HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T60082	HDAC-IN-40	2463198-51-6	98%
T60082	HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects
T67878	HDAC-IN-52	2075787-77-6	98%
T67878	HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDA...
T69735	ITF3756	2247608-27-9	98%
T69735	ITF3756 is a selective HDAC6 inhibitor.
T73181	HDAC-IN-51		98%
T73181	HDAC-IN-51 is an HDAC inhibitor.
T77334	HDAC-IN-57	2716217-79-5	98%
T77334	HDAC-IN-57 is an orally active pan-inhibitor of histone deacetylase (HDAC), inhibiting HDAC1, HDAC2, HDAC6, and HDAC8 with IC50 values of 2.07 nM, 4.71 nM, 2.4 n...
T10883L	CRA-026440 hydrochloride	847459-98-7	98%
T10883L	CRA-026440 hydrochloride is a potent and broad-spectrum HDAC inhibitor. CRA-026440 hydrochloride exhibits Ki values against recombinant HDAC isoenzymes HDAC1, HD...
T25175	BRD 9757	1423058-85-8	98%
T25175	BRD 9757 is a selective inhibitor of HDAC6 (IC50 = 30 nM).
T30579	BRD4097	1550053-19-4	98%
T30579	BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insuli...
T24133	HDAC8-IN-20a	1884231-52-0	98%
T24133	HDAC8-IN-20a is a potent and selective HDAC8 inhibitor with an IC50 of 27 nM. HDAC8-IN-20a blocks activation of growth receptor survival signals.
T10864	Corin	1808113-09-8	98%
T10864	Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
T27083	Crebinostat	1092061-61-4	98%
T27083	Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respect...
T14947	CHDI-390576	1629729-98-1	98%
T14947	CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
T14936	Ivaltinostat	936221-33-9	98%
T14936	CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
T11542	HDAC-IN-4	1252003-13-6	98%
T11542	HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
T10602	BRD 4354 ditrifluoroacetate	T10602	98%
T10602	BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
T2S0606	Bakkenolide A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T11543	HDAC-IN-5	1314890-51-1	98%
T11543	HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T11544	HDACs/mTOR Inhibitor 1	2271413-06-8	98%
T11544	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
T14305	Apicidin	183506-66-3	98%
T14305	Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative ...
T10883	CRA-026440	847460-34-8	98%
T10883	CRA-026440 is a potent, broad-spectrum HDAC inhibitor (Kis: 4, 14, 11, 15, 7, and 20 nM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10).