exchange

ESI-08 is an effective antagonist of EPAC2 with an IC50 of 8.4 μM. ESI-08 selectively blocks cAMP-induced EPAC activation but not cAMP-mediated PKA activation.

AEX Anion-exchange resin 1 is a strong anion exchange chromatographic medium with a monodisperse polystyrene/divinylbenzene (PS-DVB) matrix and a particle size of 50 μm, featuring an ion exchange group of –CH2N+(CH3)3. It is suitable for the separation and purification of biological macromolecules such as proteins, antibodies, and viral vaccines.

AEX Ion-exchange resin, commonly used as AEX packing material, is a hydrophilic polymethyl methacrylate. It has a particle size of 60μm and features the functional group -N+(CH3)3.

AEX Anion-exchange resin 2 is a commonly used material for AEX applications, serving as a strong anion exchange medium with a particle size of approximately 90μm. It is suitable for use in ion exchange chromatography.

AEX HQ Anion-exchange resin (POROS 50HQ) is a commonly used packing material in AEX. This HQ strong anion-exchange resin is capable of purifying target proteins.

CEX Ion-exchange resin is a material used for cation exchange chromatography (particle size: 60 μm).

CEX Cation-exchange resin 1 is a cation-exchange chromatography medium, based on monodisperse polystyrene/divinylbenzene (PS-DVB). With a particle size of 50 μm, its functional group is -CH2CH2CH2SO3-. CEX Cation-exchange resin 1 is suitable for the separation and purification of antibodies, VLPs, viruses, and proteins.

CEX Cation-exchange resin 2 is a strong cation-exchange resin and an ADC purification resin. It contains cross-linked poly(styrene-divinylbenzene) and exhibits excellent hydrophobicity.

FR183998 free base is an inhibitor of Na+/Ca2+ Exchanger.

ESI-05 (NSC-116966) is a specific EPAC2 (exchange protein directly activated by cAMP 2) antagonist (IC50: 0.4 μM). ESI-05 inhibits cAMP-mediated activation of EPAC2, as well as EAPC2, mediated Rap1 activation.

YM-244769 dihydrochloride is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 dihydrochloride has efficient protective effects on neurons and kidneys.

Sevelamer carbonate is a non-absorbed phosphate binding crosslinked polymer, with the same polymeric structure as sevelamer hydrochloride, in which carbonate replaces chloride as the counterion.

YM-244769 (3-Pyridinecarboxamide, N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]-) is an effective inhibitor of Na+/Ca2+ exchange 3 (NCX3) with an IC50 of 18 nM. YM-244769 has efficient protective effects on neurons and kidneys.

Na+-Ca2+Exchanger inhibitory peptide (XIP) is an inhibitor of the Na+-Ca2+ exchanger with a Ki of 200 nM. It acts non-competitively to inhibit Na+-dependent Ca2+ uptake and Na+-dependent Ca2+ efflux in sarcolemmal vesicles.

BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia and myocardial infarction.

ORM-10103 is a novel potent and selective inhibitor of the Na+/Ca2+ exchanger (NCX).ORM-10103 inhibited NCX currents with estimated IC50 values of 55 and 67 nM at -80 and 20 mV, respectively, and reduced early and delayed postdepolarization in canine hearts.

5-(N,N-Hexamethylene)-amiloride (5-HMA) is an amiloride derivative that inhibits TRPA1-mediated calcium signaling (IC50: 35 μM). It functions as an inhibitor of the Na+/H+ exchanger (NHE) with Ki values ranging from 0.013 to 2.4 μM for various NHE isoforms. Additionally, 5-HMA blocks ASIC3 channels by 51% at 20 μM.

Monensin sodium salt (Monensin A sodium salt) is an antibiotic secreted by Streptomyces cinnamaticus and acts as an ion carrier that mediates Na+/H+ exchange. Monensin is an effective inhibitor of Wnt signaling. Monensin causes a significant increase in multivesicular bodies (MVBs) and regulates exosome secretion. Monensin sodium salt exhibits biological activities including anticoccidial, antibacterial, antitumor, and cell signaling regulatory effects. Monensin sodium salt can be used in studies of cellular ion transport and metabolism.

KR-32568 is a sodium/hydrogen exchanger 1 (NHE-1) inhibitor (IC50: 230 nM) with potent cardioprotective effects. At a concentration of 10 μM, it restored cardiac systolic function in an isolated ischemic rat heart model. Additionally, KR-32568 (0.3 mg/kg) reduced myocardial infarction size in a rat model of ischemia and reperfusion injury.

SN 6 (SN6) is a selective Na+/Ca2+ exchanger (NCX) inhibitor (IC50s of NCX1: 2.9 μM , NCX2: 16 μM ,NCX3: 8.6 μM)

BI-9627 is a selective and potent sodium hydrogen exchange isomer 1 (NHE1) inhibitor.BI-9627 partially reverses the effects of DMA with IC50 values of 6 and 31 nM in the intracellular pH recovery (pHi) and human platelet lysis assays.BI-9627 is often used as a negative control for BI-0054, which can be used for the study of ischemia-reperfusion injury in isolated hearts. BI-9627 is often used as a negative control for BI-0054 and can be used to study ischemia-reperfusion injury in isolated hearts.

PPADS tetrasodiuma is a potent P2X receptor antagonist and inhibitor of the inverse mode of Na/Ca²⁺ exchange in guinea pig airway smooth muscle and is neuroprotective against glutamate/NMDA toxicity.PPADS tetrasodiuma inhibits P2X1, P2X-2, P2X-3, and P2X- 5. 5.

SM-6586 is a potent calcium channel antagonist with inhibitory effects on Na+/H+ and Na+/Ca2+ exchange channels, and can be used in the study of cerebrovascular disease and hypertension, among other diseases.

inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX)