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Proteases/Proteasome Tyrosinase

Tyrosinase

Cat No. product name
TMA0003 Trans-caffeic acid Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and...
T5552 Methyl cinnamate Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
TCS2170 2-5-dihydroxyacetophenone 1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of J...
T2A2524 4-Methoxysalicylaldehyde 2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a pot...
T7052 Gnetol Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly sup...
T2P2923 Stearic acid 1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. ...
T3S1612 Kuwanon G 1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for...
T2742 Aloin(mixture of A&B) Aloin(mixture of A&B), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
T3923 Calycosin Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 famil...
T5755 Aloesin Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first ...
T6S1597 Mulberroside A 1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosy...
T7125 4-Butylresorcinol 4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM), and is used in cosmetics as a depigmenting agent.
T5889 Kojic acid Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 µM for mushroom tyrosinase.
T5985 Glycolic acid Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products
T7394 Toceranib Phosphate Toceranib phosphate, is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR
T7438 3,5-Dimethoxyphenol 3,5-Dimethoxyphenol as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity.
T7714 Temocapil Temocapril is an inhibitor of tyrosine kinase.
T8087 Tropolone Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion
T3S1068 Oxyresveratrol 1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gli...
T4291 (+)-Isocorydine hydrochloride (+)-Isocorydine is a eukaryote protein kinases Inhibitor.
TN1325 6-Prenylnaringenin 6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin.
T0666 4-Chlorosalicylic acid 4-Chlorosalicylic acid is antimicrobial compositions comprising a metal salt and a benzoic acid analog.
T2340 AC1NS4RE It is a tyrosine kinase inhibitor.
T3827 Rhein-8-glucoside calcium salt Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
T0314 Hexylresorcinol Hexylresorcinol is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.
T3569 SU 5214 SU 5214 is a modulator of tyrosine kinase signal transduction.
T1738 Taxifolin Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
T0473 Arbutin Arbutin(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the...
T1188 Mizoribine Mizoribine belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
T0176 Isobarbaloin Isobarbaloin (Aloin) is a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
T4185 Lavendustin C Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
T6463 Deoxyarbutin DeoxyArbutin(IC50=50 nM) inhibits tyrosinase activity reversibly.
T3737 Hydroumbellic acid Hydroumbellic acid is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is...
T3403 Glabridin Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
T1210 Sodium etidronate Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, eti...
T3382 Wilforlide A Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, b...
T4182 Lavendustin B Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived gro...
T4183 Lavendustin A lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
TN1314 6-Hydroxykaempferol 6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
TN1545 D-Tyrosine D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine inhibits biofilm formatio...
TN5153 Torilin Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
TN4117 GB 1a GB 1a shows potential in vitro antioxidant activities.
TN2923 3'-Deoxy-4-O-methylsappanol 3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4.
TMA0593 Broussoflavonol F Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggrega...
TN3540 Broussonin C Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase.
TN3545 Buddlenoid A Buddlenoid A shows high inhibition of mushroom tyrosinase.
TN3644 Chlorophorin Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of...
TN3753 Dalbergioidin Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
TN3882 Dodoviscin A Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobu...
TN4148 Glyasperin C Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidat...
TC0017 Haplopine Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the c...
TN4179 Haginin A Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activ...
TN4279 Isoderrone Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, sug...
TN4580 Morachalcone A Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 u...
TN4642 Neorauflavane Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin content...
TMA2563 Pedalitin Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl ros...
TN5117 Taxiphyllin Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against...
TN5119 Taxoquinone Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important food...
TN2672 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran 2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. It also shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 ...
T2S0799 Noroxyhydrastinine Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein leve...
TN1690 Glabrene Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely...
TN2025 Oxyresveratrol 2-O-beta-D-glucopyranoside Oxyresveratrol-2-O-beta-D-glucopyranoside shows better tyrosinase inhibitory activities than kojic acid.
TN1705 Glycyrrhisoflavone Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase.
TN1772 Isoastilbin Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) wi...
TN1804 Isosilybin A Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (I...
TN1832 Kanzonol C Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sho...
TN1840 Kurarinol Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varyi...
TN1928 Methyl rosmarinate Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmari...
TN1958 Mulberroside F Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity tha...
TN2026 Oxyresveratrol 3'-O-beta-D-glucopyranoside Oxyresveratrol-3'-O-beta-D-glucopyranoside shows tyrosinase inhibitory activity, it may be a potential candidate as skin-whitening agents without posing any seri...
T10664 Calcium 2-oxoglutarate Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM).
TN2078 Pinocembrin chalcone Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic ...
TN2148 Retusin Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well ...
TN2246 Swertiajaponin Swertiajaponin possesses antimicrobial activity.
TN2280 Trametenolic acid Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and ...
TN2288 Uralenol Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as s...
TN2303 Viscumneoside III Viscumneoside III demonstrates high tyrosinase inhibition, it can be utilized in skin whitening cosmetics.
T4S1658 Benzoyloxypeoniflorin Benzoyloxypeoniflorin is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coa...
T0759 Monobenzone Monobenzone is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by mean...
Trans-caffeic acid
TMA0003CAS 501-16-6
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and...
Methyl cinnamate
T5552CAS 103-26-4
Methyl cinnamate, a tyrosinase inhibitor and a flavoring compound, has antimicrobial, antiadipogenic, vasorelaxant, and anti-inflammatory effects.
2-5-dihydroxyacetophenone
TCS2170CAS 490-78-8
1. 2, 5-Dihydroxyacetophenone possess anti-anxiety, and neuroprotective qualities. 2. 2, 5-Dihydroxyacetophenone treatment can induce a sustained activation of J...
4-Methoxysalicylaldehyde
T2A2524CAS 673-22-3
2-Hydroxy-4-methoxybenzaldehyde, a chemical compound and an isomer of Vanillin, could be used to synthesis Urolithin M7. 2-hydroxy-4-methoxybenzaldehyde is a pot...
Gnetol
T7052CAS 86361-55-9
Gnetol competitivity inhibits butyrylcholinesterase (IC50: 1.3 uM). Gnetol has a strong inhibitory effect on murine tyrosinase activity. Gnetol significantly sup...
Stearic acid
T2P2923CAS 57-11-4
1. Stearic Acid can reduce metastatic tumor burden. 2. Stearic Acid leads to dramatically reduced visceral fat likely by causing the apoptosis of preadipocytes. ...
kuwanon G
T3S1612CAS 75629-19-5
1. Kuwanon G as dual inhibitors of PTP1B and α-glucosidase enzymes, as well as insulin sensitizers, it may potentially be utilized as an effective treatment for...
Aloin(mixture of A&B)
T2742CAS 1415-73-2
Aloin(mixture of A&B), a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
Calycosin
T3923CAS 20575-57-9
Calycosin acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 famil...
Aloesin
T5755CAS 30861-27-9
Aloesin is a C-glycosylated chromone compound found in aloe (Liliaceae) that inhibits tyrosinase (IC50 = 0.9 mM), an enzyme responsible for catalyzing the first ...
Mulberroside A
T6S1597CAS 102841-42-9
1. Mulberroside has nephroprotective, hypoglycemic, and antidiabetic effects. 2. Mulberroside A is a glycosylated stilbene of oxyresveratrol; thus, the deglycosy...
4-Butylresorcinol
T7125CAS 18979-61-8
4-Butylresorcinol is a potent inhibitor of tyrosinase(IC50 : 11.27 μM), and is used in cosmetics as a depigmenting agent.
Kojic acid
T5889CAS 501-30-4
Kojic acid is a fungal metabolite that inhibits tyrosinase, an enzyme involved in melanin synthesis, with an IC50 value of 30.6 µM for mushroom tyrosinase.
Glycolic acid
T5985CAS 79-14-1
Glycolic acid is an inhibitor of tyrosinase, suppressing melanin formation,and used in skincare products
Toceranib Phosphate
T7394CAS 874819-74-6
Toceranib phosphate, is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including Flk-1/KDR, PDGFR
3,5-Dimethoxyphenol
T7438CAS 500-99-2
3,5-Dimethoxyphenol as a marker of Taxus poisoning, being present in all species of Taxus. It has potent tyrosinase-inhibiting activity.
Temocapil
T7714CAS 111902-57-9
Temocapril is an inhibitor of tyrosine kinase.
Tropolone
T8087CAS 533-75-5
Tropolone, a metal chelator, possesses weak antioxidative and radical-scavenging properties and shows a strong affinity for ferric ion
Oxyresveratrol
T3S1068CAS 29700-22-9
1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gli...
(+)-Isocorydine hydrochloride
T4291CAS 13552-72-2
(+)-Isocorydine is a eukaryote protein kinases Inhibitor.
6-Prenylnaringenin
TN1325CAS 68236-13-5
6-Prenylnaringenin is an isomer of the potent phytoestrogen, 8-prenylnaringenin.
4-Chlorosalicylic acid
T0666CAS 5106-98-9
4-Chlorosalicylic acid is antimicrobial compositions comprising a metal salt and a benzoic acid analog.
AC1NS4RE
T2340CAS 1055412-47-9
It is a tyrosine kinase inhibitor.
Rhein-8-glucoside calcium salt
T3827CAS 113443-70-2
Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium salt) shows moderate bioactivity against human Protein Tyrosine Phosphatase 1B (hPTP1B) in vitro.
Hexylresorcinol
T0314CAS 136-77-6
Hexylresorcinol is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.
SU 5214
T3569CAS 186611-04-1
SU 5214 is a modulator of tyrosine kinase signal transduction.
Taxifolin
T1738CAS 480-18-2
Taxifolin is a flavonoid in many plants such as Taxus chinensis, Siberian larch, Cedrus deodara and so on.
Arbutin
T0473CAS 497-76-7
Arbutin(β-Arbutin) is a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos and can inhibit tyrosinase and thus prevent the...
Mizoribine
T1188CAS 50924-49-7
Mizoribine belongs to the family of 1-Ribosyl-imidazolecarboxamides. Mizoribine has been investigated for the treatment of Rheumatoid Arthritis.
Isobarbaloin
T0176CAS 5133-19-7
Isobarbaloin (Aloin) is a natural anthracycline from Aloe vera, is a tyrosinase inhibitor.
lavendustin C
T4185CAS 125697-93-0
Lavendustin C is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase.
Deoxyarbutin
T6463CAS 53936-56-4
DeoxyArbutin(IC50=50 nM) inhibits tyrosinase activity reversibly.
Hydroumbellic acid
T3737CAS 5631-68-5
Hydroumbellic acid is a predicted metabolite generated by BioTransformer¹ that is produced by the metabolism of 3-(2, 4-dihydroxyphenyl)prop-2-enoic acid. It is...
Glabridin
T3403CAS 59870-68-7
Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-gluc...
Sodium etidronate
T1210CAS 7414-83-7
Etidronate Disodium is a synthetic therapeutic diphosphonate analog of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, eti...
Wilforlide A
T3382CAS 84104-71-2
Wilforlide A is a natural product, separated from the ethanolic extract of tripterygium wilfordii. High-dose wilforlide A has obvious anti-inflammatory effect, b...
lavendustin B
T4182CAS 125697-91-8
Lavendustin B is a Tyrosine Kinase Inhibitor and an inhibitor of HIV-1 integrase (IN) interaction with its cognate cellular cofactor, lens epithelium-derived gro...
lavendustin A
T4183CAS 125697-92-9
lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase.
6-Hydroxykaempferol
TN1314CAS 4324-55-4
6-Hydroxykaempferol is a competitive inhibitor of tyrosinase compared to L-DOPA, it shows also high antioxidant activities.
D-Tyrosine
TN1545CAS 556-02-5
D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine inhibits biofilm formatio...
Torilin
TN5153CAS 13018-10-5
Torilin is an inhibitor of testosterone 5 alpha-reductase, it (IC50 = 31.7 +/- 4.23 microM) shows a stronger inhibition of 5 alpha-reductase than alpha-linolenic...
GB 1a
TN4117CAS 220611-41-6
GB 1a shows potential in vitro antioxidant activities.
3'-Deoxy-4-O-methylsappanol
TN2923CAS 112408-68-1
3'-Deoxy-4-O-methylsappanol shows moderate cytotoxicities against cultured human melanoma HMV-II cells with the IC50 value of 872.0 uM ± 2.4.
Broussoflavonol F
TMA0593CAS 162558-94-3
Broussoflavonol F has antiplatelet effect, is partially due to an inhibitory effect on cyclooxygenase, can inhibit arachidonic acid (AA)-induced platelet aggrega...
Broussonin C
TN3540CAS 76045-49-3
Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase.
Buddlenoid A
TN3545CAS 142750-32-1
Buddlenoid A shows high inhibition of mushroom tyrosinase.
Chlorophorin
TN3644CAS 537-41-7
Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of...
Dalbergioidin
TN3753CAS 30368-42-4
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
Dodoviscin A
TN3882CAS 1372527-25-7
Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobu...
Glyasperin C
TN4148CAS 142474-53-1
Glyasperin C acts as a partial estrogen antagonist, it shows tyrosinase inhibitory activity (IC (50) = 0.13 +/- 0.01 microg/mL), it could be a promising candidat...
Haplopine
TC0017CAS 5876-17-5
Haplopine shows photo-activated antimicrobial activity against S. aureus. It exhibits potent melanogenesis-inhibitory activities with almost no toxicity to the c...
Haginin A
TN4179CAS 74174-29-1
Haginin A is an effective inhibitor of hyperpigmentation caused by UV irradiation or by pigmented skin disorders through downregulation via ERK and Akt/PKB activ...
Isoderrone
TN4279CAS 121747-89-5
Isoderrone shows inhibitory effects on α-glucosidase in vitro; it is a protein tyrosine phosphatase 1B (PTP1B) inhibitor, with IC50 value of 22.7 ± 1.7 uM, sug...
Morachalcone A
TN4580CAS 76472-88-3
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 u...
Neorauflavane
TN4642CAS 53734-74-0
Neorauflavane shows tyrosinase inhibition, it can inhibit tyrosinase monophenolase activity with an IC50 of 30 nM, it also can efficiently reduce melanin content...
Pedalitin
TMA2563CAS 22384-63-0
Pedalitin is a mixed-type inhibitor of tyrosinase. In the assay of α-glucosidase inhibition, rosmarinic acid is a competitive inhibitor, whereas both methyl ros...
Taxiphyllin
TN5117CAS 21401-21-8
Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against...
Taxoquinone
TN5119CAS 21764-41-0
Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important food...
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran
TN2672CAS 67736-22-5
2-(2,4-Dihydroxyphenyl)-6-hydroxybenzofuran shows radical scavenging activities. It also shows mushroom tyrosinase inhibitory activity with an IC50 value of 5.2 ...
Noroxyhydrastinine
T2S0799CAS 21796-14-5
Noroxyhydrastinine exhibits potent melanogenesis-inhibitory activities, it inhibits melanogenesis, at least in part, by inhibiting the expression of protein leve...
Glabrene
TN1690CAS 60008-03-9
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely...
Oxyresveratrol 2-O-beta-D-glucopyranoside
TN2025CAS 392274-22-5
Oxyresveratrol-2-O-beta-D-glucopyranoside shows better tyrosinase inhibitory activities than kojic acid.
Glycyrrhisoflavone
TN1705CAS 116709-70-7
Glycyrrhisoflavone is a tyrosinase inhibitor, it also shows inhibitory effects on monoamine oxidase.
Isoastilbin
TN1772CAS 54081-48-0
Isoastilbin is a dihydroflavonol glycoside compound in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) wi...
Isosilybin A
TN1804CAS 142796-21-2
Isosilybin A is a partial PPARγ agonist, it significantly induced ABCA1 protein expression, it inhibited both monophenolase (IC50=1.7-7.6μM) and diphenolase (I...
Kanzonol C
TN1832CAS 151135-82-9
Kanzonol C has antimicrobial activity, it also shows potent PTP1B inhibitory activity (IC50 value of 0.31-0.97uM). Kanzonol C has chemopreventive activity,it sho...
Kurarinol
TN1840CAS 855746-98-4
Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varyi...
Methyl rosmarinate
TN1928CAS 99353-00-1
Methyl rosmarinate is a noncompetitive tyrosinase inhibitor which is isolated from Rabdosia serra, with an IC50 of 0.28 mM for mushroom tyrosinase.Methyl rosmari...
Mulberroside F
TN1958CAS 193483-95-3
Mulberroside F shows inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells, it also exhibits superoxide scavenging activity tha...
Oxyresveratrol 3'-O-beta-D-glucopyranoside
TN2026CAS 144525-40-6
Oxyresveratrol-3'-O-beta-D-glucopyranoside shows tyrosinase inhibitory activity, it may be a potential candidate as skin-whitening agents without posing any seri...
Calcium 2-oxoglutarate
T10664CAS 71686-01-6
Calcium 2-oxoglutarate is an intermediate in the production of GTP or ATP in the Krebs cycle. It is a reversible inhibitor of tyrosinase (IC50: 15 mM).
Pinocembrin chalcone
TN2078CAS 4197-97-1
Pinocembrin chalcone has tyrosinase inhibitory activity.It also shows antimutagenic effect, which is mainly due to the inhibition of the first step of enzymatic ...
Retusin
TN2148CAS 1245-15-4
Retusin behaves as pre- and postemergent herbicides. Retusin is a weak inhibitor of ATP synthesis; it exhibits potent free-radical-scavenging capacities as well ...
Swertiajaponin
TN2246CAS 6980-25-2
Swertiajaponin possesses antimicrobial activity.
Trametenolic acid
TN2280CAS 24160-36-9
Trametenolic acid is a cytotoxic agent.It exhibits a mode of mixed inhibition with a K I of 0.9μM, K IS of 0.5μM, and an IC50 of 7.25μM.Trametenolic acid and ...
Uralenol
TN2288CAS 139163-15-8
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as s...
Viscumneoside III
TN2303CAS 118985-27-6
Viscumneoside III demonstrates high tyrosinase inhibition, it can be utilized in skin whitening cosmetics.
Benzoyloxypeoniflorin
T4S1658CAS 72896-40-3
Benzoyloxypeoniflorin is a natural product,contributes to improving blood circulation through their inhibitory effects on both platelet aggregation and blood coa...
Monobenzone
T0759CAS 103-16-2
Monobenzone is a Depigmenting Agent. The mechanism of action of monobenzone is as a Melanin Synthesis Inhibitor. The physiologic effect of monobenzone is by mean...