Nef

HIV-1 Nef-IN-1 is an inhibitor of the HIV-1 Nef protein, effectively competing for Nef-SH3Hck interactions (Kd: 6.7 μM).

Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.

Sinefungin (Adenosyl-Ornithine) is an effective inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication. Sinefungin is a SET7 9 inhibitor and ameliorates renal fibrosis by inhibiting H3K4 methylation.

Nefopam hydrochloride (Nefopam HCl) is the hydrochloride salt form of nefopam, a centrally-acting, non-opioid benzoxazocine with analgesic activity.

Nefiracetam (DM9384) are underway in Phase 2 trials. Nefiracetam, a GABAergic, cholinergic,and monoaminergic neuronal system enhancer, is used for Ro 5-4864-induced convulsions.

9-Oxotournefortiolide, Tourneforin is a useful organic compound for research related to life sciences. The catalog number is T126388 and the CAS number is 111420-61-2.

N-Desmethylnefopam D5 hydrochloride is a deuterium labeled N-Desmethylnefopam hydrochloride.

N-Desmethylnefopam is the main Nefopam metabolite .

Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.

Nefazodone (Nefadar) is an oral antidepressant that is an antagonist of postsynaptic 5-HT 2A receptor and 5-HT 2C receptor, and also inhibits the reuptake of norepinephrine, dopamine, and serotonin (SNDRI).

Norfenefrine is an adrenergic agonist used in the therapy of female stress incontinence.

Nefazodone hydrochloride (Serzone) is a serotoninergic modulating antidepressant that is used in therapy of depression, aggressive behavior and panic disorder.

1. Neferine ((-)-Neferine) has anti-tumor activities , Metabolic activation mediated by CYP3A4 and GSH depletion enhanced Neferine-induced cytotoxicity. 2. Neferine can be helpful to increase the efficacy of DOX and to achieve anticancer synergism by curbing the toxicity. 3. Neferine inhibited high glucose-induced endothelial apoptosis via blocking ROS/Akt/NF-κB pathway, which provides the evidence for using Neferine to treat diabetic vasculopathy. 4. Neferine induced apoptosis in a dose-dependent manner with the hypergeneration of reactive oxygen species, activation of MAPKs, lipid peroxidation, depletion of cellular antioxidant pool, loss of mitochondrial membrane potential, and intracellular calcium accumulation.

Neflamapimod (VX-745) , a specific and effective inhibitor of p38α(IC50=10 nM), is 22-fold greater specificity against p38β and no inhibition activity to p38γ.

9-Methylidenefluorene is a polycyclic aromatic hydrocarbon that can undergo polymerisation reactions to form π-stacking polymers, and is widely used in biochemical experiments and drug synthesis research.

Norfenefrine HCl is an α1-adrenergic receptor agonist, an endogenous neurotransmitter and sympathomimetic drug for the treatment of hypotension, causing smooth muscle contraction and vasoconstriction leading to an increase in blood pressure, and also the ability to increase glycerol levels in adipose tissue.

Sonefpeglutide is a humanized antibody that targets GLP1R.

Desmethyl Nefopam-d5 HCl is a deuterated compound of Desmethyl Nefopam HCl. Desmethyl Nefopam HCl has a CAS number of 147656-98-2.

Turneforcidine is a pyrrolizidine alkaloid with antitumor and cytotoxic properties.

1,2,3-Tri-O-methyl-7,8-methyleneflavellagic acid (catalog number TN2482, CAS number 69251-99-6) is a natural product used in life sciences research.

β-Cotonefuran is a dibenzofuran-type phytoalexin produced by plants in response to both biotic and abiotic stresses, and it is utilized in studies on Arabidopsis' response to salt stress.

Bis-N,N-glycinemethylenefluorescein is a reagent used in biochemical reactions.

Ammonium disodium pentacyanoammineferrate(II) is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

HIV-IN-6 is an HIV viral inhibitor that inhibits the replication of the HIV virus.HIV-IN-6 has anti-HIV viral activity and works by targeting Src family kinases (SFK) (e.g., Hck) that interact with the viral Nef protein.