Nef

HIV-1 Nef-IN-1 is an inhibitor of the HIV-1 Nef protein, effectively competing for Nef-SH3Hck interactions (Kd: 6.7 μM).

Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.

Nef ligand-2 is a compound that binds to Nef. It also serves as a ligand for E3 Ligase and represents the Nef Binder portion of FC-14369.

Nef-M1 (Nef-Motif-1) is an antagonist peptide targeting CXCR4 and an apoptosis (apoptosis) inducer derived from the myristoylated protein encoded by the HIV nef gene. Nef-M1 inhibits tumor angiogenesis and epithelial-mesenchymal transition (EMT) by activating the apoptotic pathway through increased levels of caspase-3 in cancer cells. Additionally, it suppresses VEGF-A, p-GSK-3β, and vimentin while enhancing E-cadherin, thereby hindering angiogenesis and EMT processes. Nef-M1 is applicable in colorectal cancer and breast cancer research.

Nef ligand-1 is the Nef Binder component of FC-14367.

HIV-IN-6 is an HIV viral inhibitor that inhibits the replication of the HIV virus.HIV-IN-6 has anti-HIV viral activity and works by targeting Src family kinases (SFK) (e.g., Hck) that interact with the viral Nef protein.

Sinefungin (Adenosyl-Ornithine) belongs to natural products and is an mRNA methyltransferase inhibitor with broad-spectrum antiviral activity. This compound possesses cell permeability and is commonly used in antiviral mechanism research and antiviral drug development.

Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.

Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic, cholinergic,and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.

9-Oxotournefortiolide, Tourneforin is a useful organic compound for research related to life sciences. The catalog number is T126388 and the CAS number is 111420-61-2.

N-Desmethylnefopam-D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.

N-Desmethylnefopam is the main Nefopam metabolite .

Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.

Nefazodone (Nefadar) is an oral antidepressant that is an antagonist of postsynaptic 5-HT 2A receptor and 5-HT 2C receptor, and also inhibits the reuptake of norepinephrine, dopamine, and serotonin (SNDRI).

Norfenefrine is an adrenergic agonist used in the therapy of female stress incontinence.

Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.

1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.

Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.

9-Methylidenefluorene is a polycyclic aromatic hydrocarbon that can undergo polymerisation reactions to form π-stacking polymers, and is widely used in biochemical experiments and drug synthesis research.

Norfenefrine HCl is an α1-adrenergic receptor agonist, an endogenous neurotransmitter and sympathomimetic drug for the treatment of hypotension, causing smooth muscle contraction and vasoconstriction leading to an increase in blood pressure, and also the ability to increase glycerol levels in adipose tissue.

Sonefpeglutide is a glucagon-like peptide analogue that targets GLP2R.

Desmethyl Nefopam-D5 hydrochloride is a deuterated compound of Desmethyl Nefopam hydrochloride. Desmethyl Nefopam hydrochloride has a CAS number of 147656-98-2.

7H-Dodecanefluoroheptane Acid (HPFHpA) (Standard) is a reference standard of 7H-Dodecanefluoroheptane Acid (HPFHpA) intended for quantitative analysis, quality control, and related biochemical research applications.

Nefazodone-[D6] Hcl (Standard) is a reference standard of Nefazodone-[D6] Hcl intended for quantitative analysis, quality control, and related biochemical research applications.