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Search Result

Search Results for " rock "

Targets

ROCK ROCK

90

Compounds

4

Natural Products

3

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T13419 ROCK-IN-1 ROCK
ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological disorders and inflammation-related diseases.
T12746 ROCK inhibitor-2 ROCK
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T67748 ROCK-IN-5 ROCK , ERK
ROCK-IN-5 (compound I-B-37) is a potent inhibitor of protein kinases, including ROCK, ERK, GSK, and AGC. ROCK-IN-5 exhibits the potential for cardiac, proliferative and neurodegenerative diseases research.
TQ0110 ROCK-IN-2 TC-S 7001,Azaindole 1 ROCK
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
T24723 ROCK-IN-D1 ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1
ROCK-IN-D1 is an effective and selective inhibitor of ROCK.
T24724 ROCK-IN-D2 ROCK inhibitor D2,ROCK IN D2,ROCK-inhibitor-D2
ROCK-IN-D2 is an effective and selective inhibitor of ROCK.
T24722 ROCK-IN-32 ROCK-inhibitor-32,ROCK inhibitor 32
ROCK-IN-32 is an effective Rho-kinase inhibitor.
T24725 ROCK-IN-D3 ROCK inhibitor D3,ROCK-inhibitor-D3
ROCK-IN-D3 is an effective and selective inhibitor of ROCK.
T4095 ZINC00881524 ROCK inhibitor ROCK
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
T6867 Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119 ROCK
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T63637 ROCK-IN-4
ROCK-IN-4 is a potent inhibitor of ROCK and maintains NO release capacity.ROCK-IN-4 reversibly depolymerizes F-actin and blocks mitochondrial respiration in human trabecular meshwork (HTM) cells.ROCK-IN-4 can be used to ...
T79833 ROCK-IN-9 ROCK
ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM. It demonstrates favorable pharmacokinetic properties in mice, achieving high in vivo exposure and oral bioavailab...
T79080 ROCK-IN-7 ROCK
ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].
T79809 ROCK-IN-8 ROCK
ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research, demonstrating an IC50 value below 100 nM [1].
T79077 ROCK-IN-6 ROCK
ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1].
T70937 ROCK-IN-(R)14f
ROCK-IN-(R)14f is a potent ROCK inhibitor.
T79905 Akt/ROCK-IN-1 ROCK
Akt/ROCK-IN-1 (B12) is a dual inhibitor targeting Akt and ROCK, exhibiting IC50 values of 0.023 nM and 1.47 nM, respectively. It possesses antitumor efficacy against neuroblastoma [1].
T12747 ROCK2-IN-2 ROCK
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T2011 RKI1313 RKI 1313,RKI-1313 ROCK
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T2155 Thiazovivin ROCK
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T1870 Y-27632 ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
TQ0187 SR-3677 ROCK , Autophagy
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T7391 SAR407899 ROCK , Rho
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T15798 LX7101 ROCK , LIM Kinase , PKA
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T7301 BDP5290 ROCK
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T1898 RKI-1447 RKI1447 ROCK
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T14960 Chroman 1 ROCK
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T2633 GSK429286A RHO-15 ROCK
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T70935 Phenoxan
Phenoxan is isolated from Polyangium; inhibits electron transport at NADH-ubiquinone oxidoreductase.
T14989 CMPD101 ROCK , GRK , PKC
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...
T7885 Afuresertib hydrochloride ROCK , Akt , PKC
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T13384L Y-33075 dihydrochloride CaMK , ROCK , PKC
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T7648 HA-100 Myosin , PKA , PKC
HA-100 is an inhibitor of protein kinase
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T4276L Hydroxyfasudil Hydroxy-Fasudil,HA-1100 ROCK , PKA
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T1911 Afuresertib GSK2110183C,GSK2110183 ROCK , Akt , PKC
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T7764 CCG-222740 ROCK , Rho , Ras
CCG-222740 is an inhibitor of Rho/MRTF pathway
TQ0319 Ripasudil K-115,Ripasudil hydrochloride dihydrate ROCK
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T3518 GSK269962A GSK269962B,GSK 269962,GSK269962A HCl ROCK , S6 Kinase
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T23308 SAR407899 hydrochloride ROCK
ATP-competitive ROCK inhibitor
T4276 Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride ROCK
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T7552 H-1152 ROCK
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T1725 Y-27632 dihydrochloride Y-27632 2HCl ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T1606 Fasudil HA-1077,AT877 ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T7492 Ripasudil free base K-115 (free base) ROCK , Antibacterial
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T3060 Fasudil hydrochloride Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
T79832 ROCK2-IN-6 ROCK
ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].
T78205 ROCK2-IN-6 hydrochloride ROCK
ROCK2-IN-6 hydrochloride (Comp A) serves as a selective inhibitor of ROCK2, applicable for research into ROCK-mediated diseases, autoimmune disorders, and inflammation [1].

Compounds

ROCK-IN-1
T13419
Synonym:
Target: ROCK
ROCK inhibitor-2
T12746
Synonym:
Target: ROCK
ROCK-IN-5
T67748
Synonym:
Target: ROCK, ERK
ROCK-IN-2
TQ0110
Synonym: TC-S 7001,Azaindole 1
Target: ROCK
ROCK-IN-D1
T24723
Synonym: ROCK inhibitor D1,ROCK IN D1,ROCK-inhibitor-D1
Target:
ROCK-IN-D2
T24724
Synonym: ROCK inhibitor D2,ROCK IN D2,ROCK-inhibitor-D2
Target:
ROCK-IN-32
T24722
Synonym: ROCK-inhibitor-32,ROCK inhibitor 32
Target:
ROCK-IN-D3
T24725
Synonym: ROCK inhibitor D3,ROCK-inhibitor-D3
Target:
ZINC00881524
T4095
Synonym: ROCK inhibitor
Target: ROCK
Belumosudil
T6867
Synonym: KD025,Rezurock,ROCK inhibitor,SLx-2119
Target: ROCK
ROCK-IN-4
T63637
Synonym:
Target:
ROCK-IN-9
T79833
Synonym:
Target: ROCK
ROCK-IN-7
T79080
Synonym:
Target: ROCK
ROCK-IN-8
T79809
Synonym:
Target: ROCK
ROCK-IN-6
T79077
Synonym:
Target: ROCK
ROCK-IN-(R)14f
T70937
Synonym:
Target:
Akt/ROCK-IN-1
T79905
Synonym:
Target: ROCK
ROCK2-IN-2
T12747
Synonym:
Target: ROCK
RKI1313
T2011
Synonym: RKI 1313,RKI-1313
Target: ROCK
Thiazovivin
T2155
Synonym:
Target: ROCK
Y-27632
T1870
Synonym:
Target: ROCK, Apoptosis
SR-3677
TQ0187
Synonym:
Target: ROCK, Autophagy
SAR407899
T7391
Synonym:
Target: ROCK, Rho
LX7101
T15798
Synonym:
Target: ROCK, LIM Kinase, PKA
BDP5290
T7301
Synonym:
Target: ROCK
RKI-1447
T1898
Synonym: RKI1447
Target: ROCK
GSK180736A
T3513
Synonym: GSK180736
Target: ROCK, GRK, PKA
Chroman 1
T14960
Synonym:
Target: ROCK
GSK429286A
T2633
Synonym: RHO-15
Target: ROCK
Phenoxan
T70935
Synonym:
Target:
CMPD101
T14989
Synonym:
Target: ROCK, GRK, PKC
Afuresertib hydrochloride
T7885
Synonym:
Target: ROCK, Akt, PKC
GSK-25
T4488
Synonym: GSK25
Target: ROCK, S6 Kinase, mTOR
Y-33075 dihydrochloride
T13384L
Synonym:
Target: CaMK, ROCK, PKC
HA-100
T7648
Synonym:
Target: Myosin, PKA, PKC
AT13148
T2482
Synonym:
Target: ROCK, SGK, Akt, PKA, S6 Kinase
Hydroxyfasudil
T4276L
Synonym: Hydroxy-Fasudil,HA-1100
Target: ROCK, PKA
Afuresertib
T1911
Synonym: GSK2110183C,GSK2110183
Target: ROCK, Akt, PKC
CCG-222740
T7764
Synonym:
Target: ROCK, Rho, Ras
Ripasudil
TQ0319
Synonym: K-115,Ripasudil hydrochloride dihydrate
Target: ROCK
GSK269962A
T3518
Synonym: GSK269962B,GSK 269962,GSK269962A HCl
Target: ROCK, S6 Kinase
SAR407899 hydrochloride
T23308
Synonym:
Target: ROCK
Hydroxyfasudil Hydrochloride
T4276
Synonym: Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride
Target: ROCK
H-1152
T7552
Synonym:
Target: ROCK
Y-27632 dihydrochloride
T1725
Synonym: Y-27632 2HCl
Target: ROCK, Apoptosis
Fasudil
T1606
Synonym: HA-1077,AT877
Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy
Ripasudil free base
T7492
Synonym: K-115 (free base)
Target: ROCK, Antibacterial
Fasudil hydrochloride
T3060
Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877
Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy
ROCK2-IN-6
T79832
Synonym:
Target: ROCK
ROCK2-IN-6 hydrochloride
T78205
Synonym:
Target: ROCK
1 2
Cat No. Product Name Synonyms Targets
TQ0183 Narciclasine Lycoricidinol ROCK
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
T4S1962 Beta-Asarone Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin NF-κB , JNK
1. beta-Asarone (Cis-Isoelemicin) may be a potential preventive drug for Alzheimer's disease. 2. Beta-Asarone prevents autophagy and synaptic loss by reducing ROCK expression in SAMP8 mice. 3. The co-administration of be...
T5S0053 Coptisine Coptisin Indoleamine 2,3-Dioxygenase (IDO)
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...
TN1533 Cucurbitacin A ROCK
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.

Natural Products

Narciclasine
TQ0183
Synonym: Lycoricidinol
Target: ROCK
beta-Asarone
T4S1962
Synonym: Cis-Isoasarone,Cis-Asarone,Cis-Isoelemicin
Target: NF-κB, JNK
Coptisine
T5S0053
Synonym: Coptisin
Target: Indoleamine 2,3-Dioxygenase (IDO)
Cucurbitacin A
TN1533
Synonym:
Target: ROCK

Recombinant Proteins

Species：
Human (1)
Mouse (1)
Rat (1)
Expression System：
E. coli (2)
in vitro E. coli expression system (1)
Tag：
N-terminal 10xHis-tagged (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
N-terminal 6xHis-tagged (1)
Cat No. Product Name Species Expression System
TMPH-03265 CMKLR2 Protein, Rat, Recombinant (His) Rat in vitro E. coli expression system
Receptor for chemoattractant adipokine chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation and energy homesotasis. Signals mainly via beta-arrestin pathway. Binding of RARRES2 activates...
TMPH-01805 ODAM Protein, Human, Recombinant (His) Human E. coli
Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of miner...
TMPH-02697 GNA12 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG). G...
Cat No. Product Name
L7700 Neural Regeneration Compound Library

529 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;

Libraries

Neural Regeneration Compound Library
L7700
Compounds: 529
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