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Chromatin/Epigenetic HDAC

HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
Cat No. product name
T2383 PanobinostatHOT Panobinostat is a potent inhibitor of all HDACs (Kis: 0.6-31 nM for HDAC1-11).
T1762 RGFP 966HOT RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM.
T6233 EntinostatHOT Entinostat (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM).
T1583 VorinostatHOT Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
T2512 MocetinostatHOT Mocetinostat is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.
T2454 Dacinostat LAQ824 (Dacinostat) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.
T1852 Belinostat Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting...
T3753 Sinapinic Acid Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and ...
T3753 Sinapinic Acid Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and ...
T3206 PAOA An effective Histone Deacetylase Inhibitor.
T3204 BML210 BML-210 is a new-type HDAC inhibitor.
T6327 Tubacin Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
T3205 UF010 UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.
T1083 Theophylline Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
T9041 AES-350 AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzy...
T6980 Scriptaid Scriptaid is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.
T1083L Theophylline monohydrate Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
T2205 Theophylline-7-acetic acid Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
T3937 Methyl L-histidinate dihydrochloride Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production with activty value of 1.8 μM
T2025 Chidamide Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on ...
T6474 Divalproex Sodium Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentrat...
T0431 PCI24781 PCI-24781 (Abexinostat) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 4...
T3199 PTACH PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
T2023 MC1568 MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
T6055 Quisinostat Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and ...
T6865 Quisinostat 2HCl Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest pote...
T3878 Raddeanin A Raddeanin A has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.
T6270 Trichostatin A Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and spe...
T2157 Histone Deacetylase Inhibitor III M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
T6695 Tasquinimod Tasquinimod is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease bloo...
T2489 Rocilinostat Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.
T1983 CAY10603 CAY10603 is a potent and selective inhibitor of HDAC6.
T1602 Valproic acid sodium salt Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
T1888 CI994 Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.
T6639 RG2833 RG2833 (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
T3516 Minomustine EDO-S101 is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.
T1966 Tubastatin A Tubastatin A is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except...
T6006 Romidepsin Romidepsin is an intravenously administered histone deacetylase inhibitor and antineoplastic agent that is approved for use in refractory or relapsed cutaneous a...
T6161 Tubastatin A HCl Tubastatin A HCl is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).
T1857 TMP269 TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respective...
T3983 TMP 195 TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor.
T3661 Citarinostat ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Up...
T2294 BG45 BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
T2078 PI3K/HDAC Inhibitor CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineop...
T3509 ACY738 ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
T1819 Nexturastat A Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
T6061 LMK235 LMK-235 is a potent HDAC inhibitor, and is used in cancer research.
T2430 HPOB HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
T6421 BRD73954 BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
T2266 SantacruzaMate A Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor.
T1535 Sodium Phenylbutyrate Sodium Phenylbutyrate, a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expres...
T3358 ITSA1 ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.
T2140 Parthenolide (-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
T6362 4SC202 4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory a...
T1890 Pracinostat Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Da...
T21715 BRD6688 BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
T10883 CRA-026440 CRA-026440 is a potent, broad-spectrum HDAC inhibitor (Kis: 4, 14, 11, 15, 7, and 20 nM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10).
T14947 CHDI-390576 CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
T11329 FT895 FT895 is a selective and  potent selective HDAC11 inhibitor with an IC50 of 3 nM.
T10602 BRD 4354 ditrifluoroacetate (315698-07-8 free base) BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
T10603 BRD-6929 BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50:  1 and 8 nM).
T11542 HDAC-IN-4 HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
T11543 HDAC-IN-5 HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T11544 HDACs/mTOR Inhibitor 1 HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
T10777 CG347B CG347B is a selective inhibitor of HDAC6.
T15605 JAK/HDAC-IN-1 JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
T8480 Tenovin-6 Hydrochloride Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pote...
T8517 PXD-101 Belinostat is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
T11706 JAK1-IN-7 JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect.
T10602L BRD 4354 BRD 4354 is an inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM for HDAC5 and HDAC9).
T16153 MS4078 MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK.
T16288 Neuropathiazol Neuropathiazol is a synthetic small molecule. It also causes neuronal differentiation of adult hippocampal neural progenitor cells.
T16415 Oxamflatin Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
T16729 Remetinostat Remetinostat is a hydroxamic acid-based inhibitor of histone deacetylase enzymes. It is under development for the treatment of cutaneous T-cell lymphoma.
T16805 RTS-V5 RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
T16936 SS-208 SS-208 is a selective HDAC6 inhibitor (IC50: 12 nM). SS-208 has anti-tumor activity in melanoma.
T16962 SW-100 SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes....
T17028 Tefinostat Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1...
T2S0606 Bakkenolide A Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
TN4288 Isoferulic acid Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
T19687 Phenylethyl isothiocyanate Phenylethyl isothiocyanate is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.
T14936 CG-200745 CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
T10255 AES-135 AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
T6392 AR42 AR-42 is an HDAC inhibitor (IC50: 30 nM).
T5347 CXD-101 CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101 has no activity against HDAC class II
T3193 Pimelic diphenylamide 106 Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively),...
T6325 PCI34051 PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).
T6481 Droxinostat Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inh...
T4370 Resminostat hydrochloride Resminostat hydrochloride is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 ...
T4389 SR4370 SR-​4370 is an HDAC inhibitor. SR-​4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR-​4370 is reported i...
T4477 4SC-202 tosylate 4SC-202 is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethyla...
T7082 HDAC8-IN-1 MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cance...
T4481 Tucidinostat Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less...
T7064 Valproic Acid Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
T6279 Givinostat hydrochloride monohydrate Givinostat hydrochloride monohydrate is an HDAC inhibitor.
T5332 TH34 TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.
T5631 SIS17 SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 ...
T14305 Apicidin Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative ...
T5830 SKLB-23bb SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
T5886 Benzenebutyric acid Benzenebutyric acid is an inhibitor of HDAC,and is an antineoplastic agent.
T7385 WT-161 WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).
T7691 NSC 3852 NSC 3852 is a potent inhibitor of histone deacetylase.
T7664 Pyroxamide Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
TQ0074 ACY-775 ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
T8508 HDAC-IN-3 HDAC-IN-3 is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.
T8233 BRD3308 BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK.
T10244 ACY-1083 ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM). It is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-...
T10245 ACY-957 ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7...
T13996 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 a...
T3108 CUDC101 CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.
Panobinostat HOT
T2383CAS 404950-80-7
Panobinostat is a potent inhibitor of all HDACs (Kis: 0.6-31 nM for HDAC1-11).
RGFP 966 HOT
T1762CAS 1357389-11-7
RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM.
Entinostat HOT
T6233CAS 209783-80-2
Entinostat (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM).
Vorinostat HOT
T1583CAS 149647-78-9
Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
Mocetinostat HOT
T2512CAS 726169-73-9
Mocetinostat is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.
Dacinostat
T2454CAS 404951-53-7
LAQ824 (Dacinostat) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.
Belinostat
T1852CAS 414864-00-9
Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting...
Sinapinic Acid
T3753CAS 530-59-6
Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and ...
Sinapinic Acid
T3753CAS 530-59-6
Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and ...
PAOA
T3206CAS 537034-15-4
An effective Histone Deacetylase Inhibitor.
BML210
T3204CAS 537034-17-6
BML-210 is a new-type HDAC inhibitor.
Tubacin
T6327CAS 537049-40-4
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
UF010
T3205CAS 537672-41-6
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.
Theophylline
T1083CAS 58-55-9
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant act...
AES-350
T9041CAS 847249-57-4
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzy...
Scriptaid
T6980CAS 287383-59-9
Scriptaid is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3.
Theophylline monohydrate
T1083LCAS 5967-84-0
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize aden...
Theophylline-7-acetic acid
T2205CAS 652-37-9
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the...
Methyl L-histidinate dihydrochloride
T3937CAS 7389-87-9
Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production with activty value of 1.8 μM
Chidamide
T2025CAS 743420-02-2
Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on ...
Divalproex Sodium
T6474CAS 76584-70-8
Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentrat...
PCI24781
T0431CAS 783355-60-2
PCI-24781 (Abexinostat) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 4...
PTACH
T3199CAS 848354-66-5
PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
MC1568
T2023CAS 852475-26-4
MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
Quisinostat
T6055CAS 875320-29-9
Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and ...
Quisinostat 2HCl
T6865CAS 875320-31-3
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest pote...
Raddeanin A
T3878CAS 89412-79-3
Raddeanin A has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.
Trichostatin A
T6270CAS 58880-19-6
Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and spe...
Histone Deacetylase Inhibitor III
T2157CAS 251456-60-7
M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
Tasquinimod
T6695CAS 254964-60-8
Tasquinimod is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease bloo...
Rocilinostat
T2489CAS 1316214-52-4
Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.
CAY10603
T1983CAS 1045792-66-2
CAY10603 is a potent and selective inhibitor of HDAC6.
Valproic acid sodium salt
T1602CAS 1069-66-5
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in blo...
CI994
T1888CAS 112522-64-2
Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.
RG2833
T6639CAS 1215493-56-3
RG2833 (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
Minomustine
T3516CAS 1236199-60-2
EDO-S101 is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.
Tubastatin A
T1966CAS 1252003-15-8
Tubastatin A is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes except...
Romidepsin
T6006CAS 128517-07-7
Romidepsin is an intravenously administered histone deacetylase inhibitor and antineoplastic agent that is approved for use in refractory or relapsed cutaneous a...
Tubastatin A HCl
T6161CAS 1310693-92-5
Tubastatin A HCl is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).
TMP269
T1857CAS 1314890-29-3
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respective...
TMP 195
T3983CAS 1314891-22-9
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor.
Citarinostat
T3661CAS 1316215-12-9
ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Up...
BG45
T2294CAS 926259-99-6
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
PI3K/HDAC Inhibitor
T2078CAS 1339928-25-4
CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineop...
ACY738
T3509CAS 1375465-91-0
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
Nexturastat A
T1819CAS 1403783-31-2
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
LMK235
T6061CAS 1418033-25-6
LMK-235 is a potent HDAC inhibitor, and is used in cancer research.
HPOB
T2430CAS 1429651-50-2
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
BRD73954
T6421CAS 1440209-96-0
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
SantacruzaMate A
T2266CAS 1477949-42-0
Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor.
Sodium Phenylbutyrate
T1535CAS 1716-12-7
Sodium Phenylbutyrate, a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expres...
ITSA1
T3358CAS 200626-61-5
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.
Parthenolide
T2140CAS 20554-84-1
(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions.
4SC202
T6362CAS 910462-43-0
4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory a...
Pracinostat
T1890CAS 929016-96-6
Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. Da...
BRD6688
T21715CAS 1404562-17-9
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
CRA-026440
T10883CAS 847460-34-8
CRA-026440 is a potent, broad-spectrum HDAC inhibitor (Kis: 4, 14, 11, 15, 7, and 20 nM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10).
CHDI-390576
T14947CAS 1629729-98-1
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
FT895
T11329CAS 2225728-57-2
FT895 is a selective and  potent selective HDAC11 inhibitor with an IC50 of 3 nM.
BRD 4354 ditrifluoroacetate (315698-07-8 free base)
T10602CAS T10602
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
BRD-6929
T10603CAS 849234-64-6
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50:  1 and 8 nM).
HDAC-IN-4
T11542CAS 1252003-13-6
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
HDAC-IN-5
T11543CAS 1314890-51-1
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
HDACs/mTOR Inhibitor 1
T11544CAS 2271413-06-8
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
CG347B
T10777CAS 1598426-03-9
CG347B is a selective inhibitor of HDAC6.
JAK/HDAC-IN-1
T15605CAS 2284621-75-4
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
Tenovin-6 Hydrochloride
T8480CAS 1011301-29-3
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pote...
PXD-101
T8517CAS 866323-14-0
Belinostat is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
JAK1-IN-7
T11706CAS 2241039-81-4
JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect.
BRD 4354
T10602LCAS 315698-07-8
BRD 4354 is an inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM for HDAC5 and HDAC9).
MS4078
T16153CAS 2229036-62-6
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK.
Neuropathiazol
T16288CAS 880090-88-0
Neuropathiazol is a synthetic small molecule. It also causes neuronal differentiation of adult hippocampal neural progenitor cells.
Oxamflatin
T16415CAS 151720-43-3
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
Remetinostat
T16729CAS 946150-57-8
Remetinostat is a hydroxamic acid-based inhibitor of histone deacetylase enzymes. It is under development for the treatment of cutaneous T-cell lymphoma.
RTS-V5
T16805CAS 2285346-31-6
RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
SS-208
T16936CAS 2245942-72-5
SS-208 is a selective HDAC6 inhibitor (IC50: 12 nM). SS-208 has anti-tumor activity in melanoma.
SW-100
T16962CAS 2126744-35-0
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes....
Tefinostat
T17028CAS 914382-60-8
Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1...
Bakkenolide A
T2S0606CAS 19906-72-0
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
Isoferulic acid
TN4288CAS 25522-33-2
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
Phenylethyl isothiocyanate
T19687CAS 2257-09-2
Phenylethyl isothiocyanate is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.
CG-200745
T14936CAS 936221-33-9
CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
AES-135
T10255CAS 2361659-61-0
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
AR42
T6392CAS 935881-37-1
AR-42 is an HDAC inhibitor (IC50: 30 nM).
CXD-101
T5347CAS 934828-12-3
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101 has no activity against HDAC class II
Pimelic diphenylamide 106
T3193CAS 937039-45-7
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively),...
PCI34051
T6325CAS 950762-95-5
PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).
Droxinostat
T6481CAS 99873-43-5
Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no inh...
Resminostat hydrochloride
T4370CAS 1187075-34-8
Resminostat hydrochloride is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8 ...
SR4370
T4389CAS 1816294-67-3
SR-​4370 is an HDAC inhibitor. SR-​4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR-​4370 is reported i...
4SC-202 tosylate
T4477CAS 1186222-89-8
4SC-202 is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethyla...
HDAC8-IN-1
T7082CAS 1417997-93-3
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung cance...
Tucidinostat
T4481CAS 1616493-44-7
Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, less...
Valproic Acid
T7064CAS 99-66-1
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mol...
Givinostat hydrochloride monohydrate
T6279CAS 732302-99-7
Givinostat hydrochloride monohydrate is an HDAC inhibitor.
TH34
T5332CAS 2196203-96-8
TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.
SIS17
T5631CAS 2374313-54-7
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 ...
Apicidin
T14305CAS 183506-66-3
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative ...
SKLB-23bb
T5830CAS 1815580-06-3
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
Benzenebutyric acid
T5886CAS 1821-12-1
Benzenebutyric acid is an inhibitor of HDAC,and is an antineoplastic agent.
WT-161
T7385CAS 1206731-57-8
WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).
NSC 3852
T7691CAS 3565-26-2
NSC 3852 is a potent inhibitor of histone deacetylase.
Pyroxamide
T7664CAS 382180-17-8
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
ACY-775
TQ0074CAS 1375466-18-4
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
HDAC-IN-3
T8508CAS 1018673-42-1
HDAC-IN-3 is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.
BRD3308
T8233CAS 1550053-02-5
BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK.
ACY-1083
T10244CAS 1708113-43-2
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM). It is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-...
ACY-957
T10245CAS 1609389-52-7
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7...
1-Naphthohydroxamic acid
T13996CAS 6953-61-3
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 a...
CUDC101
T3108CAS 1012054-59-9
CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.