Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • IκB/IKK
    (23)
  • NF-κB
    (9)
  • Autophagy
    (5)
  • COX
    (5)
  • Apoptosis
    (4)
  • Antibacterial
    (3)
  • CDK
    (3)
  • Aurora Kinase
    (2)
  • IL Receptor
    (2)
  • Others
    (9)
Filter
Search Result
Results for "

ikkα

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    38
    TargetMol | Inhibitors_Agonists
  • Peptide Products
    3
    TargetMol | Peptide_Products
  • Dye Reagents
    1
    TargetMol | Dye_Reagents
  • Natural Products
    8
    TargetMol | Natural_Products
  • Isotope Products
    1
    TargetMol | Isotope_Products
ACHP Hydrochloride
IKK-2 Inhibitor VIII
T10237406209-26-5In house
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective inhibitor of IKK-β with an IC50 of 8.5 nM.
  • Inquiry Price
6-8 weeks
Size
QTY
TargetMol | Inhibitor Sale
BAY32-5915
BAY-32-5915, BAY 32-5915, BAY 32 5915
T207701571-30-8
BAY32-5915 is an inhibitor of IKKalpha.
  • Inquiry Price
4-6 weeks
Size
QTY
Resveratrol
trans-Resveratrol, SRT 501
T1558501-36-0
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autophagy and apoptosis.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
BAY 11-7082
BAY 11-7821
T190219542-67-7
BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that suppresses TNFα-induced IκBα phosphorylation (IC50=10 μM) and also inhibits the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19 0.96 μM).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Hot
BMS-345541
IKK Inhibitor III, BMS-345541 free base, BMS345541
T6326445430-58-0In house
BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
  • Inquiry Price
Size
QTY
Vinpocetine
RGH-4405, Ethyl apovincaminate
T016742971-09-5
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
  • Inquiry Price
Size
QTY
Oxaprozin
Wy21743, Oxaprozinum
T070821256-18-8
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.
  • Inquiry Price
Size
QTY
CCCP
Carbonyl Cyanide m-Chlorophenylhydrazone, Carbonyl cyanide 3-chlorophenylhydrazone
T7081555-60-2
CCCP (Carbonyl Cyanide m-Chlorophenylhydrazone) is an oxidative phosphorylation (OXPHOS) inhibitor and mitochondrial proton carrier uncoupler. CCCP inhibits the activation of STING and its downstream signaling molecules TBK1 and IRF3.
  • Inquiry Price
Size
QTY
SC-514
GK 01140
T2118354812-17-2
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
  • Inquiry Price
Size
QTY
Dehydrocostus Lactone
Epiligulyl oxide, (-)-Dehydrocostus lactone
T2833477-43-0
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties.
  • Inquiry Price
Size
QTY
2-amino-5-phenyl-thiophene-3-carboxylic
T89104815-35-4
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC is Inhibitior of IKKβ.
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
achp
IKK-2 Inhibitor VIII
T22021406208-42-2
ACHP (IKK-2 Inhibitor VIII) is a novel selective and potent IKK inhibitor with inhibitory effects on IKK-α and IKK-β. ACHP has anti-HIV-1 activity and inhibits HIV-1 long terminal repeat (LTR)-driven gene expression through inhibition of NF-κB activation, inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR, and inhibits TNF-α-induced NF-κB (p65) recruitment to the HIV-1 LTR. ACHKP has anti-HIV-1 activity and inhibits TNF-α-induced recruitment of NF-κB (p65) to the HIV-1 LTR.
  • Inquiry Price
Size
QTY
mrt67307
MRT67307
T00971190378-57-4
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophages. MRT67307 is a kinase inhibitor that has been shown to inhibit TBK1, MARK1-4, IKKε, and NUAK1 (IC50 values are 19, 27-52, 160, and 230 nM, respectively), the salt-inducible kinases (SIKs; IC50s =250, 67, and 430 nM for SIK1, SIK2, and SIK3, respectively) and ULK1 and ULK2 (IC50s = 45 and 38 nM, respectively).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
BX795
T1830702675-74-9
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than GSK3β.
  • Inquiry Price
Size
QTY
cay10575
CAY-10575, CAY 10575
T26957916985-21-2
CAY10575 (IKK2-IN-3) is a potent IKK2 inhibitor with potential anti-inflammatory activity for the study of inflammatory and endocrine diseases.
  • Inquiry Price
6-8 weeks
Size
QTY
Olivetol
5-Pentylresorcinol, 5-n-Amylresorcinol
T3736500-66-3
Olivetol (5-n-Amylresorcinol) (5-pentylresorcinol, 5-pentyl-1,3-benzenediol) is an organic compound found in certain species of lichen; it is also a precursor in various syntheses of tetrahydrocannabinol. Olivetol has an antioxidant effect.
  • Inquiry Price
Size
QTY
BOT-64
T8705113760-29-5
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
JTP 0819958 - HOIPIN-1
T8951
JTP-0819958 is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. JTP-0819958 suppress LUBAC-mediated NF-kB activation in vitro[2].
  • Inquiry Price
Size
QTY
Protosappanin A
PTA
TJS1779102036-28-2
Protosappanin A (PTA) has anti-oxidative nitrative activities on brain immune and neuroinflammation through regulation of CD14 TLR4-dependent IKK IκB NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.
  • Inquiry Price
Size
QTY
broussonin a
TN353973731-87-0
Broussonins A and B, new phytoalexins from diseased paper mulberry. Broussonin A shows estrogenic activity with ligand-binding activity of estrogen receptor, transcriptional activity of estrogen-responsive element-luciferase reporter genes. Broussonin A c
  • Inquiry Price
Size
QTY
Aniline-d5
TMIJ-03424165-61-1
Aniline-d5 is a deuterated isotope marker of Aniline, which can be used for isotope tracing.Aniline induces toxicity to the spleen through iron overload and oxidative stress via heme oxygenase 1 up-regulation and is able to lead to a significant increase in p-IKKα and p-IKKβ, which in turn increases NF-κB and AP-1 binding activity.
  • Inquiry Price
7-10 days
Size
QTY
INH14
T5209200134-22-1
INH14 is a novel inhibitor of the IKKα β-dependent TLR inflammatory response (IC50s: 8.97 3.59 μM for IKKα IKKβ).
  • Inquiry Price
Size
QTY
TargetMol | Inhibitor Sale
HPN-01
HPN 01, HPN01
T11573928655-63-4
HPN-01 (IKK inhibitor XII) is a selective IKK inhibitor that inhibits IKK-α, IKK-β, and IKK-ε. HPN-01 reduces the severity of the disease, attenuates the immune imbalance, and prolongs the lifespan of mice in a model of autoimmune encephalomyelitis, and can be used to study immune disorders.
  • Inquiry Price
6-8 weeks
Size
QTY
Cyclo(L-Pro-L-Val)
T1251202854-40-2
Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microorganisms (e.g., R. fascians LMG 3605) and inhibits Gram-positive plant pathogens.Cyclo(L-Pro-L-Val) significantly inhibited IKKα phosphorylation and IκBα and NF-κB activation as well as iNOS and COX-2 activation in a concentration Cyclo(L-Pro-L-Val) significantly inhibited the phosphorylation of IKKα, IKKβ, IκBα, and NF-κB, as well as the activation of iNOS and COX-2 in a concentration-dependent manner, and is a potential therapeutic agent for the treatment of inflammation-related diseases.
  • Inquiry Price
Size
QTY