nef — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9039	HIV-1 Nef-IN-1		HIV Protease
	HIV-1 Nef-IN-1 is an inhibitor of HIV-1 Nef protein. It efficiently competes for Nef-SH3Hck interactions(Kd : 6.7 μM).		HIV Protease
T11538	Hck-IN-1		HIV Protease , Src , Hck
	Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for w...		HIV Protease , Src , Hck
T16886	Sinefungin	Adenosyl-Ornithine,A-9145,Antibiotic 32232RP	Others , Histone Methyltransferase , Antibiotic , Antifungal
	Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7/9 inhibitor and ameliorates r...
T5S1097	Neferine	(R)-1,2-Dimethoxyaporphine,(-)-Neferine	Apoptosis , NF-κB , Autophagy
	1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to a...		Apoptosis , NF-κB , Autophagy
T0169	Nefiracetam	DM9384,DZL-221	GABA Receptor
	Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic、 cholinergic、and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.		GABA Receptor
T0470	Nefopam hydrochloride	Fenazoxine hydrochloride,Nefopam HCl	Wnt/beta-catenin , Sodium Channel
	Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.		Wnt/beta-catenin , Sodium Channel
T3275	Nefazodone hydrochloride	Dutonin,MJ-13754-1,Serzone,BMY-13754-1,BMY-13754	5-HT Receptor , Adrenergic Receptor
	Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.		5-HT Receptor , Adrenergic Receptor
T6089	Neflamapimod	VX-745	p38 MAPK , Autophagy
	Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.		p38 MAPK , Autophagy
T19454	N-Desmethylnefopam		Others
	N-Desmethylnefopam is the main Nefopam metabolite .		Others
TN2482	1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid		Others
	1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid is a natural product for research related to life sciences. The catalog number is TN2482 and the CAS number is 69251-99-6.		Others
T126388	9-Oxotournefortiolide, Tourneforin
	9-Oxotournefortiolide, Tourneforin is a useful organic compound for research related to life sciences. The catalog number is T126388 and the CAS number is 111420-61-2.
T19453	N-Desmethylnefopam D5 hydrochloride		Others
	N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.		Others
T71821	Norfenefrine HCl
	Norfenefrine is an Adrenergic Agonist. It is used in the treatment of female stress incontinence.
T67197	9-methylidenefluorene
	Fluorenylidenemethane is an analogue of a 1,1-Diphenylethylene. Polymerization of Fluorenylidenemethane produces a π-stacked polymer.
T21451	Nefazodone	Nefadar,Dutonin,Serzone
	Nefazodone is an antidepressant. It has low affinity for the serotonin (200 nM), dopamine (360 nM), and norepinephrine (360 nM) transporters, and therefore acts as a weak serotonin-norepinephrine-dopamine reuptake inhibi...
T12788	R(+)-IAA-94	R(+)-Methylindazone	Chloride channel
	R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef).		Chloride channel
T61793	HIV-IN-6		HIV Protease
	HIV-IN-6 is an HIV viral inhibitor that inhibits the replication of the HIV virus.HIV-IN-6 has anti-HIV viral activity and works by targeting Src family kinases (SFK) (e.g., Hck) that interact with the viral Nef protein.		HIV Protease
T29217	ZINC04177596
	ZINC04177596 is a novel Nef Protein Inhibitor with anti-HIV activity.
T29222	ZINC36617540
	ZINC36617540 is a novel Nef Protein Inhibitor with anti-HIV activity.
T24017	DQBS
	DQBS is an HIV-1 Nef function antagonist.