AhR

AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines.

AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects.

AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively.

AHR agonist 3 is an agent with therapeutic activity.

AHR-12234 affects cardiac action potentials.

AHR-5333 an antiallergy agent.

AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be used in the development of SNIPER[1].

AHR-5859 fumarate is a biochemical.

AHR-13268D is a new agent of antiallergic/antihistaminic.

AHR-5904 is a biochemical.

AHR-14310C is a long-acting and nonsedating H1-antihistamine.

AHR-2244 is a psychotherapeutic agent.

AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to inhibit 5-HETE, LTB4 and LTC4 synthesis.

AHR agonist 4 (compound 24e), as an Aryl hydrocarbon receptor (AHR) agonist, modulates the immune equilibrium between Th17/22 and Treg cells. It is a lead compound under investigation for anti-psoriasis drugs and demonstrates efficacy in mitigating imiquimod (IMQ)-induced psoriasis-like skin lesions [1].

AHR-2666 is a skeletal muscle relaxant.

AHR-1900 hydrochloride is a butyrophenone derivative used in the treatment of schizophrenia.

AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrogenic properties in rat uterus.

AHR-11797 is a novel benzodiazepine antagonist.

AHR-16303B oxalate is a novel antagonist of 5-HT2 receptors.

AHR-1900 free base is a butyrophenone derivative which may be used in the treatment of schizophrenia.

AHR-5360 is a biochemical.

AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo.

AHR-5859 is a biochemical.

AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1.

AHR antagonist 5 hemimaleate is a potent antagonist (IC50 < 0.5 μM) of the orally active aryl hydrocarbon receptor (AHR). aHR antagonist 5 hemimaleate in combination with the detection site inhibitor anti-PD-1 exhibited inhibitory effects on tumor growth.

AHR-5645B fumarate is a substituted benzamide that has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes.

AHR-5645B free base is a substituted benzamide which has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes.

AhR agonist 2 (Compound 12a) is a highly potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 0.03 nM. This compound rapidly induces nuclear enrichment of AhR and initiates transcription of downstream genes, thereby promoting skin barrier repair. AhR agonist 2 shows promising potential for psoriasis research [1].

AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator.

AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.

AHR-15010 is a novel anti-arthritic agent.

AHR-10718 has an antiarrhythmic effect.

AHR-0914 is a biochemical.

AHR 376 is a biochemical.

AHR-10037 is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties as well as a high therapeutic index and low gastric toxicity. AHR-10037 was comparable to indomethacin in suppressing acute (Evans blue-carrageenan pleural effusion) and chronic (adjuvant-induced arthritis) inflammation. Studies have shown that it is converted in vivo to a prodrug of cyclooxygenase inhibitors.

AHR-16329 can be used in ocular pharmacology.

Fluzinamide (AHR-8559) has anticonvulsant effects on ignited amygdala seizures.

Cloroperone hydrochloride (AHR-6134) has anxiolytic activity and may be used in the study of neurologic disorders.

Rocastine (AHR-11325) is a selective and potent non-sedating H1 receptor antagonist.

Pridefine (Pridefina) is a pyrrolidine derivative, a reuptake blocker of catecholamines and serotonin, with antidepressant activity.

CAY10464 (AHR antagonist 7) is a potent AHR antagonist with potential antitumor activity that inhibits CYP1A1 mRNA expression and may be used to study cancer and metabolic diseases.

Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2.

Dazopride is an antiemetic agent.

Dazopride fumarate is a peristaltic used to enhance gastric emptying and block emesis.

Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .

Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds.

Azapropazone is anti-inflammatory agent. Azapropazone has uricosuric properties used to treat rheumatoid arthritis and ankylosing spondylitis. Azapropazone lowered plasma uric acid but exerted only a modest and variable uricosuric effect without altering

Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm.

Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety.

Salmefamol is a beta-adrenergic agonist. It may also be used as a bronchodilator.