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Immunology/Inflammation ROS

ROS

Reactive oxygen species (ROS) are chemically reactive chemical species containing oxygen. Examples include peroxides, superoxide, hydroxyl radical, singlet oxygen, and alpha-oxygen. The reduction of molecular oxygen (O2) produces superoxide (•O−2), which is the precursor of most other reactive oxygen species.In a biological context, ROS are formed as a natural byproduct of the normal metabolism of oxygen and have important roles in cell signaling and homeostasis. However, during times of environmental stress (e.g., UV or heat exposure), ROS levels can increase dramatically.
Cat No. product name
TN6735 Bigelovin Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR p...
TN1624 Ethyl cinnamate Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
TN1104 Cyanidin-3-O-sambubioside chloride Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
TN1141 Isodeoxyelephantopin Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
TN1146 8-Prenylnaringenin 8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,
TN1241 3,8'-Biapigenin 3, 8''-Biapigenin can modulate intracellular ROS production.
TN1290 5-Galloylquinic acid 5-Galloylquinic acid as an index for the baking intensity of oolong teas. It has antioxidant activity.
TN1372 Alpha-Amyrin Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory p...
TN1425 Bacoside A3 Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
TN1449 Brandioside Brandioside shows strong antioxidant, and neuroprotective effects, it significantly attenuates glutamate-induced neurotoxicity at concentrations ranging from 0.1...
TN1465 Cannabigerol Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also ...
TN1548 Daidzin 6''-O-malonate Daidzin 6''-O-malonate may have anticancer activity.
TN1566 Delphinidin-3-sambubioside chloride Delphinidin-3-sambubioside chloride has antioxidant activity.
TN1598 Dunnianol Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
TN1654 Futoquinol Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
TN1042 Chebulic acid Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induc...
TN1674 Garcinone D Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
TN1675 Gardenin B Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
TN1721 Gypenoside L Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also i...
TN1725 Hederacolchiside E Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by b...
TN1731 Hernandezine Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
TN1821 Kaempferol 3-O-arabinoside Kaempferol-3-O-α±-D-arabinoside displays cytotoxic and high antioxidant activity.Kaempferol-3-O-arabinoside and kaempferol-3-O-glucoside can function as antiox...
TN1846 Kushenol W Kushenol W is a natural product
TN1867 Licoricidin Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
TN1910 Malvidin chloride Malvidin chloride has anti-spermatogenic, and antioxidant activities. It can prevent endothelial dysfunction by inhibiting ROS and XO-1.
TN1916 Matairesinol Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducib...
TN1918 Medicarpin Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of p...
TN1919 Medioresinol Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
TN1949 Moracin C Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
TN1067 6'-O-Galloyl paeoniflorin 6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
TN1002 Blumeatin Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity.
TN2103 PROCYANIDIN C1 Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
T6917 Oleuropein Oleuropein is an antioxidant polyphenol isolated from olive leaf.
T3621 Brigatinib Brigatinib is a highly potent and selective ALK inhibitor.
T0773 Febuxostat Febuxostat is a xanthine oxidase Inhibitor.
T3061 Lorlatinib PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
T3415 Secoisolariciresinol diglucoside Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol Diglucoside (25...
T0877 Gallic acid Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
T6376 Allopurinol Sodium Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
T1630 Tiopronin Tiopronin, a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.
T6947 Piperlongumine Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
T1363 4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 1, 2-Dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile was reported as xanthine oxidase inhibitor.
T6699 Tempol Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
T1694 Oxypurinol Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
T0692 Allopurinol Allopurinol is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
T2841 Plumbagin Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also co...
T8347 Rifamycin S Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
T2858 Baicalein Baicalein is a xanthine oxidase inhibitor.
T2397 Topiroxostat Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
T0437 Inosine Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesi...
T0875 Acetylcysteine Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
T3374 Dihydrotanshinone I Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
T4309 CIL56 CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation ...
T2864 Lycopene Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, r...
T4957 Carnosic acid Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
T5426 DMNQ DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
T5518 N-acetylcysteine amide N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
T6S1255 Ophiopogonin D Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cancer...
TQ0288 Hexahydrocurcumin Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
T8255 (±)-Catechin hydrate (±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
TN1952 Moracin P Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
TN2126 Quercetin-3-O-glucose-6''-acetate Quercetin-3-O-glucose-6''-acetate is a NADPH oxidase inhibitor, it has antioxidant capacity.
TN5264 Xanthoxyletin Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
TN4166 Griffipavixanthone Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
TN3653 Cimidahurinine Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
TN3655 Cimiside E Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
TN3719 Cristacarpin Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
TN3726 Cudraflavone B Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
TN3741 Cyclocurcumin Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rh...
TN3753 Dalbergioidin Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
TN3779 De-O-methyllasiodiplodin De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on i...
TMA0291 Dehydroglyasperin D Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
TN3872 Diosbulbin D Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.
TN3967 Epieriocalyxin A Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
TN4038 Eupatolide Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
TN4094 Gallocatechin gallate Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
TN4263 Isoangustone A Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
TN3601 Carminic acid Carminic acid, the well-known red dyestuff from cochineal insects (Dactylopius spp.), is a potent feeding deterrent to ants. Carminic acid is an antioxidant to p...
TN4286 Isodunnianol Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
TN4394 Kobophenol A Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
TN4399 Kushenol C Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
TN4435 Licopyranocoumarin Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
TN4475 Macrocarpal C Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purific...
TMA0424 Martynoside Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynosi...
TN4604 Myricanone Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
TN4675 Nortrachelogenin Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
TN4774 Physalin A Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
TN4785 Picrasidine I Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gen...
TN4872 Pyrroside B Pyrroside B shows stronger antioxidative activity than that of α-tocopherol.
TN5050 Sprengerinin C Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
TN5174 Trichosanatine Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
TN3614 Cearoin Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
TN3517 Bisacurone Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
TN2211 Silybin B Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibit...
T5016 Tofogliflozin hydrate Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
TN2217 Sophoflavescenol Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
TN2243 Sugiol Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals....
TN2250 Syringaresinol (-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation ...
T12059L Mitoquinone mesylate Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
T14545 Berberine chloride hydrate Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. It induces ...
T13538 AlbA-DCA AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A to a dichloroacetate acid subunit. It can induce a marked increase in intracellular ROS and ...
T15213 Emeramide Emeramide is a thiol-redox antioxidant. It is also a heavy metal chelator.
T10668 Camalexin Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce RO...
T15433 GSK2795039 GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
T7709 (E/Z)-GSK5182 (E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ) ...
T13351 WY-135 WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).
T13396 Zinc Protoporphyrin Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG...
T5016 Tofogliflozin hydrate Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
TN3404 Altholactone Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
T17250 W-54011 W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a...
T22318 DS-6051b DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectiv...
T2S1975 Ponicidin Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
T3834 8-Epideoxyloganic acid 8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during ...
T3S1692 Octahydrocurcumin Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
T5526 Glycoborinine Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
T9112 (-)-Perillaldehyde (-)-Perillaldehyde shows antibacterial activity.
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
TN2501 1,5,6-Trihydroxy-3-methoxyxanthone 1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
TN2511 1,6-O,O-Diacetylbritannilactone 1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
TN2545 1-Hydroxypinoresinol 1-O-glucoside (+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/...
TN2798 20-Deoxocarnosol 20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal...
TN3208 7,3',4'-Trihydroxy-3-benzyl-2H-chromene 7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor.
T3678 Entrectinib Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...
Bigelovin
TN6735CAS 3668-14-2
Bigelovin is a selective retinoid X receptor α agonist. Bigelovin suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR p...
Ethyl cinnamate
TN1624CAS 103-36-6
Ethyl cinnamate has antifungal, and vasorelaxant effects, it can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-depe...
Cyanidin-3-O-sambubioside chloride
TN1104CAS 33012-73-6
Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NF-kB activity. It inhibits the enzyme activity by competing with the substrate for the active s...
Isodeoxyelephantopin
TN1141CAS 38927-54-7
Isodeoxyelephantopin exerts antitumor effects on several cancer cells by inducing apoptosis , cell cycle arrest , and inhibiting proliferation. It enhances apopt...
8-Prenylnaringenin
TN1146CAS 53846-50-7
8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,
3,8'-Biapigenin
TN1241CAS 101140-06-1
3, 8''-Biapigenin can modulate intracellular ROS production.
5-Galloylquinic acid
TN1290CAS 53584-43-3
5-Galloylquinic acid as an index for the baking intensity of oolong teas. It has antioxidant activity.
alpha-Amyrin
TN1372CAS 638-95-9
Alpha-Amyrin is trypsin and chymotrypsin inhibitor,it has antineoplastic,it induces proliferation of human keratinocytes.Alpha-Amyrin can as a hepatomodulatory p...
Bacoside A3
TN1425CAS 157408-08-7
Bacoside A3 has antioxidant potential, it shows comparatively higher neuroprotective response analysed as higher cell viability and decreased intracellular ROS.
Brandioside
TN1449CAS 133393-81-4
Brandioside shows strong antioxidant, and neuroprotective effects, it significantly attenuates glutamate-induced neurotoxicity at concentrations ranging from 0.1...
Cannabigerol
TN1465CAS 25654-31-3
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also ...
Daidzin 6''-O-malonate
TN1548CAS 124590-31-4
Daidzin 6''-O-malonate may have anticancer activity.
Delphinidin-3-sambubioside chloride
TN1566CAS 53158-73-9
Delphinidin-3-sambubioside chloride has antioxidant activity.
Dunnianol
TN1598CAS 139726-29-7
Dunnianol, macranthol and isodunnianol have anti-inflammatory activity, they can increase NAG-1(multiple targets related to inflammation) activity 1.5-3.0 fold a...
Futoquinol
TN1654CAS 28178-92-9
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng.
Chebulic acid
TN1042CAS 23725-05-5
Chebulic acid, a phenolcarboxylic acid compound isolated from Terminalia chebula, has potent anti-oxidant activity,which breaks the cross-links of proteins induc...
Garcinone D
TN1674CAS 107390-08-9
Garcinone D shows significant cytotoxicity against the CEM-SS cell line, with IC(50) value of 3.2 microg/ml; it exhibits dose-dependent enzyme-based microsomal a...
Gardenin B
TN1675CAS 2798-20-1
Gardenin B exhibits superior antiproliferative activity against lung, breast, colon, hepatic and leukaemia cell lines as well as in keratinocytes .
Gypenoside L
TN1721CAS 94987-09-4
Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release. It also i...
Hederacolchiside E
TN1725CAS 33783-82-3
Hederacolchiside E has antioxidant activity, it shows inhibition on lipid peroxidation of linoleic acid emulsion; it may exert its anti-inflammatory effects by b...
Hernandezine
TN1731CAS 6681-13-6
Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNFα± expression/production in human macrophage cells (THP-1 and U937 lines).
Kaempferol 3-O-arabinoside
TN1821CAS 99882-10-7
Kaempferol-3-O-α±-D-arabinoside displays cytotoxic and high antioxidant activity.Kaempferol-3-O-arabinoside and kaempferol-3-O-glucoside can function as antiox...
Kushenol W
TN1846CAS 254886-76-5
Kushenol W is a natural product
Licoricidin
TN1867CAS 30508-27-1
Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
Malvidin chloride
TN1910CAS 643-84-5
Malvidin chloride has anti-spermatogenic, and antioxidant activities. It can prevent endothelial dysfunction by inhibiting ROS and XO-1.
Matairesinol
TN1916CAS 580-72-3
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducib...
Medicarpin
TN1918CAS 32383-76-9
Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of p...
Medioresinol
TN1919CAS 40957-99-1
Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in th...
Moracin C
TN1949CAS 69120-06-5
Moracin C and D, new phytoalexins from diseased mulberry, are antifungal compounds.
6'-O-Galloyl paeoniflorin
TN1067CAS 122965-41-7
6'-O-Galloylpaeoniflorin (GPF) may be developed as a cytoprotector against ROS-mediated oxidative stress
Blumeatin
TN1002CAS 118024-26-3
Blumeatin has antioxidant properties, free radical scavenging activity,and has xanthine oxidase (XO) inhibitory activity.
PROCYANIDIN C1
TN2103CAS 37064-30-5
Procyanidin C1 is a natural product, with anti-inflammatory effects, and induces apoptosis.
Oleuropein
T6917CAS 32619-42-4
Oleuropein is an antioxidant polyphenol isolated from olive leaf.
Brigatinib
T3621CAS 1197953-54-0
Brigatinib is a highly potent and selective ALK inhibitor.
Febuxostat
T0773CAS 144060-53-7
Febuxostat is a xanthine oxidase Inhibitor.
Lorlatinib
T3061CAS 1454846-35-5
PF-06463922 is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene 1 (Ros1), wit...
Secoisolariciresinol diglucoside
T3415CAS 148244-82-0
Secoisolariciresinol Diglucoside was cytoprotective in an in vitro model of iron overload-induced redox-inflammatory damage. Secoisolariciresinol Diglucoside (25...
Gallic acid
T0877CAS 149-91-7
Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.
Allopurinol Sodium
T6376CAS 17795-21-0
Allopurinol Sodium is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.
Tiopronin
T1630CAS 1953-02-2
Tiopronin, a sulfhydryl acylated derivative of glycine, leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation.
Piperlongumine
T6947CAS 20069-09-4
Piperlongumine is a natural alkaloid from Piper longum L. It selectively kills cancer cells and strengthens the level of reactive oxygen species (ROS).
4-Methoxy-2-oxo-1,2-dihydro-pyridine-3-carbonitrile
T1363CAS 21642-98-8
1, 2-Dihydro-4-methoxy-2-oxo-3-pyridinecarbonitrile was reported as xanthine oxidase inhibitor.
Tempol
T6699CAS 2226-96-2
Tempol is a superoxide scavenger. It has anti-inflammatory, neuroprotective and analgesic effects.
Oxypurinol
T1694CAS 2465-59-0
Oxipurinol is a xanthine oxidase inhibitor. Oxipurinol is potentially used for the treatment of congestive heart failure.
Allopurinol
T0692CAS 315-30-0
Allopurinol is a Xanthine Oxidase Inhibitor. The mechanism of action of allopurinol is as a Xanthine Oxidase Inhibitor.
Plumbagin
T2841CAS 481-42-5
Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also co...
Rifamycin S
T8347CAS 13553-79-2
Rifamycin S is a potent DNA-dependent RNA polymerase inhibitor,is a quinone and an antibiotic agnet against Gram-positive bacteria
Baicalein
T2858CAS 491-67-8
Baicalein is a xanthine oxidase inhibitor.
Topiroxostat
T2397CAS 577778-58-6
Topiroxostat is a selective xanthine oxidase inhibitor developed for treatment and management of hyperuricemia and gout.
Inosine
T0437CAS 58-63-9
Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesi...
Acetylcysteine
T0875CAS 616-91-1
Acetylcysteine is the N-acetyl derivative of CYSTEINE. It is used as a mucolytic agent to reduce the viscosity of mucous secretions. It has also been shown to ha...
Dihydrotanshinone I
T3374CAS 87205-99-0
Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
CIL56
T4309CAS 300802-28-2
CIL56 is a small molecule that induces cellular ferroptosis through the production of iron-dependent reactive oxygen species (ROS). It also induces accumulation ...
Lycopene
T2864CAS 502-65-8
Lycopene is a linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, r...
Carnosic acid
T4957CAS 3650-09-7
Carnosic acid is a lipid absorption inhibitor, endowed with antioxidative, antimicrobial, photoprotective potential, and antiproliferative properties.
DMNQ
T5426CAS 6956-96-3
DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS...
N-acetylcysteine amide
T5518CAS 38520-57-9
N-Acetylcysteine amide is a cell membranes and blood brain barrier permeant thiol antioxidant and neuroprotective agent
Ophiopogonin D
T6S1255CAS 41753-55-3
Ophiopogonin D(OPD) significantly inhibited the in vitro and in vivo growth of prostate cells via RIPK1, OPD may be developed as a potential anti-prostate cancer...
Hexahydrocurcumin
TQ0288CAS 36062-05-2
Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
(±)-Catechin hydrate
T8255CAS 7295-85-4
(±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
Moracin P
TN1952CAS 102841-46-3
Moracin P exhibits potent in vitro inhibitory activity against hypoxia-inducible factor (HIF-1), which is a key mediator during adaptation of cancer cells to tum...
Quercetin-3-O-glucose-6''-acetate
TN2126CAS 54542-51-7
Quercetin-3-O-glucose-6''-acetate is a NADPH oxidase inhibitor, it has antioxidant capacity.
Xanthoxyletin
TN5264CAS 84-99-1
Xanthoxyletin shows potent antibacterial, fungicidal, and algicidal properties, it also has anticancer, and anti-inflammatory activities. It shows an inhibitory ...
Griffipavixanthone
TN4166CAS 219649-95-3
Griffipavixanthone inhibits the growth of human Non-small-cell lung cancer H520 cells in dose- and time-dependent manners, it induces cell apoptosis through mito...
Cimidahurinine
TN3653CAS 142542-89-0
Cimidahurinine can attenuate Doxorubicin (DOX)-induced cardiotoxicity in a dose-dependent manner with EC50 values of 45.79 uM; it protects against cardiotoxicity...
Cimiside E
TN3655CAS 154822-57-8
Cimiside E has anti-inflammatory activity, it selectively inhibits TNF-α-induced expression of VCAM-1 at least by upregulation of PPAR-γ, and signals for ERK1/...
Cristacarpin
TN3719CAS 74515-47-2
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
Cudraflavone B
TN3726CAS 19275-49-1
Cudraflavone B has anti-proliferative activity, mouse brain monoamine oxidase (MAO) inhibitory effects, apoptotic actions in human gastric carcinoma cells and mo...
Cyclocurcumin
TN3741CAS 153127-42-5
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rh...
Dalbergioidin
TN3753CAS 30368-42-4
Dalbergioidin exhibits tyrosinase inhibitory activity with an IC50 of 20 mM. It shows a melanin biosynthesis inhibition zone in the culture plate of Streptomyces...
De-O-methyllasiodiplodin
TN3779CAS 32885-82-8
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on i...
Dehydroglyasperin D
TMA0291CAS 517885-72-2
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 h...
Diosbulbin D
TN3872CAS 66756-57-8
Diosbulbin D shows direct toxic effect on hepatocytes, the mechanism could be associated with oxidative stress.
Epieriocalyxin A
TN3967CAS 191545-24-1
Epieriocalyxin A can suppress Caco-2 colon cancer cell growth, it could be a potential drug for colon cancer therapy in the future.
Eupatolide
TN4038CAS 6750-25-0
Eupatolide has anti-inflammatory activity, it inhibits lipopolysaccharide-induced COX-2 and iNOS expression in RAW264.7 cells by inducing proteasomal degradation...
Gallocatechin gallate
TN4094CAS 5127-64-0
Gallocatechin gallate has strong antioxidative, and anti-obesity activities, it inhibits 3T3-L1 differentiation and lipopolysaccharide induced inflammation throu...
Isoangustone A
TN4263CAS 129280-34-8
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
Carminic acid
TN3601CAS 1260-17-9
Carminic acid, the well-known red dyestuff from cochineal insects (Dactylopius spp.), is a potent feeding deterrent to ants. Carminic acid is an antioxidant to p...
Isodunnianol
TN4286CAS 139726-30-0
Isodunnianol exhibits anti-AChE activity with an IC50 value of 13.0 uM; it also exhibits neurite outgrowth-promoting activity at the concentration ranging from 0...
Kobophenol A
TN4394CAS 124027-58-3
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cell...
Kushenol C
TN4399CAS 99119-73-0
Kushenol C is a good 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenger, and it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2)....
Licopyranocoumarin
TN4435CAS 117038-80-9
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane...
Macrocarpal C
TN4475CAS 142628-53-3
Macrocarpal C, isolated from the fresh leaves of Eucalyptus globulus Labill. (Lan An) and identified as its major antifungal component by bioassay-guided purific...
Martynoside
TMA0424CAS 67884-12-2
Martynoside is a natural selective estrogen receptor modulator, which has antioxidative, anti-muscle fatigue, anticancer and antimetastatic activities. Martynosi...
Myricanone
TN4604CAS 32492-74-3
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Nortrachelogenin
TN4675CAS 34444-37-6
Nortrachelogenin is a novel agent for prostate cancer therapy with ability to inhibit Akt membrane localization and activity as well as the activation of growth ...
Physalin A
TN4774CAS 23027-91-0
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate canc...
Picrasidine I
TN4785CAS 100234-59-1
Picrasidine I has antiosteoclastogenic effect by inhibiting inflammation induced activation of MAPKs, NF-κB and ROS generation followed by suppressing the gen...
Pyrroside B
TN4872CAS 116271-35-3
Pyrroside B shows stronger antioxidative activity than that of α-tocopherol.
Sprengerinin C
TN5050CAS 88861-91-0
Sprengerinin C exerts anti-tumorigenic effects in hepatocellular carcinoma via inhibition of proliferation and angiogenesis and induction of apoptosis, it can st...
Trichosanatine
TN5174CAS 169626-16-8
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
Cearoin
TN3614CAS 52811-37-7
Cearoin has anti-inflammatory, and antiallergic activities, it can markedly inhibit inflammatory responses including LPS-induced NO production by suppressing the...
Bisacurone
TN3517CAS 120681-81-4
Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressi...
Silybin B
TN2211CAS 142797-34-0
Silybin B and silybin A are potent inhibitors of both raloxifene 4'- and 6-glucuronidation in all enzyme systems; they show strong effects on cell growth inhibit...
Tofogliflozin hydrate
T5016CAS 1201913-82-7
Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
Sophoflavescenol
TN2217CAS 216450-65-6
Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , the...
Sugiol
TN2243CAS 511-05-7
Sugiol has antioxidant efficacy, it has significant scavenging activities of 1,1-diphenyl-2-picryl hydrazyl, nitric oxide, superoxide and hydroxyl free radicals....
Syringaresinol
TN2250CAS 487-35-4
(-)-Syringaresinol may be a potential chemotherapeutic agent for the treatment of cancer; it against H/R-induced cardiomyocyte injury and death, the degradation ...
Mitoquinone mesylate
T12059LCAS 845959-50-4
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant to protect against oxidative damage.
Berberine chloride hydrate
T14545CAS 68030-18-2
Berberine chloride hydrate (Natural Yellow 18 chloride hydrate) is an alkaloid isolated from the Chinese herbal medicine Huanglian, as an antibiotic. It induces ...
AlbA-DCA
T13538CAS T13538
AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A to a dichloroacetate acid subunit. It can induce a marked increase in intracellular ROS and ...
Emeramide
T15213CAS 351994-94-0
Emeramide is a thiol-redox antioxidant. It is also a heavy metal chelator.
Camalexin
T10668CAS 135531-86-1
Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce RO...
GSK2795039
T15433CAS 1415925-18-6
GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption. GSK2795039 decreases apoptosis. GSK2795039 is an inhibitor of NADPH oxidase 2...
(E/Z)-GSK5182
T7709CAS T7709
(E/Z)-GSK5182 is a racemic compound of (E)-GSK5182 and (Z)-GSK5182 isomers. GSK5182 is a highly selective and orally active estrogen-related receptor γ (ERRγ) ...
WY-135
T13351CAS 2163060-83-9
WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).
Zinc Protoporphyrin
T13396CAS 15442-64-5
Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG...
Tofogliflozin hydrate
T5016CAS 1201913-82-7
Tofogliflozin hydrate is a potent and highly specific inhibitor of SGLT2(IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SG...
Altholactone
TN3404CAS 65408-91-5
Altholactone may be a potential antimicrobial agent, particularly in ciprofloxacin-refractory S. aureus and E. faecalis infections. It can inhibit the growth of ...
W-54011
T17250CAS 405098-33-1
W-54011 is a potent non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils (Ki: 2.2 nM). W-54011 inhibits C5a...
DS-6051b
T22318CAS 1505515-69-4
DS-6051b is a new-generation selective inhibitor of ROS1/NTRK including ROS1,NTRK1,NTRK2 and NTRK3 with IC50 of 0.207 nM,0.622 nM,2.28 nM and 0.980 nM, respectiv...
Ponicidin
T2S1975CAS 52617-37-5
Ponicidin has anti-leukemia, immunoregulatory and anti-inflammatory functions, it also has anti-viral function especially in the upper respiratory tract infectio...
8-Epideoxyloganic acid
T3834CAS 88668-99-9
8-Epideoxyloganic acid possesses bioactivities of analgesia, homeostasis and anti-inflammatory. It has the potential to serve as anti-inflammatory agents during ...
Octahydrocurcumin
T3S1692CAS 36062-07-4
Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechani...
Glycoborinine
T5526CAS 233279-39-5
Glycoborinine is a potential molecule against cancer cells, it can induce HepG2 apoptosis through the mitochondrial-dependent pathway. Glycoborinine has photo-ac...
(-)-Perillaldehyde
T9112CAS 18031-40-8
(-)-Perillaldehyde shows antibacterial activity.
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
1,5,6-Trihydroxy-3-methoxyxanthone
TN2501CAS 50868-52-5
1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
1,6-O,O-Diacetylbritannilactone
TN2511CAS 1286694-67-4
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airwa...
1-Hydroxypinoresinol 1-O-glucoside
TN2545CAS 81495-71-8
(+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/...
20-Deoxocarnosol
TN2798CAS 94529-97-2
20-Deoxocarnosol has antioxidant activity of measuring the decay of the radical cation diphenyl-picrylhydrazyl (DPPH).It also exhibits non-specific antiprotozoal...
7,3',4'-Trihydroxy-3-benzyl-2H-chromene
TN3208CAS 1111897-60-9
7,3',4'-Trihydroxy-3-benzyl-2H-chromene is a potential xanthine oxidase inhibitor.
Entrectinib
T3678CAS 1108743-60-7
Entrectinib is an inhibitor of TrkA (IC50: 1.7 nM), TrkB (IC50: 0.1 nM), and TrkC (IC50: 0.1 nM), as well as anaplastic lymphoma kinase (ALK; IC50: 1.6 nM) and C...