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IAP ligand 9
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Catalog No. T217877 Copy Product Info
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IAP ligand 9 is a SMAC mimetic and binds to the IAP (inhibitor of apoptosis protein) BIR domains, selectively targeting cIAP1-BIR3 and XIAP-BIR3, while showing minimal affinity for XIAP-BIR2, with SPR pKD values of 7.0, 8.0, and 5.0, respectively. As an IAP ligand module, it can be conjugated via linkers with degraders targeting the TEAD1 P site to form IAP-recruiting proteolysis-targeting chimeras (PROTACs/IPDs). This IPD recruits the IAPE3 ubiquitin ligase to form the TEAD1-IPD-IAP ternary complex, mediating ubiquitination and proteasome-dependent degradation of TEAD1 and inducing autodegradation of cIAP1. IAP ligand 9 and related degraders are useful in the study of solid tumors such as malignant pleural mesothelioma associated with abnormal activation of the Hippo pathway.
IAP ligand 9
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Storage & Solubility Information
| Description | IAP ligand 9 is a SMAC mimetic and binds to the IAP (inhibitor of apoptosis protein) BIR domains, selectively targeting cIAP1-BIR3 and XIAP-BIR3, while showing minimal affinity for XIAP-BIR2, with SPR pKD values of 7.0, 8.0, and 5.0, respectively. As an IAP ligand module, it can be conjugated via linkers with degraders targeting the TEAD1 P site to form IAP-recruiting proteolysis-targeting chimeras (PROTACs/IPDs). This IPD recruits the IAPE3 ubiquitin ligase to form the TEAD1-IPD-IAP ternary complex, mediating ubiquitination and proteasome-dependent degradation of TEAD1 and inducing autodegradation of cIAP1. IAP ligand 9 and related degraders are useful in the study of solid tumors such as malignant pleural mesothelioma associated with abnormal activation of the Hippo pathway. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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