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Cat No. | Product Name | Synonyms | Targets |
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T10269 | AHR antagonist 2 | Aryl Hydrocarbon Receptor | |
AHR antagonist 2 is an antagonist of the aryl hydrocarbon receptor. The IC50s for human AHR and mouse AHR are 0.885 and 2.03 nM, respectively. | |||
T39762 | AHR antagonist 5 free base | Aryl Hydrocarbon Receptor | |
AHR antagonist 5 free base is an orally active antagonist of AHR with IC50s of ~35-150 nM in human and rodent cell lines. | |||
T5622 | BAY-218 | AHR antagonist 1 | AhR , Aryl Hydrocarbon Receptor |
BAY-218 (AHR antagonist 1) is an aryl hydrocarbon receptor (AHR) antagonist , has an IC50 of 39.9 nM in human cell line. | |||
T29752 | AHR-2666 | AHR 2666 | |
AHR-2666 is a skeletal muscle relaxant. | |||
T23681 | AHR-15010 | AHR 15010 | |
AHR-15010 is a novel anti-arthritic agent. | |||
T29747 | AHR-0914 | AHR0914,AHR 0914 | |
AHR-0914 is a biochemical. | |||
T29751 | AHR-2244 | AHR 2244,AHR2244 | |
AHR-2244 is a psychotherapeutic agent. | |||
T16778 | Rocastine | AHR-11325 | Histamine Receptor |
Rocastine (AHR-11325) is a selective and potent non-sedating H1 receptor antagonist. | |||
T29746 | AHR 376 | AHR376,AHR-376 | |
AHR 376 is a biochemical. | |||
T23683 | AHR-5333 | AHR 5333,AHR5333 | |
AHR-5333 an antiallergy agent. | |||
T23677 | AHR-10718 | AHR10718,AHR 10718 | |
AHR-10718 has an antiarrhythmic effect. | |||
T23679 | AHR-13268D | AHR 13268D,AHR13268D | |
AHR-13268D is a new agent of antiallergic/antihistaminic. | |||
T6424 | Bromfenac Sodium | AHR 10282B,Bronuck,AHR 10282R | COX |
Bromfenac Sodium (AHR 10282R) is a nonsteroidal anti-inflammatory drug (NSAID), which has anti-inflammatory activity and may block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. | |||
T15302 | Fluzinamide | AHR-8559 | Others |
Fluzinamide (AHR-8559) has anticonvulsant effects on ignited amygdala seizures. | |||
T29750 | AHR-1900 hydrochloride | AHR-1900 HCl | |
AHR-1900 hydrochloride is a butyrophenone derivative used in the treatment of schizophrenia. | |||
T23682 | AHR-16303B oxalate | AHR 16303B oxalate | |
AHR-16303B oxalate is a novel antagonist of 5-HT2 receptors. | |||
T29750L | AHR-1900 free base | AHR-1900, | |
AHR-1900 free base is a butyrophenone derivative which may be used in the treatment of schizophrenia. | |||
T29748 | AHR-12234 | ||
AHR-12234 affects cardiac action potentials. | |||
T29753 | AHR-5360 | AHR5360 | |
AHR-5360 is a biochemical. | |||
T29749 | AHR-16329 | AHR16329 | |
AHR-16329 can be used in ocular pharmacology. | |||
T1280 | Nepafenac | AL 6515,AHR 9434 | COX |
Nepafenac (AHR 9434) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of nepafenac is as a Cyclooxygenase Inhibitor. The chemical classification of nepafenac is Nonsteroidal Anti-inflammatory Compounds. | |||
T29754 | AHR-5859 | ||
AHR-5859 is a biochemical. | |||
T29755 | AHR-5904 | ||
AHR-5904 is a biochemical. | |||
T23678 | AHR-11797 | ||
AHR-11797 is a novel benzodiazepine antagonist. | |||
T23684 | AHR-6293 | ||
AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties. | |||
T23676 | AHR-10037 | ||
AHR-10037 is a nonsteroidal anti-inflammatory drug with analgesic and antipyretic properties as well as a high therapeutic index and low gastric toxicity. AHR-10037 was comparable to indomethacin in suppressing acute (Ev... | |||
T23685 | AHR-9294 | ||
AHR-9294 is a novel inhibitor of H, K-ATPase. It also antagonizes gastric HCl secretion in vivo. | |||
T23680 | AHR-14310C | ||
AHR-14310C is a long-acting and nonsedating H1-antihistamine. | |||
T71590 | AHR-5645B fumarate | ||
AHR-5645B fumarate is a substituted benzamide that has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes. | |||
T10271 | AHR antagonist 4 | Others | |
AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects. | |||
T10272 | AHR antagonist 5 | Others | |
AHR antagonist 5 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist(example 39; IC50 < 0.5 μΜ). It significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1. | |||
T71053 | AHR-5333 mandelate | ||
AHR-5333 mandelate is an anti-allergy compound which has been shown to protect against antigen-induced anaphylactic collapse and ascaris antigen-induced skin hypersensitivity. AHR-5333 mandelate has also been shown to in... | |||
T1409 | Methocarbamol | Lumirelax,Metocarbamol,AHR 85,Robaxin | Sodium Channel , Carbonic Anhydrase |
Methocarbamol (AHR 85) is a centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful musc... | |||
T10273 | AhR modulator-1 | Others | |
AhR modulator-1 is a selective and orally active aryl hydrocarbon receptor (AhR) modulator. It inhibits metastasis, in part, by inhibiting prostatic VEGF production prior to tumor formation. It also possesses anti-estrog... | |||
T29754L | AHR-5859 fumarate | ||
AHR-5859 fumarate is a biochemical. | |||
T20986 | AHR agonist 3 | ||
AHR agonist 3 is an agent with therapeutic activity. | |||
T23686 | AHR-activator-1023 | Branching Morphogenesis Modulator 1023,Cpd 1023,Compound 1023,BMM 1023 | |
AHR-activator-1023 is the aryl hydrocarbon receptor activator. It is also a specific FGF2-induced branching morphogenesis modulator. | |||
T17364 | AhR Ligand-Linker Conjugates 1 | E3 Ligase Ligand-Linker Conjugates 57 | Others |
AhR Ligand-Linker Conjugates 1, also known as E3 Ligase Ligand-Linker Conjugates 57, is a chemical compound that combines an IAP ligand for the E3 ubiquitin ligase with a SNIPER linker. It is specifically designed to be ... | |||
T21352 | Salmefamol | AHR-3929,AHR3929,AHR 3929 | |
Salmefamol is a beta-adrenergic agonist. It may also be used as a bronchodilator. | |||
T79436 | AHR agonist 4 | Aryl Hydrocarbon Receptor | |
AHR agonist 4 (compound 24e), as an Aryl hydrocarbon receptor (AHR) agonist, modulates the immune equilibrium between Th17/22 and Treg cells. It is a lead compound under investigation for anti-psoriasis drugs and demonst... | |||
T61244 | AhR agonist 2 | ||
AhR agonist 2 (Compound 12a) is a highly potent agonist of the aryl hydrocarbon receptor (AhR), exhibiting an EC50 value of 0.03 nM. This compound rapidly induces nuclear enrichment of AhR and initiates transcription of ... | |||
T20197 | Amfenac sodium | AHR5850,AHR 5850 | |
Amfenac is a nonsteroidal anti-inflammatory drug. Amfenac also has acetic acid moiety. | |||
T63389 | AHR antagonist 5 hemimaleate | ||
AHR antagonist 5 hemimaleate is a potent antagonist (IC50 < 0.5 μM) of the orally active aryl hydrocarbon receptor (AHR). aHR antagonist 5 hemimaleate in combination with the detection site inhibitor anti-PD-1 exhibited ... | |||
T69174 | AHR-5645B free base | ||
AHR-5645B free base is a substituted benzamide which has been shown to inhibit 3H-spiperone binding to bovine anterior pituitary membranes. | |||
T31586 | Duoperone fumarate | AHR6646,AHR-6646,AHR 6646 | |
Duoperone fumarate is a biochemical. | |||
T30984 | Cloroperone hydrochloride | AHR-6134,AHR6134,AHR 6134 | |
Cloroperone hydrochloride is a biochemical. | |||
T10963 | Dazopride | AHR-5531 | Others |
Dazopride is an antiemetic agent. | |||
T31214 | Dazopride fumarate | AHR-5531C | |
Dazopride fumarate is a peristaltic used to enhance gastric emptying and block emesis. | |||
T25661 | Lenperone | Lenperonum,AHR-2277 [as hydrochloride] | |
Lenperone is a butyrophenone antipsychotic. Like other major tranquilizers, It has some alpha-adrenergic blocking action and is antiemetic. | |||
T7202 | ITE | AhR , Aryl Hydrocarbon Receptor | |
ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR) (Ki : 3 nM), has immunosuppressive activity. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1451 | Brevifolincarboxylic acid | AhR , Aryl Hydrocarbon Receptor , Glucosidase | |
Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 3... | |||
T6795 | Carbidopa | (S)-(-)-Carbidopa,Lodosyn | Decarboxylase , Aryl Hydrocarbon Receptor |
Carbidopa (Lodosyn) is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. | |||
T4928 | L-Kynurenine | (S)-Kynurenine | AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite |
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ... | |||
T0878 | Diosmin | Venosmine,Diosmil,Barosmin | Aryl Hydrocarbon Receptor , Norepinephrine |
Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls. | |||
TN2883 | 3',4'-Dimethoxyflavone | Others , PARP | |
3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities. | |||
T4939 | Indole-3-pyruvic acid | 3-(3-Indolyl)-2-oxopropanoic acid | Others |
Indole-3-pyruvic acid (3-(3-Indolyl)-2-oxopropanoic acid) is a compound involved in the biosynthesis of Indole-3-acetic acid, a plant hormone which plays important roles in regulating growth and responses to environmenta... | |||
T5281 | Skatole | Scatole,3-Methylindole,3-Methylindole,3-Methyl-1H-indole,beta-Methylindole | AhR , p38 MAPK , Aryl Hydrocarbon Receptor , Endogenous Metabolite , Antibacterial , Autophagy , Antifungal |
Skatole (3-Methyl-1H-indole) is produced by intestinal bacteria. Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38. | |||
T2947 | Indole-3-carbinol | I3C,3-Indolemethanol,Indole-3-Methanol | E1/E2/E3 Enzyme , NF-κB , Aryl Hydrocarbon Receptor , Endogenous Metabolite , p53 |
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation. | |||
T10938 | D-Kynurenine | (R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid,ZINC901103 | GPR , AhR , Endogenous Metabolite |
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluor... | |||
T4938 | Potassium 1H-indol-3-yl sulfate | Indoxyl sulfate potassium salt,Potassium 3-indoxyl sulfate | AhR , Endogenous Metabolite |
Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of imm... | |||
TN1222 | 26-Deoxyactein | 27-Deoxyactein,23-epi-26-Deoxyactein | NOS , CDK , NO Synthase |
23-epi-26-Deoxyactein (27-Deoxyactein) has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. It also has anti-cancer activity, it can in... | |||
T72901 | Indolokine A5 | ||
Indolokine A5, a catabolite of L-cysteine, is a potent AhR agonist . | |||
T73402 | Flavipin | ||
Flavipin is an aryl hydrocarbon receptor (Ahr) agonist that induces the expression of Ahr downstream genes in mouse CD4 + T cells and CD11b + macrophages. Flavipin inhibits the stabilizing function of Arid5a on Il23a 3′U... | |||
TN1543 | Cynaropicrin | IL Receptor , Others , TNF | |
Cynaropicrin is a potent activator of the AhR-Nrf2-Nqo1 pathway, and could therefore be applied to prevention of UVB-induced photo aging; it may be a potential anticancer agent against some leukocyte cancer cells such as... | |||
T75433 | Norisoboldine hydrochloride | ||
Norisoboldine hydrochloride is an orally active natural aryl hydrocarbon receptor ( AhR ) agonist. Norisoboldine hydrochloride, as a major isoquinoline alkaloid present in Radix Linderae, can be used for the research of ... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-00958 | AHR Protein, Human, Recombinant (His) | Human | E. coli |
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood... | |||
TMPJ-00423 | TIM-1/KIM-1/HAVCR1 Protein, Mouse, Recombinant (His) | Mouse | Human Cells |
TIM-1/KIM-1/HAVCR belongs to the immunoglobulin superfamily that cosisits 305 amino acid (aa). It is expressed by stimulated T-cells. TIM-1/KIM-1/HAVCR may play a role in T-helper cell development and the regulation of a... |