isoforms

Expression system: E. coli
Length: 2-160, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 27-191, Full Length of Mature Protein of Isoform VEGF165
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 311-426, Full Length of Mature Protein
Activity: Organoid Coculture、Cells

Expression system: E. coli
Length: 1-394, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-441, Full Length of Isoform Tau-F
Activity: ELISA

Expression system: E. coli
Length: 1-210, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-449, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-470, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-470, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 29-159, Full Length of Mature Protein
Activity: BLI、ELISA

Expression system: HEK293 Cells
Length: 29-193, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-182, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 22-170, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 22-231, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 33-205, Partial
Activity: Cell Activity

Expression system: HEK293 Cells
Length: 303-414, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 27-432, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 27-432, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-134, Extracellular Domain
Activity: Not Tested

Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating­ type receptor either has or associates non­covalently with an accessory subunit that has an immunoreceptor tyrosine­based activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG with high affinity and functions during early immune responses, whereas FcγRII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Three genes for human FcγRII (A, B, and C) and one for mouse (FcγRIIB), encoding type I transmembrane proteins with ITAM motifs (FcγRII A and C) or ITIM motifs (FcγRIIB) in their cytoplasmic domains, have been identified. Human CD32, also known as Low affinity immunoglobulin γ Fc region receptor II-a (IgG Fc receptor II-a), FcγRII A or FCGR2A Protein, is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. Associated with an ITAM-bearing adapter subunit, FcRγ, CD32a (FcγRII A) delivers an activating signal upon ligand binding, and results in the initiation of inflammatory responses including cytolysis, phagocytosis, degranulation, and cytokine production. The responses can be modulated by signals from the co-expressed inhibitory receptors such as Fcγ RII B, and the strength of the signal is dependent on the ratio of expression of the activating and inhibitory receptors.

Pro-neuregulin-1,Neuregulin-1 beta 1(NRG1) is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind β-Galactoside. LGALS14 is expressed intracellularly in placenta and eosinophils, and is released by eosinophils following allergen stimulation. LGALS14 may be involved in the development of allergic inflammation. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.

Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms (α, β, γ, and δ) with identical extracellular domains.

Expression system: E. coli
Length: 2-148, Full Length of Mature Protein
Activity: Not Tested