2474 Delta-Tocotrienol Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
TMA0291 Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN3806 Dehydroglyasperin C Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
TN3753 Dalbergioidin Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN3691 Communic acid Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
TN3655 Cimiside E Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
TN3218 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one 7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and ma...
T3229 Cytochalasin D Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
T2S1975 Ponicidin Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
T2S1040 Jolkinolide B Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
T15375 GDC-0077 GDC-0077 is an orally available and selective inhibitor of PI3Kα (IC50: 0.038 nM). GDC-0077 is more selective for mutant versus wild-type PI3Kα. It exerts its ...
T14944 CGS 15943 CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Rec...
T7166 GNE-493 GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for ...
TN1347 8-Prenylkaempferol 8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
TN2019 Orobol Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DDP...
TN1819 Kaempferol 3-neohesperidoside Kaempferol 3-neohesperidoside is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.
TN1805 Isosilybin B Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway, it has anti-prostate cancer (PCA) activit...
TN1711 Gossypetin Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-r...
TN1594 DL-Syringaresinol (+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml.
TN1504 Citreorosein Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
TN1461 (-)-Butin (-)-Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates...
TN1459 Bufarenogin Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.
TN1376 Alpha-Solanine Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
TN1367 Alismol Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for ...
TN1153 Polyporenic acid C Polyporenic acid C shows inhibitory activity against human collagenase.
TN2328 Zeylenone Zeylenone has good antitumor efficacy, it inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Zeyle...
TN1034 Sennidin B Sennidin B stimulates glucose incorporation in rat adipocytes.
TN1033 Sennidin A Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
T7944 VPS34 inhibitor 1 (Compound 19, PIK-III analogue) VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)
T7879 TASP0415914 TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
TQ0313 NVP-BAG956 NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).
TQ0229 ETP-46321 ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).
TQ0044 Seletalisib Seletalisib (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).
TQ0009 UCB9608 UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.
TQ0003 740 Y-P 740 Y-P is a potent and cell-permeable activator of PI3K.
T7343 PF-04979064 PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
TN2259 Taurocholic acid Taurocholic acid feeding shows cytoprotective effects on the biliary tree after adrenergic denervation of the liver; taurocholic acid feeding prevents tumor necr...
T12115 MSC2360844 MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).
T13862 Recilisib Recilisib is a radioprotectant,can activate AKT, PI3K activities in cells.
T12464 PI3Kγ inhibitor 1 PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.
T12589 PI3Kα/mTOR-IN-1 PI3Kα/mTOR-IN-1 is a potent dual inhibitor PI3Kα/mTOR(an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell ...
T14552 Dactolisib Tosylate Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisi...
T14511 BAY1082439 BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY108243...
T14214 AMG 511 AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits an...
T8461 SKI V SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induc...
T12469 PI4KIIIbeta-IN-9 PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .
T12468 PI4KIIIbeta-IN-10 PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).
T12467 PI4KIII beta inhibitor 3 PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
T12466 AZD3458 AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).
T12465 PI3Kγ inhibitor 2 PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).
T12463 PI3kδ inhibitor 1 PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).
T12275 NVP-QAV-572 NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).
T12462 PI3Kδ-IN-1 PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).
T12461 PI3Kdelta inhibitor 1 PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.
T12460 PI3K/mTOR Inhibitor-1 PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)
T12459 PI3K/mTOR Inhibitor-2 PI3K/mTOR Inhibitor-2 is a potent dual inhibitor of pan-PI3K/mTOR(PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 3.4/34/16/1/4.7 nM).
T12458 PI3K-IN-9 PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).
T12457 PI3K-IN-6 PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).
T12456 PI3K-IN-10 PI3K-IN-10 is a potent inhibitor of pan-PI3K .
T12455 PI3K/HDAC-IN-1 PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
T12367 Parsaclisib Parsaclisib is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
T12365 PARP/PI3K-IN-1 PARP/PI3K-IN-1 is a potent inhibitor of PARP/PI3K(pIC50 values of 8.22).
T12310 ON 146040 ON 146040 is a potent inhibitor of PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) .
T2619 CH5132799 CH5132799 has been used in trials studying the treatment of Solid Tumors.
PI103 HOT
T6143CAS 371935-74-9
PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).
Buparlisib HOT
T1827CAS 944396-07-0
Buparlisib is an orally bioavailable specific oral inhibitor of the pan-class I PI3K (IC50s: 52/166/116/nM for p110α, p110β, and p110δ).
LY294002 HOT
T2008CAS 154447-36-6
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
Isoprenaline hydrochloride HOT
T1056CAS 51-30-9
Isoproterenol is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.
3-Methyladenine HOT
T1879CAS 5142-23-4
3-Methyladenine (3-MA) is a selective PI3KV inhibitor, and the IC50s against ps34 and PI3Kγ were 25/60 μM in HeLa cells, respectively.
Idelalisib HOT
T1894CAS 870281-82-6
Idelalisib is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM). The selectivity for p110δ is 40- to 300-fold than p110α/β/γ.
Torkinib HOT
T2414CAS 1092351-67-1
Torkinib (PP 242) is a selective and ATP-competitive mTOR inhibitor (IC50: 8 nM). It also inhibits mTORC1/2 (IC50s: 30/58 nM).
Pictilisib HOT
T1994CAS 957054-30-7
Pictilisib (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).
Alpelisib HOT
T1921CAS 1217486-61-7
Alpelisib is an orally bioavailable PI3Kα inhibitor (IC50: 5 nM in a cell-free assay) with potential antineoplastic activity and minimal effect on PI3Kβ/γ/δ....
Dactolisib HOT
T2235CAS 915019-65-7
Dactolisib is an orally bioavailable inhibitor of PI3K and mTOR (IC50s: 4 nM/5 nM/7 nM/75 nM, and 20.7 nM for p110α/p110γ/p110δ/p110β and mTOR).
BGT226 free base
T6072LCAS 915020-55-2
Bgt226 is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.
TG100-115
T2672CAS 677297-51-7
TG100-115 is a PI3Kγ/δ inhibitor (IC50: 83/235 nM), with fewer effects on PI3Kα/β.
PIK293
T3348CAS 900185-01-5
PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.
KU0060648
T6557CAS 881375-00-4
KU-0060648 is a dual inhibitor of DNA-PK and PI3Kα, PI3Kβ, PI3Kδ with IC50 of 8.6 nM and 4 nM, 0.5 nM, 0.1 nM respectively, less inhibition of PI3Kγ with IC5...
Acalisib
T2682CAS 870281-34-8
Acalisib (GS-9820) is a potent and selective inhibitor of PI3Kδ.
PIK90
T2461CAS 677338-12-4
PIK-90, a DNA-PK and PI3K inhibitor, suppresses p110α( IC50=11 nM), p110γ(IC50=18 nM) and DNA-PK(IC50=13 nM) .
PIK93
T2616CAS 593960-11-3
PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
TGX221
T2661CAS 663619-89-4
TGX-221, an effective, specific, and cell membrane permeable inhibitor of the PI3K p110β catalytic subunit, is utilized for cancer treatment.
AS605240
T2248CAS 648450-29-7
AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).
AS604850
T6394CAS 648449-76-7
AS-604850 is a specific and ATP-competitive PI3Kγ inhibitor (IC50: 250 nM), 18-fold more selective for PI3Kγ than PI3Kα, and over 80-fold selectivity for PI3K...
KU55933
T2685CAS 587871-26-9
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
Apilimod
T2018CAS 541550-19-0
Apilimod inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
Myricetin
T0579CAS 529-44-2
Myricetin is a naturally-occurring flavonoid found in many grapes, berries, fruits, vegetables, herbs, as well as other plants. Walnuts are a rich dietary source...
Deguelin
T6817CAS 522-17-8
Deguelin is a PI3K/AKT Inhibitor, which is a natural product isolated from plants in the Mundulea sericea family.
Isorhamnetin
T2836CAS 480-19-3
Isorhamnetin is the methylated metabolite of quercetin. Quercetin is an important dietary flavonoid with in vitro antioxidant activity. Isorhamnetin prevents end...
ZSTK474
T6168CAS 475110-96-4
PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplasti...
PIK-75 hydrochloride
T2287CAS 372196-77-5
PIK-75 Hydrochloride is a p110α inhibitor with IC50 of 5.8 nM (200-fold more potently than p110β), isoform-specific mutants at Ser773, and also potently inhibi...
PIK75
T2667CAS 372196-67-3
PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).
PIK294
T2297CAS 900185-02-6
PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).
Voxtalisib
T7014CAS 934493-76-2
Voxtalisib (SAR245409, XL765) is a dual inhibitor of mTOR/PI3K, mostly for p110γ with IC50 of 9 nM; also inhibits DNA-PK and mTOR. Phase 1/2.
AS252424
T6208CAS 900515-16-4
AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.
LX2343
T4398CAS 333745-53-2
LX2343 is a BACE1 enzyme inhibitor with an IC50 value of 11.43±0.36 μM. LX2343 acts as a non-ATP competitive PI3K inhibitor with an IC50 of 15.99±3.23 μM. LX...
CYNARIN
T5736CAS 19870-46-3
CYNARIN is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.
IPI-549
T5432CAS 1693758-51-8
IPI-549 is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)
Leniolisib
T5166CAS 1354690-24-6
Leniolisib (CDZ173) is a potent and selective PI3Kδ inhibitor (IC50: 11 nM).
Alkannin
T4958CAS 517-88-4
Shikonin is a natural red naphthoquinone pigment, has antimicrobial, anti-tumor, and anti-inflammatory effects; a purified shikonin preparation is widely used fo...
TGR1202
T4976CAS 1532533-67-7
TGR-1202 is a PI3Kδ inhibitor.
Loureirin A
T5S0896CAS 119425-89-7
Loureirin A has an inhibitory effect on platelet activation, perhaps through an impairment of PI3K/Akt signaling.Loureirin A negatively affects agonist-induced p...
(4S)-4-Hydroxy-L-isoleucine
T2P2919CAS 55399-93-4
4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimula...
Wortmannin
T6283CAS 19545-26-7
Wortmannin is the first described PI3K inhibitor with IC50 of 3 nM, with little selectivity within the PI3K family. Also blocks autophagosome formation and poten...
LY-294002 hydrochloride
T4079CAS 934389-88-5
LY294002 is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a...
MTX211
T4296CAS 1952236-05-3
MTX-211, an inhibitor of EGFR and PI3K, is used for the therapy of cancer and other diseases.
TG100713
T6704CAS 925705-73-3
TG100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively.
Autophinib
T4219CAS 1644443-47-9
Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40 nM for autophagy in starvation induced autophagy assay and rapamy...
BQR695
T4220CAS 1513879-21-4
BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.
Desmethyl-VS-5584
T4199CAS 1246535-95-4
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer.
Momordin Ic
T3410CAS 96990-18-0
Momordin Ic might represent a potential anticancer activity, by inducing apoptosis through oxidative stress-regulated mitochondrial dysfunction involving the MAP...
NIH12848
T3556CAS 959551-10-1
NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.
GSK1059615
T2357CAS 958852-01-2
GSK1059615 has been used in trials studying the treatment of Lymphoma, Solid Tumours, Endometrial Cancer, Solid Tumor Cancer, and Metastatic Breast Cancer.
XL147 analogue
T2377CAS 956958-53-5
XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3Kα/δ/γ.
PI3065
T2083CAS 955977-50-1
PI-3065 is a novel potent and selective PI3K p110δ inhibitor.
OSI027
T6319CAS 936890-98-1
OSI-027 is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, and more than 100-fold selectivity observed for mTOR than PI3...
Pilaralisib
T2365CAS 934526-89-3
Pilaralisib is an orally available small molecule that selectively inhibits the activity of phosphoinositide-3 kinase (PI3K). Pilaralisib has been used in trials...
YM201636
T6110CAS 371942-69-7
YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.
IC87114
T2660CAS 371242-69-2
IC-87114 is a specific PI3Kδ inhibitor(IC50=0.5 μM).
PIK-inhibitors
T3190CAS 371934-59-7
PIK-inhibitors is a pan PI3K inhibitors, an analog of PI-103.
AZD6482
T6087CAS 1173900-33-8
AZD 6482 is a potent and selective p110β inhibitor with IC50 of 0.69 nM and a PI3Kβ inhibitor with IC50 of 10 nM.
PI3K-IN-2
T2265CAS 1225037-39-7
PI3K-IN-2 is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase i...
INK 128
T1838CAS 1224844-38-5
INK 128 is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activi...
Torin 1
T6045CAS 1222998-36-8
Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
CAY10505
T6433CAS 1218777-13-9
CAY10505, a form of dehydroxyl of AS-252424, is a PI3Kγ inhibitor (IC50: 33 nM).
GDC0349
T6510CAS 1207360-89-1
GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1....
Duvelisib
T1988CAS 1201438-56-3
Duvelisib is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) wit...
Gedatolisib
T1970CAS 1197160-78-3
Gedatolisib is a highly effective dual inhibitor targeting the PI3Kα/γ (IC50: 0.4/5.4 nM)and mTOR (IC50: 1.6 nM) in the PI3K/mTOR signaling pathway.
SF2523
T3986CAS 1174428-47-7
SF2523 is a highly selective and potent inhibitor.
Quercetin
T2174CAS 117-39-5
Quercetin, a natural flavonoid present in vegetables, fruit, and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor.
A66
T2418CAS 1166227-08-2
A66 is a specific and effective p110α inhibitor(IC50=32 nM).
CC223
T3351CAS 1228013-30-6
CC-223 is an orally available mTOR inhibitor with potential antitumor activity. CC-223 inhibits the activity of mTOR, which may result in the induction of tumor ...
CZC24832
T1949CAS 1159824-67-5
CZC24832 is a selective inhibitor of PI 3-kinase γ.
Omipalisib
T1861CAS 1086062-66-9
GSK2126458 is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.
WYE354
T6731CAS 1062169-56-5
WYE-354(IC50=5 nM) is an effective, selective and ATP-competitive mTOR inhibitor. It blocks mTORC2/P-AKT(S473) and mTORC1/P-S6K(T389), not P-AKT(T308). The selec...
WYE687
T6732CAS 1062161-90-3
WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(...
WAY600
T6730CAS 1062159-35-6
WAY-600 is a potent, ATP-competitive and selective inhibitor of mTOR with IC50 of 9 nM; blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) but not P-AKT(T308); sel...
Apitolisib
T1916CAS 1032754-93-0
Apitolisib, an effective, class I PI3K inhibitor for PI3Kα(IC50=5 nM), PI3Kβ(IC50=27 nM), PI3Kδ(IC50=7 nM), PI3Kγ (IC50=14 nM), is used in tr...
GNE 477
T3692CAS 1032754-81-6
GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.
Copanlisib
T6322CAS 1032568-63-0
Copanlisib is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity. Copanlisib inhibits the activation of the PI3K signaling pathw...
PF04691502
T6251CAS 1013101-36-4
PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.
Vistusertib
T1961CAS 1009298-59-2
AZD2014 is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
CC115
T3541CAS 1228013-15-7
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
APY0201
T2061CAS 1232221-74-7
APY0201 is a effective, highly specific, ATP-competitive PIKfyve inhibitor (IC50: 5.2 nM). It can interrupt the conversion of phosphatidylinositol 3-phosphate (P...
PI3Kδ-IN-2
T6330CAS 1702816-75-8
PI3Kδ-IN-2 is a potent and selective inhibitor of PI3Kδ
Voxtalisib Analogue
T1826CAS 1349796-36-6
Voxtalisib (SAR245409, XL765)Analogue is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.
AZD8186
T6773CAS 1627494-13-6
AZD8186 is an effective and specific PI3Kβ/δ inhibitor (IC50: 4/12 nM).
AZD8835
T6774CAS 1620576-64-8
AZD8835 is a mixed inhibitor of PI3Kα/δ (IC50: 6.2/5.7 nM), also with selectivity against PI3Kβ/γ (IC50: 431/90 nM).
AMG319
T6757CAS 1608125-21-8
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
NU7026
T2433CAS 154447-35-5
NU7026 is an effective DNA-PK inhibitor (IC50: 0.23 μM, in cell-free assays), 60-fold selective for DNA-PK than PI3K and no inhibition against both ATM and ATR....
GNE317
T6845CAS 1394076-92-6
GNE-317, a PI3K/mTOR inhibitor, can pass through the blood-brain barrier (BBB).
LY3023414
T6883CAS 1386874-06-1
LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, DNA-PK, and mTOR. LY3023414 has been used in trials studying the treatment of Neopla...
PIK-III
T6945CAS 1383716-40-2
PIK-III, a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates.
VPS34-IN1
T7015CAS 1383716-33-3
Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro, which does not significantly inhibit the isoforms of class I as well as cl...
GDC0084
T3705CAS 1382979-44-3
GDC-0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity. GDC-0084 specifically inhibits PI3K in the PI3K/AKT kinase (or protein kinase B) si...
GSK2636771
T2073CAS 1372540-25-4
GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advan...
ETP46464
T2084CAS 1345675-02-6
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM).
BGT226
T6072CAS 1245537-68-1
BGT226 (NVP-BGT226) is a class I PI3K/mTOR inhibitor for PI3Kα/β/γ (IC50: 4/63/38 nM) .
PI3K/HDAC Inhibitor
T2078CAS 1339928-25-4
CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineop...
GDC0326
T3985CAS 1282514-88-8
GDC-0326 is a potent and selective inhibitor of α-Isoform of Phosphoinositide 3-Kinase (PI3Kalpha inhibitor).
Taselisib
T1999CAS 1282512-48-4
Taselisib is an orally bioavailable inhibitor of the class I phosphatidylinositol 3-kinase (PI3K) alpha isoform (PIK3CA), with potential antineoplastic activity....
PF4989216
T6938CAS 1276553-09-3
PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectivel...
HS173
T2308CAS 1276110-06-5
HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).
CNX1351
T2256CAS 1276105-89-5
CNX-1351 is a potent and isoform-selective targeted covalent PI3Kα inhibitor.
Serabelisib
T3153CAS 1268454-23-4
MLN1117 (INK1117) is a p110α/β/γ/δ inhibitor (IC50: 15/4.5/1.9/13.39 μM).
GSK2292767
T6850CAS 1254036-66-2
GSK2292767 is a potent and selective PI3Kδ inhibitor.
XL388
T6030CAS 1251156-08-7
XL388 is a highly effective, specifc, ATP-competitive inhibitor of mTOR ( IC50: 9.9 nM), 1000-fold selectivity than the closely related PI3K kinases.
VS5584
T6103CAS 1246560-33-7
VS-5584 is a pan-PI3K/mTOR kinase inhibitor.
Selective PI3Kδ Inhibitor 1
T5831CAS 2088525-31-7
Selective PI3Kδ Inhibitor 1 is a PI3Kδ Inhibitor( IC50 = 0.9 nM).
IITZ-01
T6799CAS 1807988-47-1
IITZ-01 is potent autophagy inhibitor with single-agent anticancer activity ( IC50 of 2.62 μM for PI3Kγ.)
Parsaclisib HCl
T28297CAS 1995889-48-9
Parsaclisib HCl is a selectve PI3Kδ inhibitor with antitumor activity. Parsaclisib demonstrates potent activity with IC50 values ranging from 0.2 to 2 nM.
Nemiralisib
T15431CAS 1254036-71-9
Nemiralisib is a potent and highly selective inhibitor of PI3Kδ (pKi: 9.9).
SAR-260301
T16841CAS 1260612-13-2
SAR-260301 is an orally available and selective inhibitor of PI3Kβ (IC50: 23 nM).
LAS191954
T11818CAS 1403947-26-1
LAS191954 is a selective, potent and orally active PI3Kδ inhibitor for inflammatory diseases treatment(IC50 : 2.6 nM).
PQR-530
T16567CAS 1927857-61-1
PQR530 is a highly potent dual pan-PI3K/mTORC1/2 inhibitor. PQR530 inhibited protein kinase B (PKB, pSer473) and ribosomal protein S6 (pS6, pSer235/236) phospho...
BF738735
T16530CAS 1436383-95-7
BF738735 is an inhibitor of phosphatidylinositol 4-kinase III beta (IC50: 5.7 nM).
NSC781406
T16355CAS 1676893-24-5
NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).
LY117018
T15800CAS 63676-25-5
LY117018 shows antiproliferative effects on breast cancer cell lines. LY117018 is a Raloxifene analog and is a selective estrogen receptor modulator.
LTURM34
T15789CAS 1879887-96-3
LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 17...
ZD-0892
T13389CAS 171964-73-1
ZD-0892 is a selective and poten neutrophil elastaset inhibitor(human neutrophil elastase and porcine pancreatic elastase with Kis of 6.7 and 200 nM, respectivel...
(Z)-GW 5074
T13973CAS 1233748-60-1
(Z)-GW 5074 interacts with both mHTT (mutant huntingtin protein) and LC3.
IPI-3063
T15592CAS 1425043-73-7
IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).
CHMFL-PI3KD-317
T10804CAS 2244992-76-3
CHMFL-PI3KD-317 is a highly potent, selective, and orally active PI3Kδ inhibitor (IC50: 6 nM) with the antiproliferative effects on cancer cells. It inhibits PI...
Sonolisib
T16908CAS 502632-66-8
Sonolisib is an irreversible and pan-isoform inhibitor of PI3K (IC50=0.1 nM (p110α), 1.0 nM (p120γ), 2.9 nM (p110δ)).
Vps34-IN-2
T13311CAS 1523404-29-6
Vps34-IN-2 is a potent and selective Vps34 inhibitor (IC50s: 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively).
Idelalisib D5
T11610CAS 1830330-31-8
Idelalisib D5 is a deuterium-labeled Idelalisib. Idelalisib is a highly selective and orally bioavailable p110δ inhibitor.
CAL-130 Racemate
T10660L2CAS 474012-90-3
CAL-130 Racemate is the racemate of CAL-130. CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
CAL-130 Hydrochloride
T10660LCAS 1431697-78-7
CAL-130 Hydrochloride is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
CAL-130
T10660CAS 1431697-74-3
CAL-130 is a PI3Kδ and PI3Kγ inhibitor (IC50s: 1.3 and 6.1 nM).
Pictilisib dimethanesulfonate
T11381CAS 957054-33-0
Pictilisib dimethanesulfonate is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
Duvelisib R enantiomer
T11129CAS 1261590-48-0
Duvelisib R enantiomer is an enantiomer with low activity of Duvelisib and is an inhibitor of PI3K.
Umbralisib R-enantiomer
T13140CAS 1532533-69-9
Umbralisib R-enantiomer (TGR-1202 R-enantiomer) is an inhibitor of PI3Kδ, which is the less active enantiomer of TGR-1202.
Tenalisib
T13119CAS 1639417-53-0
Tenalisib (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)
GS-9901
T15420CAS 1640247-87-5
GS-9901 is a highly selective and orally active inhibitor of PI3Kδ (IC50: 1 nM). It also has the potential to treat rheumatoid arthritis.
SAR405
T12831LCAS 1523406-39-4
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor (IC50:1.2 nM; Kd:1.5 nM) that prevents autophagy and synergizes with MTOR inhibition in tumor cells. ...
Umbralisib hydrochloride
T17066CAS 1532533-78-0
Umbralisib hydrochloride is a novel PI3Kδ inhibitor (IC50 and EC50 of 22.2 nM and 24.3 nM, respectively). Umbralisib hydrochloride is also active against CK1ε ...
Copanlisib dihydrochloride
T14998CAS 1402152-13-9
Copanlisib dihydrochloride is an ATP-competitive pan-class I PI3K inhibitor (IC50s: 0.5 nM, 0.7 nM, 3.7 nM and 6.4 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ). Cop...
Hirsutenone
TN4213CAS 41137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid pero...
PIK-108
T28416CAS 901398-68-3
PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).
AS-041164
T21938CAS 6318-41-8
AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, ...
740 Y-P(TFA)(1236188-16-1 free base)
TQ0003LCAS TQ0003L
740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.
740 Y-P(TFA)(1236188-16-1 free base)
TQ0003LCAS TQ0003L
740 Y-P(TFA) is a potent and cell-permeable activator of PI3K.
Vacuolin-1
T21992CAS 351986-85-1
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin...
CAL-101
T8651CAS 1146702-54-6
CAL-101 is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, a...
Uncarinic acid E
TN5201CAS 277751-61-8
Uncarinic acid E has anti-cancer activity, it induces apoptosis in HepG2 cells via accumulation of p53, alters the Bax/Bcl-2 ratio, and activates caspases, resul...
Sprengerinin C
TN5050CAS 88861-91-0
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
Niazimicin
TN4652CAS 147821-49-6
Niazimicin are NF-B and PI3K inhibitors, which shows antimicrobial, hypotensive and spasmolytic activities. Niazimicin has potent antitumor promoting activity in...
Isoangustone A
TN4263CAS 129280-34-8
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Excisanin A
TN4046CAS 78536-37-5
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a pote...
Bakkenolide A
T2S0606CAS 19906-72-0
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
Delta-Tocotrienol
TMA2474CAS 25612-59-3
Delta-tocotrienol is a potential angiogenic inhibitor, it (2.5-5 microM) can significantly suppress human colorectal adenocarcinoma cells (DLD-1-CM) -induced tub...
Dehydroglyasperin D
TMA0291CAS 517885-72-2
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Dehydroglyasperin C
TN3806CAS 199331-35-6
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemop...
Dalbergioidin
TN3753CAS 30368-42-4
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Communic acid
TN3691CAS 2761-77-5
Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic...
Cimiside E
TN3655CAS 154822-57-8
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one
TN3218CAS 100667-52-5
7-(4-Hydroxyphenyl)-1-phenyl-4-hepten-3-one as a beneficial compound to ameliorate the deleterious effects of Aβ on dendrite integrity and cell survival, and ma...
Cytochalasin D
T3229CAS 22144-77-0
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertiliz...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
Jolkinolide B
T2S1040CAS 37905-08-1
Jolkinolide B has potent anti-inflammatory, and antitumor activities, it is able to enhance apoptosis of human leukemic HL-60 and THP-1 cells, at least in part, ...
GDC-0077
T15375CAS 2060571-02-8
GDC-0077 is an orally available and selective inhibitor of PI3Kα (IC50: 0.038 nM). GDC-0077 is more selective for mutant versus wild-type PI3Kα. It exerts its ...
CGS 15943
T14944CAS 104615-18-1
CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor. In transfected CHO cells, its Ki for human A1, A2A, A2B, and A3 Adenosine Rec...
GNE-493
T7166CAS 1033735-94-2
GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for ...
8-Prenylkaempferol
TN1347CAS 28610-31-3
8-Prenylkaempferol is an effective agent for attenuating pro-inflammatory NO induction, it may be an anti-inflammatory agent for suppressing influenza A virus-in...
Orobol
TN2019CAS 480-23-9
Orobol is an inhibitor of tyrosine-specific protein kinase and phosphatidylinositol turnover, it has sensitization effect, it can produce produced cisplatin (DDP...
Kaempferol 3-neohesperidoside
TN1819CAS 32602-81-6
Kaempferol 3-neohesperidoside is a flavonoid. Kaempferol 3-neohesperidoside exhibits insulinomimetic effect on the rat soleus muscle.
Isosilybin B
TN1805CAS 142796-22-3
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway, it has anti-prostate cancer (PCA) activit...
Gossypetin
TN1711CAS 489-35-0
Gossypetin has anti-mutagenic, anti-atherosclerotic, antioxidant, as well as cytoprotective and antimicrobial effects, it inhibits bone resorption through down-r...
DL-Syringaresinol
TN1594CAS 1177-14-6
(+)-Syringaresinol shows inhibitory activity of Helicobacter pylori motility with the IC50 value is 50 microg/ml.
Citreorosein
TN1504CAS 481-73-2
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both...
(-)-Butin
TN1461CAS 492-14-8
(-)-Butin has antioxidant activity, can protect cells against H2O2-induced apoptosis, oxidative DNA damage and oxidative mitochondrial dysfunction; it attenuates...
Bufarenogin
TN1459CAS 17008-65-0
Bufarenogin has inhibitory activity on human kidney Na(+)/K(+)-ATPase, it has cytotoxicity against HepG2 and MCF-7 human cancer cells.
alpha-Solanine
TN1376CAS 20562-02-1
Alpha-Solanine alters antioxidative enzyme activities and MDA and PCO concentrations and GST activity in fat body and midgut.
Alismol
TN1367CAS 87827-55-2
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for ...
Polyporenic acid C
TN1153CAS 465-18-9
Polyporenic acid C shows inhibitory activity against human collagenase.
Zeylenone
TN2328CAS 193410-84-3
Zeylenone has good antitumor efficacy, it inhibits proliferation and induces apoptosis in cervical carcinoma cells via PI3K/AKT/mTOR and MAPK/ERK pathways. Zeyle...
Sennidin B
TN1034CAS 517-44-2
Sennidin B stimulates glucose incorporation in rat adipocytes.
Sennidin A
TN1033CAS 641-12-3
Sennidin A, has two hydroxyanthraquinone-like moieties, exerts inhibition on NS3 helicase with IC50 values of 0.8 μM.
VPS34 inhibitor 1 (Compound 19, PIK-III analogue)
T7944CAS 1383716-46-8
VPS34 inhibitor 1 (Compound 19, PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)
TASP0415914
T7879CAS 1292300-75-4
TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). T
NVP-BAG956
TQ0313CAS 853910-02-8
NVP-BAG956 is an ATP-competitive PI3K inhibitor (IC50s: 34/56/112/444 nM for PI3Kδ/PI3Kα/PI3Kγ/PI3Kβ).
ETP-46321
TQ0229CAS 1252594-99-2
ETP-46321 is an effective and orally bioavailable PI3Kα/PI3Kδ inhibitor (Ki: 2.3/14.2 nM).
Seletalisib
TQ0044CAS 1362850-20-1
Seletalisib (UCB5857) is a potent and specific PI3Kδ inhibitor (IC50: 12 nM).
UCB9608
TQ0009CAS 1616413-96-7
UCB9608 is a selective and orally active PI4KIIIβ inhibitor (IC50: 11 nM), selective over PI3KC2 α, β, and γ lipid kinases.
740 Y-P
TQ0003CAS 1236188-16-1
740 Y-P is a potent and cell-permeable activator of PI3K.
PF-04979064
T7343CAS 1220699-06-8
PF-04979064 is a potent and selective PI3K and mTOR dual kinase inhibitor(Ki of 0.13 nM and 1.42 nM,respectively).
Taurocholic acid
TN2259CAS 81-24-3
Taurocholic acid feeding shows cytoprotective effects on the biliary tree after adrenergic denervation of the liver; taurocholic acid feeding prevents tumor necr...
MSC2360844
T12115CAS 1305267-37-1
MSC2360844 is a potent, orally active and selective inhibitor of PI3Kδ(IC50 of 145 nM).
Recilisib
T13862CAS 334969-03-8
Recilisib is a radioprotectant,can activate AKT, PI3K activities in cells.
PI3Kγ inhibitor 1
T12464CAS 1172118-03-4
PI3Kγ inhibitor 1 is a inhibitor of PI3Kδ and PI3Kγ.
PI3Kα/mTOR-IN-1
T12589CAS 1013098-90-2
PI3Kα/mTOR-IN-1 is a potent dual inhibitor PI3Kα/mTOR(an IC50 of 7 nM for PI3Kα in a cell assay, and Kis of 10.6 nM and 12.5 nM for mTOR and PI3Kα in a cell ...
Dactolisib Tosylate
T14552CAS 1028385-32-1
Dactolisib Tosylate (BEZ235 Tosylate) is an inhibitor of dual PI3K and mTOR kinase(IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively). Dactolisi...
BAY1082439
T14511CAS 1375469-38-7
BAY1082439 is highly effective in inhibiting Pten-null prostate cancer growth[1][2] and it is an orally bioavailable, selective PI3Kα/β/δ inhibitor. BAY108243...
AMG 511
T14214CAS 1253573-53-3
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits an...
SKI V
T8461CAS 24418-86-8
SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM), induc...
PI4KIIIbeta-IN-9
T12469CAS 1429624-84-9
PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .
PI4KIIIbeta-IN-10
T12468CAS 1881233-39-1
PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).
PI4KIII beta inhibitor 3
T12467CAS 1245319-54-3
PI4KIII beta inhibitor 3 is a novel and high effective inhibitor of PI4KIIIβ (IC50 of 5.7 nM).
AZD3458
T12466CAS 2132961-46-5
AZD3458 is a potent and remarkably selective inhibitor of PI3Kγ (PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ with pIC50s of 9.1, 5.1, <4.5, and 6.5 , respectively).
PI3Kγ inhibitor 2
T12465CAS 1315538-79-4
PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).
PI3kδ inhibitor 1
T12463CAS 1332075-63-4
PI3kδ inhibitor 1 is a selective inhibitor of PI3Kδ (IC50 of 3.8 nM).
NVP-QAV-572
T12275CAS 957209-68-6
NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).
PI3Kδ-IN-1
T12462CAS 1911564-39-0
PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).
PI3Kdelta inhibitor 1
T12461CAS 2242109-74-4
PI3Kdelta inhibitor 1 is a potent, selective and orally available inhibitor of PI3Kδ with an IC50 of 1.3 nM.
PI3K/mTOR Inhibitor-1
T12460CAS 1949802-49-6
PI3K/mTOR Inhibitor-1 is a potent, orally bioavailable dual inhibitor of PI3K/mTOR (PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 20/376/204/46/186 nM)
PI3K/mTOR Inhibitor-2
T12459CAS 1848242-58-9
PI3K/mTOR Inhibitor-2 is a potent dual inhibitor of pan-PI3K/mTOR(PI3Kα/PI3Kβ/PI3Kδ/PI3Kγ/mTOR with IC50s of 3.4/34/16/1/4.7 nM).
PI3K-IN-9
T12458CAS 2360875-63-2
PI3K-IN-9 is a potent and selective inhibitor of PI3Kδ(IC50 of 8.9 nM).
PI3K-IN-6
T12457CAS 1842380-77-1
PI3K-IN-6 is an oral active and highly selective inhibitor of phosphoinositide 3-kinase (PI3K) β/δ(IC50 values of 7.8 nM/5.3 nM , respectively).
PI3K-IN-10
T12456CAS 2211922-64-2
PI3K-IN-10 is a potent inhibitor of pan-PI3K .
PI3K/HDAC-IN-1
T12455CAS 2361418-52-0
PI3K/HDAC-IN-1 is a potent PI3K and HDAC dual inhibitor(IC50s of 8.1 nM and 1.4 nM, respectively).
Parsaclisib
T12367CAS 1426698-88-5
Parsaclisib is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)
PARP/PI3K-IN-1
T12365CAS 2337386-47-5
PARP/PI3K-IN-1 is a potent inhibitor of PARP/PI3K(pIC50 values of 8.22).
ON 146040
T12310CAS 1404231-34-0
ON 146040 is a potent inhibitor of PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) .
CH5132799
T2619CAS 1007207-67-1
CH5132799 has been used in trials studying the treatment of Solid Tumors.